Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization
Abstract
Angiogenesis within human atherosclerotic plaques has an important role in plaque progression as immature blood vessels leak red blood cells and inflammatory mediators into the plaque center. Accumulation of free cholesterol from red blood cell membranes potentially increases the size of the necrotic core and triggers a chain of events that promote plaque destabilization. Antiangiogenic agents have been shown to prune some tumor vessels and 'normalize' the structure and function of the remaining vasculature, thereby improving the access of chemotherapeutic agents to tumors. We propose that antiangiogenic therapy can similarly stabilize vulnerable 'rupture-prone' plaques by pruning and normalizing immature intraplaque vessels, preventing further intraplaque hemorrhage. This normalization would limit necrotic core enlargement, further luminal narrowing and the degree of inflammation. Such normalization has been realized using vascular endothelial growth factor antagonists for the treatment of cancer and age-related macular degeneration. The development of this novel approach to prevent plaque progression might add to the armamentarium of preventive measures for acute myocardial infarction, stroke and sudden cardiac death.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Anti-angiogenic agents are a drug class currently under investigation for the stabilization of atherosclerotic plaques.
“Anti-angiogenic agents are another drug class currently under investigation for the stabilization of atherosclerotic plaques26,104.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [104]
Cites
Tumor angiogenesis: therapeutic implications
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,857 · see citing works
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070 · see citing works
Self-citationNormalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 1× · see citing works
“From Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.”
BackgroundSelf-citationVirmani, R., Kolodgie, F. D., Burke, A. P., Farb, A., & Schwartz, S. M. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.5.1262 · Cited by 4,084 · see citing works
Self-citationYang, J. C., Haworth, L. R., Sherry, R. M., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Steinberg, S. M., Chen, H. X., & Rosenberg, S. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021491 · Cited by 2,681 · see citing works
Transplacental Carcinogenesis by Stilbestrol
Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640 · see citing works
Molecular regulation of vessel maturation
Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,515 · see citing works
Self-citationPegaptanib for neovascular age-related macular degeneration
Gragoudas, E. S., Adamis, A. P., Cunningham, E. T., Feinsod, M., & Guyer, D. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042760 · Cited by 2,337 · see citing works
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
Jain, R. K. (2001) · Nature Medicine · doi:10.1038/nm0901-987 · Cited by 2,184 · see citing works
Self-citationWillett, C. G., Boucher, Y., di Tomaso, E., Duda, D. G., Munn, L. L., Tong, R. T., Chung, D. C., Sahani, D. V., Kalva, S. P., Kozin, S. V., et al. (2004) · Nature Medicine · doi:10.1038/nm988 · Cited by 1,966 · see citing works
Self-citationBatchelor, T. T., Sorensen, A. G., di Tomaso, E., Zhang, W.-T., Duda, D. G., Cohen, K. S., Kozak, K. R., Cahill, D. P., Chen, P.-J., Zhu, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.021 · Cited by 1,769 · see citing works
Self-citationCoronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly
BURKE, A. P., Farb, A. A., Malcom, G. T., Liang, Y.-H., Smialek, J. E., & Virmani, R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705013361802 · Cited by 1,739 · see citing works
Self-citationIntraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., BURKE, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A. A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,491 · see citing works
Self-citationAtherosclerotic Plaque Progression and Vulnerability to Rupture
Virmani, R., Kolodgie, F. D., BURKE, A. P., Finn, A. V., Gold, H. K., Tulenko, T. N., Wrenn, S. P., & Narula, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000178991.71605.18 · Cited by 1,326 · see citing works
Self-citationAiello, L. P., Pierce, E. A., Foley, E. D., Takagi, H., Chen, H., Riddle, L. M., Ferrara, N., King, G. L., & Smith, L. E. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10457 · Cited by 1,258 · see citing works
Tong, R. T., Boucher, Y., Kozin, S. V., Winkler, F., Hicklin, D. J., & Jain, R. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0074 · Cited by 1,189 · see citing works
Self-citationKinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation
Winkler, F., Kozin, S. V., Tong, R. T., Chae, S.-S., Booth, M. F., Garkavtsev, I., Xu, L., Hicklin, D. J., Fukumura, D., di Tomaso, E., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.011 · Cited by 1,170 · see citing works
Self-citationImmune mechanisms in atherosclerosis.
