Elimination of Neoangiogenesis for Plaque Stabilization
Open accessAbstract
Emerging data suggest that intraplaque hemorrhage is critical in promoting atherosclerotic lesion instability. Because red blood cell membranes are a rich source of free cholesterol and accumulated red blood cells within plaques promote inflammation, intraplaque hemorrhage is associated with expansion of the necrotic core. Plaque hemorrhage results from the development of immature neointimal vasa vasorum. Therefore, it is proposed that molecular therapies designed to eliminate pathologic neovascularization within developing lesions will interrupt the process of hemorrhage and decrease the rate of necrotic core expansion. The elimination of intraplaque neovascularization would involve targeting of pre-existing and new vessel development. The concept of vascular regression has met some success in other neovascular-dependent diseases, including macular degeneration and malignancies. The efficacy of this novel approach is dependent on gaining critical knowledge of the environment required to support development and maturation of the vasa vasorum within varying plaque types. A multitargeted approach involving selective local antiangiogenic agents should contribute to prevention of plaque progression and its clinical consequences.
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Anti-angiogenic agents are a drug class currently under investigation for the stabilization of atherosclerotic plaques.
“Anti-angiogenic agents are another drug class currently under investigation for the stabilization of atherosclerotic plaques26,104.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [26]
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Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., Holmgren, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032691 · Cited by 10,968 · see citing works
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,857 · see citing works
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,258 · see citing works
Virmani, R., Kolodgie, F. D., Burke, A. P., Farb, A., & Schwartz, S. M. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.5.1262 · Cited by 4,084 · see citing works
Self-citationYang, J. C., Haworth, L. R., Sherry, R. M., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Steinberg, S. M., Chen, H. X., & Rosenberg, S. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021491 · Cited by 2,681 · see citing works
Coronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly
BURKE, A. P., Farb, A. A., Malcom, G. T., Liang, Y.-H., Smialek, J. E., & Virmani, R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705013361802 · Cited by 1,739 · see citing works
Self-citationOpenings Between Defective Endothelial Cells Explain Tumor Vessel Leakiness
Hashizume, H., Baluk, P., Morikawa, S., McLean, J. W., Thurston, G., Roberge, S., Jain, R. K., & McDonald, D. M. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65006-7 · Cited by 1,689 · see citing works
Intraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., BURKE, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A. A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,491 · see citing works
Self-citationAtherosclerotic Plaque Progression and Vulnerability to Rupture
Virmani, R., Kolodgie, F. D., BURKE, A. P., Finn, A. V., Gold, H. K., Tulenko, T. N., Wrenn, S. P., & Narula, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000178991.71605.18 · Cited by 1,326 · see citing works
Self-citationStatin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Crowe, T., Sasiela, W. J., Tsai, J., Orazem, J., Magorien, R. D., O'Shaughnessy, C., & Ganz, P. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042000 · Cited by 1,325 · see citing works
Benjamin, L. E., Golijanin, D., Itin, A., Pode, D., & Keshet, E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5028 · Cited by 1,234 · see citing works
Folkman, J. (2006) · Annual Review of Medicine · doi:10.1146/annurev.med.57.121304.131306 · Cited by 1,209 · see citing works
Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Cheng, C., Tempel, D., van Haperen, R., van der Baan, A., Grosveld, F. G., Daemen, M. J. A. P., Krams, R., & de Crom, R. (2006) · Circulation · doi:10.1161/circulationaha.105.590018 · Cited by 1,002 · see citing works
Pathophysiological consequences of VEGF-induced vascular permeability
Weis, S. M., & Cheresh, D. A. (2005) · Nature · doi:10.1038/nature03987 · Cited by 911 · see citing works
Demierre, M., Higgins, P., Gruber, S. B., Hawk, E. T., & Lippman, S. M. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1751 · Cited by 822 · see citing works
Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular Events
Takaya, N., Yuan, C., Chu, B., Saam, T., Underhill, H. R., Cai, J., Tran, N. T., Polissar, N. L., Isaac, C. A., Ferguson, M. S., et al. (2006) · Stroke · doi:10.1161/01.str.0000204638.91099.91 · Cited by 755 · see citing works
Self-citationAngiogenesis: regulators and clinical applications
Liekens, S., De Clercq, E., & Neyts, J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00529-3 · Cited by 748 · see citing works
Lewis A. Conner Memorial Lecture
Steinberg, D. H. (1997) · Circulation · doi:10.1161/01.cir.95.4.1062 · Cited by 743 · see citing works
Retinal angiogenesis in development and disease
