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S -Nitrosothiols in the Blood: Roles, Amounts, and Methods of Analysis
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“Of note, since the endogenous RSNO levels are low (e.g., 1–10 µmol/L for SNO-albumin),280 this approach requires consistent supply of infused RSNOs to provide continuous catalytic generation of NO at the flowing blood/polymer tubing interface.254”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [280]
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Self-citationNitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
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Self-citationExport by red blood cells of nitric oxide bioactivity
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Self-citationS-nitrosylation in health and disease
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Self-citationEssential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock
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Self-citationNitric oxide in the human respiratory cycle
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“Measurements of S-nitrosothiol compounds have used light and chemical measurement assays rather than NO-sensitive electrodes [18,25,28,29,31,32].”
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S -Nitrosoalbumin and Other S -Nitrosothiols in the Blood: Is Their Quantity of No Relevance?
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Sulfur K-edge X-ray absorption spectroscopy as an experimental probe for S-nitroso proteins
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“... ambient light is difficult to completely eliminate, and mostmethodsreportedtodatedonottakeanyprecautionsinthisregard.Furthermore,becausewholeblood mustfirstbecentrifugedtoremoveredcells,evenminimal hemolysis during this process can create free oxyhemoglobin in the plasma that can readily scavenge NO liberated from…”
BackgroundKirsch, M., & de GROOT, H. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00517.x · Cited by 14
“Within mammalian tissues, the concentration of RSNOs varies from nm to lm concentrations [3, 4].”
BackgroundNitric Oxide and the Cardiovascular System
Bohlen, H. G. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00628.x · Cited by 12
“…enter the peripheral circulation. potential exchange of NO from various regions of overall cardiovascular system through blood transport 206, 207, 228) that can interact with blood vessels that NO transit from vessel’s wall through plasma of such events has been shown by multiple models concept…”
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“-) to produce a harmful peroxynitrite (ONOO-) species (Yang et al. 2006; Stamler 2004), which is a very powerful oxidant that causes oxidative stress and cytotoxicity (Arteel et al. 1999).”
BackgroundThe Question of Balance: The Interaction Between Blood and Ozone
Bocci, V. A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8399-0_7 · Cited by 11
“NO binds partly to cysteine 67 in hemoglobin (Stamler, 2004; Foresti et al., 2006) and to GSH.”
BackgroundNitrosylation of thiols in vascular homeostasis and disease
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“Functional hemoglobin carries NO in a nitrosylated releasable form, as does albumin, cysteine, and glutathione in plasma [23,28,31,32,37,38].”
BackgroundNitric Oxide generating coating alters hematoma structure and soft tissue healing
Mendhi, J., Prasadam, I., Subramaniam, S., Bai, L., Gao, W., Batra, J., Crawford, R., Yang, Y., & Xiao, Y. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2020.100919 · Cited by 10
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Solid-State 15N and 17O NMR Studies of S-Nitrosothiols
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A Mononitrosyl Diiron(II) Compound Catalyzes the Reduction of Nitrite to Nitric Oxide
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General Aspects of Ozone Therapy
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“[3-61] Moreover, improvement of metabolism and immunological functions contribute to a favorable outcome.”
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S‐Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery
Matto, F., Kouretas, P. C., Smith, R., Ostrowsky, J., Cina, A. J., Hess, D. T., Stamler, J. S., & Reynolds, J. D. H. (2017) · Clinical and Translational Science · doi:10.1111/cts.12530 · Cited by 7
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“Justifying a protein target for S-nitrosylation is often problematic, as S-nitrosothiol is extremely unstable [32–34].”
BackgroundHemoglobina: una molécula modelo para el investigador.
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“They proposed that red blood cell (RBC) deoxyhemoglobin takes up both O2 and NO in the lung, and then, upon transit to a site of low PO2, liberates both [11,13].”
BackgroundEffects of S -Nitrosation on Hemoglobin-Induced Microvascular Damage
Burke, T. K., Teng, X., Patel, R. P., & Baldwin, A. L. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1093 · Cited by 5
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“These compounds are of fundamental importance in the physiology of the vascular bed because they enhance vasodilation and inhibit platelet-leukocyte aggregationadhesion and muscle cell proliferation (Joyner and Dietz, 1997; Kashiba et al., 1999; Stamler, 2004).”
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“39,141,142 Undesirable outcomes include metabolism of NO whilst in contact with air during delivery, to the irritant nitrogen dioxide (NO 2 ), formation of metHb and contribution to oxidative stress.”
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“It has been found that at higher levels of NO, Hb breaks NO down into metHb and nitrate (Stamler, 2004).”
Background
Metadata
- Authors
- Stamler, J. S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Stamler, Jonathan S.
- ORCID
- Stamler, Jonathan S.
- Venue
- Circulation Research
- Published
- 2004-03-05
- Volume
- 94
- Issue
- 4
- Pages
- 414-417
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2164531124
- Cited by
- 170
- References
- 32
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 9
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Keywords
- S-nitrosothiols, blood, nitric oxide, nitrosation, hemoglobin, nitrite
- MeSH terms
- Forecasting, Hemoglobins, Humans, Models, Biological, Nitric Oxide, Nitroso Compounds, Oxidation-Reduction, Oxygen, Reference Standards, Serum Albumin, Bovine, Sulfhydryl Compounds, Superoxides, Vasodilation, S-Nitrosoglutathione
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