Hansson, G. K., Jonasson, L., Seifert, P. S., & Stemme, S. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.5.567 · Cited by 1,169 · see citing works
Luttun, A., Tjwa, M., Moons, L., Wu, Y. L., Angelillo‐Scherrer, A., Liao, F., Nagy, J. A., Hooper, A. T., Priller, J., Klerck, B. D., et al. (2002) · Nature Medicine · doi:10.1038/nm731 · Cited by 1,067 · see citing works
Lessons from phase III clinical trials on anti-VEGF therapy for cancer
Jain, R. K., Duda, D. G., Clark, J. W., & Loeffler, J. S. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0403 · Cited by 1,039 · see citing works
Self-citationHealed Plaque Ruptures and Sudden Coronary Death
BURKE, A. P., Kolodgie, F. D., Farb, A. A., Weber, D. K., Malcom, G. T., Smialek, J. E., & Virmani, R. (2001) · Circulation · doi:10.1161/01.cir.103.7.934 · Cited by 922 · see citing works
Self-citationImmune Mechanisms in Atherosclerosis
Hansson, G. K. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100220 · Cited by 873 · see citing works
FERRARA, N., DAMICO, L., SHAMS, N., LOWMAN, H., & KIM, R. (2006) · Retina · doi:10.1097/01.iae.0000242842.14624.e7 · Cited by 849 · see citing works
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
Kamba, T., Tam, B. Y. Y., Hashizume, H., Haskell, A., Sennino, B., Mancuso, M. R., Norberg, S. M., O’Brien, S., Davis, R. B., Gowen, L. C., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00133.2005 · Cited by 773 · see citing works
Inai, T., Mancuso, M. R., Hashizume, H., Baffert, F., Haskell, A., Bałuk, P., Hu‐Lowe, D. D., Shalinsky, D. R., Thurston, G., Yancopoulos, G. D., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63273-7 · Cited by 759 · see citing works
Shah, P. K., Falk, E., Badimón, J. J., Fernández‐Ortíz, A., Mailhac, A. C., Villareal-Levy, G., Fallon, J. T., Regnström, J., & Fuster, V. (1995) · PubMed · Cited by 722 · see citing works
Moulton, K. S., Heller, E., Konerding, M. A., Flynn, E., Palinski, W., & Folkman, J. (1999) · Circulation · doi:10.1161/01.cir.99.13.1726 · Cited by 688 · see citing works
Statins Have Biphasic Effects on Angiogenesis
Weis, M., Heeschen, C., Glassford, A. J., & Cooke, J. P. (2002) · Circulation · doi:10.1161/hc0602.103393 · Cited by 677 · see citing works
Plaque Neovascularization Is Increased in Ruptured Atherosclerotic Lesions of Human Aorta
Moreno, P., Purushothaman, K., Fuster, V., Echeverri, D., Truszczynska, H., Sharma, S. K., Badimón, J. J., & O’Connor, W. N. (2004) · Circulation · doi:10.1161/01.cir.0000143233.87854.23 · Cited by 632 · see citing works
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
Vlodavsky, I., & Friedmann, Y. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13662 · Cited by 619 · see citing works
O’Brien, K. D., McDonald, T. O., Chait, A., Allen, M. D., & Alpers, C. E. (1996) · Circulation · doi:10.1161/01.cir.93.4.672 · Cited by 573 · see citing works
Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic Plaques
Takaya, N., Yuan, C., Chu, B., Saam, T., Polissar, N. L., Jarvik, G. P., Isaac, C. A., McDonough, J., Natiello, C., Small, R., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.504167 · Cited by 562 · see citing works
Fung, A. E., Rosenfeld, P. J., & Reichel, E. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.099598 · Cited by 535 · see citing works
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
Verheul, H. M. W., & Pinedo, H. M. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2152 · Cited by 498 · see citing works
Neovascularization in Human Atherosclerosis
Moreno, P., Purushothaman, K., Sirol, M., Levy, A. P., & Fuster, V. (2006) · Circulation · doi:10.1161/circulationaha.105.578955 · Cited by 494 · see citing works
Philippidis, P., Mason, J. C., Evans, B. J., Nadra, I., Taylor, K. M., Haskard, D. O., & Landis, R. C. (2004) · Circulation Research · doi:10.1161/01.res.0000109414.78907.f9 · Cited by 476 · see citing works
Aliello, L. P. (1995) · Medical Entomology and Zoology · Cited by 463 · see citing works
The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.
Gerrity, R. G. (1981) · PubMed · Cited by 459 · see citing works
Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin.
