The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.
Open accessAbstract
We have previously shown that the endothelin content in arteries of deoxycorticosterone acetate (DOCA)-salt hypertensive rats is increased. We designed this study to examine, using the new orally active nonselective endothelin receptor antagonist bosentan, whether this increase in vascular endothelin may contribute to elevated blood pressure and vascular hypertrophy in DOCA-salt hypertensive rats. Rats received bosentan (100 mg/kg body wt per day) for 3 weeks mixed with their food. Systolic blood pressure of DOCA-salt hypertensive rats rose to 197 +/- 5 mm Hg, and that of bosentan-treated DOCA-salt hypertensive rats was 177 +/- 4 mm Hg (P < .01). Mesenteric resistance arteries were studied on a wire myograph. The media width, ratio of media width to lumen diameter, and cross-sectional area of the media of resistance arteries of bosentan-treated DOCA-salt hypertensive rats were significantly smaller than those of untreated DOCA-salt hypertensive rats. The lumen diameter and cross-sectional area of the media of vessels of bosentan-treated rats were not different from those of uninephrectomized control rats. Vasoconstrictor responses, which were altered in DOCA-salt hypertensive rats, approached control in the bosentan-treated rats. We conclude that these results with a nonselective endothelin receptor antagonist may suggest a role for endothelin in the elevation of blood pressure and vascular hypertrophy and remodeling in DOCA-salt hypertensive rats.
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A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,729
Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K., & Masaki, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2863 · Cited by 2,517
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
Kurihara, Y., Kurihara, H., Suzuki, H., Kodama, T., Maemura, K., Nagai, R., Oda, H., Kuwaki, T., Cao, W.-H., Kamada, N., et al. (1994) · Nature · doi:10.1038/368703a0 · Cited by 981
Clozel, M., Breu, V, Gray, G. A., Kalina, B., Löffler, B. M., Burri, K., Cassal, J. M., Hirth, G., Müller, M., & Neidhart, W. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22357-6 · Cited by 661
Polar secretion of endothelin-1 by cultured endothelial cells.
Wagner, O. F., Christ, G., Wojta, J., Vierhapper, H., Parzer, S., Nowotny, P. J., Schneider, B., Waldhäusl, W., & Binder, B. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41966-7 · Cited by 639
Clozel, M., Breu, V., Burri, K., Cassal, J.-M., Fischli, W., Gray, G. A., Hirth, G., Löffier, B.-M., Müller, M., Neidhart, W., et al. (1993) · Nature · doi:10.1038/365759a0 · Cited by 518
Endothelin is a potent mitogen for rat vascular smooth muscle cells
Hirata, Y., Takagi, Y., Fukuda, Y., & Maruno, F. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90227-x · Cited by 501
The loss of endothelium-dependent vascular relaxation in hypertension.
Lockette, W., Otsuka, Y., & Carretero, O. (1986) · Hypertension · doi:10.1161/01.hyp.8.6_pt_2.ii61 · Cited by 372
Growth factor activity of endothelin on vascular smooth muscle
Bobik, A., Grooms, A., Millar, J. A., Mitchell, A., & Grinpukel, S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c408 · Cited by 316
Plasma immunoreactive endothelin in essential hypertension
Kohno, M., Yasunari, K., Murakawa, K.-I., Yokokawa, K., Horio, T., Fukui, T., & Takeda, T. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90527-k · Cited by 291
Cited by
Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis
Intengan, H. D., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/hy09t1.096249 · Cited by 979
Self-citationDavenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011833 · Cited by 772
Gupta, R. M., Hadaya, J., Trehan, A., Zekavat, S. M., Roselli, C., Klarin, D., Emdin, C. A., Hilvering, C. R. E., Bianchi, V., Mueller, C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.049 · Cited by 450
Amiri, F., Virdis, A., Neves, M. F., Iglarz, M., Seidah, N. G., Touyz, R. M., Reudelhuber, T. L., & Schiffrin, E. L. (2004) · Circulation · doi:10.1161/01.cir.0000144462.08345.b9 · Cited by 346
Self-citationVascular endothelin in hypertension
Schiffrin, E. L. (2005) · Vascular Pharmacology · doi:10.1016/j.vph.2005.03.004 · Cited by 305
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Metadata
- Authors
- Li, J. S., Larivière, R., & Schiffrin, E. L.
- Venue
- Hypertension
- Published
- 1994-08
- Volume
- 24
- Issue
- 2
- Pages
- 183-188
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2109591901
- Cited by
- 286
- References
- 18
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, J. S., Larivière, R., & Schiffrin, E. L. (1994). Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. Hypertension. https://doi.org/10.1161/01.hyp.24.2.183
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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