The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis: Antiinflammatory Monocyte-Macrophage Responses In Vitro, in Resolving Skin Blisters In Vivo, and After Cardiopulmonary Bypass Surgery
Abstract
The recently described hemoglobin scavenger receptor CD163 mediates the endocytosis of hemoglobin:haptoglobin (Hb:Hp) complexes and thereby counters Hb-induced oxidative tissue damage after hemolysis. Although CD163 has been indirectly associated with antiinflammatory and atheroprotective activity, no ligand-receptor-effector pathway has yet been described for this receptor. To understand the significance of CD163 and more clearly define downstream pathways linked to inflammatory resolution, we studied the expression and function of CD163 in human monocytes/macrophages using both in vitro and in vivo models. Differentiation of human blood monocytes into macrophages either by in vitro culture or in resolving cantharidin-induced skin blisters led to an equivalent increase (>15×) in CD163 expression. Elevated CD163 levels were also noted on circulating monocytes in cardiac surgical patients during the resolution phase of the systemic inflammatory response to cardiopulmonary bypass surgery. In each case, binding of Hb:Hp to CD163-bearing cells elicited potent interleukin-10 secretion, and this was inhibited by the anti-CD163 antibody RM3/1. Release of interleukin-10, in turn, induced heme oxygenase-1 stress protein synthesis via an autocrine mechanism. Such induction of heme oxygenase-1 was observed in vivo 24 to 48 hours after the onset of cardiopulmonary bypass surgery. These results identify novel antiinflammatory and cytoprotective effector pathways in human monocytes/macrophages related to Hb scavenging and metabolism, which may have relevance in atheroprotection, wound healing, and patient recovery postoperatively.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the same spectrum, integrin alpha V (ITGAV) displayed strong co-expression with CD163, a well known macrophage-specific marker mediating an anti-inflammatory pathway that includes IL10, and whose synthesis was shown to be well correlated with local and systemic inflammatory phenomena [37,38].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [38]
Citations
Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
Identification of the haemoglobin scavenger receptor
Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H.-J., Law, S. K. A., & Moestrup, S. K. (2001) · Nature · doi:10.1038/35051594 · Cited by 1,712
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
Yachie, A., Niida, Y., Wada, T., Igarashi, N., Kaneda, H., Toma, T., Ohta, K., Kasahara, Y., & Koizumi, S. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4165 · Cited by 1,256
Macrophage deactivation by interleukin 10.
Bogdan, C., Yoram Vodovotz, B., & Nathan, C. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.6.1549 · Cited by 1,236
Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors
Kishimoto, T., Jutila, M. A., Berg, E. L., & Butcher, E. C. (1989) · Science · doi:10.1126/science.2551036 · Cited by 1,089
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Lee, T.-S., & Chau, L.-Y. (2002) · Nature Medicine · doi:10.1038/nm0302-240 · Cited by 1,019
Cited by
Sorted by citations
Items 201–300 of 474
Immunoregulation in human malaria: the challenge of understanding asymptomatic infection
de Mendonça, V. R. R., & Barral‐Netto, M. (2015) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760150241 · Cited by 45
Jarosiewicz, M., Duchnowicz, P., Włuka, A., & Bukowska, B. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.09.016 · Cited by 44
Wagner, A., Junginger, J., Lemensieck, F., & Hewicker‐Trautwein, M. (2018) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2018.01.011 · Cited by 43
Estupiñán‐Moreno, E., Ortiz‐Fernández, L., Li, T., Hernández‐Rodríguez, J., Ciudad, L., Andrés‐León, E., Terron-Camero, L. C., Prieto‐González, S., Espígol‐Frigolé, G., Cid, M. C., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2022-222156 · Cited by 43
Levels of Soluble CD163 and Severity of Malaria in Children in Ghana
Kusi, K. A., Gyan, B. A., Goka, B. Q., Dodoo, D., Adjei, G. O., Troye‐Blomberg, M., Akanmori, B. D., & Adjimani, J. P. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00506-07 · Cited by 43
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis
da Silva, R. L. L., Santos, M. B., Almeida, P. L. S., Barros, T. S., Magalhães, L. S., Cazzaniga, R. A., Souza, P., Luz, N. F., França‐Costa, J., Borges, V. M., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005486 · Cited by 43
de Jong, A. J., Klein‐Wieringa, I. R., Andersen, S. N., Kwekkeboom, J. C., Toorn, L. H.-V., de Lange-Brokaar, B. J. E., van Delft, D., Garcia, J., Wei, W., van der Heide, H. J. L., et al. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1395-9 · Cited by 46
Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+Macrophages
Landis, R. C., Philippidis, P., Domin, J., Boyle, J. J., & Haskard, D. O. (2013) · International Journal of Inflammation · doi:10.1155/2013/980327 · Cited by 45
Self-citationIzawa, N., Kurotaki, D., Nomura, S., Fujita, T., Omata, Y., Yasui, T., Hirose, J., Matsumoto, T., Saito, T., Kadono, Y., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3689 · Cited by 40
Cox, S. E., Doherty, C. P., Atkinson, S. H., Nweneka, C. V., Fulford, A. J. C., Ghattas, H., Rockett, K. A., Kwiatkowski, D. P., & Prentice, A. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000362 · Cited by 42
Invited Review: Ruminal microbes, microbial products, and systemic inflammation
Garcia, M., Bradford, B. J., & Nagaraja, T. G. (2017) · The Professional Animal Scientist · doi:10.15232/pas.2017-01663 · Cited by 42
Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events
Ijäs, P. H., Saksi, J., Soinne, L., Tuimala, J., Jauhiainen, M., Jula, A., Kähönen, M. A. P., Kesäniemi, Y. A., Kovanen, P. T., Kaste, M., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.07.008 · Cited by 40
Day, J. R. S., Taylor, K. M., Lidington, E. A., Mason, J. C., Haskard, D. O., RANDI, A. M., & Landis, R. C. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.08.050 · Cited by 40
Self-citationHaptoglobin 2-2 Phenotype is a Risk Factor for Type 2 Diabetes in Ghana
Quaye, I. K., Ababio, G. K., & Amoah, A. G. B. (2006) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.13.90 · Cited by 40
Liu, B., Hu, B., Shao, S., Wu, W., Fan, L.-B., Bai, G., Shang, P., & Wang, X. (2015) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.08.013 · Cited by 39
Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages
Pentecost, A., Witherel, C. E., Gogotsi, Y., & Spiller, K. L. (2017) · Biomaterials Science · doi:10.1039/c7bm00294g · Cited by 32
Ferreira, D. W., Ulecia-Morón, C., Alvarado-Vazquez, P. A., Cunnane, K., Moracho-Vilrriales, C., Grosick, R. L., Cunha, T. M., & Romero-Sandoval, E. A. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.10.011 · Cited by 40
Cicuéndez, M., Casarrubios, L., Feito, M. J., Madarieta, I., Garcia-Urkia, N., Murua, O., Olalde, B., Briz, N., Diez-Orejas, R., & Portolés, M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083847 · Cited by 39
Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma
Gorbunov, N. V., Asher, L. V. S., Ayyagari, V. N., & Atkins, J. L. (2005) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.06.007 · Cited by 39
Purushothaman, K., Meerarani, P., Levy, A. P., Lento, P. A., Evrard, S., Kovacic, J. C., Briley-Saebo, K. C., Tsimikas, S., Witztum, J. L., Krishnan, P., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.011 · Cited by 38
Dai, C., Yao, X., Gordon, E. M., Barochia, A. V., Cuento, R. A., Kaler, M. M., Meyer, K. S., Keeran, K. J., Nugent, G. Z., Jeffries, K. R., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.94 · Cited by 38
Corticoids Normalize Leukocyte Production of Macrophage Migration Inhibitory Factor in Septic Shock
Maxime, V., Fitting, C., Annane, D., & Cavaillon, J. (2004) · The Journal of Infectious Diseases · doi:10.1086/426401 · Cited by 40
Rubio‐Navarro, A., Amaro-Villalobos, J. M., Lindholt, J. S., Buendía, I., Egido, J., Blanco‐Colio, L. M., Samaniego, R., Meilhac, O., Michel, J., Martı́n-Ventura, J. L., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.053 · Cited by 37
West, S. D., Goldberg, D., Ziegler, A., Krencicki, M. A., Clos, T. W. D., & Mold, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052406 · Cited by 37
Fujiwara, Y., Horlad, H., Shiraishi, D., Tsuboki, J., Kudo, R., Ikeda, T., Nohara, T., Takeya, M., & Komohara, Y. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500995 · Cited by 36
Durda, P., Raffield, L. M., Lange, E. M., Olson, N. C., Jenny, N. S., Cushman, M., Deichgræber, P., Grarup, N., Jonsson, A. E., Hansen, T. F., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024374 · Cited by 38
Maniecki, M. B., Etzerodt, A., Moestrup, S. K., Møller, H. J., & Graversen, J. H. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.02.001 · Cited by 35
Yearley, J. H., Pearson, C. B., Shannon, R. P., & Mansfield, K. G. (2007) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.0211 · Cited by 35
Moniuszko, M., Kowal, K., Rusak, M., Pietruczuk, M., Dąbrowska, M., & Bodzenta‐Łukaszyk, A. (2006) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00417-05 · Cited by 35
Kowal‐Bielecka, O., Bielecki, M., Guiducci, S., Trzcińska-Butkiewicz, B., Michalska-Jakubus, M. M., Matucci‐Cerinic, M., Brzosko, M., Krasowska, D., Chyczewski, L., & Kowal, K. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4246 · Cited by 35
Acute phase glycoproteins: bystanders or participants in carcinogenesis?