Darbonne, W. C., Rice, G. C., Möhler, M., Apple, T., Hébert, C. A., Valente, A. J., & Baker, J. B. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115442 · Cited by 452 · see citing works
Melder, R. J., Koenig, G. C., Witwer, B. P., Safabakhsh, N., Munn, L. L., & Jain, R. K. (1996) · Nature Medicine · doi:10.1038/nm0996-992 · Cited by 451 · see citing works
Self-citationPlaque Rupture and Sudden Death Related to Exertion in Men With Coronary Artery Disease
BURKE, A. P., Farb, A. A., Malcom, G. T., Liang, Y.-H., Smialek, J. E., & Virmani, R. (1999) · JAMA · doi:10.1001/jama.281.10.921 · Cited by 449 · see citing works
Self-citationRole of Angiogenesis in Cardiovascular Disease
Khurana, R., Simons, M., Martin, J. F., & Zachary, I. C. (2005) · Circulation · doi:10.1161/circulationaha.105.535294 · Cited by 445 · see citing works
Disruption of TGF-β signaling in T cells accelerates atherosclerosis
Robertson, A.-K. L., Rudling, M. J., Zhou, X., Gorelik, L., Flavell, R. A., & Hansson, G. K. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18607 · Cited by 440 · see citing works
Willett, C. G., Boucher, Y., Duda, D. G., di Tomaso, E., Munn, L. L., Tong, R. T., Kozin, S. V., Petit, L., Jain, R. K., Chung, D. C., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.5635 · Cited by 420 · see citing works
Self-citationGuetz, G. D., Uzzan, B., Nicolas, P., Cucherat, M., Morère, J., Benamouzig, R., Breau, J. L., & Perret, G.-Y. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603176 · Cited by 406 · see citing works
Advanced Atherosclerotic Lesions in the Innominate Artery of the ApoE Knockout Mouse
Rosenfeld, M. E., Polinsky, P., Virmani, R., Kauser, K. Z., Rubanyi, G. M., & Schwartz, S. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.12.2587 · Cited by 384 · see citing works
Self-citationAutiero, M., Luttun, A., Tjwa, M., & Carmeliet, P. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00263.x · Cited by 358 · see citing works
Arterial Neovascularization and Inflammation in Vulnerable Patients
Fleiner, M., Kummer, M., Mirlacher, M., Sauter, G., Cathomas, G., Krapf, R., & Biedermann, B. C. (2004) · Circulation · doi:10.1161/01.cir.0000146787.16297.e8 · Cited by 349 · see citing works
Unraveling the Reactions of Nitric Oxide, Nitrite, and Hemoglobin in Physiology and Therapeutics
Kim-Shapiro, D. B., Schechter, A. N., & Gladwin, M. T. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000204350.44226.9a · Cited by 308 · see citing works
Managing Patients Treated with Bevacizumab Combination Therapy
Gordon, M. S., & Cunningham, D. (2005) · Oncology · doi:10.1159/000088481 · Cited by 282 · see citing works
Plaque Rupture in Humans and Mice
Schwartz, S. M., Galis, Z. S., Rosenfeld, M. E., & Falk, E. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000261709.34878.20 · Cited by 255 · see citing works
Wang, N., Tabas, I. A., WINCHESTER, R. J., Stefano Ravalli, A., Rabbani, L. E., & Tall, A. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8837 · Cited by 252 · see citing works
CD163: a signal receptor scavenging haptoglobin–hemoglobin complexes from plasma
Graversen, J. H., Madsen, M. M., & Moestrup, S. K. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00144-3 · Cited by 245 · see citing works
Plaque Rupture After Short Periods of Fat Feeding in the Apolipoprotein E–Knockout Mouse
Johnson, J. L., Carson, K. G. S., Williams, H. J., Karanam, S., Newby, A. C., Angelini, G. D., George, S. J., & Jackson, C. L. (2005) · Circulation · doi:10.1161/01.cir.0000158435.98035.8d · Cited by 241 · see citing works
Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation
van den Heuvel, M. M., Tensen, C. P., van As, J., van den Berg, T. K., Fluitsma, D. M., Dijkstra, C. D., Döpp, E. A., Droste, A., van Gaalen, F. A., Sorg, C., et al. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.858 · Cited by 222 · see citing works
Kockx, M. M., Cromheeke, K. M. C., Knaapen, M., Bosmans, J. M., Meyer, G. R. Y. D., Herman, A. G., & Bult, H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000057807.28754.7f · Cited by 218 · see citing works
Davis, G. E. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90170-d · Cited by 214 · see citing works
Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation
Muñoz-Nájar, U. M., Neurath, K. M., Vumbaca, F., & Claffey, K. P. (2006) · Oncogene · doi:10.1038/sj.onc.1209273 · Cited by 209 · see citing works
Immunohistochemical study of intimal microvessels in coronary atherosclerosis.
Zhang, Y., Cliff, W. J., Schoefl, G. I., & Higgins, G. (1993) · PubMed Central · Cited by 200 · see citing works
Kohn, S., Nagy, J. A., Dvorak, H. F., & Dvořàk, A. M. (1992) · PubMed · Cited by 190 · see citing works
Dunmore, B. J., McCarthy, M. J., Naylor, A. R., & Brindle, N. P. J. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2006.08.072 · Cited by 187 · see citing works
Manegold, C., von Pawel, J., Zatloukal, P., Ramlau, R., Gorbounova, V. A., Hirsch, V., Leighl, N. B., Mezger, J., Archer, V. R., & Reck, M. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.lba7514 · Cited by 168 · see citing works
T[oacute]th, T. (2000) · Human Pathology · doi:10.1053/hupa.2000.16658 · Cited by 165 · see citing works
Ranibizumab for Neovascular Age-Related Macular Degeneration
