Hyperuricemia and xanthine oxidase in preeclampsia, revisited
Abstract
Hyperuricemia is associated with the severity of preeclampsia and with fetal outcome. Traditionally the high uric acid concentration in preeclampsia has been attributed soley to renal dysfunction. Preeclampsia is also characterized by increased free radical formation and elevated oxidative stress. Xanthine dehydrogenase/oxidase produces uric acid. Xanthine dehydrogenase/oxidase is present as two isoforms in vivo. Uric acid production is coupled with formation of reactive oxygen species when the enzyme is in the oxidase form. Several factors can increase the holoenzyme activity and the conversion of xanthine dehydrogenase/oxidase to its oxidase form. These factors include hypoxia-reperfusion, cytokines, and increased substrate availability (xanthine and hypoxanthine). Preeclampsia is characterized by hyperuricemia and signs of increased formation of reactive oxygen species and decreased levels of antioxidants. Preeclampsia is also characterized by shallow implantation, producing a relatively hypoxic maternal-fetal interface, and increased turnover of trophoblast tissue, which can result in higher xanthine and hypoxanthine concentrations and higher levels of circulating cytokines. These mechanisms can lead to increased production of uric acid and free radicals and contribute to the hyperuricemia and increased oxidative stress present in preeclampsia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gui et al. suggested that metformin reduced the rate of gestational hypertension because of its effects on endothelial function and its decrease in the production of reactive oxygen species.
“Gui et al.(75) suggested that metformin reduced the rate of gestational hypertension because of its effects on endothelial function and its decrease in the production of reactive oxygen species, the two mechanisms implicated in the pathophysiology of preeclampsia(84–94).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
Torbergsen et al. suggested that these women developed preeclampsia because their dysfunctional mitochondria could not meet the increased energy demands of pregnancy, and the failure of adequate cellular energy production led to an accumulation of ADP, which is able to mediate most of the changes seen in preeclampsia.
“Torbergsen et al. suggested that these women developed preeclampsia because their dysfunctional mitochondria could not meet the increased energy demands of pregnancy, and the failure of adequate cellular energy production led to an accumulation of ADP, which is able to mediate most of the changes seen in preeclampsia(89, 197)”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
ADP is a vasoconstrictor, causes platelet aggregation, and breaks down to uric acid.
“ADP is a vasoconstrictor, causes platelet aggregation, and breaks down to uric acid.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [89]
Cites
Harrison's Principles of Internal Medicine.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-499_2 · Cited by 12,528 · see citing works
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399 · see citing works
The Pathology of the Human Placenta
Benirschke, K., & Driscoll, S. G. (1967) · Springer eBooks · doi:10.1007/978-1-4612-9809-0 · Cited by 2,123 · see citing works
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672 · see citing works
Xanthine oxidase: biochemistry, distribution and physiology.
Parks, D. A., & Granger, D. N. (1986) · PubMed · Cited by 638 · see citing works
Lipid peroxidation in pregnancy: New perspectives on preeclampsia
Hubel, C. A., Roberts, J. M., Taylor, R. N., Musci, T. J., Rogers, G. M., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90778-3 · Cited by 445 · see citing works
Self-citationLocalization of xanthine oxidase in mammary-gland epithelium and capillary endothelium
Jarasch, E.-D., Gründ, C., Bruder, G., Heid, H., Keenan, T. W., & Franke, W. W. (1981) · Cell · doi:10.1016/0092-8674(81)90232-4 · Cited by 440 · see citing works
Roberts, J. M., Taylor, R. N., & Goldfien, A. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.8.700 · Cited by 389 · see citing works
Self-citationThe Role of Oxygen Radicals in Human Disease, with Particular Reference to the Vascular System
Halliwell, B. B. (2009) · Haemostasis · doi:10.1159/000216921 · Cited by 358 · see citing works
EMBOLISM TO THE LUNGS BY TROPHOBLAST
Attwood, H. D., & Park, W. W. (1961) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1961.tb02778.x · Cited by 267 · see citing works
PLASMA-URATE MEASUREMENTS IN PREDICTING FETAL DEATH IN HYPERTENSIVE PREGNANCY
