The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Telomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial
Open accessAbstract
Abstract —There is evidence that telomeres, the ends of chromosomes, serve as clocks that pace cellular aging in vitro and in vivo. In industrialized nations, pulse pressure rises with age, and it might serve as a phenotype of biological aging of the vasculature. We therefore conducted a twin study to investigate the relation between telomere length in white blood cells and pulse pressure while simultaneously assessing the role of genetic factors in determining telomere length. We measured by Southern blot analysis the mean length of the terminal restriction fragments (TRF) in white blood cells of 49 twin pairs from the Danish Twin Register and assessed the relations of blood pressure parameters with TRF. TRF length showed an inverse relation with pulse pressure. Both TRF length and pulse pressure were highly familial. We conclude that telomere length, which is under genetic control, might play a role in mechanisms that regulate pulse pressure, including vascular aging.
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Cites
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Cited by
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
Heritability in the genomics era — concepts and misconceptions
Visscher, P. M., Hill, W. G., & Wray, N. R. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2322 · Cited by 1,921
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061
Telomere shortening in atherosclerosis
Samani, N. J., Boultby, R., Butler, R., Thompson, J. R., & Goodall, A. H. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05633-1 · Cited by 609
Telomeres shorten at equivalent rates in somatic tissues of adults
Daniali, L., Benetos, A., Susser, E., Kark, J. D., Labat, C., Kimura, M., Desai, K. K., Granick, M., & Aviv, A. (2013) · Nature Communications · doi:10.1038/ncomms2602 · Cited by 601
Self-citation
Metadata
- Authors
- Jeanclos, E., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J. H., & Aviv, A.
- Venue
- Hypertension
- Published
- 2000-08
- Volume
- 36
- Issue
- 2
- Pages
- 195-200
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2165792590
- Cited by
- 353
- References
- 11
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jeanclos, E., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J. H., & Aviv, A. (2000). Telomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial. Hypertension. https://doi.org/10.1161/01.hyp.36.2.195
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