The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis
Open accessAbstract
This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive immunity, with its T cells, antibodies, and immunoregulatory cytokines, powerfully modulates disease activity and progression. Atherogenesis involves cross talk between and shared pathways involved in adaptive and innate immunity. Immune processes can influence the balance between cell proliferation and death, between synthetic and degradative processes, and between pro- and antithrombotic processes. Various established and emerging risk factors for atherosclerosis modulate aspects of immune responses, including lipoproteins and their modified products, vasoactive peptides, and infectious agents. As we fill in the molecular details, new potential targets for therapies will doubtless emerge.
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Cites
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The L-Arginine-Nitric Oxide Pathway
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Infectious Agents Are Not Necessary for Murine Atherogenesis
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Cited by
Inflammation in Atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.009 · Cited by 2,228
Self-citationLarge-scale association analysis identifies new risk loci for coronary artery disease
The CARDIoGRAMplusC4D Consortium, Deloukas, P., DIAGRAM Consortium, CARDIOGENICS Consortium, MuTHER Consortium, Wellcome Trust Case Control Consortium, Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2480 · Cited by 1,614
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NADPH oxidases: An overview from structure to innate immunity-associated pathologies
Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2014.89 · Cited by 944
Newby, A. C. (2005) · Physiological Reviews · doi:10.1152/physrev.00048.2003 · Cited by 817
Metadata
- Authors
- Hansson, G. K., Libby, P., Schönbeck, U., & Yan, Z.-Q.
- Venue
- Circulation Research
- Published
- 2002-08-23
- Volume
- 91
- Issue
- 4
- Pages
- 281-291
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2147340189
- Cited by
- 1,024
- References
- 8
- FWCI
- 22.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hansson, G. K., Libby, P., Schönbeck, U., & Yan, Z.-Q. (2002). Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis. Circulation Research. https://doi.org/10.1161/01.res.0000029784.15893.10
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