Redman, C. W. G., Beilin, L. J., Bonnar, J., & Wilkinson, R. H. (1976) · The Lancet · doi:10.1016/s0140-6736(76)93024-5 · Cited by 264 · see citing works
Mediator‐induced activation of xanthine oxidase in endothelial cells
Friedl, H. P., Till, G. O., Ryan, U. S., & Ward, P. A. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.13.2806779 · Cited by 218 · see citing works
Hypoxanthine as a Measurement of Hypoxia
Saugstad, O. D. (1975) · Pediatric Research · doi:10.1203/00006450-197504000-00002 · Cited by 218 · see citing works
Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface
Adachi, T., Fukushima, T., Usami, Y., & Hirano, K. (1993) · Biochemical Journal · doi:10.1042/bj2890523 · Cited by 213 · see citing works
Trophoblast deportation in pre‐eclamptic pregnancy
Chua, S., WILKINS, T., SARGENT, I. L., & Redman, C. W. G. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb15334.x · Cited by 188 · see citing works
Circulating xanthine oxidase: potential mediator of ischemic injury
Yokoyama, Y., Beckman, J. S., Beckman, T. K., Wheat, J. K., Cash, T., Freeman, B. Α., & Parks, D. A. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.258.4.g564 · Cited by 188 · see citing works
Lipid Peroxidation in Pregnancy
Walsh, S. W. (1994) · Hypertension in Pregnancy · doi:10.3109/10641959409084168 · Cited by 176 · see citing works
A STUDY OF THE VESSELS OF THE PLACENTAL BED IN NORMOTENSIVE AND HYPERTENSIVE WOMEN
Dixon, H. G., & Robertson, W. B. (1958) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1958.tb08876.x · Cited by 172 · see citing works
Sera antioxidant activity in uncomplicated and preeclamptic pregnancies
Davidge, S. T., Hubel, C. A., Brayden, R. D., Capeless, E. C., & McLaughlin, M. K. (1993) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(93)90421-r · Cited by 163 · see citing works
Self-citationDupont, G. P., Huecksteadt, T. P., Marshall, B. C., Ryan, U. S., Michael, J. R., & Hoidal, J. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115563 · Cited by 136 · see citing works
Xanthine oxidase activity in the circulation of rats following hemorrhagic shock
Tan, S., Yokoyama, Y., Dickens, E., Cash, T., Freeman, B. Α., & Parks, D. A. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90040-2 · Cited by 134 · see citing works
[78] Oxygen-derived free radicals in reperfusion injury
Sussman, M. S., & Bulkley, G. B. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86170-z · Cited by 123 · see citing works
Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues
Wajner, M., & HARKNESS, R. A. (1989) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(89)90031-7 · Cited by 115 · see citing works
THE URIC ACID CONTENT OF MATERNAL AND FETAL BLOOD
Slemons, J. M., & Bogert, L. J. (1917) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86658-3 · Cited by 104 · see citing works
Chesley, L. C., & Williams, L. O. (1945) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(45)90138-4 · Cited by 95 · see citing works
Boyle, J. A., Campbell, S. C., Duncan, A. M., Greig, W. R., & Buchanan, W. W. (1966) · Journal of Clinical Pathology · doi:10.1136/jcp.19.5.501 · Cited by 93 · see citing works
Hassoun, P. M., Yu, F., Shedd, A. L., Zulueta, J. J., Thannickal, V. J., Lanzillo, J. J., & Fanburg, B. L. (1994) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1994.266.2.l163 · Cited by 86 · see citing works
Uotila, J. T., Kirkkola, A.-L., Rorarius, M. G. F., Tuimala, R. J., & Metsä‐Ketelä, T. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90058-2 · Cited by 84 · see citing works
Effect of allopurinol in renal ischemia.
Vasko, K. A., DeWall, R. A., & Am, R. (1972) · PubMed · Cited by 80 · see citing works
MacKenzie, I. Z. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91719-x · Cited by 77 · see citing works
Purine and pyrimidine metabolism in man
Peters, G. J., ABREU, R. A. D., Gennip, A. H., Belle, H. V., & den Berghe, G. V. (1993) · Pharmacy World & Science · doi:10.1007/bf02297668 · Cited by 76 · see citing works
Super oxide and ischemia : Conversion of xanthine dehydrogenase to xanthine oxidase
Roy, R. (1983) · Medical Entomology and Zoology · Cited by 72 · see citing works
Role of xanthine oxidase and reactive oxygen intermediates in LPS- and TNF-induced pulmonary edema.
Faggioni, R., Gatti, S., Demitri, M. T., Delgado, R., Echtenacher, B., Gnocchi, P., Heremans, H., & Ghezzi, P. (1994) · PubMed · Cited by 66 · see citing works
O’Connor, M. C., HARKNESS, R. A., Simmonds, R. J., & Hytten, F. E. (1981) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1981.tb01001.x · Cited by 65 · see citing works
Endothelial cell activation as a pathogenetic factor in preeclampsia.
