Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis

Intengan, Hope D.; Schiffrin, Ernesto L.

doi:10.1161/hy09t1.096249

Cited by 979Cardiac Fibrosis and RemodelingRenin-Angiotensin System StudiesCardiovascular Health and Disease Prevention

Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis

Intengan, Hope D., Schiffrin, Ernesto L.·2001·Hypertension

DOI 10.1161/hy09t1.096249

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Abstract

Abstract — — Remodeling of large and small arteries contributes to the development and complications of hypertension. The focus of this review is some of the mechanisms involved in the remodeling of small arteries in hypertension. In hypertension, changes in small artery structure are basically of 2 kinds: (1) inward eutrophic remodeling, in which outer and lumen diameters are decreased, media/lumen ratio is increased, and cross-sectional area of the media is unaltered; and (2) hypertrophic remodeling, in which the media thickens to encroach on the lumen, resulting in increased media cross-sectional area and media/lumen ratio. Growth, apoptosis, inflammation, and fibrosis contribute to vascular remodeling in hypertension. Apoptosis is gene-regulated cell death, with minimal membrane disruption and inflammation, that counters cell proliferation and fine-tunes developmental growth. Apoptosis has been reported in hypertension to be both increased and decreased in different tissues, including blood vessels. Inflammation, which may be low grade, probably plays an important role in triggering fibrosis in cardiovascular disease and hypertension. Vascular fibrosis entails accumulation of collagen, fibronectin, and other extracellular matrix components in the vessel wall and is an important aspect of extracellular matrix remodeling in hypertension. Associated with this, there may be increases in cell-matrix attachment sites (integrins) and changes in their topographical localization that may modulate arterial structure. Imbalance in matrix metalloproteinase/tissue inhibitors of metalloproteinases may contribute to alteration in collagen turnover and extracellular matrix remodeling. Chronic vasoconstriction may lead to embedding of the contracted vessel structure in a remodeled extracellular matrix, contributing to the inward remodeling of the blood vessel as smooth muscle cells are rearranged around a smaller lumen. The resulting remodeling of small arteries may initially be adaptive, but eventually it becomes maladaptive and compromises organ function, contributing to cardiovascular complications of hypertension.

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The underlying cause of hypertension is inflammatory in nature.
“there is considerable evidence that its underlying cause is inflammatory in nature [678-686]”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [679]

