The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Correlates of Systolic Hypertension in Patients With Chronic Kidney Disease
Open accessAbstract
Hypertension in patients with chronic kidney disease (CKD) is predominantly systolic. The contribution of risk factors for hypertension to the overall systolic blood pressure (BP) is unknown. To study the relationship between risk factors for hypertension and systolic BP in patients with CKD, 232 veterans (mean age 67 years; 96% men; 20% black; 39% with diabetes mellitus; estimated glomerular filtration rate [GFR] 48 mL/min per 1.73 m 2 ) had clinic (routine and standardized measurements) and out-of-clinic (home and 24-hour ambulatory) BPs recorded. In multivariate analysis, using 17 risk factors, the log of the urine protein/creatinine ratio was the strongest predictor of systolic BP regardless of the BP measurement technique. The strength of the relationship between proteinuria and systolic BP was in the order ambulatory > home > standardized clinic > routine clinic BP measurement. Other independent predictors were age, race, and number of antihypertensive drugs used, and the model fit was better for out-of-clinic than clinic BP recordings. Estimated GFR was not an independent predictor of systolic BP by any technique. Nocturnal dipping was associated with higher estimated GFR, higher serum albumin, younger age, and less proteinuria. Proteinuria is the most important correlate of systolic BP in older men, the strongest relationship of which was with ambulatory and home systolic BP. Out-of-clinic BP recordings correlate better with target organ damage, as measured by proteinuria, and may be of greater clinical value than clinic BP recordings in predicting hypertension-related outcomes such as end-stage renal disease and death.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the ADVANCED-J study in diabetic patients and the J-HOP study showed that HBP was more closely associated with urinary albumin--creatinine excretion ratio (UACR) than OBP [27,33].”
Citations
Cites
Chobanian, A. V. (2003) · JAMA · doi:10.1001/jama.289.19.2560 · Cited by 25,386
(1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440420033005 · Cited by 3,777
O'Brien, E., Asmar, R., Beilin, L., Imai, Y., Mallion, J.-M., Mancia, G., Mengden, T., Myers, M., Padfield, P., Palatini, P., et al. (2003) · Journal of Hypertension · doi:10.1097/00004872-200305000-00001 · Cited by 1,655
de Zeeuw, D., Remuzzi, G., Parving, H., Keane, W. F., Zhang, Z., Shahinfar, S., Snapinn, S., Cooper, M. E., Mitch, W. E., & Brenner, B. M. (2004) · Circulation · doi:10.1161/01.cir.0000139860.33974.28 · Cited by 749
Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study
Modification of Diet in Renal Disease Study Group, Hunsicker, L. G., Adler, S. G., Caggiula, A. W., England, B. K., Greene, T., Kusek, J. W., Rogers, N. L., Teschan, P. E., & Beck, G. J. (1997) · Kidney International · doi:10.1038/ki.1997.260 · Cited by 698
Poggio, E. D., Wang, X., Greene, T., Lente, F. V., & Hall, P. M. (2004) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004060447 · Cited by 643
Prevalence of High Blood Pressure and Elevated Serum Creatinine Level in the United States
Coresh, J., Wei, G. L., McQuillan, G. M., Brancati, F., Levey, A. S., Jones, C. A., & Klag, M. J. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.9.1207 · Cited by 579
Agarwal, R., Nissenson, A. R., BATLLE, D. C., Coyne, D. W., Trout, J. R., & Warnock, D. G. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00366-8 · Cited by 480
Self-citationThe prognostic significance of proteinuria: The Framingham study
Kannel, W. B., Stampfer, M. J., Castelli, W. P., & Verter, J. I. (1984) · American Heart Journal · doi:10.1016/0002-8703(84)90763-4 · Cited by 376
"Non-dipper" hypertensive patients and progressive renal insufficiency: a 3-year longitudinal study.
Timio, M., Venanzi, S., Lolli, S., Lippi, G., Verdura, C., Monarca, C., & Guerrini, E. (1995) · PubMed · Cited by 302
Research works printed but not linked: 1
- 10.1161/hyp.35.1.48 · DOI
Cited by
Sorted by citations
Items 101–133 of 133
Ambulatory BP Phenotypes and Their Association with Target Organ Damage and Clinical Outcomes in CKD
Georgianos, P. I., & Agarwal, R. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02590220 · Cited by 3
Self-citationCircadian blood pressure profile in patients with chronic kidney disease stage 1-3
Pluta, A., Stróżecki, P., & Manitius, J. (2015) · Arterial Hypertension · doi:10.5603/ah.2015.0023 · Cited by 2
Management of hypertension in CKD
Chaturvedy, M. (2014) · Clinical Queries Nephrology · doi:10.1016/j.cqn.2014.03.001 · Cited by 2
Hidayati, T., Sadewa, A. H., Aththobari, J., & Marstyawan, H. N. E. S. (2015) · Journal of Medical and Bioengineering · doi:10.12720/jomb.4.3.254-258 · Cited by 2
Nagahama, A. M., Silva, V. D. S., Banin, V. B., Franco, R. J. D. S., Barretti, P., Bazan, S. G. Z., & Martín, L. C. (2024) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2023-0066pt · Cited by 1
Sex-specific effects of mild kidney dysfunction on vascular function in midlife and older adults