Roberts, J. M., Taylor, R. N., & Goldfien, A. (1991) · PubMed · Cited by 58 · see citing works
Self-citationUric acid and endogenous creatinine clearance studies in normal pregnancy and toxemias of pregnancy
Hayashi, T. T. (1956) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(56)90582-8 · Cited by 55 · see citing works
Interferons induce xanthine dehydrogenase gene expression in L929 cells
Francesco Falciani, B., Ghezzi, P., Terao, M., Cazzaniga, G., & Garattini, E. (1992) · Biochemical Journal · doi:10.1042/bj2851001 · Cited by 54 · see citing works
Role of oxygen radicals in tourniquet-related ischemia-reperfusion injury of human patients
Friedl, H. P., Till, G. O., Trentz, O., & Ward, P. A. (1991) · Journal of Molecular Medicine · doi:10.1007/bf01645168 · Cited by 53 · see citing works
High levels of xanthine oxidoreductase in rat endothelial, epithelial and connective tissue cells
Kooij, A., Bosch, K. S., Frederiks, W. M., & Noorden, C. J. F. V. (1992) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899676 · Cited by 51 · see citing works
Selective effects of preeclamptic sera on human endothelial cell procoagulant protein expression
Taylor, R. N., Casal, D., Jones, L. A., Varma, M., Martin, J. N., Jr., & Roberts, J. M. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90019-n · Cited by 47 · see citing works
Self-citationTHE VALUE OF BLOOD URIC ACID LEVELS IN TOXAEMIA OF PREGNANCY
Lancet, M., & Fisher, I. L. (1956) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1956.tb05447.x · Cited by 46 · see citing works
Localisation of xanthine oxidase to synovial endothelium.
Stevens, C. R., Benboubetra, M., Harrison, R., Sahinoglu, T., Smith, E., & Blake, D. R. (1991) · Annals of the Rheumatic Diseases · doi:10.1136/ard.50.11.760 · Cited by 42 · see citing works
CORD PLASMA HYPOXANTHINE AS A MEASURE OF FOETAL ASPHYXIA
Thiringer, K. (1983) · Acta Paediatrica · doi:10.1111/j.1651-2227.1983.tb09703.x · Cited by 42 · see citing works
Hyperuricemia in pre-eclampsia
Fadel, H. E., Northrop, G., & Misenhimer, H. R. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90786-9 · Cited by 40 · see citing works
Hällgren, R., Niklasson, F., Terént, A., Akerblom, A., & Widerlöv, E. (1983) · Stroke · doi:10.1161/01.str.14.3.382 · Cited by 39 · see citing works
Hypoxanthine: a marker for asphyxia.
Pietz, J., Guttenberg, N. A., & Gluck, L. (1988) · PubMed · Cited by 37 · see citing works
CLINICAL RELEVANCE OF COAGULATION AND RENAL CHANGES IN PRE-ECLAMPSIA
Dunlop, W., Landon, M. J., Hill, L. M., Oxley, A., & Jones, P. M. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92944-6 · Cited by 35 · see citing works
Liedholm, H., Montán, S., & Åberg, A. (1984) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348409157122 · Cited by 32 · see citing works
Metabolism of uric acid in normal and toxemic pregnancy.
Lm, H. (1978) · PubMed · Cited by 29 · see citing works
Gallery, E. D. M., & Gyory, A. Z. (1979) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(79)90039-x · Cited by 28 · see citing works
AN EVALUATION OF THE SERUM URIC ACID LEVEL IN PREGNANCY
McFarlane, C. N. (1963) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1963.tb04180.x · Cited by 28 · see citing works
O’Connor, M. C., HARKNESS, R. A., Simmonds, R. J., & Hytten, F. E. (1981) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1981.tb01000.x · Cited by 25 · see citing works
Metabolism of Uric Acid in Normal and Toxemic Pregnancy
Hill, L. M. (1979) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-197907010-00008 · Cited by 23 · see citing works
Metabolism of Uric Acid in Normal and Pathologic Pregnancy
Beaufils, M., Uzan, S., Donsimoni, R., Brault, D., & Colau, J. C. (2015) · Contributions to nephrology · doi:10.1159/000396023 · Cited by 23 · see citing works
Maguire, M. H., Szabó, I., Slégel, P., & King, C. R. (1992) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(92)80152-g · Cited by 22 · see citing works
Maguire, M. H., Westermeyer, F. A., & King, C. R. (1986) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)83624-5 · Cited by 21 · see citing works
The Metabolism of Urate in Pre-Eclampsia
SEITCHIK, J. N. (1956) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)37509-3 · Cited by 21 · see citing works
Purine nucleotide catabolism in placenta
Hayashi, T. T., Baldridge, R. C., Olmsted, P. S., & Kimmel, D. L. (1964) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(64)90504-6 · Cited by 19 · see citing works
Tubulointerstitial Diseases of the Kidney
Truong, L. D., & Eknoyan, G. (1998) · Pathology Case Reviews · doi:10.1097/00132583-199807000-00004 · Cited by 19 · see citing works
Transplacental passage of nucleotides, nucleosides, and bases
Hayashi, T. T., & Garvey, B. I. (1968) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(68)90406-7 · Cited by 16 · see citing works
Serum uric acid in pre-eclampsia and eclampsia.
