The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
The vasodilator action of insulin. Implications for the insulin hypothesis of hypertension.
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Thus, in normal humans, hyperinsulinemia increases sympathetic nerve activity, but does not increase blood pressure because the sympathetic activation is offset by a direct vasodilator action of insulin82”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Insulin Resistance in Essential Hypertension
Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M. A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., & Bevilacqua, S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170605 · Cited by 2,344
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465
Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man
Rowe, J. W., Young, J. B., Minaker, K. L., Stevens, A. L., Pallotta, J., & Landsberg, L. (1981) · Diabetes · doi:10.2337/diab.30.3.219 · Cited by 1,143
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
DeFronzo, R. A., Cooke, C. R., Andres, R., Faloona, G. R., & Davis, P. J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107996 · Cited by 1,104
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
Anderson, E. A., Hoffman, R. P., Balon, T. W., Sinkey, C. A., & Mark, A. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115260 · Cited by 1,075
Self-citationLaakso, M., Edelman, S. V., Brechtel, G., & Baron, A. D. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114644 · Cited by 930
Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM
Laakso, M., Edelman, S. V., Brechtel, G., & Baron, A. D. (1992) · Diabetes · doi:10.2337/diab.41.9.1076 · Cited by 470
Resistance to Insulin-Stimulated-Glucose Uptake in Patients with Hypertension*
Shen, D. C., Shieh, S.-M., Fuh, M. M.-T., WU, D.-A., Chen, Y. I., & Reaven, G. M. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-3-580 · Cited by 420
Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells.
Stout, R. W., Bierman, E. L., & Ross, R. (1975) · Circulation Research · doi:10.1161/01.res.36.2.319 · Cited by 405
LANDSBERG, L. (1986) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068066 · Cited by 373
Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure.
Baron, A., Brechtel, G., Johnson, A., & Hardin, D. S. (1993) · Hypertension · doi:10.1161/01.hyp.21.2.129 · Cited by 362
Berne, C., Fagius, J., Pollare, T., & Hjemdahl, P. (1992) · Diabetologia · doi:10.1007/bf00399935 · Cited by 293
Effects of insulin upon ion transport
Moore, R. D. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90013-8 · Cited by 276
Insulin Infusion in Conscious Dogs
Liang, C., Doherty, J. U., FAILLACE, R. T., Maekawa, K., Arnold, S., Gavras, H. P., & Hood, W. B. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110572 · Cited by 276
Insulin and blood pressure in obesity.
Lucas, C. P., Estigarribia, J., Darga, L. L., & Reaven, G. M. (1985) · Hypertension · doi:10.1161/01.hyp.7.5.702 · Cited by 273
The hemodynamic link between insulin resistance and hypertension
Julius, S., Gudbrandsson, T., Jamerson, K., Shahab, S., & Andersson, O. (1991) · Journal of Hypertension · doi:10.1097/00004872-199111000-00001 · Cited by 239
Landin‐Wilhelmsen, K., Tengborn, L., & Smith, U. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00328.x · Cited by 224
Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans.
Anderson, E. A., Balon, T. W., Hoffman, R. P., Sinkey, C. A., & Mark, A. L. (1992) · Hypertension · doi:10.1161/01.hyp.19.6.621 · Cited by 220
Self-citationBeta adrenergic-mediated vasodilator response to insulin in the human forearm.
Creager, M. A., Liang, C., & Coffman, J. D. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24198-2 · Cited by 192
Effect of insulin on central catecholamines
Sauter, A., Goldstein, M., Engel, J., & Ueta, K. (1983) · Brain Research · doi:10.1016/0006-8993(83)90691-1 · Cited by 181
Insulin differentially regulates systemic and skeletal muscle vascular resistance
Baron, A., & Brechtel, G. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.1.e61 · Cited by 179
Effects of peptides and non-peptides on isolated arterial smooth muscles: Role of endothelium
D’Orléans-Juste, P., Dion, S., Mizrahi, J. L., & Regoli, D. C. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90515-1 · Cited by 172
Somatostatin inhibition of fructose-induced hypertension.
