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Cited by 51Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityCardiac Fibrosis and Remodeling

Diastolic Compliance Is Reduced in Obese Rabbits

Carroll, Joan F., Summers, Richard L., Dzielak, David J., Cockrell, Kathy, Montani, Jean-Pierre, Mizelle, H. Leland·1999·Hypertension
DOI 10.1161/01.hyp.33.3.811
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Abstract

Abstract —Obesity often leads to symptoms of cardiopulmonary congestion associated with normal systolic but abnormal diastolic function. This study analyzed alterations in passive diastolic compliance in obesity using the rabbit model. New Zealand White rabbits were fed a normal (n=8) or 10% added fat diet (n=8). After 12 weeks, rabbits fed the high fat diet developed obesity (5.34±0.11 versus 3.68±0.04 kg, P ≤0.05) and left ventricular hypertrophy (1.37±0.07 versus 0.98±0.03 g dry weight, P ≤0.05). Compliance was assessed with the isolated heart preparation by analyzing the passive end-diastolic left ventricular pressure-volume relationship. The pressure-volume relation was fit to an exponential function by regression analysis; results showed that the modulus of stiffness was greater in obese than in lean rabbits (1.21±0.16 versus 0.83±0.05, P ≤0.05), indicating that diastolic compliance was reduced. Computer simulation analyses suggested that an isolated reduction in diastolic compliance may contribute to elevated cardiac filling pressures and exercise intolerance. These data suggest that diastolic compliance is reduced early in the development of obesity and may be an important component in the reduction of cardiac reserve in obesity.

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  • LVH has often been observed in most animal models reported to date, including mice, rats, rabbits, and dogs.

    “LVH has often been observed in most models reported to date, such as mice and rats (to be discussed in more detail below) as well as rabbits (38) and dogs (364).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [38]

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Authors
Carroll, J. F., Summers, R. L., Dzielak, D. J., Cockrell, K., Montani, J.-P., & Mizelle, H. L.
Affiliations
University of Fribourg (CH)
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-03
Volume
33
Issue
3
Pages
811-815
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.33.3.811
OpenAlex
W2130775195
Cited by
51
References
26
Citations by year
2025: 1 · 2020: 4 · 2018: 1 · 2014: 5 · 2012: 1
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute (51971, HL‐51971, P01HL051971)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
obesity, diastolic compliance, left ventricular diastolic function, left ventricular hypertrophy, high-fat diet, pressure-volume relationship, cardiac filling pressure, exercise intolerance, cardiac reserve, rabbit model
MeSH terms
Animals, Blood Pressure, Compliance, Computer Simulation, Coronary Circulation, Disease Models, Animal, Female, Heart, Heart Rate, Obesity, Physical Conditioning, Animal, Rabbits, Rest

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