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Cited by 311

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Short- and Long-Term Incidence of Stroke in White-Coat Hypertension

Open access
Verdecchia, Paolo, Reboldi, Gian Paolo, Angeli, Fabio, Schillaci, Giuseppe, Schwartz, Joseph E., Pickering, Thomas G., Imai, Yutaka, Ohkubo, Takayoshi, Kario, Kazuomi·2005·Hypertension

Abstract

White-coat hypertension (WCH) has been associated with a low risk for stroke, but long-term data are scanty. We analyzed individual data from 4 prospective cohort studies from the United States, Italy, and Japan that used comparable methodology for 24-hour noninvasive ambulatory blood pressure monitoring (ABPM). Overall, 4406 subjects with essential hypertension and 1549 healthy normotensive controls who were untreated at the time of initial ABPM were followed for a median of 5.4 years up to censoring or occurrence of a first stroke. At entry, mean age of subjects was 56 years (range 18 to 97). Prevalence of WCH was 9%. During follow-up, there were 213 new cases of stroke. Stroke rate (×100 person years) was 0.35 in the normotensive group, 0.59 in the WCH group, and 0.65 in the group with ambulatory hypertension. In a multivariate analysis, the adjusted hazard ratio for stroke was 1.15 (95% confidence interval [CI], 0.61 to 2.16) in the WCH group ( P =0.66) and 2.01 (95% CI, 1.31 to 3.08) in the ambulatory hypertension group ( P =0.001) compared with the normotensive group. After the sixth year of follow-up, the incidence of stroke tended to increase in the WCH group, and the corresponding hazard curve crossed that of the ambulatory hypertension group by the ninth year of follow-up. In conclusion, WCH was not associated with a definitely increased risk of stroke during the total follow-up period. However, WCH might not be a benign condition for stroke in the long term.

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Metadata

Authors
Verdecchia, P., Reboldi, G. P., Angeli, F., Schillaci, G., Schwartz, J. E., Pickering, T. G., Imai, Y., Ohkubo, T., & Kario, K.
Venue
Hypertension
Published
2005-02
Volume
45
Issue
2
Pages
203-208
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
OpenAlex
W2004724717
Cited by
311
References
2
FWCI
21.21
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Short- and Long-Term Incidence of Stroke in White-Coat Hypertension. https://app.cochat.ai/papers/10.1161/01.hyp.0000151623.49780.89
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Verdecchia, P., Reboldi, G. P., Angeli, F., Schillaci, G., Schwartz, J. E., Pickering, T. G., Imai, Y., Ohkubo, T., & Kario, K. (2005). Short- and Long-Term Incidence of Stroke in White-Coat Hypertension. Hypertension. https://doi.org/10.1161/01.hyp.0000151623.49780.89

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