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Hemoglobin and Its Scavenger Protein Haptoglobin Associate with ApoA-1-containing Particles and Influence the Inflammatory Properties and Function of High Density Lipoprotein

Watanabe, J., Grijalva, V. R., Hama, S. Y., Barbour, K. W., Berger, F. G., Navab, M., Fogelman, A. M., & Reddy, S. T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017202 · Cited by 117 · see citing works

Functional Immune Anatomy of the Liver—As an Allograft

Demetris, A. J., Bellamy, C. O. C., Gandhi, C. R., Prost, S., Nakanuma, Y., & Stolz, D. B. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13749 · Cited by 115 · see citing works

CXCL4-induced macrophages in human atherosclerosis

Domschke, G., & Gleissner, C. A. (2017) · Cytokine · doi:10.1016/j.cyto.2017.08.021 · Cited by 107 · see citing works

Toxicological Consequences of Extracellular Hemoglobin: Biochemical and Physiological Perspectives

Buehler, P. W., & D’Agnillo, F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2799 · Cited by 107 · see citing works

Heme Oxygenase-1 Deficiency and Oxidative Stress: A Review of 9 Independent Human Cases and Animal Models

Yachie, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041514 · Cited by 99 · see citing works

Changes in transcriptome of macrophages in atherosclerosis

Chistiakov, D. A., Bobryshev, Y. V., & Orekhov, A. N. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12591 · Cited by 98 · see citing works

Pathological Conditions Involving Extracellular Hemoglobin: Molecular Mechanisms, Clinical Significance, and Novel Therapeutic Opportunities for α 1 -Microglobulin

Olsson, M. G., Allhorn, M., Bülow, L., Hansson, S. R., Ley, D., Olsson, M. L., Schmidtchen, A., & Åkerström, B. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4282 · Cited by 96 · see citing works

Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies

Schaer, D. J., & Buehler, P. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013433 · Cited by 96 · see citing works

Hepatic Macrophage Activation and the LPS Pathway in Patients With Alcoholic Hepatitis: A Prospective Cohort Study

Sandahl, T. D., Grønbæk, H., Møller, H. J., Støy, S. H., Thomsen, K. L., Dige, A. K., Agnholt, J. S., Hamilton-Dutoit, S. J., Thiel, S., & Vilstrup, H. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.262 · Cited by 96 · see citing works

‘Ride on the ferrous wheel’ – The cycle of iron in macrophages in health and disease

Nairz, M., Schroll, A., Demetz, E., Tancevski, I., Theurl, I., & Weiss, G. (2015) · Immunobiology · doi:10.1016/j.imbio.2014.09.010 · Cited by 89 · see citing works

Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

Schaer, C. A., Deuel, J., Bittermann, A. G., García‐Rubio, I., Schoedon, G., Spahn, D. R., Wepf, R. A., Vallelian, F., & Schaer, D. J. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.113 · Cited by 92 · see citing works

Organ Preservation into the 2020s: The Era of Dynamic Intervention

Petrenko, O., Carnevale, M. E., Somov, A. Y., Osorio, J., Rodriguez, J. V., Guibert, E. E., Fuller, B. J., & Froghi, F. (2019) · Transfusion Medicine and Hemotherapy · doi:10.1159/000499610 · Cited by 91 · see citing works

Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity

Buehler, P. W., Humar, R., & Schaer, D. J. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.02.004 · Cited by 89 · see citing works

Gating the Radical Hemoglobin to Macrophages: The Anti-Inflammatory Role of CD163, a Scavenger Receptor

Schaer, D. J., Alayash, A. I., & Buehler, P. W. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1576 · Cited by 88 · see citing works

Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α1-microglobulin

May, K., Rosenlöf, L. W., Olsson, M. G., Centlow, M., Mörgelin, M., Larsson, I. A. S., Cederlund, M., Rutardóttir, S., Siegmund, W., Schneider, H., et al. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.017 · Cited by 87 · see citing works

Plaque neovascularization: defense mechanisms, betrayal, or a war in progress

Moreno, P. R., Purushothaman, M., & Purushothaman, K. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06497.x · Cited by 80 · see citing works

CD163-Mediated Hemoglobin-Heme Uptake Activates Macrophage HO-1, Providing an Antiinflammatory Function

Abraham, N. G., & Drummond, G. (2006) · Circulation Research · doi:10.1161/01.res.0000249616.10603.d6 · Cited by 87 · see citing works

Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation

Bonecchi, R., Borroni, E. M., Anselmo, A., Doni, A., Savino, B., Mirolo, M., Fabbri, M., Jala, V. R., Haribabu, B., Mantovani, A., et al. (2008) · Blood · doi:10.1182/blood-2007-08-108316 · Cited by 86 · see citing works

Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune Responses

Avdic, S., Cao, J. Z., McSharry, B. P., Clancy, L. E., Brown, R., Steain, M. C., Gottlieb, D. J., Abendroth, A., & Slobedman, B. (2013) · Journal of Virology · doi:10.1128/jvi.00912-13 · Cited by 84 · see citing works

Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury

Zhang, Z., Zhang, Z.-Y., Wu, Y., & Schluesener, H. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.038 · Cited by 83 · see citing works

The reaction of hydrogen peroxide with hemoglobin induces extensive α-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways

Vallelian, F., Pimenova, T., Pereira, C. P., Abraham, B., Mikolajczyk, M. G., Schoedon, G., Zenobi, R., Alayash, A. I., Buehler, P. W., & Schaer, D. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.07.013 · Cited by 80 · see citing works

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

Vallelian, F., Schaer, C. A., Kämpfer, T., Gehrig, P., Duerst, E., Schoedon, G., & Schaer, D. J. (2010) · Blood · doi:10.1182/blood-2010-04-277319 · Cited by 80 · see citing works

The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection

Gorp, H. V., Breedam, W. V., Delputte, P., & Nauwynck, H. (2009) · Archives of Virology · doi:10.1007/s00705-009-0527-1 · Cited by 79 · see citing works

Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm

Hugelshofer, M., Buzzi, R. M., Schaer, C. A., Richter, H., Akeret, K., Anagnostakou, V., Mahmoudi, L., Vaccani, R., Vallelian, F., Deuel, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130630 · Cited by 77 · see citing works

Peripheral Artery Disease Is Associated With a High CD163/TWEAK Plasma Ratio

Moreno, J. A., Dejouvencel, T., Labreuche, J., Smadja, D. M., Dussiot, M., Martı́n-Ventura, J. L., Egido, J., Gaussem, P., Emmerich, J., Michel, J., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.203364 · Cited by 79 · see citing works

Heme and haemoglobin direct macrophage Mhem phenotype and counter foam cell formation in areas of intraplaque haemorrhage

Boyle, J. J. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328356b145 · Cited by 79 · see citing works

CD163 Expression in Neurons After Experimental Intracerebral Hemorrhage

Liu, R., Cao, S., Hua, Y., Keep, R. F., Huang, Y., & Xi, G. (2017) · Stroke · doi:10.1161/strokeaha.117.016850 · Cited by 78 · see citing works

Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes

Pfefferlé, M., Ingoglia, G., Schaer, C. A., Yalamanoglu, A., Buzzi, R. M., Dubach, I. L., Tan, G., López-Cano, E. Y., Schulthess-Lutz, N., Hansen, K., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137282 · Cited by 75 · see citing works

Genome-Wide Detection of CNVs and Their Association with Meat Tenderness in Nelore Cattle

da Silva, V. H., Regitano, L. C. D. A., Geistlinger, L., Pértille, F., Giachetto, P. F., Brassaloti, R. A., Morosini, N. S., Zimmer, R., & Coutinho, L. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157711 · Cited by 75 · see citing works

Monocyte-Derived Dendritic Cells Perform Hemophagocytosis to Fine-Tune Excessive Immune Responses

Ohyagi, H., Onai, N., Sato, T., Yotsumoto, S., Liu, J., Akiba, H., Yagita∥, H., Atarashi, K., Honda, K., Roers, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.019 · Cited by 74 · see citing works

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

Lipiski, M., Deuel, J., Baek, J. H., Engelsberger, W. R., Buehler, P. W., & Schaer, D. J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5089 · Cited by 73 · see citing works

Hemoglobin Can Attenuate Hydrogen Peroxide–Induced Oxidative Stress by Acting as an Antioxidative Peroxidase

Widmer, C. C., Pereira, C. P., Gehrig, P., Vallelian, F., Schoedon, G., Buehler, P. W., & Schaer, D. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2826 · Cited by 72 · see citing works

CD163 favors Mycobacterium leprae survival and persistence by promoting anti‐inflammatory pathways in lepromatous macrophages

Moura, D. F., Mattos, K. A., Amadeu, T. P., Andrade, P. R., Sales, J. D. S., Schmitz, V., Nery, J. A. C., Pinheiro, R. O., & Sarno, E. N. (2012) · European Journal of Immunology · doi:10.1002/eji.201142198 · Cited by 71 · see citing works

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

Deuel, J., Vallelian, F., Schaer, C. A., Puglia, M., Buehler, P. W., & Schaer, D. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.09.016 · Cited by 71 · see citing works

Hemoglobin-induced neuronal degeneration in the hippocampus after neonatal intraventricular hemorrhage

Garton, T. P., He, Y., Garton, H. J. L., Keep, R. F., Xi, G., & Strahle, J. M. (2016) · Brain Research · doi:10.1016/j.brainres.2015.12.060 · Cited by 70 · see citing works