Fadel, H. E., Ms, S., Mahran, M., el-Din, D. S., & el-Mahallawi, M. N. (1969) · PubMed · Cited by 14 · see citing works
Significance of uric acid clearance in preeciampsia
Yoshimura, A., Ideura, T., Iwasaki, S., & Koshikawa, S. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90953-5 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 63 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
Johnson, R. J., Kang, D., Feig, D. I., Kivlighn, S. D., Kanellis, J., Watanabe, S., Tuttle, K. R., Rodríguez‐Iturbe, B., Herrera-Acosta, J., & Mazzali, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000069700.62727.c5 · Cited by 1,354 · see citing works
Etiology and pathogenesis of preeclampsia: Current concepts
Dekker, G., & Sibai, B. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70160-7 · Cited by 760 · see citing works
Oxidative Stress in the Pathogenesis of Preeclampsia
Hubel, C. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-139.x · Cited by 673 · see citing works
Self-citationBurton, G. J., Yung, H.-W., Cindrova-Davies, T., & Charnock-Jones, D. S. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.003 · Cited by 502 · see citing works
Endothelial dysfunction and preeclampsia: role of oxidative stress
Sanchez-Aranguren, L. C., Prada, C. E., Riaño-Medina, C. E., & López, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00372 · Cited by 439 · see citing works
Hung, T., Skepper, J. N., Jones, D. S., & Burton, G. J. (2002) · Circulation Research · doi:10.1161/01.res.0000024411.22110.aa · Cited by 397 · see citing works
Schwartz, R. B., Feske, S. K., Polak, J. F., Girolami, U. D., Iaia, A., Beckner, K. M., Bravo, S. M., Klufas, R. A., Chai, R. Y., & Jt, R. (2000) · Radiology · doi:10.1148/radiology.217.2.r00nv44371 · Cited by 388 · see citing works
A longitudinal study of biochemical variables in women at risk of preeclampsia
Chappell, L. C., Seed, P. T., Briley, A. L., Kelly, F. J., Hunt, B. J., Jones, D. S., Mallet, A. I., & Poston, L. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.122969 · Cited by 351 · see citing works
Preeclampsia: A renal perspective
Karumanchi, S. A., Maynard, S. E., Stillman, I. E., Epstein, F. H., & Sukhatme, V. P. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00316.x · Cited by 314 · see citing works
Guerby, P., Tasta, O., Swiader, A., Pont, F., Bujold, E., Parant, O., Vayssière, C., Salvayre, R., & Nègre‐Salvayre, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101861 · Cited by 309 · see citing works
Hypoxia and Reoxygenation: a Possible Mechanism for Placental Oxidative Stress in Preeclampsia
Hung, T., & Burton, G. J. (2006) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/s1028-4559(09)60224-2 · Cited by 289 · see citing works
Oxygen, the Janus gas; its effects on human placental development and function
Burton, G. J. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00978.x · Cited by 281 · see citing works
Invasive Cytotrophoblasts Manifest Evidence of Oxidative Stress in Preeclampsia
Many, A., Hubel, C. A., Fisher, S. J., Roberts, J. M., & Zhou, Y. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64733-5 · Cited by 278 · see citing works
Self-citationJohnson, R. J., Kivlighn, S. D., Kim, Y.-G., Suga, S., & Fogo, A. B. (1999) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(99)70295-7 · Cited by 263 · see citing works
Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253 · see citing works
Accuracy of serum uric acid in predicting complications of pre‐eclampsia: a systematic review
Thangaratinam, S., Ismail, K., Sharp, S., Coomarasamy, A., & Khan, K. S. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00908.x · Cited by 210 · see citing works
Chappell, L. C., Seed, P. T., CStat, Kelly, F. J., Briley, A. L., Hunt, B. J., Jones, D. S., Mallet, A. I., & Poston, L. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.125735 · Cited by 209 · see citing works
Lala, P. K., & Chakraborty, C. (2003) · Placenta · doi:10.1016/s0143-4004(03)00063-8 · Cited by 188 · see citing works
Review: Oxygen and trophoblast biology – A source of controversy
Tuuli, M. G., Longtine, M. S., & Nelson, D. M. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.013 · Cited by 158 · see citing works
Powers, R. W., Bodnar, L. M., Ness, R. B., Cooper, K. M., Gallaher, M. J., Frank, M. P., Daftary, A. R., & Roberts, J. M. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.066 · Cited by 151 · see citing works
Self-citationElevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre‐eclampsia
Smárason, A. K., Allman, K. G., Young, D., & Redman, C. W. G. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb11528.x · Cited by 146 · see citing works
Oxidative stress in pre-eclampsia
Bowen, R. S., Moodley, J., Dutton, M. F., & Theron, A. J. (2001) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2001.080008719.x · Cited by 145 · see citing works
