GSK3 takes centre stage more than 20 years after its discovery

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Wnt signaling and cancer

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Specificity and mechanism of action of some commonly used protein kinase inhibitors.

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β‐catenin is a target for the ubiquitin–proteasome pathway

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Neurodegenerative Tauopathies

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The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

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Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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Apoptosis in neurodegenerative disorders

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Linking Colorectal Cancer to Wnt Signaling

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Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

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Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

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Molecular cloning and expression of glycogen synthase kinase‐3/factor A.

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

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Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

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Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene

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Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

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Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

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Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

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Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.

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Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

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Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

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Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

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Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

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Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

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Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

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Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

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Control of p70 S6 kinase by kinase activity of FRAP in vivo

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A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

Frame, S., Cohen, P., & Biondi, R. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00253-2 · Cited by 703 · see citing works

Crystal Structure of Glycogen Synthase Kinase 3β

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The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

Hart, M. J., Concordet, J., Lassot, I., Albert, I., Santos, R., Durand, H., Perret, C., Rubinfeld, B., Margottin-Goguet, F., Bénarous, R., et al. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80091-8 · Cited by 670 · see citing works

Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

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Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation.

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Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

Matsuzawa, S.-I., & Reed, J. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00242-8 · Cited by 587 · see citing works

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

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Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

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Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

Kishida, S., Yamamoto, H., Ikeda, S., Kishida, M., Sakamoto, I., Koyama, S., & Kikuchi, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10823 · Cited by 491 · see citing works

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

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The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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Ras Enhances Myc Protein Stability

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Casein kinase I transduces Wnt signals

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Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal

Hetman, M., Cavanaugh, J. E., Kimelman, D., & Xia, Z. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02567.2000 · Cited by 440 · see citing works

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

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Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling

Ding, V. W., Chen, R., & McCormick, F. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005342200 · Cited by 428 · see citing works

wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

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Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

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Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1

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Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

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WNT-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor–Mediated Transcription

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Structure of GSK3beta reveals a primed phosphorylation mechanism.

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Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

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Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

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Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

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Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

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Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration

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Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

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Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

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An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling

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Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons

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Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

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Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

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Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus.

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Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

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Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

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Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis

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Inhibition of GSK-3β leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium

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Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

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Glycogen Synthase from Rabbit Skeletal Muscle; Effect of Insulin on the State of phosphorylation of the Seven Phosphoserine Residues in vivo

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Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

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Frequent Nuclear/Cytoplasmic Localization of β-Catenin without Exon 3 Mutations in Malignant Melanoma

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Glycogen synthase kinase 3β phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones

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Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin

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A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

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Exogenous Expression of β-Catenin Regulates Contact Inhibition, Anchorage-Independent Growth, Anoikis, and Radiation-Induced Cell Cycle Arrest

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G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal Apoptosis

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Biochemical interactions in the wnt pathway

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Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

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Lithium-induced respecification of pattern in Xenopus laevis embryos

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Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

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Casein kinase 2 associates with and phosphorylates Dishevelled

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The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia

Banerji, V., Frumm, S. M., Ross, K. N., Li, L. S., Schinzel, A. C., Hahn, C. K., Kakoza, R. M., Chow, K. T., Ross, L., Alexe, G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci46465 · Cited by 105 · see citing works

Inhibition of transient receptor potential channel 5 reverses 5-Fluorouracil resistance in human colorectal cancer cells

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Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei

Iwahana, E., Akiyama, M., Miyakawa, K., Uchida, A., Kasahara, J., Fukunaga, K., Hamada, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03322.x · Cited by 103 · see citing works

The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents

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Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins

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Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells

Wang, R., Xia, L., Gabrilove, J., Waxman, S., & Jing, Y. (2013) · Leukemia · doi:10.1038/leu.2012.180 · Cited by 85 · see citing works

Glycogen Synthase Kinase-3β Is Involved in the Phosphorylation and Suppression of Androgen Receptor Activity

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The Mechanisms Behind Rapid Antidepressant Effects of Ketamine: A Systematic Review With a Focus on Molecular Neuroplasticity

Kang, M. J. Y., Hawken, E., & Vazquez, G. H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.860882 · Cited by 77 · see citing works

Inhibition of autophagy enhances the effects of the <scp>AKT</scp> inhibitor <scp>MK</scp>‐2206 when combined with paclitaxel and carboplatin in <i><scp>BRAF</scp></i> wild‐type melanoma

Rebecca, V. W., Massaro, R. R., Fedorenko, I. V., Sondak, V. K., Anderson, A. R. A., Kim, E., Amaravadi, R. K., Maria‐Engler, S. S., Messina, J. L., Gibney, G. T., et al. (2014) · Pigment Cell &amp; Melanoma Research · doi:10.1111/pcmr.12227 · Cited by 58 · see citing works

Ketamine regulates the presynaptic release machinery in the hippocampus

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Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3 -Negative Feedback Pathway

Liu, L., & Eisenman, R. N. (2012) · Genes &amp; Cancer · doi:10.1177/1947601912448067 · Cited by 47 · see citing works

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes

Aiston, S., Hampson, L. J., Arden, C., Iynedjian, P. B., & Agius, L. (2006) · Diabetologia · doi:10.1007/s00125-005-0068-4 · Cited by 38 · see citing works

GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells

Si, J., Mueller, L., & Collins, S. J. (2011) · Leukemia · doi:10.1038/leu.2011.171 · Cited by 30 · see citing works

Wnt signaling: Axin--More Than a Scaffold

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Roles of mammalian sterile 20‐like kinase 2‐dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2‐related kinases

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Wnt Signaling: Multivesicular Bodies Hold GSK3 Captive

Niehrs, C., & Acebrón, S. P. (2010) · Cell · doi:10.1016/j.cell.2010.12.003 · Cited by 31 · see citing works

Synthesis of a Glycogen Synthase Kinase-3 Inhibitor

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Axin negatively affects tau phosphorylation by glycogen synthase kinase 3β

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