Liew, G., & Mitchell, P. (2007) · New England Journal of Medicine · doi:10.1056/nejmc063011 · Cited by 156 · see citing works
Levy, A. P., Levy, J. E., Kalet-Litman, S., Miller‐Lotan, R., Levy, N. S., Asaf, R., Guetta, J., Yang, C., Purushothaman, K., Fuster, V., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251020.24399.a2 · Cited by 152 · see citing works
Cholesterol and phospholipid metabolism in macrophages
Tabas, I. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00146-3 · Cited by 143 · see citing works
Chen, Y., Nakashima, Y., Tanaka, K.-I., Shiraishi, S., Nakagawa, K., & Sueishi, K. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.1.131 · Cited by 126 · see citing works
A Simple Method of Plaque Rupture Induction in Apolipoprotein E–Deficient Mice
Sasaki, T., Kuzuya, M., Nakamura, K., Cheng, X. W., Shibata, T., Sato, K., & Iguchi, A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000219687.71607.f7 · Cited by 120 · see citing works
Adventitial Mast Cells Connect With Sensory Nerve Fibers in Atherosclerotic Coronary Arteries
Laine, P., Naukkarinen, A., Heikkilä, L. J., Penttilä, A., & Kovanen, P. T. (2000) · Circulation · doi:10.1161/01.cir.101.14.1665 · Cited by 118 · see citing works
Tabas, I. A., Marathe, S. V., Keesler, G. A., Beatini, N., & Shiratori, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22773 · Cited by 111 · see citing works
Lappalainen, H., Laine, P., Pentikäinen, M. O., Sajantila, A., & Kovanen, P. T. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000140820.51174.8d · Cited by 104 · see citing works
Genentech discloses safety concerns over Avastin
Ratner, M. A. (2004) · Nature Biotechnology · doi:10.1038/nbt1004-1198 · Cited by 98 · see citing works
Carotid rupture and intraplaque hemorrhage: Immunophenotype and role of cells involved
Milei, J., Parodi, J. C., Alonso, G. F., Barone, A., Grana, D. R., & Matturri, L. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70169-3 · Cited by 96 · see citing works
Skillings, J. R., Johnson, D. H., Miller, K. D., Kabbinavar, F. F., Bergsland, E. K., Holmgren, E. B., Holden, S. N., Hurwitz, H. I., & Scappaticci, F. A. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.23.16_suppl.3019 · Cited by 95 · see citing works
Blood flow through vasa vasorum of coronary arteries in atherosclerotic monkeys.
Heistad, D. D., & Armstrong, M. L. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.3.326 · Cited by 92 · see citing works
Myocyte loss in chronic heart failure
Rayment, N. B., Haven, A. J., Madden, B. P., Murday, A. J., Trickey, R. J., Shipley, M. J., Davies, M. J., & Katz, D. R. (1999) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199906)188:2 · Cited by 57 · see citing works
When neoangiogenesis ricochets
Virmani, R., Narula, J., & Farb, A. A. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70144-9 · Cited by 54 · see citing works
Self-citationDrimal, J., Zúrová-Nedelcevová, J., Knezl, V., Sotníková, R., & Navarová, J. (2006) · PubMed · Cited by 36 · see citing works
The significance of free blood in liquid and solid tumours.
van den Brenk, H. A., Crowe, M. C., Kelly, H. D. B., & Stone, M. G. (1977) · PubMed Central · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
Carmeliet, P., & Jain, R. K. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3455 · Cited by 1,678 · see citing works
Self-citationNormalization of the Vasculature for Treatment of Cancer and Other Diseases
Goel, S., Duda, D. G., Xu, L., Munn, L. L., Boucher, Y., Fukumura, D., & Jain, R. K. (2011) · Physiological Reviews · doi:10.1152/physrev.00038.2010 · Cited by 1,605 · see citing works
Self-citationAntiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Jain, R. K. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.006 · Cited by 1,589 · see citing works
Self-citationJain, R. K., di Tomaso, E., Duda, D. G., Loeffler, J. S., Sorensen, A. G., & Batchelor, T. T. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2175 · Cited by 1,408 · see citing works
Self-citationNormalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers
Jain, R. K. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.3653 · Cited by 1,248 · see citing works
Self-citationNormalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges
Martin, J. D., Seano, G., & Jain, R. K. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114700 · Cited by 530 · see citing works
Self-citationEl‐Sawy, H. S., Al-Abd, A. M., Ahmed, T. A., El‐Say, K. M., & Torchilin, V. P. (2018) · ACS Nano · doi:10.1021/acsnano.8b06104 · Cited by 435 · see citing works
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Goel, S., Wong, A. H.-K., & Jain, R. K. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006486 · Cited by 352 · see citing works
Self-citationGuo, L., Akahori, H., Harari, E., Smith, S. L., Polavarapu, R., Karmali, V., Otsuka, F., Gannon, R. L., Braumann, R. E., Dickinson, M. H., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93025 · Cited by 323 · see citing works
Self-citationEndothelial cell metabolism in health and disease: impact of hypoxia
Wong, B. W., Marsch, E., Treps, L., Baes, M. I., & Carmeliet, P. (2017) · The EMBO Journal · doi:10.15252/embj.201696150 · Cited by 277 · see citing works
The shunt problem: control of functional shunting in normal and tumour vasculature
