Physiological aspects of primary hypertension.
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Arteriolar remodeling in hypertension, which makes the elevation of total peripheral resistance partly dependent on structural factors, is in large part mediated by sympathetic neural influences through direct effects on components of the arterial vascular wall.
“Finally, the arteriolar remodeling that characterizes hypertension and makes the elevation of total peripheral resistance partly dependent on structural factors, ie, an increased wall-to-lumen ratio, has been found to be in large part mediated by sympathetic neural influences throughout direct effects on the different components of the arterial vascular wall52,53.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [53]
The onset of hypertension is associated with sympathetic hyperactivity, while eventually the severity of hypertension is maintained, in part, by the occurrence of end-organ structural changes.
“These findings have provided support to the theory that the onset of hypertension is associated with sympathetic hyperactivity, while, eventually, the severity of hypertension is maintained, in part, by the occurrence of end-organ structural changes (11,34).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [34]
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Krantz, D. S., & Manuck, S. B. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.435 · Cited by 949 · see citing works
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Parati, G., Saul, J. P., Di Rienzo, M., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1276 · Cited by 849 · see citing works
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Unnerstall, J. R., Kopajtic, T. A., & Kuhar, M. J. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90030-4 · Cited by 708 · see citing works
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Guimarães, S., & Moura, D. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01495-9 · Cited by 697 · see citing works
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Oparil, S., Zaman, M. A., & Calhoun, D. A. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-9-200311040-00011 · Cited by 680 · see citing works
Initiation of hypertension in utero and its amplification throughout life.
Law, C., de Swiet, M., Osmond, C., Fayers, P. M., Barker, D. J., Cruddas, A. M., & Fall, C. H. D. (1993) · BMJ · doi:10.1136/bmj.306.6869.24 · Cited by 643 · see citing works
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642 · see citing works
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Blascovich, J., Spencer, S. J., Quinn, D. M., & Steele, C. M. (2001) · Psychological Science · doi:10.1111/1467-9280.00340 · Cited by 628 · see citing works
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Mancia, G., & Grassi, G. (2014) · Circulation Research · doi:10.1161/circresaha.114.302524 · Cited by 627 · see citing works
“In addition, the concomitant alterations of sympathetic and parasympathetic cardiovascular control that develop in secondary hypertension have been less extensively documented and remain somewhat controversial.(1,4,6)”
BackgroundSchiffrin, E. L., Park, J. B., Intengan, H. D., & Touyz, R. M. (2000) · Circulation · doi:10.1161/01.cir.101.14.1653 · Cited by 617 · see citing works
Angiogenesis in skeletal and cardiac muscle
HUDLICKÁ, O., Brown, M. D., & Egginton, S. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.369 · Cited by 615 · see citing works
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Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works
“influences throughout direct effects on the different components of the arterial vascular wall.(52,53) In discussing the evidence in favor and against adrenergic overdrive as hallmark of the hypertensive state, it is worthy to mentioning that sympathetic activation may not be confined to the essential or idiopathic hy…”
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Messerli, F. H., Grossman, E., & Goldbourt, U. (1998) · JAMA · doi:10.1001/jama.279.23.1903 · Cited by 556 · see citing works
Renal injury from angiotensin II-mediated hypertension.
Johnson, R. J., Alpers, C. E., Yoshimura, A., Lombardi, D. M., Pritzl, P., Floege, J., & Schwartz, S. M. (1992) · Hypertension · doi:10.1161/01.hyp.19.5.464 · Cited by 534 · see citing works
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Role of stress in the pathogenesis of the metabolic syndrome
Rosmond, R. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.05.007 · Cited by 516 · see citing works
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Rizzoni, D., Porteri, E., Boari, G. E. M., Ciuceis, C. D., Sleiman, I., Muiesan, M. L., Castellano, M., Miclini, M., & Agabiti‐Rosei, E. (2003) · Circulation · doi:10.1161/01.cir.0000095031.51492.c5 · Cited by 494 · see citing works
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PDGF and cardiovascular disease
Raines, E. W. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.004 · Cited by 484 · see citing works
“Arterial resistance and blood flow are controlled by sympathetic nerves and catecholamines through their reversible effects on SMC contraction [59].”
