The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Angiogenesis Inhibitors Endostatin or TNP-470 Reduce Intimal Neovascularization and Plaque Growth in Apolipoprotein E–Deficient Mice
Open accessAbstract
Background —Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the progression of atherosclerosis is unknown. In this report, we first demonstrate that intimal vessels occur in advanced lesions of apolipoprotein E–deficient (apoE −/−) mice. To test the hypothesis that intimal vessels promote atherosclerosis, we investigated the effect of angiogenesis inhibitors on plaque growth in apoE −/− mice. Methods and Results —ApoE −/− mice were fed a 0.15% cholesterol diet. At age 20 weeks, mice were divided into 3 groups and treated for 16 weeks as follows: group 1, recombinant mouse endostatin, 20 mg · kg −1 · d −1 ; group 2, fumagillin analogue TNP-470, 30 mg/kg every other day; and group 3, control animals that received a similar volume of buffer. Average cholesterol levels were similar in all groups. Plaque areas were quantified at the aortic origin. Median plaque area before treatment was 0.250 mm 2 (range, 0.170 to 0.348; n=10). Median plaque areas were 0.321 (0.238 to 0.412; n=10), 0.402 (0.248 to 0.533; n=15), and 0.751 mm 2 (0.503 to 0.838; n=12) for the endostatin, TNP-470, and control groups, respectively ( P ≤0.0001). Therefore, endostatin and TNP-470 inhibited plaque growth during the treatment period by 85% and 70%. Intimal smooth muscle cell contents of plaques from control and treated mice were similar. Conclusions —Prolonged treatment with either angiogenesis inhibitor reduced plaque growth and intimal neovascularization in apoE −/− mice. Although the mechanism of plaque inhibition induced by these agents is not established, these results suggest that intimal neovascularization may promote plaque development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Small-molecule drugs like the fumagillin analogue TNP-470, endostatin or angiostatin reduced plaque angiogenesis and inhibited advanced atherosclerosis in APOE-knockout mice after prolonged treatment for 16 weeks105,106.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [105]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Self-citationGalis, Z. S., Sukhova, G. K., Lark, M. W., & Libby, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117619 · Cited by 2,537
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Boehm, T., Folkman, J., Browder, T., & O'Reilly, M. S. (1997) · Nature · doi:10.1038/37126 · Cited by 1,683
Self-citationSynthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
Ingber, D. E., Fujita, T., KISHIMOTO, S., Sudo, K., KANAMARU, T., Brem, H., & Folkman, J. (1990) · Nature · doi:10.1038/348555a0 · Cited by 1,301
Self-citationQuantitative assessment of atherosclerotic lesions in mice
Paigen, B. J., Morrow, A., Holmes, P. A., Mitchell, D., & Williams, R. A. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90202-4 · Cited by 952
Hypothesis: Vasa Vasorum and Neovascularization of Human Coronary Arteries
Barger, A. C., Beeuwkes, R., Lainey, L. L., & Silverman, K. (1984) · New England Journal of Medicine · doi:10.1056/nejm198401193100307 · Cited by 850
Activated macrophages induce vascular proliferation
Polverini, P. J., Cotran, R. S., Gimbrone, M. A., & Unanue, E. R. (1977) · Nature · doi:10.1038/269804a0 · Cited by 805
A Lamellar Unit of Aortic Medial Structure and Function in Mammals
Wolinsky, H., & Glagov, S. K. (1967) · Circulation Research · doi:10.1161/01.res.20.1.99 · Cited by 751
Sin, N., Meng, L., Wang, M. Q. W., Wen, J., Bornmann, W. G., & Crews, C. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6099 · Cited by 634
Flagged first, then by citations
Research works printed but not linked: 9
- Koester W. Endarteritis and arteritis. Berl Klin Wochenschr. 1876;13:454–455.
- 10.1161/circ.93.4.672 · DOI
- Paterson JC. Capillary rupture with intimal hemorrhage as a causative factor in coronary thrombosis. Arch Pathol. 1938;25:474–487.
- 10.1161/atv91.14.4.7511933 · DOI
- 10.1161/atv91.14.1.8274468 · DOI
- 10.1161/res.20.1.99 · DOI
- 10.1161/res.79.4.757 · DOI
- Abe J, Zhou W, Takuwa N, Taguchi J, Kurokawa K, Kumada M, Takuwa Y. A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product in vascular endothelial cells. Cancer Res. 1994;54:3407–3412.
- Couffinhal T, Kearney M, Witzenbichler B, Chen D, Murohara T, Losordo DW, Symes J, Isner JM. VEGF(VPF) in normal and atherosclerotic human arteries. Am J Pathol. 1997;150:1673–1685.
Cited by
Sorted by citations
Items 101–105 of 105
Hilfiker, A., Hilfiker-Kleiner, D., Fuchs, M., Kaminski, K., Lichtenberg, A., Rothkötter, H.-J., Schieffer, B., & Drexler, H. (2002) · Circulation · doi:10.1161/01.cir.0000021426.87274.62 · Cited by 114
Jain, R. K., Finn, A. V., Kolodgie, F. D., Gold, H. K., & Virmani, R. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0979 · Cited by 117
Elimination of Neoangiogenesis for Plaque Stabilization
Kolodgie, F. D., Narula, J., Yuan, C., Burke, A. P., Finn, A. V., & Virmani, R. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.083 · Cited by 96
Targeting vasa vasorum dysfunction to prevent atherosclerosis
Boyle, E. C., Sedding, D. G., & Haverich, A. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.08.003 · Cited by 60
CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model
Matsumae, H., Yoshida, Y., Ono, K., Togi, K., Inoue, K., Furukawa, Y., Nakashima, Y., Kojima, Y., Nobuyoshi, M., Kita, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.162362 · Cited by 59
Metadata
- Authors
- Moulton, K. S., Heller, E., Konerding, M. A., Flynn, E., Palinski, W., & Folkman, J.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Circulation
- Published
- 1999-04-06
- Volume
- 99
- Issue
- 13
- Pages
- 1726-1732
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2152639592
- Cited by
- 688
- References
- 26
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 10 · 2022: 15 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 10 · 2017: 21 · 2016: 20 · 2015: 17 · 2014: 23 · 2013: 21 · 2012: 19
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5k11hl002563-06)
- National Heart, Lung, and Blood Institute (K11-HL02563)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cerebrovascular and Carotid Artery Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- angiogenesis inhibitors, endostatin, TNP-470, atherosclerotic plaque growth, ApoE-deficient mice, atherosclerosis progression, smooth muscle cells, cholesterol diet
- MeSH terms
- O-(Chloroacetylcarbamoyl)fumagillol, Animals, Aorta, Thoracic, Apolipoproteins E, Cell Count, Cell Division, Collagen, Cyclohexanes, Male, Muscle, Smooth, Vascular, Neovascularization, Pathologic, Peptide Fragments, Sesquiterpenes, Time Factors, Tunica Intima, Mice, Knockout, Endostatins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