Dempsey, E., & Rudd, P. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06420.x · Cited by 35
Heme oxygenase system in hepatic ischemia-reperfusion injury
Richards, J. A. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i48.6068 · Cited by 34
Haemoglobin scavenger receptor: function in relation to disease.
Zuwała−Jagiełło, J. (2006) · Acta Biochimica Polonica · doi:10.18388/abp.2006_3338 · Cited by 34
Differential Regulation of Hepatic Heme Oxygenase-1 Protein With Aging and Heat Stress
Bloomer, S. A., Zhang, H. J., Brown, K. E., & Kregel, K. C. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln056 · Cited by 34
Pro-Resolving Molecules—New Approaches to Treat Sepsis?
Buechler, C., Pohl, R., & Aslanidis, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030476 · Cited by 34
Molecular cloning and characterization of markers and cytokines for equid myeloid cells
Steinbach, F., Stark, R., Ibrahim, S. M., El-Gawad, E., Ludwig, H., Walter, J. H., Commandeur, U., & Mauel, S. (2005) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2005.07.015 · Cited by 34
Lu, D., Jiao, X., Jiang, W., Yang, L., Gong, Q., Wang, X., Wei, M., & Gong, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115042 · Cited by 34
Novel translational model of resolving inflammation triggered by UV‐killed E. coli
Motwani, M. P., Flint, J., Maeyer, R. P. H. D., Fullerton, J. N., Smith, A. M., Marks, D. J., & Gilroy, D. W. (2016) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.43 · Cited by 36
Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders
Skuratovskaia, D., Vulf, M. A., Хазиахматова, О. Г., Malashchenko, V. V., Komar, A., Shunkin, E. O., Shupletsova, V. V., Гончаров, А. Г., Urazova, O. I., & Litvinova, L. S. (2020) · Biomedicines · doi:10.3390/biomedicines8100400 · Cited by 34
Zhou, Z., Behymer, M., & Guchhait, P. (2010) · Anemia · doi:10.1155/2011/918916 · Cited by 36
Serum levels of CD163 and TWEAK in patients with pulmonary arterial hypertension
Jasiewicz, M., Kowal, K., Kowal‐Bielecka, O., Knapp, M., Skiepko, R., Bodzenta‐Łukaszyk, A., Sobkowicz, B., Musial, W. J., & Kamiński, K. A. (2014) · Cytokine · doi:10.1016/j.cyto.2013.12.013 · Cited by 33
Aboulhoda, B. E., & Fattah, S. A. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2879-x · Cited by 33
The metabolic characteristic of decidual immune cells and their unique properties in pregnancy loss*
Zhang, T., Shen, H., Qin, X., & Li, M. (2022) · Immunological Reviews · doi:10.1111/imr.13085 · Cited by 33
The role of mononuclear phagocyte system in IgA nephropathy: pathogenesis and prognosis
Liu, Y., Gong, Y., & Xu, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1192941 · Cited by 31
Eligini, S., Cosentino, N., Fiorelli, S., Fabbiocchi, F., Niccoli, G., Refaat, H., Camera, M., Calligaris, G., Martini, S. D., Bonomi, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44847-3 · Cited by 31
Yeager, M. P., Pioli, P. A., Wardwell, K., Beach, M. L., Martel, P., Lee, H. K., Rassias, A. J., & Guyre, P. M. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181875fb0 · Cited by 32
Bullers, S. J., Baker, S. C., Ingham, E., & Southgate, J. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0628 · Cited by 31
Bielecki, M., Kowal, K., Lapinska, A., Chyczewski, L., & Kowal‐Bielecka, O. (2013) · Advances in Medical Sciences · doi:10.2478/v10039-012-0076-9 · Cited by 31
Costa‐Mallen, P., Checkoway, H., Zabeti, A., Edenfield, M. J., Swanson, P. D., Longstreth, W. T., Franklin, G. M., Smith‐Weller, T., & Sadrzadeh, S. M. H. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30593 · Cited by 31
Takahashi, H., Hatta, Y., Iriyama, N., Hasegawa, Y., Uchida, H., Nakagawa, M., Makishima, M., Takeuchi, J., & Takei, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113722 · Cited by 31