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Mancia, G., Grassi, G., Giannattasio, C., & Seravalle, G. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.724 · Cited by 471 · see citing works
Stress hormones in health and illness: The roles of work and gender
Lundberg, U. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.014 · Cited by 466 · see citing works
“Folkow (1982) described a model of how elevated bloodpressure responses could lead to sustained hypertension by successive thickening of the artery walls and narrowing of the blood vessels, thus increasing the peripheral resistance in the cardiovascular system.”
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Intengan, H. D., & Schiffrin, E. L. (2000) · Hypertension · doi:10.1161/01.hyp.36.3.312 · Cited by 459 · see citing works
How to assess sympathetic activity in humans
Grassi, G., & Esler, M. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917060-00001 · Cited by 455 · see citing works
Blood Pressure Reactivity to Psychological Stress Predicts Hypertension in the CARDIA Study
Matthews, K. A., Katholi, C. R., McCreath, H., Whooley, M. A., Williams, D. R., Zhu, S., & Markovitz, J. H. (2004) · Circulation · doi:10.1161/01.cir.0000133415.37578.e4 · Cited by 436 · see citing works
Blood pressure in smokers and nonsmokers: Epidemiologic findings
Green, M. S., JUCHA, E., & Luz, Y. (1986) · American Heart Journal · doi:10.1016/0002-8703(86)90645-9 · Cited by 421 · see citing works
Blaustein, M. P. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.6.c1367 · Cited by 413 · see citing works
Purinergic Signaling and Vascular Cell Proliferation and Death
Burnstock, G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.105360 · Cited by 414 · see citing works
Interactions between cardiovascular and pain regulatory systems
Randich, A., & Maixner, W. D. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90057-5 · Cited by 409 · see citing works
Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats.
Lüscher, T. F., Raij, L. R., & Vanhoutte, P. M. (1987) · Hypertension · doi:10.1161/01.hyp.9.2.157 · Cited by 404 · see citing works
The immunology of hypertension
Norlander, A. E., Madhur, M. S., & Harrison, D. G. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171773 · Cited by 401 · see citing works
“There is also remodeling of vessels in hypertension, initially described by Folkow (1982), in which the vascular lumen is narrowed as the media thickens.”
BackgroundWork and its role in shaping the social gradient in health
Clougherty, J. E., Souza, K., & Cullen, M. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05338.x · Cited by 392 · see citing works
Altura, B. M., Altura, B. T., Gebrewold, A., Ising, H., & Gunther, T. (1984) · Science · doi:10.1126/science.6701524 · Cited by 369 · see citing works
Growth in utero, adult blood pressure, and arterial compliance.
Martyn, C. N., Barker, D. J. P., Jespersen, S., Greenwald, S. E., Osmond, C., & Berry, C. L. (1995) · Heart · doi:10.1136/hrt.73.2.116 · Cited by 362 · see citing works
Cardiovascular reactivity to the cold pressor test as a predictor of hypertension.