Gariano, R. F., & Gardner, T. W. (2005) · Nature · doi:10.1038/nature04482 · Cited by 707 · see citing works
Moulton, K. S., Heller, E., Konerding, M. A., Flynn, E., Palinski, W., & Folkman, J. (1999) · Circulation · doi:10.1161/01.cir.99.13.1726 · Cited by 688 · see citing works
Kolodgie, F. D., BURKE, A. P., Farb, A. A., Gold, H. K., Yuan, J., Narula, J., Finn, A. V., & Virmani, R. (2001) · Current Opinion in Cardiology · doi:10.1097/00001573-200109000-00006 · Cited by 686 · see citing works
Self-citationAntonetti, D. A., Barber, A. J., Hollinger, L. A., Wolpert, E. B., & Gardner, T. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23463 · Cited by 685 · see citing works
Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis
Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641 · see citing works
Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic Plaques
Takaya, N., Yuan, C., Chu, B., Saam, T., Polissar, N. L., Jarvik, G. P., Isaac, C. A., McDonough, J., Natiello, C., Small, R., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.504167 · Cited by 562 · see citing works
Self-citationRedgrave, J. N. E., Lovett, J. K., Gallagher, P. J., & Rothwell, P. M. (2006) · Circulation · doi:10.1161/circulationaha.105.589044 · Cited by 529 · see citing works
Signaling and Functions of Angiopoietin-1 in Vascular Protection
Brindle, N. P. J., Saharinen, P., & Alitalo, K. K. (2006) · Circulation Research · doi:10.1161/01.res.0000218275.54089.12 · Cited by 485 · see citing works
Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin.
Darbonne, W. C., Rice, G. C., Möhler, M., Apple, T., Hébert, C. A., Valente, A. J., & Baker, J. B. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115442 · Cited by 452 · see citing works
Plaque Rupture and Sudden Death Related to Exertion in Men With Coronary Artery Disease
BURKE, A. P., Farb, A. A., Malcom, G. T., Liang, Y.-H., Smialek, J. E., & Virmani, R. (1999) · JAMA · doi:10.1001/jama.281.10.921 · Cited by 449 · see citing works
Self-citationDor, Y., Djonov, V., Abramovitch, R., Itin, A., Fishman, G. I., Carmeliet, P., Goelman, G., & Keshet, E. (2002) · The EMBO Journal · doi:10.1093/emboj/21.8.1939 · Cited by 389 · see citing works
Winter, P. M., Neubauer, A. M., Caruthers, S. D., Harris, T. D., Robertson, J. D., Williams, T. A., Schmieder, A. H., Hu, G., Allen, J. S., Lacy, E. K., et al. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000235724.11299.76 · Cited by 379 · see citing works
Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.
Kwon, H. M., Sangiorgi, G., Ritman, E. L., McKenna, C. J., Holmes, D. R., Schwartz, R., & Lerman, A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1568 · Cited by 294 · see citing works
Integration of the Non-genomic and Genomic Actions of Estrogen
Pedram, A., Razandi, M., Aitkenhead, M., Hughes, C. C. W., & Levin, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m210106200 · Cited by 293 · see citing works
Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells
Neote, K. S., Darbonne, W. C., Ogez, J. R., Horuk, R., & Schall, T. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31379-6 · Cited by 292 · see citing works
Kietselaer, B. L. J. H., Reutelingsperger, C. P. M., Heidendal, G. A. K., Daemen, M. J. A. P., Mess, W. H., Hofstra, L., & Narula, J. (2004) · New England Journal of Medicine · doi:10.1056/nejm200404013501425 · Cited by 281 · see citing works
Self-citationVerbeek, B. S., Feltkamp‐Vroom, T. M., Adriaansen-slot, S. S., Ottenhoff-Kalff, A. E., GEERTZEMA, J. G. N., Hennipman, A., & Rijksen, G. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199612)180:4 · Cited by 268 · see citing works
The Price of Sight — Ranibizumab, Bevacizumab, and the Treatment of Macular Degeneration
Steinbrook, R. (2006) · New England Journal of Medicine · doi:10.1056/nejmp068185 · Cited by 255 · see citing works
Wilson, S. H., Herrmann, J., Lerman, L. O., Holmes, D. R., Claudio Napoli, A., Ritman, E. L., & Lerman, A. (2002) · Circulation · doi:10.1161/hc0402.104119 · Cited by 221 · see citing works
Kockx, M. M., Cromheeke, K. M. C., Knaapen, M., Bosmans, J. M., Meyer, G. R. Y. D., Herman, A. G., & Bult, H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000057807.28754.7f · Cited by 218 · see citing works
Davis, G. E. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90170-d · Cited by 214 · see citing works
Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy
Melillo, G. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0235 · Cited by 165 · see citing works
VEGF transiently disrupts gap junctional communication in endothelial cells
Suarez, S., & Ballmer‐Hofer, K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.6.1229 · Cited by 147 · see citing works
Angiogenesis in atherosclerosis: gathering evidence beyond speculation
Moulton, K. S. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000245261.71129.f0 · Cited by 142 · see citing works
Duh, E. J., Yang, H. S., Haller, J. A., de Juan, E., Humayun, M. S., Gehlbach, P. L., Melia, M., Pieramici, D. J., Harlan, J. B., Campochiaro, P. A., et al. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.015 · Cited by 141 · see citing works
Ii, M., & Losordo, D. W. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.06.012 · Cited by 131 · see citing works
αvβ3-integrin imaging: a new approach to characterise angiogenesis?
