Association between arterial properties and renal sodium handling in a general population.
Open accessAbstract
Mean arterial pressure drives pressure-natriuresis and determines arterial structure and function. In a population sample, we investigated the relation between arterial characteristics and renal sodium handling as assessed by the clearance of endogenous lithium. We ultrasonographically measured diameter, cross-sectional compliance (CC) and distensibility (DC) of the carotid, brachial, and femoral arteries in 1069 untreated subjects (mean age: 41.6 years; 50.1% women; 18.8% hypertensive subjects). While accounting for covariates and standardizing for the sodium excretion rate in both sexes, CC and DC of the femoral artery increased with higher fractional distal sodium reabsorption. Differences associated with a 1-SD change in fractional distal reabsorption of sodium were 51.7 mm(2)/kPax10(-3) (95% CI: 23.9 to 79.5; P=0.0002) and 0.56x10(-3)/kPa (95% CI: 0.17 to 0.94; P=0.004) for femoral CC and DC, respectively. In women as well as in men, a 1-SD increment in fractional proximal sodium reabsorption was associated with decreases in femoral and brachial diameter, amounting to 111.6 mum (95% CI: 38.2 to 185.1; P=0.003) and 52.5 mum (95% CI: 10.0 to 94.9; P=0.016), respectively. There was no consistent association between the properties of the elastic carotid artery and renal sodium handling. In conclusion, higher fractional sodium reabsorption in the distal nephron is associated with higher femoral CC and DC, and higher proximal sodium reabsorption is associated with decreased brachial and femoral diameters. These findings demonstrate that there might be an influence of renal sodium handling on arterial properties or vice versa or that common mechanisms might influence both arterial and renal function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The fraction of water load passively reabsorbed in the proximal tubule also includes sodium reabsorbed in the loop of Henle.
“Taking into account details of laboratory measurements, this fraction also includes sodium reabsorbed in the loop of Henle (Seidlerová et al., 2006).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Seidlerová et al., 2006
The Abstract says lithium is reabsorbed alongside sodium and water in the proximal tubule, but may also be partially reabsorbed in the loop of Henle. The Renal Sodium Handling section defines the estimated proximal sodium-reabsorption fraction using lithium excretion. Together, these passages support a possible contribution from loop reabsorption to the estimate, but do not establish that it necessarily includes sodium reabsorbed there. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Safar, M. E., Levy, B. I., & Struijker-Boudier, H. A. J. (2003) · Circulation · doi:10.1161/01.cir.0000069826.36125.b4 · Cited by 1,195 · see citing works
Self-citationDefinitions and characteristics of sodium sensitivity and blood pressure resistance.
Weinberger, M. H., Miller, J. Z., Luft, F. C., Grim, C. E., & Fineberg, N. S. (1986) · Hypertension · doi:10.1161/01.hyp.8.6_pt_2.ii127 · Cited by 775 · see citing works
Costerousse, O., Allegrini, J., Lopez, M., & Alhenc‐Gelas, F. (1993) · Biochemical Journal · doi:10.1042/bj2900033 · Cited by 507 · see citing works
Staessen, J. A., Wang, J., Bianchi, G., & Birkenhäger, W. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13302-8 · Cited by 478 · see citing works
Self-citationBortel, L. M. V., Balkestein, E. J., Spek, J. J., Vanmolkot, F. H. M., Staessen, J. A., Kragten, J. A., Vredeveld, J. W., Safar, M. E., Struijker-Boudier, H. A. J., & Hoeks, A. P. G. (2001) · Journal of Hypertension · doi:10.1097/00004872-200106000-00007 · Cited by 380 · see citing works
Self-citationZoccali, C., Benedetto, F. A., Maas, R., Mallamaci, F., Tripepi, G. L., Malatino, L., & Diaeresis]ger, R. B. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v132490 · Cited by 315 · see citing works
Obesity is associated with increased arterial stiffness from adolescence until old age
Zebekakis, P. E., Nawrot, T. S., Thijs, L., Balkestein, E. J., Spek, J. J., Bortel, L. M. V., Struijker-Boudier, H. A. J., Safar, M. E., & Staessen, J. A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000179511.93889.e9 · Cited by 276 · see citing works
Self-citationFujiwara, N., Osanai, T., Kamada, T., Katoh, T., Takahashi, K., & Okumura, K. (2000) · Circulation · doi:10.1161/01.cir.101.8.856 · Cited by 242 · see citing works
Matsuoka, H., Itoh, S., Kimoto, M., Kohno, K., Tamai, O., Wada, Y., Yasukawa, H., Iwami, G., Okuda, S., & Imaizumi, T. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.242 · Cited by 229 · see citing works
Staessen, J. A., Wang, J., Brand, E., Barlassina, C., Birkenhäger, W. H., Herrmann, S.-M., Fagard, R. H., Tizzoni, L., & Bianchi, G. (2001) · Journal of Hypertension · doi:10.1097/00004872-200108000-00002 · Cited by 228 · see citing works
Self-citationSalt-dependent renal effects of an angiotensin II antagonist in healthy subjects.
