The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Adrenergic and Reflex Abnormalities in Obesity-Related Hypertension
Open accessAbstract
Abstract —Previous studies have shown that essential hypertension and obesity are both characterized by sympathetic activation coupled with a baroreflex impairment. The present study was aimed at determining the effects of the concomitant presence of the 2 above-mentioned conditions on sympathetic activity as well as on baroreflex cardiovascular control. In 14 normotensive lean subjects (aged 33.5±2.2 years, body mass index 22.8±0.7 kg/m 2 [mean±SEM]), 16 normotensive obese subjects (body mass index 37.2±1.3 kg/m 2 ), 13 lean hypertensive subjects (body mass index 24.0±0.8 kg/m 2 ), and 16 obese hypertensive subjects (body mass index 37.5±1.3 kg/m 2 ), all age-matched, we measured beat-to-beat arterial blood pressure (by Finapres device), heart rate (HR, by ECG), and postganglionic muscle sympathetic nerve activity (MSNA, by microneurography) at rest and during baroreceptor stimulation and deactivation induced by stepwise intravenous infusions of phenylephrine and nitroprusside, respectively. Blood pressure values were higher in lean hypertensive and obese hypertensive subjects than in normotensive lean and obese subjects. MSNA was significantly ( P <0.01) greater in obese normotensive subjects (49.1±3.0 bursts per 100 heart beats) and in lean hypertensive subjects (44.5±3.3 bursts per 100 heart beats) than in lean normotensive control subjects (32.2±2.5 bursts per 100 heart beats); a further increase was detectable in individuals with the concomitant presence of obesity and hypertension (62.1±3.4 bursts per 100 heart beats). Furthermore, whereas in lean hypertensive subjects, only baroreflex control of HR was impaired, in obese normotensive subjects, both HR and MSNA baroreflex changes were attenuated, with a further attenuation being observed in obese hypertensive patients. Thus, the association between obesity and hypertension triggers a sympathetic activation and an impairment in baroreflex cardiovascular control that are greater in magnitude than those found in either of the above-mentioned abnormal conditions alone.
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“elevation in subcutaneous adiposity does not alter the baroreflex.”
From Rapid Onset of Renal Sympathetic Nerve Activation in Rabbits Fed a High-Fat Diet (2012) · cites this paper as [31]
In the citing paper
“The hypertension in obesity is characterized by a reduction in baroreceptor inhibition in humans 31 when there is significant visceral adiposity”
From Rapid Onset of Renal Sympathetic Nerve Activation in Rabbits Fed a High-Fat Diet (2012) · cites this paper as [31]
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Cites
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Sympathetic Activation in Obese Normotensive Subjects
Grassi, G., Seravalle, G., Cattaneo, B. M., Bolla, G. B., Lanfranchi, A., Colombo, M., Giannattasio, C., Brunani, A., Cavagnini, F., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.560 · Cited by 614
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Baroreflex Control of Sympathetic Nerve Activity in Essential and Secondary Hypertension
Grassi, G., Cattaneo, B. M., Seravalle, G., Lanfranchi, A., & Mancia, G. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.68 · Cited by 526
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Die Pathogenese der Hypertonie
Weidmann, P., & Allemann, Y. (2001) · Cardiovascular Medicine · doi:10.3390/cardiovascmed4060069
Antza, C., Belančić, A., Jordan, J., Esteban, A., Oliveras, A., McNally, R., Anyfanti, P., Versmissen, J., Fernández‐Alfonso, M. S., Kotsis, V., et al. (2026) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70798
Sympathetic vascular transduction in adults with hypertension and obesity-associated hypertension
Manferdelli, G., Hissen, S. L., Wakeham, D. J., Oghatiyan, A., Davis, S. L., Sarma, S., Levine, B. D., Fadel, P. J., & Hearon, C. M. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00298.2026
RISK FACTORS FOR THE DEVELOPMENT OF ARTERIAL HYPERTENSION AND ITS COMPLICATIONS IN YOUNG PEOPLE
Ledovskikh, S. R., & Ragino, Y. I. (2026) · Complex Issues of Cardiovascular Diseases · doi:10.17802/2306-1278-2026-15-1-84-96
Metadata
- Authors
- Grassi, G., Seravalle, G., Dell’Oro, R., Turri, C., Bolla, G. B., & Mancia, G.
- Affiliations
- IRCCS Istituto Auxologico Italiano (IT)
- Venue
- Hypertension
- Published
- 2000-10
- Volume
- 36
- Issue
- 4
- Pages
- 538-542
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1979098009
- Cited by
- 305
- References
- 39
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 14 · 2018: 5 · 2017: 13 · 2016: 14 · 2015: 16 · 2014: 17 · 2013: 22 · 2012: 14
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- obesity, obesity-related hypertension, baroreflex sensitivity, sympathetic nervous system, muscle sympathetic nerve activity, heart rate, baroreceptor stimulation, phenylephrine, sodium nitroprusside, cardiovascular regulation
- MeSH terms
- Adrenergic Fibers, Adult, Blood Pressure, Electrocardiography, Electrophysiology, Female, Heart Rate, Humans, Hypertension, Infusions, Intravenous, Male, Middle Aged, Nitroprusside, Obesity, Phenylephrine, Pressoreceptors, Thinness, Baroreflex, Sympathetic Fibers, Postganglionic
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