The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Arterial Stiffness Is Related to Systemic Inflammation in Essential Hypertension
Abstract
The acute phase–reactant high-sensitivity C-reactive protein, a marker of vascular inflammation and an atherosclerotic risk factor, is related to arterial stiffness in healthy subjects and in systemic vasculitis. To explore the relationship between markers of inflammation, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein with arterial stiffness, we studied untreated patients (n=78; 56% male; 47±1 years of age; mean±SEM) with essential hypertension. After overnight fast, augmentation index and pulse wave velocity were assessed noninvasively and related to plasma levels of inflammatory markers measured by ELISA. Pulse wave velocity was significantly related to plasma high-sensitivity C-reactive protein ( r =0.31; P <0.001), TNF-α, ( r =0.30; P <0.001) and IL-6 ( r =0.21; P <0.05). There was also a relationship between heart rate–corrected augmentation index to high-sensitivity C-reactive protein ( r =0.37; P <0.001), IL-6 ( r =0.24; P <0.05), and TNF-α ( r =0.19, P =0.06). High-sensitivity C-reactive protein was an independent predictor of pulse wave velocity and augmentation index in a multiple stepwise regression model. High-sensitivity C-reactive protein, a marker of systemic inflammation, is independently related to pulse wave velocity, a marker of aortic stiffness, and augmentation index, a manifestation of wave reflection, in essential hypertension.
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C-Reactive Protein Levels and Outcomes after Statin Therapy
Ridker, P. M., Cannon, C. P., Morrow, D., Rifai, N., Rose, L. M., McCabe, C. H., Pfeffer, M. A., & Braunwald, E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042378 · Cited by 2,292
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Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., Joshipura, K., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,174
The influence of heart rate on augmentation index and central arterial pressure in humans
Wilkinson, I. B., MacCallum, H., Flint, L., Cockcroft, J. R., Newby, D. E., & Webb, D. J. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00263.x · Cited by 1,091
Arterial stiffness, wave reflections, and the risk of coronary artery disease
Weber, T., Auer, J., O’Rourke, M. F., Kvas, E., Lassnig, E., Berent, R., & Eber, B. (2004) · Circulation · doi:10.1161/01.cir.0000105767.94169.e3 · Cited by 1,081
Arterial wave reflections and survival in end-stage renal failure
London, G. M., Blacher, J., Pannier, B., Guérin, A. P., Marchais, S. J., & Safar, M. E. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.434 · Cited by 853
Blood Pressure and Inflammation in Apparently Healthy Men
Chae, C. U., Lee, R. T., Rifai, N., & Ridker, P. M. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.399 · Cited by 716
Fichtlscherer, S., Rosenberger, G., Walter, D. H., Breuer, S., Dimmeler, S., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.102.9.1000 · Cited by 665
Cited by
Ridker, P. M. (2016) · Circulation Research · doi:10.1161/circresaha.115.306656 · Cited by 1,002
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Ridker, P. M., Libby, P., MacFadyen, J. G., Thuren, T., Ballantyne, C., Fonseca, F., Koenig, W., Shimokawa, H., Everett, B. M., & Glynn, R. J. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy310 · Cited by 544
The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults
Frey, D. J., Fleshner, M., & Wright, K. P. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.003 · Cited by 330
Recent Advances in Arterial Stiffness and Wave Reflection in Human Hypertension
Laurent, S., & Boutouyrie, P. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.076166 · Cited by 281
Metadata
- Authors
- Mahmud, A., & Feely, J.
- Venue
- Hypertension
- Published
- 2005-11
- Volume
- 46
- Issue
- 5
- Pages
- 1118-1122
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2140655158
- Cited by
- 346
- References
- 34
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- closed
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