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Cited by 561Diet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic Diseases

Fructose metabolism and metabolic disease

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Hannou, Sarah A., Haslam, Danielle E., McKeown, Nicola M., Herman, Mark A.·2018·Journal of Clinical Investigation
DOI 10.1172/jci96702PMC PMC5785258
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Abstract

Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.

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  • High dietary fructose intake has been proposed to induce adverse health effects and has been associated with the development of metabolic disease.

    “It should be noted that high dietary fructose intake has been proposed to induce adverse health effects and has been associated with the development of metabolic disease (Hannou et al. 2018; Tappy, 2018).”

    From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Hannou et al. 2018

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Cited by

Sorted by citations

Authors
Hannou, S. A., Haslam, D. E., McKeown, N. M., & Herman, M. A.
Affiliations
  • Duke University (US)
  • Tufts University (US)
Corresponding author
Herman, Mark A.
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2018-02-01
Volume
128
Issue
2
Pages
545-555
ISSN
  • 0021-9738 (ISSN-L)
  • 1558-8238
DOI
10.1172/jci96702
PMC
PMC5785258
OpenAlex
W2785515118
Cited by
561
References
24
Citations by year
2026: 45 · 2025: 73 · 2024: 65 · 2023: 67 · 2022: 88 · 2021: 105 · 2020: 67 · 2019: 37 · 2018: 13 · 2014: 1
FWCI
8.54
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
Funders
  • U.S. Department of Agriculture (58-1950-4-003)
  • American Heart Association (16CSA28590003)
  • National Institutes of Health
  • Agricultural Research Service (58-1950-4-003)
  • National Heart, Lung, and Blood Institute (T32HL069772)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100425)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
fructose metabolism, fructose consumption, metabolic syndrome, obesity, diabetes mellitus, cardiometabolic disease, sugar consumption
MeSH terms
Sugars, Animals, Fructose, Glucose, Humans, Hypertension, Liver, Risk Factors, Gene Expression Profiling, Metabolic Syndrome, Adiposity, Glucose Transporter Type 2

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