The immunology of preeclampsia
Dekker, G., & Sibai, B. M. (1999) · Seminars in Perinatology · doi:10.1016/s0146-0005(99)80057-3 · Cited by 142 · see citing works
Vascular Endothelial Growth Factor Is Increased in Patients With Preeclampsia
Kupferminc, M. J., Daniel, Y., Englender, T., Bar‐Am, A., Many, A., Jaffa, A. J., Gull, I., & Lessing, J. B. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00519.x · Cited by 128 · see citing works
Self-citationKaya, M. G., Uyarel, H., Akpek, M., Kalay, N., Ergelen, M., Ayhan, E., Işık, T., Çiçek, G., Elçik, D., Şahin, Ö., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.09.042 · Cited by 120 · see citing works
Pregnancy-Related Hypertension
Roberts, J. M., & Funai, E. F. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4224-2.50038-7 · Cited by 120 · see citing works
Self-citationThe role of oxygen in prenatal growth: studies in the chick embryo
Giussani, D. A., Salinas, C. E., Villena, M., & Blanco, C. E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141572 · Cited by 120 · see citing works
The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy
Lim, K.-H., Friedman, S. A., Ecker, J. L., Kao, L., & Kilpatrick, S. J. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70549-6 · Cited by 115 · see citing works
Peraçoli, J. C., Rudge, M. V. C., & Peraçoli, M. T. S. (2007) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00455.x · Cited by 114 · see citing works
Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals
Ishizaka, N., Ishizaka, Y., Toda, E.-I., Hashimoto, H., Nagai, R., & Yamakado, M. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.04.016 · Cited by 109 · see citing works
Mulla, M. J., Salmon, J. E., Chamley, L., Brosens, J. J., Boeras, C., Kavathas, P., & Abrahams, V. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065237 · Cited by 109 · see citing works
Role of reactive oxygen species in gynecologic diseases
Sharma, R. K., & Agarwal, A. K. (2004) · Reproductive Medicine and Biology · doi:10.1111/j.1447-0578.2004.00068.x · Cited by 106 · see citing works
Uric acid, endothelial dysfunction and pre-eclampsia
Kang, D., Finch, J., Nakagawa, T., Karumanchi, S. A., Kanellis, J., Granger, J. P., & Johnson, R. J. (2004) · Journal of Hypertension · doi:10.1097/00004872-200402000-00001 · Cited by 105 · see citing works
Akpek, M., Kaya, M. G., Uyarel, H., Yarlıoğlueş, M., Kalay, N., Günebakmaz, Ö., Doğdu, O., Ardıç, İ., Elçik, D., Şahin, Ö., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.07.021 · Cited by 102 · see citing works
Reslan, O. M., & Khalil, R. A. (2010) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152510792481234 · Cited by 93 · see citing works
Study of Plasma Factors Associated With Neutrophil Activation and Lipid Peroxidation in Preeclampsia
Barden, A. E., Ritchie, J., Walters, B. N. J., Michael, C., Rivera, J., Mori, T. A., Croft, K. D., & Beilin, L. J. (2001) · Hypertension · doi:10.1161/hy1101.092969 · Cited by 90 · see citing works
Lam, C., Lim, K.-H., Kang, D., & Karumanchi, S. A. (2005) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.09.009 · Cited by 89 · see citing works
The prognostic role of serum uric acid levels in preeclampsia: A meta‐analysis
Bellos, I., Pergialiotis, V., Loutradis, D., & Daskalakis, G. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13865 · Cited by 86 · see citing works
The renal response to preeclampsia
Moran, P., Lindheimer, M. D., & Davison, J. M. (2004) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.07.008 · Cited by 79 · see citing works
Koopmans, C. M., van Pampus, M. G., Groen, H., Aarnoudse, J. G., van den Berg, P. P., & Mol, B. W. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.05.014 · Cited by 76 · see citing works
Renal Physiology and Disease in Pregnancy
Conrad, K. P., & Karumanchi, S. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00081-1 · Cited by 74 · see citing works
Pregnancy-induced hypertension and insulin resistance, evidence for a connection
Innes, K. E., & Wimsatt, J. (1999) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.1999.780401.x · Cited by 67 · see citing works
Dietary l-arginine prevents fetal growth restriction in rats
Vosatka, R. J., Hassoun, P. M., & Harvey-Wilkes, K. B. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)80007-0 · Cited by 65 · see citing works
Tsukimori, K., Yoshitomi, T., Morokuma, S., Fukushima, K., & Wake, N. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.289 · Cited by 60 · see citing works
Cystatin C, β‐2‐microglobulin and β‐trace protein in pre‐eclampsia
Kristensen, K. H., Wide‐Swensson, D., SCHMIDT, C., Blirup-Jensen, S., Lindström, V., Strevens, H., & GRUBB, A. O. (2007) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340701318133 · Cited by 58 · see citing works
The Role of Uric Acid in Preeclampsia: Is Uric Acid a Causative Factor or a Sign of Preeclampsia?