Reaven, G. M., Ho, H., & Hoffmann, B. B. (1989) · Hypertension · doi:10.1161/01.hyp.14.2.117 · Cited by 158
Antihypertensive effects of CS-045 treatment in obese Zucker rats
Yoshioka, S., Nishino, H., Shiraki, T., Ikeda, K., Koike, H., Okuno, A., Wada, M., Fujiwara, T., & Horikoshi, H. (1993) · Metabolism · doi:10.1016/0026-0495(93)90175-n · Cited by 153
Effects of Insulin on Hemodynamics and Metabolism in Human Forearm
Natali, A., Buzzigoli, G., Taddei, S., Santoro, D., Cerri, M., Pedrinelli, R., & Ferrannini, E. (1990) · Diabetes · doi:10.2337/diab.39.4.490 · Cited by 139
Sustained hyperinsulinemia increases arterial pressure in conscious rats
Brands, M. W., Hildebrandt, D. A., Mizelle, H. L., & Hall, J. E. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.4.r764 · Cited by 136
Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines?
Hall, J. E., Brands, M. W., Kivlighn, S. D., Mizelle, H. L., Hildebrandt, D. A., & Gaillard, C. A. (1990) · Hypertension · doi:10.1161/01.hyp.15.5.519 · Cited by 116
Relationship between blood pressure and plasma insulin in non-obese and obese non-diabetic subjects
Bonora, E., Zavaroni, I., Alpi, O., Pezzarossa, A., Bruschi, F., Dall’Aglio, E., Guerra, L., Coscelli, C., & BUTTURINI, U. (1987) · Diabetologia · doi:10.1007/bf00296995 · Cited by 113
Kinetics of In Vivo Muscle Insulin-Mediated Glucose Uptake in Human Obesity
Laakso, M., Edelman, S. V., Olefsky, J. M., Brechtel, G., Wallace, P., & Baron, A. (1990) · Diabetes · doi:10.2337/diab.39.8.965 · Cited by 99
Independent stimulation of glucose metabolism and Na+-K+ exchange by insulin in the human forearm
Ferrannini, E., Taddei, S., Santoro, D., Natali, A., Boni, C. D., Chiaro, D. D., & Buzzigoli, G. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.6.e953 · Cited by 96
The Hemodynamic Response to Chronic Hyperinsulinemia in Conscious Dogs
Brands, M. W., Mizelle, H. L., Gaillard, S., Hildebrandt, D. A., & Hall, J. E. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.2.164 · Cited by 96
Nonuniform regional sympathetic nerve responses to hyperinsulinemia in rats
Morgan, D. A., Balon, T. W., Ginsberg, B. H., & Mark, A. L. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.2.r423 · Cited by 92
Self-citationHypotensive and sedative effects of insulin in autonomic failure.
Mathias, C. J., da Costa, D. F., Fosbraey, P., Christensen, N. J., & Bannister, R. (1987) · BMJ · doi:10.1136/bmj.295.6591.161 · Cited by 84
Renal and Cardiovascular Effects of Exogenous Insulin in Healthy Volunteers
Gans, R. O. B., van Toorn, L., Bilo, H. J. G., Nauta, J. J. P., Heine, R. J., & Donker, A. J. M. (1991) · Clinical Science · doi:10.1042/cs0800219 · Cited by 81
Lack of association between blood pressure and insulin in patients with insulinoma
Tsutsu, N., Nunoi, K., Kodama, T., Nomiyama, R., Iwase, M., & FUJISHIMA, M. (1990) · Journal of Hypertension · doi:10.1097/00004872-199005000-00014 · Cited by 78
Effect of insulin on plasma norepinephrine and 3,4-dihydroxyphenylalanine in obese men
O’Hare, J. A., Minaker, K. L., Meneilly, G. S., Rowe, J. W., Pallotta, J. A., & Young, J. B. (1989) · Metabolism · doi:10.1016/0026-0495(89)90118-2 · Cited by 72
Insulin-Stimulated Vascular Relaxation: Role of Ca2+-ATPase
Zemel, M. B., Johnson, B. A., & Ambrozy, S. A. (1992) · American Journal of Hypertension · doi:10.1093/ajh/5.9.637 · Cited by 71
Insulin resistance and blood pressure regulation in obese and nonobese subjects. Special lecture.