CD163 as a Potential Biomarker of Monocyte Activation in Ischemic Stroke Patients
Greco, R., Demartini, C., Zanaboni, A. M., Tumelero, E., Persico, A., Candeloro, E., Morotti, A., Amantea, D., & Tassorelli, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136712 · Cited by 29
Cross-talk between endocytic clearance and secretion in macrophages
Kzhyshkowska, J. G., & Krusell, L. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.03.007 · Cited by 31
Levy, A. P. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.002 · Cited by 29
Krzyszczyk, P., Kang, H. J., Kumar, S., Meng, Y., O'Reggio, M. D., Patel, K. P., Pires, I. S., Yarmush, M. L., Schloss, R. S., Palmer, A. F., et al. (2020) · Wound Repair and Regeneration · doi:10.1111/wrr.12814 · Cited by 28
Kowal, K., Møller, H. J., DuBuske, L. M., Moestrup, S. K., & Bodzenta‐Łukaszyk, A. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02573.x · Cited by 28
Heme Oxygenase-1 Dysregulation in the Brain: Implications for HIVAssociated Neurocognitive Disorders
Ambegaokar, S. S., & Kolson, D. L. (2014) · Current HIV Research · doi:10.2174/1570162x12666140526122709 · Cited by 30
Graney, P. L., Lurier, E. B., & Spiller, K. L. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00747 · Cited by 29
Lefebvre-Lavoie, J., Lussier, J. G., & Theoret, C. L. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00018.2005 · Cited by 28
Non‐invasive Markers of Portal Hypertension
Sutton, H., Dhawan, A. K., & Grammatikopoulos, T. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001882 · Cited by 27
Impaired functional capacity of polarised neonatal macrophages
Dreschers, S., Ohl, K., Schulte, N., Tenbrock, K., & Orlikowsky, T. W. (2020) · Scientific Reports · doi:10.1038/s41598-019-56928-4 · Cited by 27
Potential Anti-Diabetic Activity of Pueraria lobata Flower (Flos Puerariae) Extracts
Lertpatipanpong, P., Janpaijit, S., Park, E.-Y., Kim, C., & Baek, S. J. (2020) · Molecules · doi:10.3390/molecules25173970 · Cited by 28
Koláčková, M., Kudlová, M., Kunes, P., Lonský, V., Manďák, J., Andrýs, C., Jankovičová, K., & Krejsek, J. (2008) · Mediators of Inflammation · doi:10.1155/2008/235461 · Cited by 27
Inflammation in Skeletal Muscle Regeneration
Tidball, J. G. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6768-6_12 · Cited by 27
Macrophage CD163 expression in cerebrospinal fluid: association with subarachnoid hemorrhage outcome
Thomas, A. J., Ogilvy, C. S., Griessenauer, C. J., & Hanafy, K. A. (2018) · Journal of neurosurgery · doi:10.3171/2018.2.jns172828 · Cited by 27
Do, T., Tan, R., Bennett, M. F., Medvedovic, M., Grom, A. A., Shen, N., Thornton, S., & Schulert, G. S. (2017) · Journal of Leukocyte Biology · doi:10.1002/jlb.2a0317-107r · Cited by 26
Drug Trafficking into Macrophages via the Endocytotic Receptor CD163
Graversen, J. H., & Moestrup, S. K. (2015) · Membranes · doi:10.3390/membranes5020228 · Cited by 26
Naranmandura, H., & Suzuki, K. T. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700383g · Cited by 26
Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer
Patten, D. A., Wilkinson, A. L., O'Keeffe, A., & Shetty, S. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1733876 · Cited by 26
Yamazaki, H., Ohta, K., Tsukiji, H., Toma, T., Hashida, Y., Ishizaki, A., Saito, T., Arai, S., Koizumi, S., & Yachie, A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.136 · Cited by 25
Jude, C., Dejicà, D., Samaşcă, G., Bălăcescu, L., & Bălăcescu, O. (2012) · Rheumatology International · doi:10.1007/s00296-012-2459-4 · Cited by 25
Aubouy, A., Olagnier, D. P., Bertin, G. I., Ezinmègnon, S., Majorel, C., Mimar, S., Massougbodji, A., Deloron, P., Pipy, B., & Coste, A. (2015) · Malaria Journal · doi:10.1186/s12936-015-0888-8 · Cited by 27