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Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524 · see citing works
Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407 · see citing works
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.
Galis, Z. S., Sukhova, G. K., Lark, M. W., & Libby, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117619 · Cited by 2,537 · see citing works
Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction
Suwaidi, J. M. S. A., Hamasaki, S., Higano, S. T., Nishimura, R. A., Holmes, D. R., & Lerman, A. (2000) · Circulation · doi:10.1161/01.cir.101.9.948 · Cited by 2,044 · see citing works
Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients
Perticone, F., Ceravolo, R., Pujia, A., Ventura, G., Iacopino, S., Scozzafava, A., Ferraro, A., Chello, M., Mastroroberto, P., Verdecchia, P., et al. (2001) · Circulation · doi:10.1161/01.cir.104.2.191 · Cited by 1,059 · see citing works
Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells
Touyz, R. M., & Schiffrin, E. L. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01471-6 · Cited by 933 · see citing works
Self-citation
Oxidant Signaling in Vascular Cell Growth, Death, and Survival
Irani, K. (2000) · Circulation Research · doi:10.1161/01.res.87.3.179 · Cited by 748 · see citing works
Angiotensin II type 2 receptor mediates programmed cell death.
Yamada, T., Horiuchi, M., & Dzau, V. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.156 · Cited by 700 · see citing works
Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.
Galis, Z. S., Muszynski, M., Sukhova, G. K., SIMON‐MORRISSEY, E., Unemori, E., Lark, M. W., Amento, E. P., & Libby, P. (1994) · Circulation Research · doi:10.1161/01.res.75.1.181 · Cited by 646 · see citing works
Small artery structure in hypertension. Dual processes of remodeling and growth.
Heagerty, A. M., Aalkjær, C., Bund, S. J., Korsgaard, N., & Mulvany, M. J. (1993) · Hypertension · doi:10.1161/01.hyp.21.4.391 · Cited by 644 · see citing works
Matrix metalloproteinases and diseases of the CNS
Yong, V. W., Forsyth, P. A., Bell, R. B., Krekoski, C. A., & Edwards, D. R. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01169-7 · Cited by 635 · see citing works
Correction of Arterial Structure and Endothelial Dysfunction in Human Essential Hypertension by the Angiotensin Receptor Antagonist Losartan
Schiffrin, E. L., Park, J. B., Intengan, H. D., & Touyz, R. M. (2000) · Circulation · doi:10.1161/01.cir.101.14.1653 · Cited by 617 · see citing works
Self-citation
Remodeling of cerebral arterioles in chronic hypertension.
Baumbach, G. L., & Heistad, D. D. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.968 · Cited by 496 · see citing works
Angiotensin Induces Inflammatory Activation of Human Vascular Smooth Muscle Cells
Kranzhöfer, R., Schmidt, J., Pfeiffer, C. A. H., Hagl, S., Libby, P., & Kübler, W. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.7.1623 · Cited by 480 · see citing works
Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.
Itoh, H., Mukoyama, M., Pratt, R. E., Gibbons, G. H., & Dzau, V. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116454 · Cited by 469 · see citing works
Structure and Mechanical Properties of Resistance Arteries in Hypertension
Intengan, H. D., & Schiffrin, E. L. (2000) · Hypertension · doi:10.1161/01.hyp.36.3.312 · Cited by 459 · see citing works
Self-citation
Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II
Pagano, P. J., Clark, J. K., Cifuentes-Pagano, M. E., Clark, S. M., Callis, G. M., & Quinn, M. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14483 · Cited by 455 · see citing works
Interactions of Transforming Growth Factor-β and Angiotensin II in Renal Fibrosis
Border, W. A., & Noble, N. A. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.181 · Cited by 439 · see citing works
Reactive oxygen species as mediators of angiotensin II signaling
Griendling, K. K., & Ushio‐Fukai, M. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00136-1 · Cited by 417 · see citing works
NF-κB Inhibition Ameliorates Angiotensin II–Induced Inflammatory Damage in Rats
Müller, D. N., Dechend, R., Mervaala, E. M. A., Park, J.-K., Schmidt, F. H., Fiebeler, A., Theuer, J., Breu, V., Ganten, D., Haller, H. G., et al. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.193 · Cited by 404 · see citing works
Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro.
Liaw, L., de Almeida, M. A. G., Hart, C. E., Schwartz, S. M., & Giachelli, C. M. (1994) · Circulation Research · doi:10.1161/01.res.74.2.214 · Cited by 393 · see citing works
Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice
Weiss, D., Kools, J. J., & Taylor, W. R. (2001) · Circulation · doi:10.1161/01.cir.103.3.448 · Cited by 368 · see citing works
Structure, Endothelial Function, Cell Growth, and Inflammation in Blood Vessels of Angiotensin II–Infused Rats
Diep, Q. N., Mabrouk, M. E., Cohn, J. S., Endemann, D., Amiri, F., Virdis, A., Neves, M. F., & Schiffrin, E. L. (2002) · Circulation · doi:10.1161/01.cir.0000016049.86468.23 · Cited by 345 · see citing works
Self-citation
Vasoactive Substances Regulate Vascular Smooth Muscle Cell Apoptosis
Pollman, M. J., Yamada, T., Horiuchi, M., et al. (1996) · Circulation Research · doi:10.1161/01.res.79.4.748 · Cited by 343 · see citing works
Angiotensin II Activates Nuclear Transcription Factor κB Through AT1and AT2in Vascular Smooth Muscle Cells
Ruiz‐Ortega, M., Lorenzo, Ó., Rupérez, M., König, S., Wittig, B., & Egido, J. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1266 · Cited by 331 · see citing works
Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension
Park, J. B., & Schiffrin, E. L. (2001) · Journal of Hypertension · doi:10.1097/00004872-200105000-00013 · Cited by 325 · see citing works
Self-citation
Structural Alterations in Subcutaneous Small Arteries of Normotensive and Hypertensive Patients With Non–Insulin-Dependent Diabetes Mellitus
Rizzoni, D., Porteri, E., Guelfi, D., Muiesan, M. L., Valentini, U., Cimino, A., Girelli, A., Rodella, L. F., Bianchi, R., Sleiman, I., et al. (2001) · Circulation · doi:10.1161/01.cir.103.9.1238 · Cited by 302 · see citing works
Effect of Antihypertensive Treatment on Small Arteries of Patients With Previously Untreated Essential Hypertension
Thybo, N. K., Stephens, N., Cooper, A., et al. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.474 · Cited by 300 · see citing works
Abnormalities of the Extracellular Degradation of Collagen Type I in Essential Hypertension
Laviades, C., Varo, N., Fernández, J., Mayor, G., Gil, M. J., Monreal, I., & Dı́ez, J. (1998) · Circulation · doi:10.1161/01.cir.98.6.535 · Cited by 299 · see citing works
Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.
Li, J. S., Larivière, R., & Schiffrin, E. L. (1994) · Hypertension · doi:10.1161/01.hyp.24.2.183 · Cited by 290 · see citing works
Self-citation
Mechanical Strain–Induced Extracellular Matrix Production by Human Vascular Smooth Muscle Cells
O'Callaghan, C. J., & Williams, B. (2000) · Hypertension · doi:10.1161/01.hyp.36.3.319 · Cited by 289 · see citing works
Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats.
Larivière, R., Thibault, G., & Schiffrin, E. L. (1993) · Hypertension · doi:10.1161/01.hyp.21.3.294 · Cited by 283 · see citing works
Self-citation
Effects of a beta-blocker or a converting enzyme inhibitor on resistance arteries in essential hypertension.
Schiffrin, E. L., Deng, L.-Y., & Larochelle, P. M. (1994) · Hypertension · doi:10.1161/01.hyp.23.1.83 · Cited by 265 · see citing works
Self-citation
Apoptosis in Target Organs of Hypertension
Hamet, P., Richard, L., Dam, T.-V., Teíger, E., Orlov, S. N., Gaboury, L. A., Gossard, F., & Tremblay, J. (1995) · Hypertension · doi:10.1161/01.hyp.26.4.642 · Cited by 249 · see citing works
Repair of Coronary Arterioles After Treatment With Perindopril in Hypertensive Heart Disease
Schwartzkopff, B., Brehm, M. U., Mundhenke, M., et al. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.220 · Cited by 240 · see citing works
Vascular Hypertrophy and Remodeling in Secondary Hypertension
Rizzoni, D., Porteri, E., Castellano, M., et al. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.785 · Cited by 239 · see citing works
PPARα Activator Effects on Ang II–Induced Vascular Oxidative Stress and Inflammation
Diep, Q. N., Amiri, F., Touyz, R. M., Cohn, J. S., Endemann, D., Neves, M. F., & Schiffrin, E. L. (2002) · Hypertension · doi:10.1161/01.hyp.0000037969.41360.cc · Cited by 235 · see citing works
Self-citation
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.
Levy, B. I., Bénessiano, J., Henrion, D., Caputo, L., Heymes, C., Duriez, M., Poitevin, P., & Samuel, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118807 · Cited by 232 · see citing works
Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies.
Fogerty, F. J., Akiyama, S. K., Yamada, K. M., & Mosher, D. F. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.2.699 · Cited by 230 · see citing works
Resistance Artery Mechanics, Structure, and Extracellular Components in Spontaneously Hypertensive Rats
Intengan, H. D., Thibault, G., Li, J., et al. (1999) · Circulation · doi:10.1161/01.cir.100.22.2267 · Cited by 217 · see citing works
Self-citation
Increased Serum Concentrations of Procollagen Peptides in Essential Hypertension
Dı́ez, J., Laviades, C., Mayor, G., Gil, M. J., & Monreal, I. (1995) · Circulation · doi:10.1161/01.cir.91.5.1450 · Cited by 217 · see citing works
Hypertension-Induced End-Organ Damage
Luft, F. C., Mervaala, E. M. A., Müller, D. N., et al. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.212 · Cited by 206 · see citing works
Mechanics and Composition of Human Subcutaneous Resistance Arteries in Essential Hypertension
Intengan, H. D., Deng, L. Y., Li, J. S., & Schiffrin, E. L. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.569 · Cited by 198 · see citing works
Self-citation
Apoptosis (Programmed Cell Death) in Arteries of the Neonatal Lamb
Cho, A., Courtman, D. W., & Langille, B. L. (1995) · Circulation Research · doi:10.1161/01.res.76.2.168 · Cited by 198 · see citing works
Comparison of Effects of Angiotensin I– Converting Enzyme Inhibition and β-Blockade for 2 Years on Function of Small Arteries From Hypertensive Patients
Schiffrin, E. L., & Deng, L.-Y. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.699 · Cited by 192 · see citing works
Self-citation
Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a three-dimensional disector.
Mulvany, M. J., Baandrup, U. T., & Gundersen, H. J. G. (1985) · Circulation Research · doi:10.1161/01.res.57.5.794 · Cited by 189 · see citing works
Prevention of Aortic Fibrosis by Spironolactone in Spontaneously Hypertensive Rats
Bénétos, A., Lacolley, P. J., & Safar, M. E. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.6.1152 · Cited by 186 · see citing works
Effect of captopril and enalapril on endothelial function in hypertensive patients.
Creager, M. A., & Roddy, M. A. (1994) · Hypertension · doi:10.1161/01.hyp.24.4.499 · Cited by 184 · see citing works
Enhanced expression of endothelin-1 gene in resistance arteries in severe human essential hypertension