Pries, A. R., Höpfner, M., le Noble, F. A. C., Dewhirst, M. W., & Secomb, T. W. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2895 · Cited by 264 · see citing works
Systemic Delivery of Oncolytic Viruses: Hopes and Hurdles
Ferguson, M. S., Lemoine, N. R., & Wang, Y. (2012) · Advances in Virology · doi:10.1155/2012/805629 · Cited by 231 · see citing works
Sedding, D. G., Boyle, E. C., Demandt, J. A. F., Sluimer, J. C., Dutzmann, J., Haverich, A., & Bauersachs, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00706 · Cited by 228 · see citing works
Diversity of macrophage phenotypes and responses in atherosclerosis
Jinnouchi, H., Guo, L., Sakamoto, A., Torii, S., Sato, Y., Cornelissen, A., Kuntz, S. H., Paek, K. H., Fernandez, R., Fuller, D. T., et al. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03371-3 · Cited by 219 · see citing works
Self-citationVEGF inhibitors in the treatment of cerebral edema in patients with brain cancer
Gerstner, E. R., Duda, D. G., di Tomaso, E., Ryg, P. A., Loeffler, J. S., Sorensen, A. G., Ivy, P. S., Jain, R. K., & Batchelor, T. T. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.14 · Cited by 208 · see citing works
Self-citationVasa Vasorum in Normal and Diseased Arteries
Mulligan‐Kehoe, M. J., & Simons, M. (2014) · Circulation · doi:10.1161/circulationaha.113.007189 · Cited by 195 · see citing works
Optical and Multimodality Molecular Imaging
Jaffer, F. A., Libby, P., & Weissleder, R. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.165530 · Cited by 183 · see citing works
Perfluorocarbon Nanoemulsions for Quantitative Molecular Imaging and Targeted Therapeutics
Kaneda, M. M., Caruthers, S. D., Lanza, G. M., & Wickline, S. A. (2009) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9643-z · Cited by 183 · see citing works
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
Jain, R. K. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2346 · Cited by 167 · see citing works
Self-citationThyroid hormone and atherosclerosis
Ichiki, T. (2009) · Vascular Pharmacology · doi:10.1016/j.vph.2009.09.004 · Cited by 145 · see citing works
Stabilisation of atherosclerotic plaques
Ylä-Herttuala, S., Bentzon, J., Daemen, M., Falk, E., Garcia-Garcia, H., Herrmann, J., Hoefer, I., Jukema, J., Krams, R., Kwak, B., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th10-12-0784 · Cited by 128 · see citing works
Wu, C., Lee, C., & Ho, Y. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2434 · Cited by 123 · see citing works
Inflammatory angiogenesis in atherogenesis—a double-edged sword
Ribatti, D., Levi‐Schaffer, F., & Kovanen, P. T. (2008) · Annals of Medicine · doi:10.1080/07853890802186913 · Cited by 121 · see citing works
Chakroborty, D., Sarkar, C., Yu, H., Wang, J., Liu, Z., Dasgupta, P., & Basu, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108696108 · Cited by 119 · see citing works
The Vulnerable Atherosclerotic Plaque: Scope of the Literature
Alsheikh-Ali, A. A. A., Kitsios, G. D., Balk, E. M., Lau, J. W. Y., & Ip, S. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-6-201009210-00272 · Cited by 114 · see citing works
RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans
Suffee, N., Hlawaty, H., Meddahi‐Pellé, A., Maillard, L., Louedec, L., Haddad, O., Martin, L., Laguillier, C., Richard, B., Oudar, O., et al. (2012) · Angiogenesis · doi:10.1007/s10456-012-9285-x · Cited by 112 · see citing works
Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization
de Vries, M. R., & Quax, P. H. A. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000339 · Cited by 108 · see citing works
Promoting Mechanisms of Vascular Health
Moreno, P., Sanz, J., & Fuster, V. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.057 · Cited by 106 · see citing works
Atherosclerotic plaque development and instability: A dual role for VEGF
Holm, P. W., Slart, R. H. J. A., Zeebregts, C. J., Hillebrands, J., & Tio, R. A. (2008) · Annals of Medicine · doi:10.1080/07853890802516507 · Cited by 106 · see citing works
Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions
Lanza, G., Winter, P. M., Caruthers, S. D., Hughes, M. S., Hu, G., Schmieder, A. H., & Wickline, S. A. (2010) · Angiogenesis · doi:10.1007/s10456-010-9166-0 · Cited by 91 · see citing works
Egleton, R. D., Brown, K. C., & Dasgupta, P. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.10.007 · Cited by 91 · see citing works
Plaque neovascularization: defense mechanisms, betrayal, or a war in progress
Moreno, P. R., Purushothaman, M., & Purushothaman, K. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06497.x · Cited by 80 · see citing works
Significance of intraplaque neovascularisation for vulnerability: optical coherence tomography study
Tian, J., Hou, J., Xing, L., Kim, S., Yonetsu, T., Kato, K., Lee, H., Zhang, S., Yu, B., & Jang, I. (2012) · Heart · doi:10.1136/heartjnl-2012-302445 · Cited by 73 · see citing works
Atherosclerosis: from biology to pharmacological treatment
Riccioni, G., & Sblendorio, V. (2012) · Journal of Geriatric Cardiology · doi:10.3724/sp.j.1263.2012.02132 · Cited by 66 · see citing works
Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis
Kawabe, J.-I., & Hasebe, N. (2014) · BioMed Research International · doi:10.1155/2014/701571 · Cited by 65 · see citing works
FDG–PET imaging of atherosclerosis: Do we know what we see?