Haubner, R. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0136-0 · Cited by 127 · see citing works
Vasa vasorum imaging: A new window to the clinical detection of vulnerable atherosclerotic plaques
CARLIER, S. G., Kakadiaris, I. A., Dib, N., Vavuranakis, M., O’Malley, S. M., Gul, K. M., Hartley, C. J., Metcalfe, R. W., Mehran, R., Stefanadis, C., et al. (2005) · Current Atherosclerosis Reports · doi:10.1007/s11883-005-0040-2 · Cited by 116 · see citing works
The cellular reactions to experimental intracerebral hemorrhage
Koeppen, A. H., Dickson, A. C., & McEvoy, J. A. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00215-n · Cited by 100 · see citing works
Carotid rupture and intraplaque hemorrhage: Immunophenotype and role of cells involved
Milei, J., Parodi, J. C., Alonso, G. F., Barone, A., Grana, D. R., & Matturri, L. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70169-3 · Cited by 96 · see citing works
Nonlinear intravascular ultrasound contrast imaging
Goertz, D. E., Frijlink, M. E., de Jong, N., & van der Steen, A. F. W. (2006) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.01.001 · Cited by 91 · see citing works
Sata, M., Nishimatsu, H., Osuga, J.-I., Tanaka, K., Ishizaka, N., Ishibashi, S., Hirata, Y., & Nagai, R. (2004) · Hypertension · doi:10.1161/01.hyp.0000126186.29571.41 · Cited by 83 · see citing works
Changes in gene expression in atherosclerotic plaques analyzed using DNA array
Hiltunen, M., Tuomisto, T. T., Niemi, M., Bräsen, J. H., Rissanen, T. T., Törönen, P., Vajanto, I., & Ylä‐Herttuala, S. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00187-9 · Cited by 82 · see citing works
Apoptosis in atherogenesis: implications for plaque destabilization.
Mm, K., & Ag, H. (1998) · PubMed · Cited by 81 · see citing works
Apoptosis and angiogenesis are induced in the unstable coronary atherosclerotic plaque
Chen, F., Eriksson, P. O., Kimura, T., Herzfeld, I., & Valen, G. (2005) · Coronary Artery Disease · doi:10.1097/00019501-200505000-00009 · Cited by 77 · see citing works
Vasa Vasorum of the Intracranial Arteries
Takaba, M., Endo, S., Kurimoto, M., Kuwayama, N., Nishijima, M., & Takaku, A. (1998) · Acta Neurochirurgica · doi:10.1007/s007010050118 · Cited by 76 · see citing works
Myocyte loss in chronic heart failure
Rayment, N. B., Haven, A. J., Madden, B. P., Murday, A. J., Trickey, R. J., Shipley, M. J., Davies, M. J., & Katz, D. R. (1999) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199906)188:2 · Cited by 57 · see citing works
Cholesterol Granuloma of the Maxillary Sinus
Leon, M. E., Chavez, C., Fyfe, B. S., Nagorsky, M. J., & Garcia, F. U. (2002) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2002-126-0217-cgotms · Cited by 55 · see citing works
When neoangiogenesis ricochets
Virmani, R., Narula, J., & Farb, A. A. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70144-9 · Cited by 54 · see citing works
Self-citationOcular versus Extraocular Neovascularization: Mirror Images or Vague Resemblances
Campochiaro, P. A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1494 · Cited by 46 · see citing works
Stefanadis, C., Toutouzas, K. P., Stefanadi, E., Kolodgie, F. D., Virmani, R., & Kipshidze, N. N. (2006) · PubMed · Cited by 32 · see citing works
Self-citationUltrastructure of experimentally produced subcutaneous haematomas in the rabbit
Lalonde, J. ‐. A., & Ghadially, F. N. (1977) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02889435 · Cited by 14 · see citing works
Ishihara, T., Sano, J., Yamanami, S., Yamashita, Y., Takahashi, M., Uchino, F., & Matsumoto, N. (1987) · Acta Pathologica Japonica · doi:10.1111/j.1440-1827.1987.tb00397.x · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Hegyi L, Skepper JN, Cary NR, Mitchinson MJ. Foam cell apoptosis and the development of the lipid core of human atherosclerosis. J Pathol 1996;180:423-9.
