The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.
Open accessAbstract
The effects of 9 months of orally administered captopril (25-50 mg/kg body wt/day) on aortic atherosclerosis was examined in normotensive Watanabe heritable hyperlipidemic rabbits. Captopril caused a significant decrease in aortic atherosclerosis. Total aortic surface involvement by lesions was reduced from 48 +/- 3.6% in control Watanabe rabbits to 30 +/- 3.9% with captopril treatment (p less than 0.01). Most of the decrease could be accounted for by a marked reduction in atherosclerosis of descending thoracic aortas from 49 +/- 5.2% to 15 +/- 3.9% in control and captopril-related groups, respectively (p less than 0.001). Significant decrease in cholesterol content of descending thoracic aorta was also observed in captopril-treated rabbits. Microscopic examination of the arterial lesions in captopril-treated animals suggested a relative decrease in cellularity and increase in extracellular matrix as compared with untreated animals. These studies indicate that captopril has a potent antiatherosclerotic action in the Watanabe heritable hyperlipidemic rabbit.
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Cited by
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Vascular inflammation and the renin-angiotensin system
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Metadata
- Authors
- Chobanian, A. V., Haudenschild, C. C., Nickerson, C., & Drago, R.
- Venue
- Hypertension
- Published
- 1990-03
- Volume
- 15
- Issue
- 3
- Pages
- 327-331
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2069445171
- Cited by
- 411
- References
- 10
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit. https://app.cochat.ai/papers/10.1161/01.hyp.15.3.327
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- Chobanian, A. V., Haudenschild, C. C., Nickerson, C., & Drago, R. (1990). Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit. Hypertension. https://doi.org/10.1161/01.hyp.15.3.327
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