Rocchini, A. P. (1991) · Hypertension · doi:10.1161/01.hyp.17.6.837 · Cited by 62
Circumventricular Organs: Receptors and Mediators of Direct Peptide Hormone Action on Brain
van Houten, M., & Posner, B. I. (1983) · Advances in metabolic disorders · doi:10.1016/b978-0-12-027310-2.50015-3 · Cited by 61
Does Chronic Hyperinsulinemia Cause Hypertension?
Hall, J. E., Coleman, T. G., & Mizelle, H. L. (1989) · American Journal of Hypertension · doi:10.1093/ajh/2.3.171 · Cited by 57
Laakso, M., Edelman, S. V., Brechtel, G., & Baron, A. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.2.e199 · Cited by 56
Influences of exogenous insulin on arterial blood pressure measurements of the rat
Edwards, J. G., & Tipton, C. M. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.6.2335 · Cited by 47
Changes of sympathetic nerve activity induced by 2-deoxy-D-glucose infusion in humans
Fagius, J., & Berne, C. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.6.e714 · Cited by 33
Carretta, R., Fabris, B., Fabio Fischetti, I., Costantini, M., Biasi, F. D., Muiesan, S., Bardelli, M., Vran, F., & Campanacci, L. (1989) · Journal of Hypertension · doi:10.1097/00004872-198900076-00094 · Cited by 29
rnsdottir, S. G., Anderson, E. A., Elam, M., Sellgren, J., & Mark, A. L. (1993) · Journal of Hypertension · doi:10.1097/00004872-199312050-00248 · Cited by 10
Self-citationAllwood, M. J., & Ginsburg, J. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006355 · Cited by 8
Hypotensive and sedative effects of insulin in autonomic failure.
Jansen, R. W. M. M., & Hoefnagels, W. H. L. (1987) · BMJ · doi:10.1136/bmj.295.6599.671-b · Cited by 8
Cited by
Sorted by citations
Reaven, G. M., Lithell, H., & Landsberg, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602083340607 · Cited by 1,435
Carretero, O. A., & Oparil, S. (2000) · Circulation · doi:10.1161/01.cir.101.3.329 · Cited by 1,155
Vickers, M. H., Breier, B. H., Cutfield, W. S., Hofman, P. L., & Gluckman, P. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.1.e83 · Cited by 999
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616
Self-citationThe Metabolic Syndrome in Overweight Hispanic Youth and the Role of Insulin Sensitivity
Cruz, M. L., Weigensberg, M. J., Huang, T. T. ‐., Ball, G. D. C., Shaibi, G. Q., & Goran, M. I. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031188 · Cited by 601
Metadata
- Authors
- Anderson, E. A., & Mark, A. L.
- Venue
- Hypertension
- Published
- 1993-02
- Volume
- 21
- Issue
- 2
- Pages
- 136-141
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1832341580
- Cited by
- 242
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2020: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 21.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (14388, 5p50hl044546-05, 5r29hl043514-05, HL14388)
- National Heart, Lung, and Blood Institute (HL-43514, HL-14388, HL-44546, P01HL014388)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin, vasodilation, insulin resistance, hypertension pathogenesis
- MeSH terms
- Animals, Blood Pressure, Humans, Hyperinsulinism, Hypertension, Insulin, Insulin Resistance, Sympathetic Nervous System, Vasodilation, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