Decidua Basalis Mesenchymal Stem Cells Favor Inflammatory M1 Macrophage Differentiation In Vitro
Abumaree, M., Harthy, S. A., Subayyil, A. M. A., Alshabibi, M. A., Abomaray, F., Khatlani, T., Kalionis, B., El-Muzaini, M. F., Jumah, M. A., Jawdat, D. M., et al. (2019) · Cells · doi:10.3390/cells8020173 · Cited by 25
Foresti, R., Bains, S. K., Sulc, F., Farmer, P. J., Green, C. J., & Motterlini, R. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.097907 · Cited by 26
Furukoji, E., Gi, T., Yamashita, A., Moriguchi‐Goto, S., Kojima, M., Sugita, C., Sakae, T., Sato, Y. Z., Hirai, T., & Asada, Y. (2016) · Thrombosis Journal · doi:10.1186/s12959-016-0122-0 · Cited by 24
Macrophage Hemoglobin Scavenger Receptor and Ferritin Accumulation in Human Atherosclerotic Lesions
Li, W., XU, L., & Yuan, X. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.025 · Cited by 23
Meerarani, P., Krishnan, P., Purushothaman, K., Baber, U., Tarricone, A. N., Pérez, J. S., Wiley, J. M., Kini, A. S., Sharma, S. K., Fuster, V., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.252122 · Cited by 23
Identification of a human intestinal myeloid cell subset that regulates gut homeostasis
Barman, S., Kayama, H., Okuzaki, D., Ogino, T., Osawa, H., Matsuno, H., Mizushima, T., Mori, M., Nishimura, J., & Takeda, K. (2016) · International Immunology · doi:10.1093/intimm/dxw034 · Cited by 23
Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase-1
Tomczyk, M., Kraszewska, I., Dulak, J., & Jaźwa, A. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.08.011 · Cited by 24
Alvarado-Vazquez, P. A., Grosick, R. L., Moracho-Vilrriales, C., Ward, E., Threatt, T. B., & Romero-Sandoval, E. A. (2018) · Journal of Pain Research · doi:10.2147/jpr.s186372 · Cited by 24
Nunes, P. R., Romão‐Veiga, M., Peraçoli, J. C., Costa, R., Oliveira, L. G., Borges, V. T. M., & Peraçoli, M. T. S. (2019) · Immunologic Research · doi:10.1007/s12026-019-09078-8 · Cited by 24
Napolioni, V., Giannì, P., Carpi, F. M., Concetti, F., & Lucarini, N. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.006 · Cited by 23
The inflammatory effect of cardiopulmonary bypass on leukocyte extravasation in vivo
Evans, B., Haskard, D. O., Finch, J. R., Hambleton, I. R., Landis, R. C., & Taylor, K. M. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.08.071 · Cited by 23
Self-citationPolymerized Hemoglobin With Increased Molecular Size Reduces Toxicity in Healthy Guinea Pigs
Williams, A. T., Muller, C. R., Eaker, A. M., Belcher, D. A., Bolden‐Rush, C., Palmer, A. F., & Cabrales, P. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00039 · Cited by 22
Cytoprotective Role of Haptoglobin in Brain After Experimental Intracerebral Hemorrhage
Zhao, X., Song, S., Sun, G., Zhang, J., Strong, R., Zhang, L., Grotta, J. C., & Aronowski, J. A. (2011) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-7091-0693-8_17 · Cited by 22
Acute Phase Proteins as Biomarkers in Animal Health and Welfare
Gómez-Laguna, J., Francisco, J., Francisco, J., Irene, M., Barranco, I., & Carrasco, L. (2011) · InTech eBooks · doi:10.5772/19166 · Cited by 22
Łapuć, I., Bołkuń, Ł., Eljaszewicz, A., Rusak, M., Łuksza, E., Singh, P., Mikłasz, P., Piszcz, J. A., Ptaszyńska‐Kopczyńska, K., Jasiewicz, M., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4088 · Cited by 23
Mechanisms and Clinical Complications of Hemolysis in Sickle Cell Disease and Thalassemia
Kato, G. J., & Gladwin, M. T. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596582.016 · Cited by 22
Haptoglobin Enhances Cardiac Transplant Rejection
Shen, H., Heuzey, E., Mori, D. N., Wong, C. K., Colangelo, C. M., Chung, L. M., Bruce, C., Slizovskiy, I. B., Booth, C. J., Kreisel, D., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.305406 · Cited by 21