Menkes, M., Matthews, K. A., Krantz, D. S., Lundberg, U., Mead, L. A., Qaqish, B. F., Liang, K.-Y., Thomas, C. B., & Pearson, T. A. (1989) · Hypertension · doi:10.1161/01.hyp.14.5.524 · Cited by 356 · see citing works
Venous occlusion plethysmography in cardiovascular research: methodology and clinical applications
Wilkinson, I. B., & Webb, D. J. (2001) · British Journal of Clinical Pharmacology · doi:10.1046/j.0306-5251.2001.01495.x · Cited by 355 · see citing works
Stress and Alcohol Interaction: An Update of Human Research
Pohorecky, L. A. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00543.x · Cited by 341 · see citing works
Hemodynamic Correlates of Blood Pressure Across the Adult Age Spectrum
Mitchell, G. F., Wang, N., Palmisano, J. N., Larson, M. G., Hamburg, N. M., Vita, J. A., Levy, D. A., Benjamin, E. J., & Vasan, R. S. (2010) · Circulation · doi:10.1161/circulationaha.109.914507 · Cited by 340 · see citing works
Morning Surge in Blood Pressure and Cardiovascular Risk
Kario, K. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.157149 · Cited by 341 · see citing works
Harrap, S. B., van der Merwe, W. M., Griffin, S. A., et al. (1990) · Hypertension · doi:10.1161/01.hyp.16.6.603 · Cited by 338 · see citing works
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Folkow, B. (1990) · Hypertension · doi:10.1161/01.hyp.16.1.89 · Cited by 336 · see citing works
Self-citationPark, J. B., & Schiffrin, E. L. (2001) · Journal of Hypertension · doi:10.1097/00004872-200105000-00013 · Cited by 325 · see citing works
Cardiac and vascular pathophysiology in hypertension
Mayet, J., & Hughes, A. (2003) · Heart · doi:10.1136/heart.89.9.1104 · Cited by 321 · see citing works
Retinal Arteriolar Diameter and Risk for Hypertension
Wong, T. Y., Klein, R., Sharrett, A. R., et al. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-4-200402170-00006 · Cited by 319 · see citing works
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Weber, K. T., Anversa, P., Armstrong, P. W., Brilla, C. G., Burnett, J. C., Cruickshank, J. M., Devereux, R. B., Giles, T. D., Korsgaard, N., Leier, C. V., et al. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90130-f · Cited by 312 · see citing works
Potenza, M. A., Marasciulo, F. L., Chieppa, D. M., Brigiani, G. S., Formoso, G., Quon, M. J., & Montagnani, M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00092.2005 · Cited by 314 · see citing works
“Elevated peripheral vascular resistance is an important component of the development of hypertension in SHR (18).”
BackgroundAalkjær, C., Heagerty, A. M., Petersen, K. K., et al. (1987) · Circulation Research · doi:10.1161/01.res.61.2.181 · Cited by 309 · see citing works
“-(2) Although increased wall-thickness-to-lumen-diameter ratio has previously been demonstrated by hemodynamic measurements(34) and by histologic measurements on autopsy material,(56) there is still some lack of quantitative information concerning the structure of the resistance vasculature in essential hypertension.(…”
BackgroundResultThybo, N. K., Stephens, N., Cooper, A., et al. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.474 · Cited by 300 · see citing works
Role of the sympathetic nervous system in human hypertension
Grassi, G. M. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816121-00019 · Cited by 286 · see citing works
Drager, L. F., Bortolotto, L. A., Figueiredo, A. C., da Silva, B. C., Krieger, E. M., & Lorenzi‐Filho, G. (2007) · CHEST Journal · doi:10.1378/chest.06-2703 · Cited by 284 · see citing works
Visceral fat accumulation: the missing link between psychosocial factors and cardiovascular disease?
Björntorp, P. A. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00431.x · Cited by 283 · see citing works
Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta
Küng, C. F., & Lüscher, T. F. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.194 · Cited by 281 · see citing works
Mukai, Y., Shimokawa, H., Matoba, T., Kandabashi, T., Satoh, S., Hiroki, J., Kaibuchi, K., & Takeshita, A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0735fje · Cited by 278 · see citing works
Two point mutations within the adducin genes are involved in blood pressure variation.
Bianchi, G., Tripodi, G., Casari, G., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3999 · Cited by 279 · see citing works
Regulation of brain function by exercise
Sutoo, D., & Akiyama, K. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00030-5 · Cited by 275 · see citing works
"White coat" versus "sustained" borderline hypertension in Tecumseh, Michigan.
Julius, S., Mejia, A., Jones, K. L., Krause, L. C., Schork, N. J., van de Ven, C., Johnson, E. H., Pétrin, J., Sekkarie, M. A., & Kjeldsen, S. E. (1990) · Hypertension · doi:10.1161/01.hyp.16.6.617 · Cited by 271 · see citing works
“We accept Folkow's concept that minimal forearm vascular resistance is a measure of vascular hypertrophy in the forearm.(17) After ischemic reperby gest on O cber (2)4, 2017 http://hyhajournals.”
