The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy
Open accessAbstract
Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart disease. Such remodeling involves the production and destruction of extracellular matrix proteins, cell proliferation and migration, and apoptotic and necrotic cell death. Cardiac fibroblasts are crucially involved in these processes, producing growth factors and cytokines that act as autocrine and paracrine factors, as well as extracellular matrix proteins and proteinases. Recent studies have shown that the interactions between cardiac fibroblasts and cardiomyocytes are essential for the progression of cardiac remodeling. This review addresses the functional role played by cardiac fibroblasts and the molecular mechanisms that govern their activity during cardiac hypertrophy and remodeling. A particular focus is the recent progress toward our understanding of the transcriptional regulatory mechanisms involved.
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Cites
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Sano, M., Fukuda, K., Sato, T., Kawaguchi, H., Suematsu, M., Matsuda, S., Koyasu, S., Matsui, H., Yamauchi-Takihara, K., Harada, M., et al. (2001) · Circulation Research · doi:10.1161/hh2001.098873 · Cited by 298
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Cited by
Iorga, A., Cunningham, C. M., Moazeni, S., Ruffenach, G., Umar, S., & Eghbali, M. (2017) · Biology of Sex Differences · doi:10.1186/s13293-017-0152-8 · Cited by 914
Bernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 894
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
Fu, X., Khalil, H., Kanisicak, O., Boyer, J. G., Vagnozzi, R. J., Maliken, B. D., Sargent, M. A., Prasad, V., Valiente-Alandi, I., Blaxall, B. C., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98215 · Cited by 636
Cardiac fibroblasts: friend or foe?
Baudino, T. A., Carver, W., Giles, W., & Borg, T. K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00023.2006 · Cited by 427
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
Billia, F., Hauck, L., Konecny, F., Rao, V., Shen, J., & Mak, T. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106291108 · Cited by 414
Metadata
- Authors
- Manabe, I., Shindo, T., & Nagai, R.
- Venue
- Circulation Research
- Published
- 2002-12-13
- Volume
- 91
- Issue
- 12
- Pages
- 1103-1113
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2169804106
- Cited by
- 512
- References
- 8
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy. https://app.cochat.ai/papers/10.1161/01.res.0000046452.67724.b8
- The paper
- Manabe, I., Shindo, T., & Nagai, R. (2002). Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy. Circulation Research. https://doi.org/10.1161/01.res.0000046452.67724.b8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
