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Cited by 459

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Structure and Mechanical Properties of Resistance Arteries in Hypertension: Role of Adhesion Molecules and Extracellular Matrix Determinants

Open access
Intengan, Hope D., Schiffrin, Ernesto L.·2000·Hypertension
DOI 10.1161/01.hyp.36.3.312
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Abstract

Abstract—Abnormalities of resistance arteries may play a role in the pathogenesis and pathophysiology of hypertension in experimental animals and humans. Vessels that, when relaxed, measure <400 μm in lumen diameter act as the major site of vascular resistance and include a network of small arteries (lumen ≈100 to 400 μm) and arterioles (<100 μm). Because increased peripheral resistance is generated by a narrowed lumen diameter, significant effort has been focused on determining the mechanisms that reduce lumen size. Three important vascular components are clearly involved, including alterations of vascular structure, mechanics (stiffness), and function. Structural abnormalities comprise a reduced lumen diameter and thickening of the vascular media, resulting in an increased media-lumen ratio. Changes in the mechanical properties of an artery, particularly increased stiffness, may also result in a reduced lumen diameter. These vascular abnormalities may be caused or influenced by the expression and/or topographic localization of extracellular matrix components, such as collagen and elastin, and by changes in cell-extracellular fibrillar attachment sites, such as adhesion molecules like integrins. This article discusses the abnormalities of resistance arteries in hypertension and reviews the evidence suggesting an important role for adhesive and extracellular matrix determinants.

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Metadata

Authors
Intengan, H. D., & Schiffrin, E. L.
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-09
Volume
36
Issue
3
Pages
312-318
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.36.3.312
OpenAlex
W2165971798
Cited by
459
References
86
FWCI
9.40
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Structure and Mechanical Properties of Resistance Arteries in Hypertension: Role of Adhesion Molecules and Extracellular Matrix Determinants. https://app.cochat.ai/papers/10.1161/01.hyp.36.3.312
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Intengan, H. D., & Schiffrin, E. L. (2000). Structure and Mechanical Properties of Resistance Arteries in Hypertension: Role of Adhesion Molecules and Extracellular Matrix Determinants. Hypertension. https://doi.org/10.1161/01.hyp.36.3.312

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.