Darvish, S., Coppock, M. E., Murray, K. O., Craighead, D. H., Chonchol, M., Nowak, K. L., Seals, D. R., & Rossman, M. J. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00332.2025 · Cited by 1
Evaluation of some factors affecting the risk of kidney damage in patients with hypertension
Gharishvandi, F., Kazerouni, F., Rahimipour, A., & Nasiri, M. (2014) · Archives of Advances in Biosciences · doi:10.22037/jps.v5i4.7786 · Cited by 1
Yap, Y., Chuang, H., Chi, W., Lin, C.-H., Wu, Y.-W., Chang, P.-C., & Liu, Y. (2013) · International Urology and Nephrology · doi:10.1007/s11255-013-0378-2 · Cited by 1
THE PARTICULARITIES OF ABPM PARAMETERS IN HYPERTENSIVE PATIENTS WITH NON-DIALYSIS CKD
Mincă, A., Comşa, M. O., Manea, M. M., Tănăsescu, M. D., Dragoș, D., Penescu, M. N., & Ionescu, D. (2017) · Romanian Medical Journal · doi:10.37897/rmj.2017.4.3 · Cited by 1
Management of hypertension in advanced kidney disease
Georgianos, P. I., & Agarwal, R. (2022) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000812 · Cited by 1
Self-citationBalzer, E. R., Koch, M. S., Drewnowski, B., dos Santos, F. A., Baroni, G., Schuinski, A. F. M., & Vellosa, J. C. R. (2022) · Research Society and Development · doi:10.33448/rsd-v11i8.31150 · Cited by 1
Jovanovic, D. B. (2014) · Биомедицинска истраживања · doi:10.7251/bii1401047j
Clinic versus home blood pressure measurements in patients with CKD
Stanton, R. C. (2006) · Current Diabetes Reports · doi:10.1007/s11892-006-0078-8
Home blood pressure monitoring for detection and control of hypertension: a call for action
Bustamante, P. J., & Agarwal, R. (2008)
Self-citationHermida, R. C., Ayala, D. E., Smolensky, M. H., & Portaluppi, F. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3450-8_11
Epidemiology of Hypertension in Chronic Kidney Disease
Wang, A. Y.-M. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6436-9_1
Ryu, J., Cha, R.-H., Lee, H., Kim, Y. S., Lee, J. P., Song, Y., Kim, S. G., & Kim, S. J. (2019) · Electrolytes & Blood Pressure · doi:10.5049/ebp.2019.17.2.36
Yavuz, Y., Bıyık, Z., Çelik, G., & Altıntepe, L. (2019) · Kocaeli Medical Journal · doi:10.5505/ktd.2019.56514
Julario, R., Nugraha, R. A., Khrisna, B. P. D., Putra, T. S., Mulia, E. P. B., Intan, R. E., & Alkaff, F. F. (2021) · medRxiv · doi:10.1101/2021.01.15.21249916
Clemons, D., Lee, A., Ajmeri, S., Terrigno, V. R., Zaid, J., Hunter, K. M., & Roy, S. (2021) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4515
Resistant Hypertension in Patients with Chronic Kidney Disease
Wali, M., Naik, S. R., & Ram, C. V. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1982-6_3
Hypertension and Chronic Kidney Disease – An Unhappy Marriage
Feldman, H. A. (2022) · Physician Assistant Clinics · doi:10.1016/j.cpha.2021.11.003
Ambulatory Blood Pressure in Patients with Chronic Kidney Disease
Asch, W. S., Santos, S. F. F., & Peixoto, A. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-22771-9_14
Georgianos, P. I., Vaios, V., Sgouropoulou, V., & Liakopoulos, V. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003149
Shimizu, Y., Kawashiri, S., Noguchi, Y., Matsuzaka, Y., Nakamichi, S., Nagata, Y., Maeda, T., & Hayashida, N. (2022) · Research Square · doi:10.21203/rs.3.rs-1767674/v1
Hypertension and Chronic Kidney Disease
Georgianos, P. I., & Agarwal, R. (2023) · Springer eBooks · doi:10.1007/978-3-031-42045-0_5
Self-citationYosafianti, P., Yanto, A., & Pranata, S. (2024) · Scripta Medica · doi:10.5937/scriptamed55-48753
Herenda, V., Rebić, D., Hasanspahić, S., Hamzić-Mehmedbašić, A., Ribić-Mrkonja, A., & Odobašić, M. (2024) · Liječnički vjesnik · doi:10.26800/lv-146-7-8-5
Interaction of Renal Disease and Blood Pressure Control
Berbari, A. E., & Daouk, N. A. (2025) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-031-81292-7_18
Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
Santos, S. F. F., & Peixoto, A. J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-978-3_16
El‐Toukhy, S., Smolensky, M. H., & Hermida, R. C. (2026) · JMIR Research Protocols · doi:10.2196/108386
Metadata
- Authors
- Agarwal, R., & Andersen, M. J.
- Affiliations
- Richard L. Roudebush VA Medical Center (US)
- ORCID
- Agarwal, Rajiv
- Venue
- Hypertension
- Published
- 2005-09
- Volume
- 46
- Issue
- 3
- Pages
- 514-520
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2122393326
- Cited by
- 133
- References
- 29
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 11 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32dk062711-02)
- National Institute of Diabetes and Digestive and Kidney Diseases (5T32DK062711-02)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- systolic hypertension, chronic kidney disease, proteinuria, urine protein-to-creatinine ratio, ambulatory blood pressure monitoring, home blood pressure monitoring, estimated glomerular filtration rate, nocturnal blood pressure dipping, veterans, diabetes mellitus, antihypertensive drugs, target organ damage
- MeSH terms
- Aged, Antihypertensive Agents, Blood Pressure, Blood Pressure Determination, Chronic Disease, Cross-Sectional Studies, Female, Renal Dialysis, Humans, Hypertension, Kidney Diseases, Kidney Failure, Chronic, Male, Proteinuria, Risk Factors, Sleep, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