Burnier, M., Rutschmann, B., Nussberger, J., Versaggi, J. A., Shahinfar, S., Waeber, B., & Brunner, H. R. (1993) · Hypertension · doi:10.1161/01.hyp.22.3.339 · Cited by 194 · see citing works
Self-citationEstimating dietary sodium intake in individuals receiving a randomly fluctuating intake.
Luft, F. C., Fineberg, N. S., & Sloan, R. S. (1982) · Hypertension · doi:10.1161/01.hyp.4.6.805 · Cited by 160 · see citing works
Skrabal, F., Herholz, H., Neumayr, M., Hamberger, L., Ledochowski, M., Sporer, H., Hörtnagl, H., Schwarz, S., & Schönitzer, D. (1984) · Hypertension · doi:10.1161/01.hyp.6.2.152 · Cited by 146 · see citing works
Kool, M. J. F., Merode, T. V., Reneman, R. S., et al. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.5.610 · Cited by 145 · see citing works
Quinkler, M., Meyer, B., Bumke-Vogt, C., Grossmann, C., Gruber, U., Oelkers, W., Diederich, S., & Bahr, V (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460789 · Cited by 130 · see citing works
Evidence for an interaction between adducin and Na+-K+-ATPase: relation to genetic hypertension
Ferrandi, M., Salardi, S., Tripodi, G., Barassi, P., Rivera, R. F., Manunta, P., Goldshleger, R., Ferrari, P., Bianchi, G., & KARLISH, S. J. D. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.4.h1338 · Cited by 129 · see citing works
Self-citationQuality control of the blood pressure phenotype in the European Project on Genes in Hypertension
Kuznetsova, T., Staessen, J. A., Kawecka−Jaszcz, K., Babeanu, S., Casiglia, E., Filipovský, J., Nachev, C., IuP, N., Peleskã, J., & O'Brien, E. T. (2002) · Blood Pressure Monitoring · doi:10.1097/00126097-200208000-00003 · Cited by 103 · see citing works
Self-citationProgesterone binding to mineralocorticoid receptors: in vitro and in vivo studies
Myles, K., & Funder, J. W. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e601 · Cited by 102 · see citing works
Pressure natriuresis. Role of renal interstitial hydrostatic pressure.
Granger, J. P. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i9 · Cited by 99 · see citing works
Carotid and Femoral Artery Stiffness in Relation to Three Candidate Genes in a White Population
Balkestein, E. J., Staessen, J. A., Wang, J., et al. (2001) · Hypertension · doi:10.1161/hy1101.095992 · Cited by 91 · see citing works
Self-citationKool, M. J. F., Lustermans, F. A., Breed, J. G. S., et al. (1995) · Journal of Hypertension · doi:10.1097/00004872-199508000-00004 · Cited by 85 · see citing works
Balkestein, E. J., Wang, J. G., Struijker-Boudier, H. A. J., et al. (2002) · Journal of Hypertension · doi:10.1097/00004872-200208000-00018 · Cited by 65 · see citing works
Self-citationKielstein, J. T., Simmel, S., Bode‐Böger, S. M., Roth, H. J., Schmidt-Gayk, H., Haller, H. G., & Fliser, D. (2004) · Kidney & Blood Pressure Research · doi:10.1159/000078838 · Cited by 63 · see citing works
Lithium infusion to study sodium handling in unanesthetized hypertensive rats.
Biollaz, J., Waeber, B., Diézi, J., et al. (1986) · Hypertension · doi:10.1161/01.hyp.8.2.117 · Cited by 63 · see citing works
Vascular distensibility and compliance in salt-sensitive and salt-resistant borderline hypertension
Draaijer, P., Kool, M. J. F., Maessen, J. M. C., Bortel, L. M. V., de Leeuw, P. W., van Hooff, J. P., & Leunissen, K. M. L. (1993) · Journal of Hypertension · doi:10.1097/00004872-199311000-00007 · Cited by 57 · see citing works
Renal sodium handling in patients with untreated hypertension and white coat hypertension.