Schiffrin, E. L., Deng, L., Sventek, P., et al. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715010-00005 · Cited by 183 · see citing works
Self-citation
Structure and function of resistance arteries of hypertensive patients treated with a p-blocker or a calcium channel antagonist
Schiffrin, E. L., & Deng, L. (1996) · Journal of Hypertension · doi:10.1097/00004872-199610000-00014 · Cited by 182 · see citing works
Self-citation
Distribution of Type I, III, IV and V Collagen in Normal and Atherosclerotic Human Arterial Wall: Immunomorphological Characteristics
Shekhonin, B. V., Domogatsky, S. P., Muzykantov, V. R., Idelson, G. L., & Rukosuev, V. S. (1985) · Collagen and Related Research · doi:10.1016/s0174-173x(85)80024-8 · Cited by 179 · see citing works
Improvement of Coronary Flow Reserve After Long-term Therapy With Enalapril
Motz, W., & Strauer, B. E. (1996) · Hypertension · doi:10.1161/01.hyp.27.5.1031 · Cited by 177 · see citing works
Stretch-Induced Collagen Synthesis in Cultured Smooth Muscle Cells from Rabbit Aortic Media and a Possible Involvement of Angiotensin II and Transforming Growth Factor-β
Li, Q., Muragaki, Y., Hatamura, I., Ueno, H., & Ooshima, A. (1998) · Journal of Vascular Research · doi:10.1159/000025570 · Cited by 174 · see citing works
Histology of subcutaneous small arteries from patients with essential hypertension.
Korsgaard, N., Aalkjær, C., Heagerty, A. M., et al. (1993) · Hypertension · doi:10.1161/01.hyp.22.4.523 · Cited by 174 · see citing works
Angiotensin II Activates Collagen I Gene Through a Mechanism Involving the MAP/ER Kinase Pathway
Tharaux, P.-L., Chatziantoniou, C., Fakhouri, F., & Dussaule, J.-C. (2000) · Hypertension · doi:10.1161/01.hyp.36.3.330 · Cited by 173 · see citing works
Effect of the Angiotensin II Type 1 Receptor Blocker Candesartan on Endothelial Function in Patients With Essential Hypertension
Ghiadoni, L., Virdis, A., Magagna, A., Taddei, S., & Salvetti, A. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.501 · Cited by 171 · see citing works
Smooth Muscle Apoptosis During Vascular Regression in Spontaneously Hypertensive Rats
deBlois, D., Tea, B.-S., Dam, T.-V., Tremblay, J., & Hamet, P. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.340 · Cited by 169 · see citing works
Fibronectin Expression and Aortic Wall Elastic Modulus in Spontaneously Hypertensive Rats
Bézie, Y., Lamazière, J. D., Laurent, S., et al. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.7.1027 · Cited by 166 · see citing works
Increased Collagen Synthesis in Blood Vessels of Hypertensive Rats and Its Reversal by Antihypertensive Agents
Ooshima, A., Fuller, G. C., Cardinale, G. J., et al. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.8.3019 · Cited by 165 · see citing works
Myocardial Fibrosis in DOCA-Salt Hypertensive Rats
Ammarguellat, F., Larouche, I., & Schiffrin, E. L. (2001) · Circulation · doi:10.1161/01.cir.103.2.319 · Cited by 155 · see citing works
Self-citation
Inward Remodeling Follows Chronic Vasoconstriction in Isolated Resistance Arteries
Bakker, E. N. T. P., van der Meulen, E. T., van den Berg, B. M., Everts, V. E., Spaan, J. A. E., & VanBavel, E. (2002) · Journal of Vascular Research · doi:10.1159/000048989 · Cited by 154 · see citing works
Structural properties of rat mesenteric small arteries after 4-wk exposure to elevated or reduced blood flow
Pourageaud, F., & Mey, J. G. R. D. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1699 · Cited by 150 · see citing works
Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats.
Kim, S., Ohta, K., Hamaguchi, A., et al. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09620-x · Cited by 148 · see citing works
Osteopontin overexpression is associated with arterial smooth muscle cell proliferation in vitro.
Gadeau, A., Campan, M., Millet, D., et al. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.1.120 · Cited by 140 · see citing works
Progressive improvement in the structure of resistance arteries of hypertensive patients after 2 years of treatment with an angiotensin i-converting enzyme inhibitor comparison with effects of a ?-locker
Schiffrin, E. L., DENG, L., & Larochelle, P. M. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)96211-2 · Cited by 135 · see citing works
Self-citation
Overexpression of Bax Protein and Enhanced Apoptosis in the Left Ventricle of Spontaneously Hypertensive Rats
Fortuño, M. A., Ravassa, S., Etayo, J. C., & Dı́ez, J. (1998) · Hypertension · doi:10.1161/01.hyp.32.2.280 · Cited by 133 · see citing works
Structure and Function of Small Arteries in Salt-Induced Hypertension
d’Uscio, L. V., Barton, M., Shaw, S., Moreau, P. R., & Lüscher, T. F. (1997) · Hypertension · doi:10.1161/01.hyp.30.4.905 · Cited by 128 · see citing works
Morphometric Study of Structural Changes in the Mesenteric Blood Vessels of Spontaneously Hypertensive Rats
Lee, R. M. K. W., Garfield, R. E., Forrest, J. B., et al. (2008) · Blood Vessels · doi:10.1159/000158460 · Cited by 125 · see citing works
Effect of crossing over hypertensive patients from a beta-blocker to an angiotensin receptor antagonist on resistance artery structure and on endothelial function
Schiffrin, E. L., Park, J. B., & Pu, Q. (2002) · Journal of Hypertension · doi:10.1097/00004872-200201000-00011 · Cited by 122 · see citing works
Self-citation
Cardiomyocyte Apoptosis and Cardiac Angiotensin-Converting Enzyme in Spontaneously Hypertensive Rats
Dı́ez, J., Panizo, Á., Hernández, M., Vega, F., Sola, I., Fortuño, M. A., & Pardo, J. (1997) · Hypertension · doi:10.1161/01.hyp.30.5.1029 · Cited by 120 · see citing works