- Jeziorska M, Woolley DE. Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries. J Pathol 1999;188:189 -96.
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Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis
Sluimer, J. C., & Daemen, M. J. A. P. (2009) · The Journal of Pathology · doi:10.1002/path.2518 · Cited by 371 · see citing works
Ritman, E. L., & Lerman, A. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.020 · Cited by 242 · see citing works
Sedding, D. G., Boyle, E. C., Demandt, J. A. F., Sluimer, J. C., Dutzmann, J., Haverich, A., & Bauersachs, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00706 · Cited by 228 · see citing works
Singh, N., Moody, A. R., Gladstone, D. J., Leung, G., Ravikumar, R., Zhan, J. Q., & Maggisano, R. (2009) · Radiology · doi:10.1148/radiol.2522080792 · Cited by 228 · see citing works
Vasa Vasorum in Normal and Diseased Arteries
Mulligan‐Kehoe, M. J., & Simons, M. (2014) · Circulation · doi:10.1161/circulationaha.113.007189 · Cited by 195 · see citing works
Contrast-Enhanced Ultrasound Imaging of the Vasa Vasorum
Staub, D., Schinkel, A. F. L., Coll, B., Coli, S., van der Steen, A. F. W., Reed, J. D., Krueger, C. G., Thomenius, K. E., Adam, D., Sijbrands, E. J. G., et al. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2010.02.007 · Cited by 179 · see citing works
Arithmetic of vulnerable plaques for noninvasive imaging
Narula, J., Garg, P. K., Achenbach, S. S., Motoyama, S., Virmani, R., & Strausś, H. W. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1247 · Cited by 167 · see citing works
Self-citationWinter, P. M., Caruthers, S. D., Zhang, H., Williams, T. A., Wickline, S. A., & Lanza, G. M. (2008) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2008.06.003 · Cited by 166 · see citing works
Koskinas, K. C., Chatzizisis, Y. S., Baker, A. B., Edelman, E. R., Stone, P. H., & Feldman, C. L. (2009) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328331630b · Cited by 125 · see citing works
Macrophage-targeted nanomedicine for chronic diseases immunotherapy
Song, Y., Huang, Y., Zhou, F., Ding, J., & Zhou, W. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.08.090 · Cited by 126 · see citing works
Inflammatory angiogenesis in atherogenesis—a double-edged sword
Ribatti, D., Levi‐Schaffer, F., & Kovanen, P. T. (2008) · Annals of Medicine · doi:10.1080/07853890802186913 · Cited by 121 · see citing works
Promoting Mechanisms of Vascular Health
Moreno, P., Sanz, J., & Fuster, V. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.057 · Cited by 106 · see citing works
Pfenniger, A., Chanson, M., & Kwak, B. R. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.05.011 · Cited by 93 · see citing works
Vascular endothelial growth factors in cardiovascular medicine
Testa, U., Pannitteri, G., & Condorelli, G. (2008) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e3283117d37 · Cited by 86 · see citing works
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Azevedo, A., do Prado, A. F., Antonio, R. C., Issa, J. P. M., & Gerlach, R. F. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12282 · Cited by 83 · see citing works
Arterial remodeling in vascular disease: a key role for hyaluronan and versican
Thomas, N. (2008) · Frontiers in bioscience · doi:10.2741/3052 · Cited by 82 · see citing works
Free cholesterol in atherosclerotic plaques: where does it come from?
