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Cited by 720

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Prognostic Value of Nocturnal Cheyne-Stokes Respiration in Chronic Heart Failure

Open access
Lanfranchi, Paola A., Braghiroli, Alberto, Bosimini, Enzo, Mazzuero, Giorgio, Colombo, Roberto, Donner, Claudio F., Giannuzzi, Pantaleo·1999·Circulation
DOI 10.1161/01.cir.99.11.1435
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Abstract

Background —Nocturnal Cheyne-Stokes respiration (CSR) occurs frequently in patients with chronic heart failure (CHF), and it may be associated with sympathetic activation. The aim of the present study was to evaluate whether CSR could affect prognosis in patients with CHF. Methods and Results —Sixty-two CHF patients with left ventricular ejection fraction ≤35%, in NYHA class II to III, underwent clinical evaluation, Doppler echocardiography, ergospirometry, phenylephrine test, Holter recording, and a sleep study to evaluate the occurrence of CSR, expressed as percentage of periodic breathing, and apnea/hypopnea index (AHI) (ie, the number of apneas and hypopneas per hour of recording). During a mean follow-up of 28±13 months, 15 patients died of cardiac causes. Nonsurvivors were in a higher NYHA functional class than survivors ( P <0.001) and had a more depressed left ventricular ejection fraction ( P <0.03), a shorter deceleration time of early filling ( P <0.05), larger left and right atria ( P <0.05 and P <0.02, respectively) and a lower peak V̇ o 2 ( P <0.05). Nonsurvivors also spent a greater percentage of the night in periodic breathing ( P <0.01) with a greater AHI ( P <0.03) and showed lower values of diurnal baroreflex sensitivity ( P <0.05) and of heart rate variability (sdNN: P <0.01). Multivariate analysis revealed the AHI (χ 2 , 10.4; P <0.01), followed by left atrial area (χ 2 , 5.7; P <0.01), as the only independent and additional predictors of subsequent cardiac death. Patients at very high risk for fatal outcome could be identified by an AHI ≥30/h and left atria ≥25 cm 2 . Conclusions —The AHI is a powerful independent predictor of poor prognosis in clinically stable patients with CHF. The presence of an AHI ≥30/h adds prognostic information compared with other clinical, echocardiographic, and autonomic data and identifies patients at very high risk for subsequent cardiac death.

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Metadata

Authors
Lanfranchi, P. A., Braghiroli, A., Bosimini, E., Mazzuero, G., Colombo, R., Donner, C. F., & Giannuzzi, P.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-03-23
Volume
99
Issue
11
Pages
1435-1440
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.99.11.1435
OpenAlex
W2104435385
Cited by
720
References
25
FWCI
7.27
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Prognostic Value of Nocturnal Cheyne-Stokes Respiration in Chronic Heart Failure. https://app.cochat.ai/papers/10.1161/01.cir.99.11.1435
The paper
Lanfranchi, P. A., Braghiroli, A., Bosimini, E., Mazzuero, G., Colombo, R., Donner, C. F., & Giannuzzi, P. (1999). Prognostic Value of Nocturnal Cheyne-Stokes Respiration in Chronic Heart Failure. Circulation. https://doi.org/10.1161/01.cir.99.11.1435

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.