Khaliq, O. P., Konoshita, T., Moodley, J., & Naicker, T. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0878-7 · Cited by 57 · see citing works
Augmented oxidative stress as well as antioxidant capacity in maternal circulation in preeclampsia
Harsem, N. K., Brække, K., & Staff, A. C. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.11.014 · Cited by 57 · see citing works
Karabulut, A. B., Kafkaslı, A., Burak, F., & Gözükara, E. M. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1152 · Cited by 56 · see citing works
Bretelle, F., Sabatier, F., Blann, A. D., D’Ercole, C., Boutiere, B., Mutin, M., Boubli, L., Sampol, J., & Dignat‐George, F. (2001) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2001.00259.x · Cited by 56 · see citing works
Antioxidant therapy to prevent preeclampsia
Roberts, J. M., & Speer, P. D. (2004) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.07.004 · Cited by 55 · see citing works
Self-citationYang, Y., Wang, Y., Zeng, X., Ma, X.-J., Zhao, Y., Qiao, J., Cao, B., Li, Y.-X., Ji, L., & Wang, Y. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1150 · Cited by 53 · see citing works
Murata, M., Fukushima, K., Takao, T., Seki, H., Takeda, S., & Wake, N. (2013) · Journal of Reproduction and Development · doi:10.1262/jrd.2012-053 · Cited by 53 · see citing works
Burton, G. J., & Hung, T. (2003) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539503001049 · Cited by 52 · see citing works
Total free radical trapping antioxidant potential in pre‐eclampsia
Kharb, S. (2000) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(99)00198-8 · Cited by 52 · see citing works
Perlman, J. M., & Risser, R. C. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70016-2 · Cited by 51 · see citing works
Assessing the Role of Uric Acid as a Predictor of Preeclampsia
Corominas, A. I., Medina, Y., Balconi, S., Casale, R., Farina, M., Martínez, N., & Damiano, A. E. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.785219 · Cited by 49 · see citing works
Association of serum uric acid level and coronary blood flow
Yıldız, A., Yılmaz, R., Demirbağ, R., Gür, M., Baş, M. M., & Erel, Ö. (2007) · Coronary Artery Disease · doi:10.1097/mca.0b013e3282f0a2a7 · Cited by 49 · see citing works
Physical well-being in women with a history of severe preeclampsia
Roes, E. M., Raijmakers, M. T. M., Schoonenberg, M. P. G., Wanner, N., Peters, W. H. M., & Steegers, E. A. P. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050500127740 · Cited by 49 · see citing works
Soluble Flt‐1 as a diagnostic marker of pre‐eclampsia
Woolcock, J., Hennessy, A., Xu, B., Thornton, C. E., Tooher, J., Makris, A., & Ogle, R. F. (2008) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2007.00804.x · Cited by 45 · see citing works
Pre‐eclamptic toxaemia: the role of uterine artery Doppler
Chappell, L. C., & Bewley, S. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10118.x · Cited by 45 · see citing works
High uric acid level associated with increased arterial stiffness in apparently healthy women
Fang, J.-I., Wu, J., Yang, Y., Wang, R.-H., Lu, F., & Chang, C. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.024 · Cited by 43 · see citing works
Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
Manjareeka, M., & Nanda, S. (2012) · International Journal of Medical Science and Public Health · doi:10.5455/ijmsph.2013.2.43-47 · Cited by 42 · see citing works
The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review
Annesi, L., Tossetta, G., Borghi, C., & Piani, F. (2024) · Antioxidants · doi:10.3390/antiox13101234 · Cited by 41 · see citing works
Davidge, S. T., de Groot, C. J. M., & Taylor, R. N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407866-6.00009-2 · Cited by 41 · see citing works
Başar, N., Şen, N., Özcan, F., Erden, G., Kanat, S., Sökmen, E., İşleyen, A., Yüzgeçer, H., Özlü, M. F., Yıldırımkaya, M., et al. (2011) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e318214ebaf · Cited by 40 · see citing works
Uric acid and cardiovascular disease: a renal-cardiac relationship?
