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Cited by 709

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Angiotensin II Stimulation of NAD(P)H Oxidase Activity: Upstream Mediators

Seshiah, Puvi N., Weber, David S., Rocic, Petra, Valppu, Liisa, Taniyama, Yoshihiro, Griendling, Kathy K.·2002·Circulation Research
DOI 10.1161/01.res.0000033523.08033.16
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Abstract

Angiotensin II (Ang II)–stimulated hypertrophy of vascular smooth muscle cells is mediated by reactive oxygen species (ROS) derived from NAD(P)H oxidases. The upstream signaling mechanisms by which Ang II activates these oxidases are unclear but may include protein kinase C, tyrosine kinases, phosphatidylinositol-3-kinase, and Rac, a small molecular weight G protein. We found that Ang II–stimulated ROS production is biphasic. The first phase occurs rapidly (peak at 30 seconds) and is dependent on protein kinase C activation. The larger second phase of ROS generation (peak at 30 minutes) requires Rac activation, because inhibition of Rac by either Clostridium difficile toxin A or dominant-negative Rac significantly inhibits Ang II–induced ROS production. Phosphatidylinositol-3-kinase inhibitors (wortmannin or LY294002) and the epidermal growth factor (EGF) receptor kinase blocker AG1478 attenuate both Rac activation and ROS generation. The upstream activator of EGF receptor transactivation, c-Src, is also required for ROS generation, because PP1, an Src kinase inhibitor, abrogates the Ang II stimulation of both responses. These results suggest that c-Src, EGF receptor transactivation, phosphatidylinositol-3-kinase, and Rac play important roles in the sustained Ang II–mediated activation of vascular smooth muscle cell NAD(P)H oxidases and provide insight into the integrated signaling mechanisms whereby Ang II stimulation leads to activation of the growth-related NAD(P)H oxidases.

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Metadata

Authors
Seshiah, P. N., Weber, D. S., Rocic, P., Valppu, L., Taniyama, Y., & Griendling, K. K.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-09-06
Volume
91
Issue
5
Pages
406-413
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.0000033523.08033.16
OpenAlex
W2133150758
Cited by
709
References
42
FWCI
28.29
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Angiotensin II Stimulation of NAD(P)H Oxidase Activity: Upstream Mediators. https://app.cochat.ai/papers/10.1161/01.res.0000033523.08033.16
The paper
Seshiah, P. N., Weber, D. S., Rocic, P., Valppu, L., Taniyama, Y., & Griendling, K. K. (2002). Angiotensin II Stimulation of NAD(P)H Oxidase Activity: Upstream Mediators. Circulation Research. https://doi.org/10.1161/01.res.0000033523.08033.16

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.