Sheikine, Y., & Akram, K. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.002 · Cited by 63 · see citing works
Thyroid Hormone and Vascular Remodeling
Ichiki, T. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.32755 · Cited by 62 · see citing works
SLEVIN, M. A., Krupiński, J., & Badimón, L. (2009) · Vascular Cell · doi:10.1186/2040-2384-1-4 · Cited by 61 · see citing works
Vessel Growth and Function: Depiction with Contrast-enhanced MR Imaging
Oostendorp, M., Post, M. J., & Backes, W. H. (2009) · Radiology · doi:10.1148/radiol.2512080485 · Cited by 58 · see citing works
Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1
Komaravolu, R. K., Adam, C., Moonen, J.-R. A. J., Harmsen, M. C., Goebeler, M., & Schmidt, M. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu236 · Cited by 55 · see citing works
Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles
Wang, S., He, H., Mao, Y., Zhang, Y., & Gu, N. (2024) · Advanced Science · doi:10.1002/advs.202308298 · Cited by 55 · see citing works
Zhang, R., Pan, D., Cai, X., Yang, X., Senpan, A., Allen, J. S., Lanza, G. M., & Wang, L. V. (2014) · Theranostics · doi:10.7150/thno.10014 · Cited by 55 · see citing works
Guo, L., Harari, E., Virmani, R., & Finn, A. V. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309045 · Cited by 50 · see citing works
Self-citationAnari, F. M., Ramamurthy, C., & Zibelman, M. R. (2018) · Future Oncology · doi:10.2217/fon-2017-0585 · Cited by 50 · see citing works
Anti‐angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis
Caruthers, S. D., Cyrus, T., Winter, P. M., Wickline, S. A., & Lanza, G. M. (2009) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.9 · Cited by 49 · see citing works
Mutually Supportive Mechanisms of Inflammation and Vascular Remodeling
Whiteford, J. R., Rossi, G. D., & Woodfin, A. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.05.001 · Cited by 47 · see citing works
Neovascularization of the atherosclerotic plaque
van Hinsbergh, V. W. M., Eringa, E. C., & Daemen, M. J. A. P. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000210 · Cited by 46 · see citing works
Multifunctional regulation of angiogenesis by high-density lipoproteins
Prosser, H. C. G., Tan, J. T. M., Dunn, L., Patel, S., Vanags, L. Z., Bao, S., Ng, M., & Bursill, C. A. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt234 · Cited by 45 · see citing works
Arderiu, G., Espinosa, S., Peña, E., Aledo, R., & Badimón, L. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju036 · Cited by 44 · see citing works
Perfluorocarbon Nanoparticles for Physiological and Molecular Imaging and Therapy
Chen, J., Pan, H., Lanza, G. M., & Wickline, S. A. (2013) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2013.08.004 · Cited by 44 · see citing works
Metz, S., Beer, A. J., Settles, M., Pelisek, J., Botnar, R. M., Rummeny, E. J., & Heider, P. (2010) · International journal of cardiac imaging · doi:10.1007/s10554-010-9736-7 · Cited by 43 · see citing works
Dall, J. L., Ho‐Tin‐Noé, B., Louedec, L., Meilhac, O., Roncal, C., Carmeliet, P., Germain, S., Michel, J., & Houard, X. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp253 · Cited by 42 · see citing works
Targeting phosphoinositide 3-kinase γ to fight inflammation and more
Barberis, L., & Hirsch, E. (2008) · Thrombosis and Haemostasis · doi:10.1160/th07-10-0632 · Cited by 40 · see citing works
Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery
Li, X., Sui, Z., Li, X., Xu, W., Guo, Q., Sun, J., & Jing, F. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s164905 · Cited by 40 · see citing works
Pan, D., Pham, C. T. N., Weilbaecher, K. N., Tomasson, M. H., Wickline, S. A., & Lanza, G. M. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1355 · Cited by 39 · see citing works
Role of CX3CR1 Receptor in Monocyte/Macrophage Driven Neovascularization
Kumar, A. H. S., Martin, K., Turner, E. C., Büneker, C. K., Dorgham, K., Déterre, P., & Caplice, N. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057230 · Cited by 37 · see citing works
Guo, M.-Y., Cai, Y., Yao, X., & Li, Z. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.04.031 · Cited by 36 · see citing works
Khodabandeh, Z., Valilo, M., Velaei, K., & Tazehkand, A. P. (2022) · Breast Cancer · doi:10.1007/s12282-022-01369-7 · Cited by 34 · see citing works
Mesenteric Ischemia in Patients with End-Stage Renal Disease: A Nationwide Longitudinal Study
Li, S., Chen, Y., Chen, T., Tsai, L.-W., Yang, W.-C., & Chen, T.-W. (2012) · American Journal of Nephrology · doi:10.1159/000338451 · Cited by 33 · see citing works