ET A Receptor Antagonist Prevents Blood Pressure Elevation and Vascular Remodeling in Aldosterone-Infused Rats
Park, J. B., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/01.hyp.37.6.1444 · Cited by 119 · see citing works
Self-citation
Serum Markers of Collagen Type I Metabolism in Spontaneously Hypertensive Rats
Dı́ez, J., Panizo, Á., Gil, M. J., et al. (1996) · Circulation · doi:10.1161/01.cir.93.5.1026 · Cited by 119 · see citing works
Effect of early onset angiotensin converting enzyme inhibition on myocardial capillaries.
Unger, T., Mattfeldt, T., Lamberty, V., et al. (1992) · Hypertension · doi:10.1161/01.hyp.20.4.478 · Cited by 116 · see citing works
Angiotensin II Stimulates Collagen Synthesis in Human Vascular Smooth Muscle Cells
Ford, C. M., Li, S., & Pickering, J. G. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.8.1843 · Cited by 116 · see citing works
The Effects of Endothelin-1 on Collagen Type I and Type III Synthesis in Cultured Porcine Coronary Artery Vascular Smooth Muscle Cells
Rizvi, M. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0023 · Cited by 112 · see citing works
Deoxycorticosterone Acetate Plus Salt Induces Overexpression of Vascular Endothelin-1 and Severe Vascular Hypertrophy in Spontaneously Hypertensive Rats
Schiffrin, E. L., Larivière, R., Li, J. S., Sventek, P., & Touyz, R. M. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.769 · Cited by 112 · see citing works
Self-citation
Capillary rarefaction in the forearm skin in essential hypertension
Prasad, A., Dunnill, G., Mortimer, P. S., et al. (1995) · Journal of Hypertension · doi:10.1097/00004872-199502000-00015 · Cited by 107 · see citing works
Stretch‐induced endothelin B receptor‐mediated apoptosis in vascular smooth muscle cells
Cattaruzza, M., Dimigen, C., Ehrenreich, H., et al. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.991 · Cited by 106 · see citing works
Effects of enalapril and amlodipine on small-artery structure and composition, and on endothelial dysfunction in spontaneously hypertensive rats
Sharifi, A. M., Li, J.-S., Endemann, D., & Schiffrin, E. L. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816040-00007 · Cited by 104 · see citing works
Self-citation
Requirement for Protein Kinase C in Reactive Oxygen Species–Induced Apoptosis of Vascular Smooth Muscle Cells
Li, P., Maasch, C., Haller, H. G., Dietz, R., & von Harsdorf, R. (1999) · Circulation · doi:10.1161/01.cir.100.9.967 · Cited by 96 · see citing works
In Vivo Study of AT1and AT2Angiotensin Receptors in Apoptosis in Rat Blood Vessels
Diep, Q. N., Li, J., & Schiffrin, E. L. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.617 · Cited by 95 · see citing works
Self-citation
Proapoptotic and Growth-Inhibitory Role of Angiotensin II Type 2 Receptor in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats In Vivo
Tea, B.-S., Sarkissian, S. D., Touyz, R. M., Hamet, P., & deBlois, D. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1069 · Cited by 95 · see citing works
Endothelium-Dependent Relaxation of Small Arteries from Essential Hypertensive Patients: Mechanisms and Comparison with Normotensive Subjects and with Responses of Vessels from Spontaneously Hypertensive Rats
Deng, L.-Y., Li, J., & Schiffrin, E. L. (1995) · Clinical Science · doi:10.1042/cs0880611 · Cited by 95 · see citing works
Self-citation
Enhanced Expression of the Endothelin-1 Gene in Blood Vessels of DOCA-Salt Hypertensive Rats: Correlation with Vascular Structure
Schiffrin, E. L., re, R. L. E., Li, J., et al. (2008) · Journal of Vascular Research · doi:10.1159/000159151 · Cited by 94 · see citing works
Self-citation
Effect of hypertension on fibronectin expression in the rat aorta.
Takasaki, I., Chobanian, A. V., Sarzani, R., & Brecher, P. I. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45828-0 · Cited by 93 · see citing works
Structural changes of large conduit arteries in hypertension
Safar, M. E., Girerd, X. J., & Laurent, S. (1996) · Journal of Hypertension · doi:10.1097/00004872-199605000-00002 · Cited by 92 · see citing works
Localization of vascular resistance changes during hypertension.
Bohlen, H. G. (1986) · Hypertension · doi:10.1161/01.hyp.8.3.181 · Cited by 92 · see citing works
Interaction of mRNAs for Angiotensin II Type 1 and Type 2 Receptors to Vascular Remodeling in Spontaneously Hypertensive Rats
Otsuka, S., Sugano, M., Makino, N., Sawada, S., Hata, T., & Niho, Y. (1998) · Hypertension · doi:10.1161/01.hyp.32.3.467 · Cited by 89 · see citing works
Apoptosis Occurs in Endothelial Cells during Hypertension-Induced Microvascular Rarefaction
Gobe, G. C., Browning, J., Howard, T., Hogg, N., Winterford, C. M., & Cross, R. B. (1997) · Journal of Structural Biology · doi:10.1006/jsbi.1996.3835 · Cited by 89 · see citing works
Apoptosis in vasculature of spontaneously hypertensive rats *1Effect of an angiotensin converting enzyme inhibitor and a calcium channel antagonist
Sharifi, A. M., & Schiffrin, E. L. (1998) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00120-4 · Cited by 89 · see citing works
Self-citation
Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic Mice During Inhibition of Nitric Oxide Synthesis
Boffa, J., Tharaux, P., Placier, S., Ardaillou, R., Dussaule, J., & Chatziantoniou, C. (1999) · Circulation · doi:10.1161/01.cir.100.18.1901 · Cited by 88 · see citing works
Vasodilatation, not hypotension, improves resistance vessel design during treatment of essential hypertension: a literature survey
Christensen, K. L., & Mulvany, M. J. (2001) · Journal of Hypertension · doi:10.1097/00004872-200106000-00002 · Cited by 87 · see citing works