Culleton, B. F. (2001) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200105000-00012 · Cited by 37 · see citing works
Absorption spectra of xanthines in aqueous solution: a computational study
Gómez, S., Giovannini, T., & Cappelli, C. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp05420k · Cited by 35 · see citing works
In vitro bioactivity of extracts from seeds of Cassia absus L. growing in Pakistan
Ahmad, S., Hassan, A., Rehman, T., Basit, A., Tahir, A., & Arshad, M. A. (2019) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2019.100258 · Cited by 34 · see citing works
Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?
Zharikov, S. I., Swenson, E. R., Lanaspa, M. A., Block, E. R., Patel, J. M., & Johnson, R. J. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.12.023 · Cited by 34 · see citing works
Schuiling, G. A., Koiter, T. R., & Faas, M. M. (1997) · Human Reproduction · doi:10.1093/humrep/12.10.2087 · Cited by 34 · see citing works
XANTHINE OXIDASE ACTIVATION IN MILD GESTATIONAL HYPERTENSION
Németh, I., Tálosi, G., Papp, A., & BODA, D. (2002) · Hypertension in Pregnancy · doi:10.1081/prg-120002905 · Cited by 33 · see citing works
Yalamati, P., Bhongir, A. V., Betha, K., Verma, R., & Dandge, S. (2015) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20150737 · Cited by 33 · see citing works
Yıldırım, A., Altınkaynak, K., Aksoy, H., Sahin, Y. N., & Akçay, F. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1090 · Cited by 32 · see citing works
Vitamin A and causes of maternal mortality: association and biological plausibility
Faisel, H., & Pittrof, R. (2000) · Public Health Nutrition · doi:10.1017/s1368980000000367 · Cited by 32 · see citing works
Choi, H. Y., Kim, S., Choi, A. R., Kim, S. G., Kim, H., Lee, J. E., Kim, H. J., & Park, H. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180406 · Cited by 31 · see citing works
Urinary hypoxanthine and xanthine levels in acute coronary syndromes
Turgan, N., Habif, S., Gülter, C., Şenol, B., MUTAF, I., Özmen, D., Bayındır, O., Boydak, B., & Turgan, N. (1999) · International Journal of Clinical & Laboratory Research · doi:10.1007/s005990050084 · Cited by 31 · see citing works
Estimation of Serum Uric Acid as an Indicator of Severity of Preeclampsia and Perinatal Outcome
Nair, A. M., & S., S. C. (2016) · The Journal of Obstetrics and Gynecology of India · doi:10.1007/s13224-016-0933-8 · Cited by 29 · see citing works
Effect of docosahexaenoic acid on oxidative stress in placental trophoblast cells
Shoji, H., Franke, C., Demmelmair, H., & Koletzko, B. V. (2009) · Early Human Development · doi:10.1016/j.earlhumdev.2009.02.003 · Cited by 28 · see citing works
Güllü, H., Erdoğan, D., Çalışkan, M., Tok, D., Kulaksızoğlu, S., Yı́ldı́rı́r, A., & Müderrisoğlu, H. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.10.019 · Cited by 28 · see citing works
Prenatal screening, epidemiology, diagnosis, and management of preeclampsia
Lyell, D. J., Lambert-Messerlian, G. M., & Giudice, L. C. (2003) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(03)00027-1 · Cited by 27 · see citing works
Relation between Serum Uric Acid and Plasma Adenosine Levels in Women with Preeclampsia
Suzuki, S., Yoneyama, Y., Sawa, R., Otsubo, Y., Takeuchi, T., & Araki, T. (2001) · Gynecologic and Obstetric Investigation · doi:10.1159/000052918 · Cited by 26 · see citing works
Strontium and its role in preeclampsia
Barneo-Caragol, C., Martínez‐Morillo, E., Rodríguez‐González, S., Lequerica–Fernández, P., Vega‐Naredo, I., & Menéndez, F. V. Á. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.01.003 · Cited by 25 · see citing works
Insights into the relationship between serum uric acid and pulmonary hypertension (Review)
Zhou, Y., Chen, M., Zheng, J. J., Shui, X., He, Y. Z., Luo, H., & Lei, W. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.13133 · Cited by 24 · see citing works
Mihu, D., Sabău, L. I., Costin, N., Ciortea, R., Măluţan, A. M., & Mihu, C. M. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.600796 · Cited by 24 · see citing works
Increased Xanthine Oxidase in the Skin of Preeclamptic Women
Bainbridge, S. A., Deng, J., & Roberts, J. M. (2009) · Reproductive Sciences · doi:10.1177/1933719108329817 · Cited by 24 · see citing works
Self-citationUric acid as an important biomarker in hypertensive disorders in pregnancy
Kondareddy, T., & Prathap, T. (2016) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20164348 · Cited by 23 · see citing works
Association of Serum Uric Acid with Preeclampsia: A Case Control Study
Sultana, R., Ahmed, S., Sultana, N., Karim, S. F., & Atia, F. (2013) · Delta Medical College Journal · doi:10.3329/dmcj.v1i2.15918 · Cited by 22 · see citing works
Serum uric Acid level and diverse impacts on regional arterial stiffness and wave reflection.