CD11b+, Ly6G+ Cells Produce Type I Interferon and Exhibit Tissue Protective Properties Following Peripheral Virus Infection

Fischer, M. A., Davies, M. L., Reider, I. E., Heipertz, E. L., Epler, M., Sei, J. J., Ingersoll, M. A., van Rooijen, N., Randolph, G. J., & Norbury, C. C. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002374 · Cited by 63 · see citing works

The Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1

Hull, T. D., Agarwal, A., & George, J. F. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5673 · Cited by 65 · see citing works

Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury

Akeret, K., Buzzi, R. M., Schaer, C. A., Thomson, B. R., Vallelian, F., Wang, S., Willms, J. F., Sebök, M., Held, U., Deuel, J., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211020629 · Cited by 64 · see citing works

Carbon monoxide and the eye: Implications for glaucoma therapy

Bucolo, C., & Drago, F. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.013 · Cited by 63 · see citing works

Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: An In Vitro and In Vivo Study

Fiorelli, S., Porro, B., Cosentino, N., Minno, A. D., Manega, C. M., Fabbiocchi, F., Niccoli, G., Fracassi, F., Barbieri, S., Marenzi, G., et al. (2019) · Cells · doi:10.3390/cells8040356 · Cited by 63 · see citing works

Heme Degradation in Pathophysiology of and Countermeasures to Inflammation-Associated Disease

Haines, D. D., & Tósaki, Á. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249698 · Cited by 66 · see citing works

A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds: Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition

Fujiwara, Y., Takeya, M., & Komohara, Y. (2014) · BioMed Research International · doi:10.1155/2014/348539 · Cited by 60 · see citing works

Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study

Adams, J. N., Cox, A. J., Freedman, B. I., Langefeld, C. D., Carr, J. J., & Bowden, D. W. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-31 · Cited by 59 · see citing works

In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis

Moreno, J. A., Ortega‐Gómez, A., Delbosc, S., Beaufort, N., Sorbets, E., Louedec, L., Esposito‐Farèse, M., Tubach, F., Nicoletti, A., Steg, P. G., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr123 · Cited by 59 · see citing works

CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system

Schaer, C. A., Vallelian, F., Imhof, A., Schoedon, G., & Schaer, D. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0706453 · Cited by 55 · see citing works

Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation

Schaer, C. A., Vallelian, F., Imhof, A., Schoedon, G., & Schaer, D. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407226 · Cited by 54 · see citing works

Deletion of Chitinase-3-like 1 accelerates stroke development through enhancement of Neuroinflammation by STAT6-dependent M2 microglial inactivation in Chitinase-3-like 1 knockout mice

Im, J. H., Yeo, I. J., Park, P. H., Choi, D. Y., Han, S., Yun, J., & Hong, J. T. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113082 · Cited by 53 · see citing works

Clearance and Control Mechanisms of Hemoglobin from Cradle to Grave

Schaer, D. J., & Alayash, A. I. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2923 · Cited by 52 · see citing works

Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization

Lagan, A. L., Melley, D. D., Evans, T. W., & Quinlan, G. J. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00169.2007 · Cited by 52 · see citing works

Haptoglobin increases the vulnerability of CD 163‐expressing neurons to hemoglobin

Chen‐Roetling, J., & Regan, R. F. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13720 · Cited by 51 · see citing works

CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response

Moestrup, S. K., & Møller, H. J. (2004) · Annals of Medicine · doi:10.1080/07853890410033171 · Cited by 444 · see citing works

Gating the Radical Hemoglobin to Macrophages: The Anti-Inflammatory Role of CD163, a Scavenger Receptor

Schaer, D. J., Alayash, A. I., & Buehler, P. W. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1576 · Cited by 88 · see citing works

Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis: Antiinflammatory Monocyte-Macrophage Responses In Vitro, in Resolving Skin Blisters In Vivo, and After Cardiopulmonary Bypass Surgery

Philippidis, P., Mason, J. C., Evans, B. J., Nadra, I., Taylor, K. M., Haskard, D. O., & Landis, R. C. (2004) · Circulation Research · doi:10.1161/01.res.0000109414.78907.f9 · Cited by 476 · see citing works

Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery.

Philippidis, P., Mason, J., Evans, B., Nadra, I., Taylor, K., Haskard, D., & Landis, R. (2004) · UCL Discovery (University College London) · Cited by 22 · see citing works

CD163-Mediated Hemoglobin-Heme Uptake Activates Macrophage HO-1, Providing an Antiinflammatory Function

Abraham, N. G., & Drummond, G. (2006) · Circulation Research · doi:10.1161/01.res.0000249616.10603.d6 · Cited by 87 · see citing works