Tian, J., Hu, S., Sun, Y., Yu, H., Han, X., Cheng, W., Ban, X., Zhang, S., Yu, B., & Jang, I. (2012) · Heart · doi:10.1136/heartjnl-2012-302775 · Cited by 33 · see citing works
THSD1preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE−/−mice
Haasdijk, R. A., den Dekker, W. K., Cheng, C., Tempel, D., Szulcek, R., Bos, F. L., Hermkens, D. M. A., Chrifi, I., Brandt, M. M., Dijk, C. V., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw015 · Cited by 32 · see citing works
Coronary Plaque Neovascularization and Hemorrhage
Finn, A. V., & Jain, R. K. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2009.11.001 · Cited by 31 · see citing works
Self-citationUpdate on oncolytic viral therapy – targeting angiogenesis
Tysome, J. R., Lemoine, N. R., & Wang, Y. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s46974 · Cited by 31 · see citing works
Regression of coronary atherosclerosis: Current evidence and future perspectives
Koskinas, K. C., Windecker, S., & Räber, L. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2015.05.004 · Cited by 30 · see citing works
Tian, J., Ren, X., Uemura, S., Dauerman, H. L., Prasad, A., Toma, C., Jia, H., Abtahian, F., Vergallo, R., Hu, S., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.03.013 · Cited by 30 · see citing works
AKT as locus of cancer angiogenic robustness and fragility
Radisavljevic, Z. M. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24115 · Cited by 28 · see citing works
Comparison of Neoatherosclerosis and Neovascularization Between Patients With and Without Diabetes
Gao, L., Park, S., Jang, Y., Lee, S., Kim, C. J., Minami, Y., Ong, D., Soeda, T., Vergallo, R., Lee, H., et al. (2015) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2015.02.020 · Cited by 28 · see citing works
Outside-in, inside-out: Proteomic analysis of endothelial stress mediated by 7-ketocholesterol
Rosa-Fernandes, L., Maselli, L. M. F., Maeda, N. Y., Palmisano, G., & Bydlowski, S. P. (2017) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.06.008 · Cited by 25 · see citing works
Guo, M.-Y., Cai, Y., He, C., & Li, Z. (2018) · Annals of Biomedical Engineering · doi:10.1007/s10439-018-02173-1 · Cited by 26 · see citing works
Vascular effects of glycoprotein130 ligands — Part I: Pathophysiological role
Demyanets, S., Huber, K., & Wojta, J. (2011) · Vascular Pharmacology · doi:10.1016/j.vph.2011.12.004 · Cited by 23 · see citing works
Wang, L., Li, G., Chen, Q., & Ke, D. (2015) · Metabolism · doi:10.1016/j.metabol.2015.07.008 · Cited by 23 · see citing works
Angiogenesis imaging with vascular-constrained particles: the why and how
Lanza, G. M., Caruthers, S. D., Winter, P. M., Hughes, M. S., Schmieder, A. H., Hu, G., & Wickline, S. A. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1502-5 · Cited by 22 · see citing works
Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature
Subudhi, S., Lee, S., & Jain, R. K. (2026) · Cell · doi:10.1016/j.cell.2026.03.016 · Cited by 21 · see citing works
Self-citationKhoi, P. N., Park, J. S., Kim, N. H., & Jung, Y. D. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.002 · Cited by 21 · see citing works
Kyriakakis, E., Cavallari, M., Pfaff, D., Fabbro, D., Mestan, J., Philippova, M., Libero, G. D., Erné, P., & Resink, T. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211097 · Cited by 20 · see citing works
Rengan, R., Maity, A. M., Stevenson, J. P., & Hahn, S. M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2760 · Cited by 19 · see citing works
The value of multi-slice-computed tomography coronary angiography for risk stratification
van Werkhoven, J. M., Bax, J. J., Nucifora, G., Jukema, J. W., Kroft, L. J. M., Roos, A., & Schuijf, J. D. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-009-9144-3 · Cited by 18 · see citing works
Shibata, Y., Kikuchi, R., Ishii, H., Suzuki, S., Harada, K., Hirayama, K., Suzuki, A., Tatami, Y., Kondo, K., & Murohara, T. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.12.042 · Cited by 18 · see citing works
Atherosclerotic Pre-Conditioning Affects the Paracrine Role of Circulating Angiogenic Cells Ex-Vivo
Eslava-Alcón, S., Extremera-García, M. J., Sánchez-Gomar, I., Beltrán-Camacho, L., Rosal‐Vela, A., Muñoz, J., Ibarz, N., Alonso-Piñero, J. A., Rojas-Torres, M., Jiménez-Palomares, M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155256 · Cited by 18 · see citing works
Qu, Y., Chen, L., Pardee, A. D., Taylor, J. L., Wesa, A. K., & Storkus, W. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001294 · Cited by 16 · see citing works
Xu, B., Jin, X., Wu, W., Zhang, W., Zhu, Q., Zhang, D., Sun, N., Wu, C., Kang, G., Zhai, L., et al. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5926 · Cited by 13 · see citing works
