The vasodilator action of insulin. Implications for the insulin hypothesis of hypertension.
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In normal humans, hyperinsulinemia increases sympathetic nerve activity but does not increase blood pressure because the sympathetic activation is offset by a direct vasodilator action of insulin.
“Thus, in normal humans, hyperinsulinemia increases sympathetic nerve activity, but does not increase blood pressure because the sympathetic activation is offset by a direct vasodilator action of insulin82”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [82]
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- Authors
- Anderson, E. A., & Mark, A. L.
- Venue
- Hypertension
- Published
- 1993-02
- Volume
- 21
- Issue
- 2
- Pages
- 136-141
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1832341580
- Cited by
- 242
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2020: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 21.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (14388, 5p50hl044546-05, 5r29hl043514-05, HL14388)
- National Heart, Lung, and Blood Institute (HL-43514, HL-14388, HL-44546, P01HL014388)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin, vasodilation, insulin resistance, hypertension pathogenesis
- MeSH terms
- Animals, Blood Pressure, Humans, Hyperinsulinism, Hypertension, Insulin, Insulin Resistance, Sympathetic Nervous System, Vasodilation, Genetic Predisposition to Disease
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