Kolodgie, F. D., BURKE, A. P., Nakazawa, G., Cheng, Q., Xu, X., & Virmani, R. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282efa35b · Cited by 79 · see citing works
Self-citationPolymer‐based therapeutics: nanoassemblies and nanoparticles for management of atherosclerosis
Lewis, D. R., Kamisoglu, K., York, A. W., & Moghe, P. V. (2011) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.145 · Cited by 74 · see citing works
The role of complement activation in atherogenesis: the first 40 years
Vlaicu, S. I., Tatomir, A., Rus, V., Mekala, A. P., Mircea, P. A., Niculescu, F. I., & Rus, H. (2015) · Immunologic Research · doi:10.1007/s12026-015-8669-6 · Cited by 70 · see citing works
In Search of the “Vulnerable Plaque”
Ambrose, J. A. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.12.041 · Cited by 64 · see citing works
Models to Study Atherosclerosis: A Mechanistic Insight
Singh, V., Tiwari, R. L., Dikshit, M., & Barthwal, M. K. (2009) · Current Vascular Pharmacology · doi:10.2174/157016109787354097 · Cited by 63 · see citing works
Genesis and Dynamics of Atherosclerotic Lesions: Implications for Early Detection
Badimón, J. J., Ibáñez, B., & Cimmino, G. (2009) · Cerebrovascular Diseases · doi:10.1159/000200440 · Cited by 57 · see citing works
Dutertre, C., Clément, M., Morvan, M., Schäkel, K., Castier, Y., Alsac, J.-M., Michel, J., & Nicoletti, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089983 · Cited by 56 · see citing works
Lysophosphatidic acid effects on atherosclerosis and thrombosis
Sugden, M. C., & Holness, M. J. (2011) · Clinical Lipidology · doi:10.2217/clp.11.38 · Cited by 55 · see citing works
Subbotin, V. M. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.05.017 · Cited by 50 · see citing works
Fernández, A. B., Wong, T. Y., Klein, R., Collins, D. E., Burke, G. L., Cotch, M. F., Klein, B. E. K., Sadeghi, M. M., & Chen, J. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2011.09.044 · Cited by 49 · see citing works
Giannarelli, C., Alique, M., Rodriguez, D. T., Yang, D. K., Jeong, D., Calcagno, C., Hutter, R., Millon, A., Kovacic, J. C., Weber, T., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.006614 · Cited by 49 · see citing works
Cardiovascular Risk and Antiangiogenic Therapy for Age-related Macular Degeneration
Tuñón, J., Ruiz‐Moreno, J. M., Martı́n-Ventura, J. L., Blanco‐Colio, L. M., Lorenzo, Ó., & Egido, J. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2009.02.003 · Cited by 48 · see citing works
Xu, S., Liu, C. A., & Gotlieb, A. I. (2009) · Cardiovascular Pathology · doi:10.1016/j.carpath.2009.09.007 · Cited by 47 · see citing works
MR Imaging of the Arterial Vessel Wall: Molecular Imaging from Bench to Bedside
Makowski, M. R., & Botnar, R. M. (2013) · Radiology · doi:10.1148/radiol.13102336 · Cited by 45 · see citing works
Yao, J., Gao, W., Wang, Y., Wang, L., Diabakte, K., Li, J., Yang, J., Jiang, Y., Liu, Y., Guo, S., et al. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.10.007 · Cited by 44 · see citing works
Yunoki, K., Naruko, T., Komatsu, R., Ehara, S., Shirai, N., Sugioka, K., Nakagawa, M., Kitabayashi, C., Ikura, Y., Itoh, A., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp257 · Cited by 43 · see citing works
Selwaness, M., van den Bouwhuijsen, Q. J. A., Verwoert, G. C., Dehghan, A., Mattace-Raso, F. U. S., Vernooij, M. W., Franco, O. H., Albert Hofman, D., van der Lugt, A., Wentzel, J. J., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.198267 · Cited by 43 · see citing works
Fibroblast growth factor‐2/platelet‐derived growth factor enhances atherosclerotic plaque stability
Mao, Y., Liu, X. Q., Song, Y., Zhai, C., Xu, X., Zhang, L., & Zhang, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14850 · Cited by 42 · see citing works
Zeng, Z.-Z., Yao, H., Staszewski, E. D., Rockwood, K. F., Markwart, S. M., Fay, K. S., Spalding, A. C., & Livant, D. L. (2009) · Translational Oncology · doi:10.1593/tlo.08187 · Cited by 40 · see citing works
Plummer, E. M., Thomas, D. M., Destito, G., Shriver, L. P., & Manchester, M. (2012) · Nanomedicine · doi:10.2217/nnm.11.185 · Cited by 40 · see citing works
Characterization of Coronary Atherosclerosis by Magnetic Resonance Imaging