The Alpha 9-Nicotinic Acetylcholine Receptor Serves as a Molecular Target for Breast Cancer Therapy
Ho, Y. S., Lee, C., & Wu, C.-H. (2011) · Journal of Experimental & Clinical Medicine · doi:10.1016/j.jecm.2011.10.007 · Cited by 10 · see citing works
Common Vascular Toxicities of Cancer Therapies
Herrmann, J. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.07.003 · Cited by 8 · see citing works
Differential Effects of Fondaparinux and Bemiparin on Angiogenic and Vasculogenesis-like processes
Pozzo, E. D., Barsotti, M., Bendinelli, S., Martelli, A., Calderone, V., Balbarini, A., Martini, C., & Stefano, R. D. (2012) · Thrombosis Research · doi:10.1016/j.thromres.2012.03.013 · Cited by 7 · see citing works
Deng, C., Liu, Z., Zhang, W., Deng, Y., Liu, H., Bai, Z., Rong, J., Deng, W., Gu, N., Shen, Y., et al. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2412341 · Cited by 5 · see citing works
Ramachandran, S., Calcagno, C., Mani, V., Robson, P. M., & Fayad, Z. A. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24224 · Cited by 5 · see citing works
Lu, M., Peng, P., Lichen, Z., Shaohua, L., Yuan, F., Zhang, H., Liu, S., He, Y., Xihai, Z., & Cai, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.815150 · Cited by 4 · see citing works
Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer
Munn, L. L., Stylianopoulos, T., Jain, N. K., Hardin, C. C., Khandekar, M. J., & Jain, R. K. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4750 · Cited by 4 · see citing works
Self-citationModes of Neovascularization in Tumors and Clinical Translation of Antiangiogenic Therapy
Jain, R. K., Fukumura, D., & Duda, D. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.05502-7 · Cited by 3 · see citing works
Self-citationKolodgie, F. D., Finn, A. V., Narula, J., & Virmani, R. (2010) · Springer eBooks · doi:10.1007/978-90-481-9495-7_9 · Cited by 3 · see citing works
Self-citationAngiogenesis in Development, Disease, and Regeneration
Jain, R. K., & Fukumura, D. (2008) · Springer eBooks · doi:10.1007/978-0-387-74660-9_6 · Cited by 3 · see citing works
Self-citationThe role of vasa vasorum in carotid stenosis
Svetlikov, A. V., Шаповалов, А. С., PIGAREVSKY, P. V., Maltseva, S. V., Lukin, S. V., & Gurevich, V. S. (2025) · International Angiology · doi:10.23736/s0392-9590.25.05445-8 · Cited by 2 · see citing works
Thatcher, J. E., Welch, T. R., Eberhart, R. C., Schelly, Z. A., & DiMaio, J. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06681.x · Cited by 2 · see citing works
Extremera-García, M. J., Rojas-Torres, M., Priego, B., Beltrán-Camacho, L., Eslava-Alcón, S., Rodríguez-Martín, F. J., Benítez-Camacho, J., Ballesteros-Ribelles, A., Martínez‐Val, A., Olsen, J. V., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00438-z · Cited by 1 · see citing works
Lyrawati, D. (2013) · Jurnal Kedokteran Brawijaya · doi:10.21776/ub.jkb.2008.024.01.6 · Cited by 1 · see citing works
Pan, D., Cui, G., Pham, C. T. N., Tomasson, M. H., Weilbaecher, K. N., & Lanza, G. M. (2017) · ACS symposium series · doi:10.1021/bk-2017-1271.ch008 · Cited by 1 · see citing works
Therapeutic Potential of Novel Modulators of Neovascularization
Rahman, S., Patel, Y., Wijelath, E. S., & Sobel, M. (2008) · Future Cardiology · doi:10.2217/14796678.4.4.409 · Cited by 1 · see citing works
Loria, V., Cosentino, N., Rocco, A., & Niccoli, G. (2011) · InTech eBooks · doi:10.5772/19205 · Cited by 1 · see citing works
33. Micromanaging Atherogenesis
Wang, S.-S., & Anderson, C. (2015) · Atherosclerosis · doi:10.1002/9781118828533.ch33
- Authors
- Jain, R. K., Finn, A. V., Kolodgie, F. D., Gold, H. K., & Virmani, R.
- Affiliations
- Harvard University (US)
- CVPath Institute (US)
- Corresponding author
- Jain, Rakesh K
- Gold, Herman K
- Venue
- Nature Clinical Practice Cardiovascular Medicine
- Published
- 2007-09
- Volume
- 4
- Issue
- 9
- Pages
- 491-502
- ISSN
- 1743-4297 (ISSN-L)
- 1743-4300
- OpenAlex
- W2024455227
- Cited by
- 117
- References
- 80
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 14
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Clinical Practice Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P01CA080124)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- anti-angiogenic therapy, atherosclerotic plaque, plaque stabilization, intraplaque hemorrhage, angiogenesis, vascular normalization, vulnerable plaque, necrotic core, plaque progression, acute myocardial infarction, stroke, sudden cardiac death
- MeSH terms
- Coronary Artery Disease, Coronary Vessels, Hemorrhage, Humans, Neovascularization, Pathologic, Angiogenesis Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review