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Ambulatory Arterial Stiffness Index Derived From 24-Hour Ambulatory Blood Pressure Monitoring

Open access
Li, Yan, Wang, Ji-Guang, Dolan, Eamon, Gao, Ping-Jin, Guo, Hui-Feng, Nawrot, Tim, Stanton, Alice V., Zhu, Ding-Liang, O’Brien, Eoin, Staessen, Jan A.·2006·Hypertension

Abstract

We hypothesized that 1 minus the slope of diastolic on systolic pressure during 24-hour ambulatory monitoring (ambulatory arterial stiffness index [AASI]) might reflect arterial stiffness. We compared AASI with established measures of arterial stiffness and studied its distribution in Chinese and European populations. We used 90207 SpaceLabs monitors and the SphygmoCor device to measure AASI, central and peripheral pulse pressures, the central (CAIx) and peripheral (PAIx) systolic augmentation indexes, and aortic pulse wave velocity. In 166 volunteers, the correlation coefficient between AASI and pulse wave velocity was 0.51 ( P <0.0001). In 348 randomly recruited Chinese subjects, AASI correlated ( P <0.0001) with CAIx ( r =0.48), PAIx ( r =0.50), and central pulse pressure ( r =0.50). AASI increased with age and mean arterial pressure but decreased with body height. Both before and after adjustment for arterial wave reflections by considering height and heart rate as covariates, AASI correlated more ( P <0.0001) closely with CAIx and PAIx than 24-hour pulse pressure. Among normotensive subjects, the 95th percentile of AASI was 0.55 in Chinese and 0.57 in 1617 Europeans enrolled in the International Database on Ambulatory Blood Pressure Monitoring. The upper boundary of the 95% prediction interval of AASI in relation to age ranged from 0.53 at 20 years to 0.72 at 80 years. In conclusion, AASI is a new index of arterial stiffness that can be easily measured under ambulatory conditions. Pending additional validation in outcome studies, normal values of AASI are probably <0.50 and 0.70 in young and older subjects, respectively.

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Metadata

Authors
Li, Y., Wang, J.-G., Dolan, E., Gao, P.-J., Guo, H.-F., Nawrot, T., Stanton, A. V., Zhu, D.-L., O’Brien, E., & Staessen, J. A.
Venue
Hypertension
Published
2006-03
Volume
47
Issue
3
Pages
359-364
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
OpenAlex
W2144140589
Cited by
371
References
29
FWCI
18.37
Type
journal article
Language
en
Open access
bronze

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Li, Y., Wang, J.-G., Dolan, E., Gao, P.-J., Guo, H.-F., Nawrot, T., Stanton, A. V., Zhu, D.-L., O’Brien, E., & Staessen, J. A. (2006). Ambulatory Arterial Stiffness Index Derived From 24-Hour Ambulatory Blood Pressure Monitoring. Hypertension. https://doi.org/10.1161/01.hyp.0000200695.34024.4c

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