The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing
Abstract
Renal arteries (RAs) dilate in response to hypoxia, whereas the pulmonary arteries (PAs) constrict. In the PA, O 2 tension is detected by an unidentified redox sensor, which controls K + channel function and thus smooth muscle cell (SMC) membrane potential and cytosolic calcium. Mitochondria are important regulators of cellular redox status and are candidate vascular O 2 sensors. Mitochondria-derived activated oxygen species (AOS), like H 2 O 2 , can diffuse to the cytoplasm and cause vasodilatation by activating sarcolemmal K + channels. We hypothesize that mitochondrial diversity between vascular beds explains the opposing responses to hypoxia in PAs versus RAs. The effects of hypoxia and proximal electron transport chain (pETC) inhibitors (rotenone and antimycin A) were compared in rat isolated arteries, vascular SMCs, and perfused organs. Hypoxia and pETC inhibitors decrease production of AOS and outward K + current and constrict PAs while increasing AOS production and outward K + current and dilating RAs. At baseline, lung mitochondria have lower respiratory rates and higher rates of AOS and H 2 O 2 production. Similarly, production of AOS and H 2 O 2 is greater in PA versus RA rings. SMC mitochondrial membrane potential is more depolarized in PAs versus RAs. These differences relate in part to the lower expression of proximal ETC components and greater expression of mitochondrial manganese superoxide dismutase in PAs versus RAs. Differential regulation of a tonically produced, mitochondria-derived, vasodilating factor, possibly H 2 O 2 , can explain the opposing effects of hypoxia on the PAs versus RAs. We conclude that the PA and RA have different mitochondria.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several studies have correlated low circulating MPO levels with better cardiovascular prognosis (239, 260, 644, 690, 1059).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [644]
Citations
Cites
Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626
Salvioli, S., Ardizzoni, A., Franceschi, C., & Cossarizza, A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00669-8 · Cited by 1,007
Palmer, J. W., Tandler, B., & Hoppel, C. L. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75283-1 · Cited by 830
Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.
Freeman, B. Α., & Crapo, J. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68544-3 · Cited by 752
[29] Mitochondrial membrane potential monitored by JC-1 dye
Reers, M., Smiley, S. T., Mottola-Hartshorn, C., Chen, A., Mei, L., & Chen, L. B. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)60154-6 · Cited by 684
Duchen, M. R. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.001aa.x · Cited by 610
Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts
Nicholls, D. G., & Ward, M. W. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01534-9 · Cited by 563
Cross, A. R., & Jones, O. T. G. (1986) · Biochemical Journal · doi:10.1042/bj2370111 · Cited by 551
Li, Y., Zhu, H., Kuppusamy, P., Roubaud, V., Zweier, J. L., & Trush, M. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2015 · Cited by 526
The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels
Weir, E. K., & Archer, S. L. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781921 · Cited by 466
Self-citation
Cited by
Sorted by citations
Items 301–306 of 306
The Effect of Hypoxia on Local Vascular Tone Regulation in the Systemic Circulation
Gaynullina, D. K., Shvetsova, A. A., Babkina, I., Savinkova, I. G., & Kamkina, O. V. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026050030
Sartori, M. R., Amir, A., & Wilson, R. J. A. (2026) · The Journal of Physiology · doi:10.1113/jp289341
Alteracions vasculars pulmonars induïdes per l’exposició a fum de tabac en un model animal de MPOC
Andrés, E. F. (2011) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Norton, & Elbert, C. (2015) · UNM’s Digital Repository (University of New Mexico)
Mitochondrial Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction
Chandel, N. S. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7858-7_15
Redox Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction
Olschewski, A., & Weir, Ε. K. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7858-7_16
Metadata
- Authors
- Michelakis, E. D., Hampl, V., Nsair, A., Wu, X., Harry, G., Haromy, A., Gurtu, R., & Archer, S. L.
- Affiliations
- University of Alberta (CA)
- From the Department of Medicine (Cardiology) and the Vascular Biology Group (E.D.M., A.N., X.W., G.H., A.L., R.G., S.L.A.), University of Alberta, Edmonton, Alberta, Canada; and Charles University, Physiology (V.H.), Prague, Czech Republic.
- Venue
- Circulation Research
- Published
- 2002-06-28
- Volume
- 90
- Issue
- 12
- Pages
- 1307-1315
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2146572449
- Cited by
- 309
- References
- 49
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 12 · 2015: 13 · 2014: 12 · 2013: 13 · 2012: 12
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- mitochondrial diversity, hypoxia, pulmonary artery, renal artery, reactive oxygen species, hydrogen peroxide, electron transport chain inhibitors, rotenone, antimycin A, smooth muscle cells, potassium channels, mitochondrial membrane potential, manganese superoxide dismutase, redox signaling, pulmonary vasoconstriction, renal vasodilation
- MeSH terms
- Animals, Cells, Cultured, Electron Transport, Humans, Hydrogen Peroxide, Kidney, Lung, Mitochondria, Muscle, Smooth, Vascular, Oxidation-Reduction, Pulmonary Artery, Pulmonary Circulation, Renal Artery, Renal Circulation, Rotenone, Uncoupling Agents, Vasoconstriction, Vasodilation, Potassium Channels, Cell Hypoxia, Reactive Oxygen Species, Culture Techniques, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