Makowski, M. R., Henningsson, M., Spuentrup, E., Kim, W. Y., Maintz, D. C., Manning, W. J., & Botnar, R. M. (2013) · Circulation · doi:10.1161/circulationaha.113.002681 · Cited by 40 · see citing works
Purushothaman, K., Meerarani, P., Levy, A. P., Lento, P. A., Evrard, S., Kovacic, J. C., Briley-Saebo, K. C., Tsimikas, S., Witztum, J. L., Krishnan, P., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.011 · Cited by 38 · see citing works
Sakamoto, M., Taoka, T., Nakagawa, H., Takayama, K., Wada, T., Myouchin, K., Akashi, T., Miyasaka, T., Fukusumi, A., Iwasaki, S., et al. (2009) · Neuroradiology · doi:10.1007/s00234-009-0623-7 · Cited by 35 · see citing works
The vulnerable coronary plaque: update on imaging technologies
Rosa, G. M., Bauckneht, M., Masoero, G., Mach, F., Quercioli, A., Seitun, S., Balbi, M., Brunelli, C., Parodi, A., Nencioni, A., et al. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-02-0121 · Cited by 34 · see citing works
MR Molecular Imaging of Aortic Angiogenesis
Cai, K., Caruthers, S. D., Huang, W., Williams, T. A., Zhang, H., Wickline, S. A., Lanza, G. M., & Winter, P. M. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2010.03.012 · Cited by 33 · see citing works
Romero, J. M., Umeton, R. P., Atkinson, W., Meader, A., Jaimes, C. E., LaMuraglia, G. M., Jaff, M. R., Buonanno, F. S., Almandoz, J. E. D., & González, R. G. (2013) · Stroke · doi:10.1161/strokeaha.113.002400 · Cited by 32 · see citing works
Imaging of the Vulnerable Plaque: Noninvasive and Invasive Techniques
Lerakis, S., Συνετός, Α., Toutouzas, K., Vavuranakis, M., Τσιάμης, Ε., Stefanadis, C., & Lerakis, S. (2008) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31816c7bdf · Cited by 30 · see citing works
Circulating Smooth Muscle Progenitors and Atherosclerosis
Albiero, M., Menegazzo, L., & Fadini, G. P. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.12.001 · Cited by 28 · see citing works
SLEVIN, M. A., Badimón, L., Grau-Olivares, M., Ramis, M., Sendra, J., Morrison, M., & Krupiński, J. (2009) · Molecular BioSystems · doi:10.1039/b916175a · Cited by 27 · see citing works
Pharmacotherapy of coronary atherosclerosis
Finn, A. V., Kramer, M. C. A., Vorpahl, M., Kolodgie, F. D., & Virmani, R. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902988494 · Cited by 27 · see citing works
Self-citationMultiple Roles of Connexins in Atherosclerosis- and Restenosis-Induced Vascular Remodelling
Morel, S. (2014) · Journal of Vascular Research · doi:10.1159/000362122 · Cited by 23 · see citing works
Nies, K., Smits, L. J. M., Kassem, M., Nederkoorn, P. J., van Oostenbrugge, R. J., & Kooi, M. E. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.718438 · Cited by 22 · see citing works
Toupchian, O., Sotoudeh, G., Mansoori, A., Nasli‐Esfahani, E., Djalali, M., Keshavarz, S. A., & Koohdani, F. (2016) · Journal of clinical lipidology · doi:10.1016/j.jacl.2016.02.013 · Cited by 22 · see citing works
Risky communication in atherosclerosis and thrombus formation
Meens, M. J. P. M. T., Pfenniger, A., & Kwak, B. R. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13553 · Cited by 18 · see citing works
Li, X., Wu, M., Li, J., Guo, Q., Zhao, Y., & Zhang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906512 · Cited by 16 · see citing works
Kurata, M., Nose, M., Shimazu, Y., Aoba, T., Kohada, Y., Yorioka, S., Suehiro, S., Fukuoka, E., Matsumoto, S., Watanabe, H., et al. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.12.003 · Cited by 16 · see citing works
Galis, Z. S., & Lessner, S. M. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2009.06.001 · Cited by 15 · see citing works
Stefanadis, C., Toutouzas, K. P., Tsiamis, E. G., Vavuranakis, M., Stefanadi, E., & Kipshidze, N. N. (2008) · EuroIntervention · doi:10.4244/eijv3i4a82 · Cited by 15 · see citing works
Laboratory medicine for molecular imaging of atherosclerosis
Mangge, H., Almer, G., Stelzer, I., Reininghaus, E. Z., & Prassl, R. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.06.029 · Cited by 14 · see citing works
Dichotomy in Hedgehog Signaling between Human Healthy Vessel and Atherosclerotic Plaques
Queiroz, K. C. S., Bijlsma, M. F., Tio, R. A., Zeebregts, C. J., Dunaeva, M., Ferreira, C. V., Fuhler, G. M., Kuipers, E. J., Alves, M. M., Rezaee, F., et al. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00250 · Cited by 13 · see citing works
