The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
1,25-Dihydroxyvitamin D 3 Increases In Vitro Vascular Calcification by Modulating Secretion of Endogenous Parathyroid Hormone–Related Peptide
Abstract
Background —A significant association between vascular calcification and osteoporosis has been noted, suggesting that calcium homeostasis is important in vascular calcification as well as in osteoporosis. Moreover, results of our previous studies suggest that calcium-regulating hormones such as parathyroid hormone–related peptide (PTHrP) may modulate vascular calcification. Therefore, we hypothesized that 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] may have a direct impact on the calcium-regulating system of vascular smooth muscle cells, resulting in deposition of calcium in vascular wall. Methods and Results —We investigated the effect of 1,25(OH) 2 D 3 on in vitro calcification by bovine vascular smooth muscle cells (BVSMCs). 1,25(OH) 2 D 3 dose dependently increased BVSMC calcification and alkaline phosphatase activity. 1,25(OH) 2 D 3 also decreased secretion of PTHrP by BVSMCs in a dose-dependent manner and depressed its gene expression. Furthermore, exogenous PTHrP (fragment 1-34) antagonized the stimulatory effect of 1,25(OH) 2 D 3 on BVSMCs. Finally, 1,25(OH) 2 D 3 dose dependently increased the expression of the osteopontin gene, one of the bone matrix proteins in BVSMCs, contributing to its stimulatory action on BVSMC calcification. Conclusions —These data suggest that 1,25(OH) 2 D 3 exerts a stimulatory effect on vascular calcification through direct inhibition of the expression of PTHrP in BVSMCs as an endogenous inhibitor of vascular calcification. Moreover, the stimulatory effects of 1,25(OH) 2 D 3 on alkaline phosphatase activity and osteopontin expression may contribute to its promoting action in vascular calcification.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vitamin D3and Calcium to Prevent Hip Fractures in Elderly Women
Chapuy, M. C., Arlot, M. E., Duboeuf, F., Brun, J., Crouzet, B., Arnaud, S., Delmas, P. D., & Meunier, P. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212033272305 · Cited by 2,950
Riggs, B. L., & Melton, L. J. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606263142605 · Cited by 1,915
Bone morphogenetic protein expression in human atherosclerotic lesions.
Boström, K., Watson, K. E., Horn, S., Wortham, C., Herman, I. M., & Demer, L. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116391 · Cited by 1,020
Giachelli, C. M., Bae, N., Almeida, M., Denhardt, D. T., Alpers, C. E., & Schwartz, S. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116755 · Cited by 641
High expression of genes for calcification-regulating proteins in human atherosclerotic plaques.
Shanahan, C. M., Cary, N. R., Metcalfe, J. C., & Weissberg, P. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117246 · Cited by 611
Active Serum Vitamin D Levels Are Inversely Correlated With Coronary Calcification
Watson, K. E., Abrolat, M. L., Malone, L. L., Hoeg, J. M., Doherty, T., Detrano, R., & Demer, L. L. (1997) · Circulation · doi:10.1161/01.cir.96.6.1755 · Cited by 482
Noda, M., Vogel, R. L., Craig, A. M., Prahl, J., DeLuca, H. F., & Denhardt, D. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9995 · Cited by 464
TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.
Watson, K. E., Boström, K., Ravindranath, R., Lam, T., Norton, B., & Demer, L. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117205 · Cited by 460
Diffuse calcification in human coronary arteries. Association of osteopontin with atherosclerosis.
Fitzpatrick, L. A., Severson, A., Edwards, W. D., & Ingram, R. T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117501 · Cited by 359
OWEN, T. A., ARONOW, M. S., BARONE, L. M., BETTENCOURT, B., STEIN, G. S., & LIAN, J. B. (1991) · Endocrinology · doi:10.1210/endo-128-3-1496 · Cited by 347
Cited by
Vascular Calcification: The Killer of Patients with Chronic Kidney Disease
Mizobuchi, M., Towler, D., & Slatopolsky, E. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008070692 · Cited by 542
Pathophysiology of Vascular Calcification in Chronic Kidney Disease
Moe, S. M., & Chen, N. X. (2004) · Circulation Research · doi:10.1161/01.res.0000141775.67189.98 · Cited by 502
Somjen, D., Weisman, Y., Kohen, F., Gayer, B., Limor, R., Sharon, O., Jaccard, N., Knoll, E., & Stern, N. (2005) · Circulation · doi:10.1161/01.cir.0000160353.27927.70 · Cited by 366
Shoji, T., Shinohara, K., Kimoto, E., Emoto, M., Tahara, H., Koyama, H., Inaba, M., Fukumoto, S., Ishimura, E., Miki, T., et al. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg513 · Cited by 351
Self-citationUremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels
Moe, S. M., Duan, D., Doehle, B. P., O'Neill, K. D., & Chen, N. X. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00820.x · Cited by 321
Metadata
- Authors
- Jono, S., Nishizawa, Y., Shioi, A., & Morii, H.
- Venue
- Circulation
- Published
- 1998-09-29
- Volume
- 98
- Issue
- 13
- Pages
- 1302-1306
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2164591127
- Cited by
- 294
- References
- 30
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: 1,25-Dihydroxyvitamin D 3 Increases In Vitro Vascular Calcification by Modulating Secretion of Endogenous Parathyroid Hormone–Related Peptide. https://app.cochat.ai/papers/10.1161/01.cir.98.13.1302
- The paper
- Jono, S., Nishizawa, Y., Shioi, A., & Morii, H. (1998). 1,25-Dihydroxyvitamin D 3 Increases In Vitro Vascular Calcification by Modulating Secretion of Endogenous Parathyroid Hormone–Related Peptide. Circulation. https://doi.org/10.1161/01.cir.98.13.1302
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
