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Cited by 39Sodium Intake and HealthRenin-Angiotensin System StudiesBlood Pressure and Hypertension Studies

Renal segmental tubular response to salt during the normal menstrual cycle

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Pechère-Bertschi, Antoinette, Maillard, Marc, Stalder, Hans, Brunner, Hans R., Burnier, Michel·2002·Kidney International
DOI 10.1046/j.1523-1755.2002.00158.x
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Abstract

Background It has been suggested that women gain weight and develop peripheral edema during the luteal phase of the menstrual cycle because they tend to retain sodium and water. However, there is actually no clear evidence for physiological, cyclic variations in renal sodium handling during the menstrual cycle. We prospectively assessed the changes in segmental renal sodium handling occurring during the menstrual cycle in response to changes in salt intake.Methods Thirty-five normotensive women were enrolled. Seventeen women were randomized and studied in the follicular and 18 in the luteal phases of their menstrual cycle. All women were assigned at random to receive a low (40 mmol/day) or a high (250 mmol/day) sodium diet for seven days on two consecutive menstrual cycles. Renal sodium handling and hemodynamics were measured at the end of each diet period.Results The changes in sodium intake induced comparable variations in sodium excretion in both phases of the menstrual cycle. In the follicular phase, the increase in salt intake was associated with no change in renal hemodynamics, an increased fractional excretion of lithium (FELi) and a decreased fractional distal reabsorption of sodium (FDRNa), suggesting that sodium reabsorption is reduced both in the proximal and the distal tubules. In contrast, in the luteal phase, the renal response to salt was characterized by a significant renal vasodilation and a marked salt escape from the distal nephron, compared to the women investigated in the follicular phase (P < 0.01). Sodium reabsorption by the proximal nephron was not reduced as indicated by the unchanged FELi.Conclusions These results show that the segmental renal handling of sodium differs markedly in the two phases of the menstrual cycle. They suggest that the female hormones modulate the renal handling of sodium at the proximal and distal segments of the nephron in young normotensive women.

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  • Progesterone alters serum electrolyte balance through progesterone-mediated increases in aldosterone.

    “alters serum electrolyte balance through progesterone-mediated increases in aldosterone [74–77]”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [75]

    The paper’s opening passage (indexed under Abstract; page unavailable) describes increases in both progesterone and aldosterone during the luteal phase, and its discussion links progesterone to renal sodium handling. It does not establish that progesterone causes the aldosterone increase or report a resulting change in serum electrolyte balance; instead, it describes progesterone as potentially opposing aldosterone’s action. (LLM, conf=0.83)

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Authors
Pechère-Bertschi, A., Maillard, M., Stalder, H., Brunner, H. R., & Burnier, M.
Affiliations
Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author
Burnier, Michel
ORCID
Venue
Kidney International
Publisher
Elsevier BV
Published
2002-02
Volume
61
Issue
2
Pages
425-431
ISSN
0085-2538 (ISSN-L)
DOI
10.1046/j.1523-1755.2002.00158.x
OpenAlex
W2075834428
Cited by
39
References
39
Citations by year
2025: 1 · 2023: 7 · 2022: 2 · 2021: 2 · 2019: 1 · 2016: 1 · 2015: 2 · 2013: 3 · 2012: 1
FWCI
2.03
Type
journal article
Language
en
Open access
Licence
Locations
  • Kidney International (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (42543, 45005)
  • Centre Hospitalier Universitaire Vaudois
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
menstrual cycle, luteal phase, follicular phase, renal sodium handling, salt intake, sodium excretion, proximal nephron, distal nephron, renal vasodilation, sex hormones, water retention, peripheral edema
MeSH terms
Adult, Aldosterone, Blood Pressure, Female, Follicular Phase, Humans, Kidney Tubules, Distal, Kidney Tubules, Proximal, Lithium, Luteal Phase, Atrial Natriuretic Factor, Progesterone, Prospective Studies, Renal Circulation, Renin, Water-Electrolyte Balance, Sodium Chloride, Dietary

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