Angiotensin II Type 2 Receptors Stimulate Collagen Synthesis in Cultured Vascular Smooth Muscle Cells
Mifune, M., Sasamura, H., Shimizu‐Hirota, R., et al. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.845 · Cited by 87 · see citing works
Apoptosis of vascular smooth muscle cells. Protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non-transformed rat vascular smooth muscle cells.
Leszczyński, D., Zhao, Y., Luokkamäki, M., et al. (1994) · PubMed · Cited by 86 · see citing works
Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertensive patients
Schiffrin, E. L., Pu, Q., & Park, J. B. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02290-7 · Cited by 85 · see citing works
Self-citation
Morphology of resistance arteries and comparison of effects of vasoconstrictors in mild essential hypertensive patients.
Schiffrin, E. L., Deng, L., & Larochelle, P. M. (1993) · PubMed · Cited by 84 · see citing works
Self-citation
Vascular Endothelin-1 Gene Expression and Synthesis and Effect on Renal Type I Collagen Synthesis and Nephroangiosclerosis During Nitric Oxide Synthase Inhibition in Rats
Tharaux, P., Chatziantoniou, C., Casellas, D., Fouassier, L., Ardaillou, R., & Dussaule, J. (1999) · Circulation · doi:10.1161/01.cir.99.16.2185 · Cited by 83 · see citing works
Role of transforming growth factor-beta 1 in the cellular growth response to angiotensin II.
Koibuchi, Y., Lee, W.-S., Gibbons, G. H., et al. (1993) · Hypertension · doi:10.1161/01.hyp.21.6.1046 · Cited by 83 · see citing works
Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats
Deng, L.-Y., & Schiffrin, E. L. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.6.h1782 · Cited by 83 · see citing works
Self-citation
Effects of Cilazapril on Vascular Structure and Function in Essential Hypertension
Kiowski, W., Linder, L., Nüesch, R., et al. (1996) · Hypertension · doi:10.1161/01.hyp.27.3.371 · Cited by 82 · see citing works
Effects of Antihypertensive Agents on Local Arterial Distensibility and Compliance
Bortel, L. M. V., Kool, M. J. F., & Boudier, H. A. S. (1995) · Hypertension · doi:10.1161/01.hyp.26.3.531 · Cited by 77 · see citing works
Collagen Biosynthesis in Blood Vessels of Brain and Other Tissues of the Hypertensive Rat
Ooshima, A., Fuller, G. C., Cardinale, G. J., et al. (1975) · Science · doi:10.1126/science.171771 · Cited by 76 · see citing works
Cellular hypertrophy in mesenteric resistance vessels from renal hypertensive rats.
Korsgaard, N., & Mulvany, M. J. (1988) · Hypertension · doi:10.1161/01.hyp.12.2.162 · Cited by 76 · see citing works
Effect of endothelin antagonism on blood pressure and vascular structure in renovascular hypertensive rats
Li, J.-S., Knafo, L., Turgeon, A., et al. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.1.h88 · Cited by 75 · see citing works
Effects of Endothelin-1 and Vasopressin on Resistance Arteries of Spontaneously Hypertensive Rats
Deng, L., & Schiffrin, E. L. (1992) · American Journal of Hypertension · doi:10.1093/ajh/5.11.817 · Cited by 70 · see citing works
Self-citation
Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a three-dimensional disector.
JMulvany, M., UBaandrup, & JGundersen, H. (1985) · Circulation Research · Cited by 69 · see citing works
Apoptosis in aorta of deoxycorticosterone acetate-salt hypertensive rats
Sharifi, A. M., & Schiffrin, E. L. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00011 · Cited by 68 · see citing works
Self-citation
Collagen synthesis in cultured aortic smooth muscle cells. Modulation by collagen lattice culture, transforming growth factor-beta 1, and epidermal growth factor.
Schlumberger, W., Thie, M., Rauterberg, J., & Robenek, H. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.6.1660 · Cited by 63 · see citing works
Effects of an Angiotensin-Converting Enzyme Inhibitor and a β-Blocker on Cerebral Arterioles in Rats
Chillon, J., & Baumbach, G. L. (1999) · Hypertension · doi:10.1161/01.hyp.33.3.856 · Cited by 60 · see citing works
Increased apoptosis in the heart of genetic hypertension, associated with increased fibroblasts
Liu, J. Z. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00382-x · Cited by 60 · see citing works
Biomechanical properties and chemical composition of the aorta in genetic hypertensive rats
Mizutani, K., Ikeda, K., Kawai, Y., et al. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917040-00005 · Cited by 59 · see citing works
Apoptosis and vascular wall remodeling in hypertension
Hamet, P., deBlois, D., Dam, T.-V., Richard, L., Teíger, E., Tea, B.-S., Orlov, S. N., & Tremblay, J. (1996) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y96-076 · Cited by 57 · see citing works
Is the Regulation of Apoptosis Altered in Smooth Muscle Cells of Adult Spontaneously Hypertensive Rats?
Dı́ez, J., Panizo, Á., Hernández, M., et al. (1997) · Hypertension · doi:10.1161/01.hyp.29.3.776 · Cited by 52 · see citing works
A reduced elastic modulus of vascular wall components in hypertension?
Mulvany, M. J. (1992) · Hypertension · doi:10.1161/01.hyp.20.1.7 · Cited by 52 · see citing works
Some pharmacological and elastic characteristics of isolated subcutaneous small arteries from patients with essential hypertension
Thybo, N. K., Mulvany, M. J., Jastrup, B., Nielsen, H., & r, C. A. (1996) · Journal of Hypertension · doi:10.1097/00004872-199608000-00009 · Cited by 51 · see citing works
Angiotensin II alters aortic fibronectin independently of hypertension.
Himeno, H., Crawford, D. C., Hosoi, M., et al. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.823 · Cited by 48 · see citing works