The diagnostic value of soluble CD163 in patients presenting with chest pain
Willemsen, H. M., van der Horst, I. C. C., Nieuwland, W., Slart, R., Zeebregts, C. J., de Boef, E., Schuitemaker, J. H. N., Zijlstra, F., & Tio, R. A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.028 · Cited by 13 · see citing works
Xu, B., Jin, X., Wu, W., Zhang, W., Zhu, Q., Zhang, D., Sun, N., Wu, C., Kang, G., Zhai, L., et al. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5926 · Cited by 13 · see citing works
Molecular Imaging in Cardiovascular Diseases
Botnar, R. M., Ebersberger, H. U., Noerenberg, D., Jansen, C. H. P., Wiethoff, A. J., Schuster, A., Kasner, M., Walter, T., Knobloch, G., Höppe, P., et al. (2015) · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · doi:10.1055/s-0034-1385451 · Cited by 13 · see citing works
Intrusion Through the Fragile Back Door
Mause, S. F., & Weber, C. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.01.047 · Cited by 13 · see citing works
Fedak, A., Chrzan, R. M., Chukwu, O., & Urbanik, A. (2020) · Journal of Ultrasonography · doi:10.15557/jou.2020.0032 · Cited by 12 · see citing works
Ma, X., Wang, J., Li, Z., Zhou, X., Liang, X., Wang, J., Duan, Y., & Zhao, P. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s382738 · Cited by 11 · see citing works
Téllez, A., Schuster, D. S., Alviar, C. L., López-Berenstein, G., Sanguino, A. M., Ballantyne, C. M., Perrard, X. D., Schulz, D. G., Rousselle, S. D., Kałuża, G. L., et al. (2011) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2011.03.007 · Cited by 11 · see citing works
Atherosclerosis in the Back Yard
Herrmann, J., & Lerman, A. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.042 · Cited by 10 · see citing works
Vavuranakis, M., Kakadiaris, I. A., Papaioannou, T., O’Malley, S. M., CARLIER, S. G., Naghavi, M., & Stefanadis, C. (2007) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.5.5.917 · Cited by 9 · see citing works
Common Vascular Toxicities of Cancer Therapies
Herrmann, J. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.07.003 · Cited by 8 · see citing works
Expression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease
Zhmurov, Ç. S., Timirci‐Kahraman, Ö., Amadou, F. Z., Fazlıoğulları, O., Başaran, C., Çatal, T., Zeybek, Ü., & Bermek, H. (2016) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2015.0252 · Cited by 6 · see citing works
Coronary Vessel Wall Imaging: State of the Art and Future Directions
Wurster, T. H., Landmesser, U., Engel, L., Bigalke, B., & Makowski, M. (2019) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-019-9493-5 · Cited by 5 · see citing works
Bone Marrow–Derived Matrix Metalloproteinase-14
Shimokawa, H. (2008) · Circulation · doi:10.1161/circulationaha.107.756346 · Cited by 5 · see citing works
Accumulation of nano-sized particles in a murine model of angiogenesis
Wittenborn, T. R., Larsen, E., Nielsen, T., Rydtoft, L. M., Hansen, L., Nygaard, J. V., Vorup‐Jensen, T., Kjems, J., Horsman, M. R., & Nielsen, N. C. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.127 · Cited by 4 · see citing works
Vascular Connexins in Restenosis After Balloon Injury
Morel, S., & Kwak, B. R. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-505-7_22 · Cited by 4 · see citing works
New approaches to the concept of primary prevention of atherosclerosis
Ford, M. A., Allison, T. G., & Lerman, A. (2008) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-008-0008-y · Cited by 4 · see citing works
Atherosclerotic Plaque Imaging
Lavín, B., Gebhardt, P., Phinikaridou, A., & Botnar, R. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-53001-7_8 · Cited by 3 · see citing works
Lavín, B., Phinikaridou, A., Henningsson, M., & Botnar, R. M. (2014) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-014-9309-6 · Cited by 3 · see citing works
Eliminating Plaque Angiogenesis
Koutouzis, M., & Kyriakides, Z. S. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.036 · Cited by 3 · see citing works
Liu, X., Li, X., Wang, X. W., Zhao, J., Liu, C., Wang, S., Xia, Z., & Xu, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-07395-7 · Cited by 2 · see citing works
The role of vasa vasorum in carotid stenosis
Svetlikov, A. V., Шаповалов, А. С., PIGAREVSKY, P. V., Maltseva, S. V., Lukin, S. V., & Gurevich, V. S. (2025) · International Angiology · doi:10.23736/s0392-9590.25.05445-8 · Cited by 2 · see citing works