BackgroundSchiffrin, E. L., Deng, L.-Y., & Larochelle, P. M. (1994) · Hypertension · doi:10.1161/01.hyp.23.1.83 · Cited by 265 · see citing works
“However, it is clear that the structural abnormalities, particularly as a result of the increased media-lumen ratio, amplify vasoconstrictor responses, thus contributing significantly to exaggerated vascular tone.(16) Studies in animals and humans have attempted to establish whether antihypertensive therapy may correc…”
BackgroundThe sympathetic nervous system and blood pressure in humans: implications for hypertension
Fisher, J. P., & Paton, J. F. R. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.66 · Cited by 259 · see citing works
Prospective cohort study of retinal vessel diameters and risk of hypertension
Wong, T. Y., Shankar, A., Klein, R., et al. (2004) · BMJ · doi:10.1136/bmj.38124.682523.55 · Cited by 253 · see citing works
Schiffrin, E. L., & Touyz, R. M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00262.2004 · Cited by 249 · see citing works
“Whether there is amplification of vasoconstrictor responses by the structural or mechanical reduction of lumen diameter according to the law of Laplace (47, 48, 80, 199, 200) is controversial (75).”
Apoptosis in Target Organs of Hypertension
Hamet, P., Richard, L., Dam, T.-V., Teíger, E., Orlov, S. N., Gaboury, L. A., Gossard, F., & Tremblay, J. (1995) · Hypertension · doi:10.1161/01.hyp.26.4.642 · Cited by 250 · see citing works
DiBona, G. F. (2003) · Hypertension · doi:10.1161/01.hyp.0000047205.52509.8a · Cited by 250 · see citing works
Amberg, G. C., Bonev, A. D., Rossow, C. F., Nelson, M. T., & Santana, L. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18684 · Cited by 259 · see citing works
“Sustained increases in arterial tone are an essential component in the development of hypertension (3, 4).”
Vascular Hypertrophy and Remodeling in Secondary Hypertension
Rizzoni, D., Porteri, E., Castellano, M., et al. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.785 · Cited by 239 · see citing works
Large conduit arteries in hypertension: role of the vascular renin-angiotensin system.
Dzau, V. J., & Safar, M. E. (1988) · Circulation · doi:10.1161/01.cir.77.5.947 · Cited by 237 · see citing works
The relationship between systemic hypertension and obstructive sleep apnea: Facts and theory
Fletcher, E. C. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80395-7 · Cited by 236 · see citing works
Sympathetic overactivity in hypertension. A moving target
JULIUS, S., & NESBITT, S. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)00287-7 · Cited by 237 · see citing works
Laurent, S., Girerd, X. J., Mourad, J., Lacolley, P. J., Beck, L., Boutouyrie, P., Mignot, J. P., & Safar, M. E. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.7.1223 · Cited by 236 · see citing works
Elevated blood pressure and personality: A meta-analytic review.
Jorgensen, R. S., Johnson, B. T., Kolodziej, M. E., & Schreer, G. E. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.120.2.293 · Cited by 229 · see citing works
“As discussed by Folkow (1987b), this pattern of vigorous psychophysiologic reactivity is appropriate for the "harsh realities of primitive life" (p.”
BackgroundAngiotensin-Converting Enzyme and Vascular Remodeling
Heeneman, S., Sluimer, J. C., & Daemen, M. J. A. P. (2007) · Circulation Research · doi:10.1161/circresaha.107.148338 · Cited by 223 · see citing works
Pharmacology of smooth muscle cell replication.
Jackson, C. L., & Schwartz, S. M. (1992) · Hypertension · doi:10.1161/01.hyp.20.6.713 · Cited by 224 · see citing works
Őri, Z., Monir, G., Weiss, J., Sayhouni, X., & Singer, D. H. (1992) · Cardiology Clinics · doi:10.1016/s0733-8651(18)30231-5 · Cited by 233 · see citing works
Altura, B. M., Altura, B. T., & Gebrewold, A. (1983) · Science · doi:10.1126/science.6836278 · Cited by 223 · see citing works
Amberg, G. C., Bonev, A. D., Rossow, C. F., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318684 · Cited by 217 · see citing works
Location of Resistance Arteries
Christensen, K. L., & Mulvany, M. J. (2001) · Journal of Vascular Research · doi:10.1159/000051024 · Cited by 216 · see citing works
Relationship between central sympathetic activity and stages of human hypertension
Smith, P. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2003.10.010 · Cited by 215 · see citing works
Corcoran Lecture. Sympathetic hyperactivity and coronary risk in hypertension.
