NADPH oxidases: An overview from structure to innate immunity-associated pathologies

Panday, Arvind; Sahoo, Malaya K; Osorio, Diana; Batra, Sanjay

doi:10.1038/cmi.2014.89

Cited by 944Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

NADPH oxidases: An overview from structure to innate immunity-associated pathologies

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Panday, Arvind, Sahoo, Malaya K, Osorio, Diana, Batra, Sanjay·2015·Cellular & Molecular Immunology

DOI 10.1038/cmi.2014.89PMC PMC4654378

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Abstract

Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are lethal to cells, and the overproduction of these molecules leads to a myriad of devastating diseases. The key producers of ROS in many cells are the NOX family of NADPH oxidases, of which there are seven members, with various tissue distributions and activation mechanisms. NADPH oxidase is a multisubunit enzyme comprising membrane and cytosolic components, which actively communicate during the host responses to a wide variety of stimuli, including viral and bacterial infections. This enzymatic complex has been implicated in many functions ranging from host defense to cellular signaling and the regulation of gene expression. NOX deficiency might lead to immunosuppression, while the intracellular accumulation of ROS results in the inhibition of viral propagation and apoptosis. However, excess ROS production causes cellular stress, leading to various lethal diseases, including autoimmune diseases and cancer. During the later stages of injury, NOX promotes tissue repair through the induction of angiogenesis and cell proliferation. Therefore, a complete understanding of the function of NOX is important to direct the role of this enzyme towards host defense and tissue repair or increase resistance to stress in a timely and disease-specific manner.

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During oxidative burst, cells convert O2 to •O2 using NOx and then to H2O2 through superoxide dismutase.
“During the oxidative burst process, cells utilize O2 and convert it to •O2 using the mitochondrial-membrane–bound enzyme NOx [148] and after to H2O2 through a family of enzymes called superoxide dismutase SOD [149].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [148]

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Research works printed but not linked: 4

Cheng G, Ritsick D, Lambeth JD. Nox3 regulation by NOXO1, p47phox, and p67phox. J Biol Chem 2004; 279: 34250-34255.
Yu L, Zhen L, Dinauer MC. Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunits. J Biol Chem 1997; 272: 27288-27294. 109
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Authors: Panday, A., Sahoo, M. K., Osorio, D., & Batra, S.
Affiliations: Louisiana State University (US)
Stanford Medicine (US)
Corresponding author: Batra, Sanjay
ORCID: Panday, Arvind
Sahoo, Malaya K
Batra, Sanjay
Venue: Cellular & Molecular Immunology
Publisher: Springer Science and Business Media LLC
Published: 2014-09-29
Volume: 12
Issue: 1
Pages: 5-23
ISSN: 1672-7681 (ISSN-L)
2042-0226
DOI: 10.1038/cmi.2014.89
PMC: PMC4654378
OpenAlex: W2167872299
Cited by: 944
References: 295
Citations by year: 2026: 48 · 2025: 61 · 2024: 89 · 2023: 120 · 2022: 135 · 2021: 153 · 2020: 100 · 2019: 56 · 2018: 63 · 2017: 74 · 2016: 35 · 2015: 9 · 2014: 1
FWCI: 3.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Cellular and Molecular Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences (R15-1R15ES023151-01, R15ES023151)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: NADPH oxidase, reactive oxygen species, innate immunity, host defense, oxidative stress, autoimmune disease, cancer, tissue repair, angiogenesis, viral and bacterial infections, immunosuppression, apoptosis, gene expression regulation, enzyme structure
MeSH terms: Animals, DNA Damage, Humans, Immunity, Innate, Immune System Diseases, Infections, Molecular Conformation, NADH, NADPH Oxidoreductases, Structure-Activity Relationship, Wound Healing, Reactive Oxygen Species, Neovascularization, Physiologic

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NADPH oxidases: An overview from structure to innate immunity-associated pathologies

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