Molecular Imaging of Atherosclerosis
Tawakol, A. A., Narula, J., Narula, J., Narula, J., Narula, J., & Jaffer, F. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5551-6_12 · Cited by 2 · see citing works
Self-citationПогорелова, О. А., Fomicheva, O. A., Tripoten, M. I., Круглый, Л. Б., Владимировна, Г. Е., Shingareeva, F. F., Иосифович, Х. Г., IuA, K., Попкова, Т. В., & Balakhonova, T. V. (2020) · Russian Cardiology Bulletin · doi:10.36396/ms.2020.15.4.008 · Cited by 1 · see citing works
A3 Adenosine Receptors, HIF-1 Modulation and Atherosclerosis
Gessi, S., MacLennan, S., Leung, E., & Borea, P. A. (2009) · Springer eBooks · doi:10.1007/978-90-481-3144-0_14 · Cited by 1 · see citing works
Téllez, A., Sanguino, A. M., Ballantyne, C., & Granada, J. F. (2011) · Cardiovascular and Metabolic Science · Cited by 1 · see citing works
Nucleic Acid Aptamers for Cardiovascular Therapeutics
Pendergrast, P. S., Thompson, K. M., & Schaub, R. G. (2008) · Springer eBooks · doi:10.1007/978-3-540-78709-9_14
Perfluorocarbon Nanoparticles: A Multidimensional Platform for Targeted Image‐Guided Drug Delivery
Lanza, G. M., Caruthers, S. D., Schmieder, A. H., Winter, P. M., Cyrus, T., & Wickline, S. A. (2011) · doi:10.1002/9780470767047.ch30
da Silva, J. F. A., Chamié, D., Costa, J. R., Abizaid, A., Feres, F., de Sá, F. C. F., Passos, R. L. E., Mattos, L. A., Staico, R., Chaves, A. J., et al. (2009) · Revista Brasileira de Cardiologia Invasiva · doi:10.1590/s2179-83972009000200013
Purushothaman, K., Meerarani, P., Levy, A. P., Sharma, S. K., Fuster, V., & Moreno, P. (2010) · Springer eBooks · doi:10.1007/978-90-481-9495-7_10
Chin, G. F., Misran, M., Tang, P., & Lee, P. F. (2012) · doi:10.1109/icobe.2012.6179071
Vascular repair mechanisms : Experimental, physiological and clinical studies.
Razuvajev, A. (2009) · Figshare
L'imaging della placca vulnerabile
Guagliumi, G., Musumeci, G., Pierli, C., Fineschi, M., & Musuraca, A. C. (2010) · Giornale italiano di cardiologia · doi:10.1714/664.7726
Ribonucleotide Reductase Inhibitors for Restenosis
Mutchler, M. M. (2008) · OhioLink ETD Center (Ohio Library and Information Network)
IVUS and IVUS-derived methods for vulnerable plaque assessment
Kaple, R., Maehara, A., & Mintz, G. S. (2009) · CRC Press eBooks · doi:10.3109/9781841847214-13
Moreno, P., Alviar, C. L., Sanz, J., & Fuster, V. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2358-8.00059-0
No Epicardial Fat, No Plaque Rupture
Torii, S., & Nakazawa, G. (2020) · Circulation Journal · doi:10.1253/circj.cj-20-0249
Molecular Imaging of Atherosclerosis
Osborn, E. A., Albaghdadi, M. S., Libby, P., & Jaffer, F. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816386-3.00086-7
Atherosclerotic Plaque Imaging
Lavín, B., Phinikaridou, A., Andía, M. E., Lacerda, S., Henningsson, M., Makowski, M. R., & Botnar, R. M. (2019) · Contemporary cardiology · doi:10.1007/978-1-4939-8841-9_14
Tukhbatullin, M. G., Fomina, E. E., Bayazova, N. I., & Зуфарович, Х. М. (2022) · Springer eBooks · doi:10.1007/978-3-030-91764-7_18
- Authors
- Kolodgie, F. D., Narula, J., Yuan, C., Burke, A. P., Finn, A. V., & Virmani, R.
- Affiliations
- CVPath Institute (US)
- University of California, Irvine (US)
- University of Washington (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Virmani, Renu
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 49
- Issue
- 21
- Pages
- 2093-2101
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W62949326
- Cited by
- 96
- References
- 61
- Citations by year
- 2025: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 8 · 2013: 6 · 2012: 9
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01 HL61799-02, R01HL061799)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- neoangiogenesis, intraplaque hemorrhage, plaque stabilization, atherosclerotic plaque instability, vasa vasorum, anti-angiogenic therapy, vascular regression, plaque neovascularization, inflammation
- MeSH terms
- Coronary Artery Disease, Coronary Vessels, Diagnostic Imaging, Hemorrhage, Humans, Hypercholesterolemia, Inflammation, Necrosis, Neovascularization, Pathologic, Vasa Vasorum, Tunica Intima, Angiogenesis Inhibitors
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