Validation of the cantharidin‐induced skin blister as an in vivo model of inflammation
Dinh, P., Corazza, F., Mestdagh, K., Kassengera, Z., Doyen, V., & Michel, O. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04020.x · Cited by 21
Morrell, E. D., Holton, S. E., Lawrance, M., Orlov, M., Franklin, Z., Mitchem, M. A., DeBerg, H., Gersuk, V. H., Garay, A., Barnes, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43223-0 · Cited by 20
The Endocytosis and Signaling of the γδ T Cell Coreceptor WC1 Are Regulated by a Dileucine Motif
Hsu, H., Baldwin, C. L., & Telfer, J. C. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402020 · Cited by 20
Pathology of plaque haemorrhage and neovascularization of coronary artery
Kodama, T., Narula, N., Agozzino, M., & Arbustini, E. (2012) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e328356a5f2 · Cited by 20
Macrophage Phenotyping in Atherosclerosis by Proteomics
Eligini, S., Gianazza, E., Mallia, A., Ghilardi, S., & Banfi, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032613 · Cited by 19
The Haptoglobin genotype predicts cardio-renal mortality in type 1 diabetes
Costacou, T., & Orchard, T. J. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.11.011 · Cited by 19
Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta‐Analysis
Gaastra, B., Glazier, J., Bulters, D. O., & Galea, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6747940 · Cited by 20
Haptoglobin genotype and aneurysmal subarachnoid hemorrhage
Gaastra, B., Ren, D., Alexander, S. A., Bennett, E. R., Bielawski, D., Blackburn, S., Borsody, M. K., Doré, S., Galea, J. P., Garland, P., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007397 · Cited by 19
Pérez, C., Ezquerra, Á., Ortuño, E., Gómez, N., García-Briones, M., de la Riva, P. M., Alonso, F., Revilla, C., & Domı́nguez, J. (2008) · Spanish Journal of Agricultural Research · doi:10.5424/sjar/200806s1-374 · Cited by 19
Escate, R., Padró, T., Borrell-Pagés, M., Suades, R., Aledo, R., Mata, P., & Badimón, L. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12993 · Cited by 19
Cobalt Protoporphyrin Attenuates Rat Obstructive Nephropathy: Role of Cellular Infiltration
Iwai, T., Kitamoto, K., Teramoto, K., Machida, Y., Tamada, S., Yukimura, T., Iwao, H., Nakatani, T., & Miura, K. (2008) · Urology · doi:10.1016/j.urology.2007.11.123 · Cited by 18
Mocny, J. C., Olson, J. S., & Connell, T. D. (2007) · Infection and Immunity · doi:10.1128/iai.00407-07 · Cited by 18
Metadata
- Authors
- Philippidis, P., Mason, J. C., Evans, B. J., Nadra, I., Taylor, K. M., Haskard, D. O., & Landis, R. C.
- Affiliations
- Hammersmith Hospital (GB)
- Venue
- Circulation Research
- Published
- 2004-01-09
- Volume
- 94
- Issue
- 1
- Pages
- 119-126
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2143009142
- Cited by
- 476
- References
- 43
- Citations by year
- 2026: 16 · 2025: 12 · 2024: 7 · 2023: 15 · 2022: 20 · 2021: 18 · 2020: 25 · 2019: 23 · 2018: 18 · 2017: 27 · 2016: 17 · 2015: 34 · 2014: 20 · 2013: 26 · 2012: 31
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- CD163, haptoglobin, hemoglobin-haptoglobin complex, IL-10, heme oxygenase-1, monocytes, macrophages, inflammation resolution, cardiopulmonary bypass, hemolysis, anti-inflammatory pathways, atheroprotection, wound healing
- MeSH terms
- CD163 Antigen, Aged, Coronary Artery Bypass, Blister, Cardiopulmonary Bypass, Cells, Cultured, Female, Haptoglobins, Heme Oxygenase (Decyclizing), Hemoglobins, Humans, Inflammation, Macrophages, Male, Membrane Proteins, Middle Aged, Monocytes, Receptors, Cell Surface, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Interleukin-10, Autocrine Communication, Heme Oxygenase-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review