CoChat
Sign Up
Cited by 853Cardiovascular Health and Disease PreventionRenal and Vascular PathologiesCardiovascular Function and Risk Factors

Arterial wave reflections and survival in end-stage renal failure

London, Gérard M., Blacher, Jacques, Pannier, Bruno, Guérin, Alain P., Marchais, Sylvain J., Safar, Michel E.·2001·Hypertension
DOI 10.1161/01.hyp.38.3.434
Open this paper in CoChat — free account

Abstract

The increased effect of arterial wave reflections on central arteries like the common carotid artery seen in end-stage renal failure (ESRF) patients favors myocardial hypertrophy and oxygen consumption and alters coronary blood flow distribution. Nevertheless, the impact of wave reflection on the outcome and end points such as mortality remains to be demonstrated. One hundred eighty ESRF patients (age, 54+/-16 years) were monitored for 52+/-36 months (mean+/-SD). Seventy deaths, including 40 cardiovascular (CV) and 30 non-CV events, occurred. At entry, patients, in addition to standard clinical and biochemical analyses, underwent aortic pulse wave velocity measurement and determination of arterial wave reflexion by applanation tonometry on the common carotid artery that was expressed as augmentation index. Cox analyses demonstrated that predictors of all-cause and CV mortality were age, aortic pulse wave velocity, low diastolic blood pressure, preexisting CV disease, and increased augmentation index, whereas the prescription of an ACE inhibitor had a favorable effect on survival. After adjustment for all confounding factors, the risk ratio for each 10% increase in augmentation index was 1.51 (95% confidence interval, 1.23 to 1.86; P<0.0001) for all-cause mortality and 1.48 (95% confidence interval, 1.16 to 1.90; P<0.0001) for CV mortality. These results provide the first direct evidence that in ESRF patients increased effect of arterial wave reflections is an independent predictor of all-cause and CV mortality.

Integrity signals

Registry

Crossref · 10.1161/01.hyp.38.3.434

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Large-artery stiffness and wave reflections are important determinants of left ventricular function, coronary blood flow, and mechanical integrity of arteries.

    “Large-artery stiffness and wave reflections are important determinants of left ventricular (LV) function, coronary blood flow, and mechanical integrity of arteries and have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk (4 -12).”

    From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [11]

  • Large-artery stiffness and wave reflections have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk.

    “Large-artery stiffness and wave reflections are important determinants of left ventricular (LV) function, coronary blood flow, and mechanical integrity of arteries and have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk (4 -12).”

    From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [11]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
London, G. M., Blacher, J., Pannier, B., Guérin, A. P., Marchais, S. J., & Safar, M. E.
Affiliations
  • Service d’Hémodialyse, Hôpital F.H. Manhès, Fleury-Mérogis (G.M.L., B.P., A.P.G., S.J.M.), Ste-Geneviève-des-Bois, and Service de Médecine Interne, Hôpital Broussais (J.B., M.E.S.), Paris, France.
  • Centre Hospitalier Frèderic-Henri Manhès (FR)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-09
Volume
38
Issue
3
Pages
434-438
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.38.3.434
OpenAlex
W1998710298
Cited by
853
References
28
Citations by year
2026: 4 · 2025: 10 · 2024: 16 · 2023: 18 · 2022: 15 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 23 · 2017: 28 · 2016: 28 · 2015: 43 · 2014: 43 · 2013: 38 · 2012: 63
FWCI
20.21
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
arterial wave reflection, end-stage renal disease, augmentation index, aortic pulse wave velocity, common carotid artery, cardiovascular mortality, all-cause mortality, ACE inhibitors, mortality risk factors, applanation tonometry
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Arteries, Blood Flow Velocity, Blood Pressure, Cardiovascular Diseases, Femoral Artery, Follow-Up Studies, Humans, Kidney Failure, Chronic, Middle Aged, Prognosis, Cohort Studies, Survival Rate, Survival Analysis, Carotid Artery, Common

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review