Collagen I and III and Mechanical Properties of Conduit Arteries in Rats with Genetic Hypertension
CLERC, P., Renaud, J. F., Blacher, J., et al. (1999) · Journal of Vascular Research · doi:10.1159/000025637 · Cited by 45 · see citing works
Blockade of Angiotensin II Type 1 Receptors: Effect on Carotid and Radial Artery Structure and Function in Hypertensive Humans
Bénétos, A., Gautier, S., Laflèche, A., et al. (2000) · Journal of Vascular Research · doi:10.1159/000025708 · Cited by 45 · see citing works
Glomerular cell proliferation and apoptosis in uninephrectomized spontaneously hypertensive rats
Rodrı́guez-López, A. M., Flores, O., Arévalo, M. A., et al. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.06810.x · Cited by 44 · see citing works
Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage
Nishikawa, K. (1998) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000634 · Cited by 43 · see citing works
Time course of apoptosis in small resistance arteries of spontaneously hypertensive rats
Rizzoni, D., Rodella, L. F., Porteri, E., et al. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018070-00010 · Cited by 43 · see citing works
Fibronectin biosynthesis in the rat aorta in vitro. Changes due to experimental hypertension.
Saouaf, R., Takasaki, I., Eastman, E. M., et al. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115420 · Cited by 40 · see citing works
Functional Aspects of Vascular Tenascin-C Expression
Hahn, A. W. A., Kern, F., Jonas, U., et al. (2008) · Journal of Vascular Research · doi:10.1159/000159090 · Cited by 40 · see citing works
Acute and chronic hemodynamic effects of drugs with different actions on adrenergic receptors: A comparison between alpha blockers and different types of beta blockers with and without vasodilating effect
Lund‐Johansen, P., & Omvik, P. (1991) · Cardiovascular Drugs and Therapy · doi:10.1007/bf03029729 · Cited by 39 · see citing works
DNA Synthesis and Apoptosis in Smooth Muscle Cells From a Model of Genetic Hypertension
Devlin, A. M., Clark, J. S., Reid, J. L., et al. (2000) · Hypertension · doi:10.1161/01.hyp.36.1.110 · Cited by 37 · see citing works
Pathophysiology of smooth muscle in hypertension
Lee, R. M. K. W., Owens, G. K., Scott‐Burden, T., et al. (1995) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y95-073 · Cited by 36 · see citing works
Arterial Vasodilation and Vascular Connective Tissue Changes in Spontaneously Hypertensive Rats
Tsoporis, J. N., KEELEY, F. W., Lee, R. M. K. W., et al. (1998) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199806000-00022 · Cited by 36 · see citing works
Life and Death in the Microcirculation: a Role for Angiotensin II
Greene, A. S. (1998) · Microcirculation · doi:10.1111/j.1549-8719.1998.tb00060.x · Cited by 34 · see citing works
Apoptosis in the muscular arteries from young spontaneously hypertensive rats
Dickhout, J. G., & Lee, R. M. K. W. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917100-00008 · Cited by 28 · see citing works
Morphological and functional alterations of mesenteric small resistance arteries in early renal hypertension in rats
Deng, L.-Y., & Schiffrin, E. L. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.4.h1171 · Cited by 27 · see citing works
Self-citation
Proteoglycan Production by Vascular Smooth Muscle Cells From Resistance Arteries of Hypertensive Rats
Castro, C., Cruzado, M., Miatello, R. M., & Risler, N. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.893 · Cited by 25 · see citing works
Vascular Smooth Muscle Cell Phenotype Influences Glycosaminoglycan Composition and Growth Effects of Extracellular Matrix
Hein, M., Fischer, J. W., Kim, D., et al. (2008) · Journal of Vascular Research · doi:10.1159/000159174 · Cited by 22 · see citing works
Susceptibility to apoptosis measured by MYC, BCL-2, and BAX expression in arterioles and capillaries of adult spontaneously hypertensive rats
Vega, F. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00045-x · Cited by 22 · see citing works
Respective role of humoral factors and blood pressure in aortic remodeling of DOCA hypertensive rats
Karam, H., Heudes, D., GONZALES, M., et al. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)00119-7 · Cited by 20 · see citing works
Nifedipine induces apoptosis in cultured vascular smooth muscle cells from spontaneously hypertensive rats
Stead, S., Werstiuk, E. S., & Lee, R. M. K. W. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00687-1 · Cited by 17 · see citing works
Transforming Growth Factor-β and Receptor Tyrosine Kinase–Activating Growth Factors Negatively Regulate Collagen Genes in Smooth Muscle of Hypertensive Rats
Bray, P., Agrotis, A., & Bobik, A. (1998) · Hypertension · doi:10.1161/01.hyp.31.4.986 · Cited by 16 · see citing works
Connective tissue accumulation in the left coronary artery of young SHR.
Anversa, P., Melissari, M., Tardini, A., et al. (1984) · Hypertension · doi:10.1161/01.hyp.6.4.526 · Cited by 10 · see citing works
Is the extracellular degradation of collagen type I fibers depressed in spontaneously hypertensive rats with myocardial fibrosis?
Dı́ez, J., & Hernández, M. (1996) · PubMed · Cited by 9 · see citing works
Effects of hypertension and aging on fibronectin expression in aorta of Dahl salt-sensitive rats
Takasaki, I., Takizawa, T., Sugimoto, K., et al. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.4.h1523 · Cited by 6 · see citing works
Effect of ETA receptor antagonist on hypertrophy and collagen deposition in heart and aorta in response to chronic aldosterone infusion
Park, J. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)01727-7 · Cited by 1 · see citing works