Burnier, M., Biollaz, J., Magnin, J., et al. (1994) · Hypertension · doi:10.1161/01.hyp.23.4.496 · Cited by 57 · see citing works
Self-citationRenal function in relation to three candidate genes
Wang, J.-G., Staessen, J. A., Tizzoni, L., Brand, E., Birkenhäger, W. H., Fagard, R. H., Herrmann, S.-M., & Bianchi, G. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.29205 · Cited by 51 · see citing works
Self-citationMagnin, J., Decosterd, L. A., Centeno, C., Burnier, M., Diézi, J., & Biollaz, J. (1996) · Pharmaceutica Acta Helvetiae · doi:10.1016/s0031-6865(96)00020-9 · Cited by 40 · see citing works
Self-citationRenal segmental tubular response to salt during the normal menstrual cycle
Pechère-Bertschi, A., Maillard, M., Stalder, H., Brunner, H. R., & Burnier, M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00158.x · Cited by 39 · see citing works
Self-citationCarotid Artery Mechanical Properties of Dahl Salt-Sensitive Rats
Bénétos, A., Bouaziz, H., Albaladéjo, P., et al. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.272 · Cited by 38 · see citing works
Arterial stiffness, hydrochlorothiazide and converting enzyme inhibition in essential hypertension.
Benetos, A., Laflèche, A., Asmar, R. G., Gautier, S., Safar, A. M., & Safar, M. E. (1996) · PubMed · Cited by 38 · see citing works
Cwynar, M., Staessen, J. A., Tichá, M., Nawrot, T. S., Citterio, L., Kuznetsova, T., Wojciechowska, W., Stolarz, K., Filipovský, J., Kawecka−Jaszcz, K., et al. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000166836.70935.e7 · Cited by 35 · see citing works
Self-citationBiophysical principles of vascular diagnosis
Hoeks, A. P. G., & Reneman, R. S. (1995) · Journal of Clinical Ultrasound · doi:10.1002/jcu.1870230203 · Cited by 30 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Staessen JA, Wang J, Bianchi G, Birkenha ¨ger WH. Essential hyper- tension. Lancet. 2003;361:1629 -1641.
Cited by
Sorted by citations
Bochud, M., Staessen, J. A., Maillard, M., Mazeko, M. J., Kuznetsova, T., Woodiwiss, A., Richart, T., Norton, G., Thijs, L., Elston, R., et al. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832104b1 · Cited by 63 · see citing works
Self-citationKutumova, E., Kiselev, I., Sharipov, R., Lifshits, G., & Kolpakov, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746300 · Cited by 16 · see citing works
“Taking into account details of laboratory measurements, this fraction also includes sodium reabsorbed in the loop of Henle (Seidlerová et al., 2006).”
- Authors
- Seidlerová, J., Staessen, J. A., Maillard, M., Nawrot, T., Zhang, H., Bochud, M., Kuznetsova, T., Richart, T., Van Bortel, L. M., Struijker-Boudier, H. A., Manunta, P., Burnier, M., Fagard, R., & Filipovský, J.
- Affiliations
- From the Studies Coordinating Centre (J.S., J.A.S., T.N., H.Z., T.K., T.R., R.F.), Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium; the Faculty of Medicine in Pilsen (J.S., J.F.), Charles University, Pilsen, Czech Republic; the Division of Hypertension and Cardiovascular Medicine (M.M., M. Bochud, M. Burnier), University of Lausanne, Lausanne, Switzerland; the Department of Cardiology (H.Z.), First Affiliated...
- University of Milan (IT)
- ORCID
- Venue
- Hypertension
- Published
- 2006-10
- Volume
- 48
- Issue
- 4
- Pages
- 609-615
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2166477052
- Cited by
- 25
- References
- 33
- Citations by year
- 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Hypertension (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- IRIS (submittedVersion)
- Lirias (submittedVersion, cc-by)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Keywords
- renal sodium handling, pressure natriuresis, lithium clearance, fractional sodium reabsorption, arterial compliance, arterial distensibility, arterial diameter, femoral artery, brachial artery, carotid artery, distal nephron, proximal sodium reabsorption, sex differences
- MeSH terms
- Absorption, Adult, Arteries, Brachial Artery, Carotid Arteries, Compliance, Elasticity, Female, Femoral Artery, Humans, Hypertension, Kidney, Kidney Tubules, Distal, Kidney Tubules, Proximal, Male, Middle Aged, Natriuresis, Sodium, Ultrasonography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