Bian, S., Guo, H., Ye, P., Luo, L., Wu, H., & Xiao, W. (2012) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
Kristensen, K. H., Strevens, H., Lindström, V., GRUBB, A. O., & Wide‐Swensson, D. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510802007804 · Cited by 20 · see citing works
Fukushima, K., Murata, M., Tsukimori, K., Eisuke, K., & Wake, N. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.40 · Cited by 19 · see citing works
The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia
Barbouti, A., Varvarousis, D., & Kanavaros, P. (2025) · Antioxidants · doi:10.3390/antiox14050529 · Cited by 18 · see citing works
McMaster‐Fay, R. A. (2008) · Bioscience hypotheses · doi:10.1016/j.bihy.2008.01.002 · Cited by 18 · see citing works
Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword
Ekpenyong, C. E. (2014) · American Journal of Internal Medicine · doi:10.11648/j.ajim.20140206.15 · Cited by 18 · see citing works
Etani, R., Kataoka, T., Kanzaki, N., Sakoda, A., Tanaka, H., Ishimori, Y., Mitsunobu, F., & Yamaoka, K. (2016) · Journal of Radiation Research · doi:10.1093/jrr/rrw014 · Cited by 18 · see citing works
The Kidney in Normal Pregnancy and Preeclampsia
Conrad, K. P., Gaber, L. W., & Lindheimer, M. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374213-1.00017-3 · Cited by 18 · see citing works
Renal Physiology and Disease in Pregnancy
Lindheimer, M. D., Conrad, K. P., & Karumanchi, S. A. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50086-3 · Cited by 18 · see citing works
Dong, X., Chao-bo, B. A. I., & Nao, J. (2017) · Clinical Radiology · doi:10.1016/j.crad.2017.06.009 · Cited by 18 · see citing works
Significance of Serum Uric Acid in Pregnancy Induced Hypertension
Niraula, A., Lamsal, M., Majhi, S., Khan, S. A., & Basnet, P. (2017) · Journal of the National Medical Association · doi:10.1016/j.jnma.2017.01.009 · Cited by 17 · see citing works
Singh, U., Solanki, V., Mehrotra, S., & Sharma, R. (2018) · The Journal of Obstetrics and Gynecology of India · doi:10.1007/s13224-018-1124-6 · Cited by 17 · see citing works
El-Gharib, M., FARAHAT, M. N. M. R., Mahfouz, A., & Morad, M. A. (2013) · Journal of Basic and Clinical Reproductive Sciences · doi:10.4103/2278-960x.112582 · Cited by 17 · see citing works
- Authors
- Many, A., Hubel, C. A., & Roberts, J. M.
- Affiliations
- Magee-Womens Research Institute (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 174
- Issue
- 1
- Pages
- 288-291
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2139903790
- Cited by
- 187
- References
- 63
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 16 · 2013: 6 · 2012: 8
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD030367, 1 PO1 HD 30367-01, 1 PO1 HD 30367-02)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- hyperuricemia, xanthine oxidase, xanthine dehydrogenase, preeclampsia, oxidative stress, reactive oxygen species, uric acid formation, trophoblast, maternal-fetal interface, hypoxia-reperfusion, cytokines, implantation depth, fetal outcomes
- MeSH terms
- Female, Humans, Kidney, Pre-Eclampsia, Pregnancy, Uric Acid, Xanthine Dehydrogenase, Xanthine Oxidase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