Julius, S. (1993) · Hypertension · doi:10.1161/01.hyp.21.6.886 · Cited by 215 · see citing works
Accelerated risk of hypertensive blood pressure recordings among alzheimer caregivers
Shaw, W. S., Patterson, T. L., Ziegler, M. G., Dimsdale, J. E., Semple, S. J., & Grant, I. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00084-1 · Cited by 211 · see citing works
“blood pressure increases [8–10].”
Conduit artery compliance and distensibility are not necessarily reduced in hypertension.
Hayoz, D., Rutschmann, B., Perret, F., Niederberger, M., Tardy, Y., Mooser, V., Nussberger, J., Waeber, B., & Brunner, H. R. (1992) · Hypertension · doi:10.1161/01.hyp.20.1.1 · Cited by 207 · see citing works
Retinal Arteriolar Narrowing Is Associated With 5-Year Incident Severe Hypertension
Smith, W. T., Wang, J. J., Wong, T. Y., Rochtchina, E., Klein, R., Leeder, S., & Mitchell, P. L. R. (2004) · Hypertension · doi:10.1161/01.hyp.0000140772.40322.ec · Cited by 206 · see citing works
The Role of Mechanical Stresses in Microvascular Remodeling
Skalak, T. C., & Price, R. J. (1996) · Microcirculation · doi:10.3109/10739689609148284 · Cited by 206 · see citing works
Central sympathetic overactivity: Maladies and mechanisms
Fisher, J. P., Young, C. N., & Fadel, P. J. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.02.003 · Cited by 202 · see citing works
“This can lead to abnormal wall to lumen ratio, increased resistance to flow and accelerate the progression of atherosclerosis (Failla et al., 1999; Folkow, 1982).”
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Light, K. C., Koepke, J. P., Obrist, P. A., et al. (1983) · Science · doi:10.1126/science.6836285 · Cited by 204 · see citing works
Sorkin, E. M., & Clissold, S. P. (1987) · Drugs · doi:10.2165/00003495-198733040-00002 · Cited by 202 · see citing works
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Vascular wound healing and neointima formation induced by perivascular electric injury in mice.
Carmeliet, P., Moons, L., Stassen, J. M., Mol, M. D., Bouché, A., van den Oord, J. J., Kockx, M. M., & Collen, D. (1997) · Europe PMC (PubMed Central) · Cited by 197 · see citing works
LONG‐TERM REGULATION OF ARTERIAL BLOOD PRESSURE BY HYPOTHALAMIC NUCLEI: SOME CRITICAL QUESTIONS
Dampney, R., Horiuchi, J., Killinger, S., Sheriff, M., Tan, P. S. P., & McDowall, L. M. (2005) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2005.04205.x · Cited by 196 · see citing works
- Authors
- Folkow, B.
- Corresponding author
- Folkow, B
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1982-04
- Volume
- 62
- Issue
- 2
- Pages
- 347-504
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1765750524
- Cited by
- 1,768
- References
- 0
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 18 · 2019: 21 · 2018: 23 · 2017: 24 · 2016: 26 · 2015: 26 · 2014: 22 · 2013: 21 · 2012: 31
- FWCI
- 47.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- essential hypertension, blood pressure regulation, cardiovascular physiology
- MeSH terms
- Adrenal Cortex, Animals, Arteries, Blood Volume, Carbon Monoxide, Cardiovascular System, Cardiovascular Physiological Phenomena, Defense Mechanisms, Diet, Electrophysiology, Heart, Cardiomegaly, Hemodynamics, Hormones, Humans, Hypertension, Hypertrophy, Hypothalamus, Kidney, Limbic System, Mineralocorticoids, Muscle, Smooth, Vascular, Muscles, Nervous System, Proprioception, Proteins, Rabbits, Reflex, Sodium Chloride, Stress, Psychological, Vascular Resistance, Natriuretic Agents, Mice, Rats
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