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Research works printed but not linked: 5

Mulvany MJ, Baumbach GL, Aalkjaer C, Heagerty AM, Korsgaard N, Schiffrin EL, Heistad DD. Vascular remodeling. Hypertension. 1996;28: 505-506.
Deng LY, Schiffrin EL. Morphologic and functional alterations of mes- enteric small resistance arteries in early renal hypertension in the rat. Am J Physiol. 1991;261:H1171-H1177.
Kim S, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, Inada Y, Ishimura Y, Chatani F, Iwao H. Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-␤1 and extra- cellular matrix in cardiac and vascular tissues of hypertensive rats. J Pharmacol Exp Ther. 1995;273:509 -515.
Intengan HD, Schiffrin EL. Collagen degradation is diminished in mes- enteric arteries of spontaneously hypertensive rats after hypertension is established. Hypertension. 1999;34:329. Abstract.
Benetos A, Lacolley P, Safar ME. Prevention of aortic fibrosis by spi- ronolactone in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol. 1997;17:1152-1156.

Sorted by citations

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Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41
Natarajan, N., Hori, D., Flavahan, S., Steppan, J., Flavahan, N. A., Berkowitz, D. E., & Pluznick, J. L. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00089.2016 · Cited by 441 · see citing works
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Gonzalez-Cadavid, N. F., & Rajfer, J. (2005) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0201 · Cited by 168 · see citing works
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Bernini, G., Galetta, F., Franzoni, F., Bardini, M., Taurino, C., Bernardini, M., Ghiadoni, L., Bernini, M., Santoro, G., & Salvetti, A. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e32831286fd · Cited by 136 · see citing works
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Authors: Intengan, H. D., & Schiffrin, E. L.
Affiliations: University of California, San Francisco (US)
ORCID: Schiffrin, Ernesto L.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-09
Volume: 38
Issue: 3
Pages: 581-587
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hy09t1.096249
OpenAlex: W2097792029
Cited by: 979
References: 140
Citations by year: 2026: 21 · 2025: 38 · 2024: 26 · 2023: 37 · 2022: 46 · 2021: 43 · 2020: 39 · 2019: 36 · 2018: 38 · 2017: 46 · 2016: 69 · 2015: 51 · 2014: 56 · 2013: 41 · 2012: 52
FWCI: 4.40
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council Canada
Canadian Institutes of Health Research (37917)
Medical Research Council
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: vascular remodeling, small arteries, apoptosis, inflammation, vascular fibrosis, extracellular matrix, integrins, matrix metalloproteinases, tissue inhibitors of metalloproteinases, collagen turnover, vasoconstriction, smooth muscle cells, media-to-lumen ratio
MeSH terms: Animals, Blood Pressure, Blood Vessels, Fibrosis, Humans, Hypertension, Inflammation, Models, Biological, Apoptosis

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Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis

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