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S -Nitrosothiols in the Blood: Roles, Amounts, and Methods of Analysis
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“Of note, since the endogenous RSNO levels are low (e.g., 1–10 µmol/L for SNO-albumin),280 this approach requires consistent supply of infused RSNOs to provide continuous catalytic generation of NO at the flowing blood/polymer tubing interface.254”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [280]
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Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
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Self-citationNitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238
Self-citationEndogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.
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Self-citationExport by red blood cells of nitric oxide bioactivity
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Self-citationS-nitrosylation in health and disease
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Self-citationEssential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock
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Protein S-nitrosylation: Purview and parameters
Hess, D. T., Matsumoto, A., Kim, S.-O., Marshall, H. E., & Stamler, J. S. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1569 · Cited by 2,153
“Protein S -nitrosothiol: turnover and homeostasis Analysis of the S–N-bond dissociation energies of many RSNOs (where R is the organic moiety that bears the SNO) has shown that (unimolecular) homolytic decomposition (that is, the scission of the S–N bond to yield the NO• and thiyl radicals) is typically precluded, and…”
BackgroundSelf-citationHuman serum albumin: From bench to bedside
Fanali, G., di Masi, A., Trezza, V., Marino, M., Fasano, M., & Ascenzi, P. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.12.002 · Cited by 2,008
Methods to detect nitric oxide and its metabolites in biological samples
Bryan, N. S., & Grisham, M. B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.026 · Cited by 1,005
“However, it along with all methodologies has its limitations and remains a topic of intense discussion and controversy [77,89-92] specifically regarding its efficacy and specificity for detecting and quantifying RSNOs in hemoglobin and red cells.”
BackgroundTsikas, D. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.07.054 · Cited by 897
Vascular nitric oxide: Beyond eNOS
Zhao, Y., Vanhoutte, P. M., & Leung, S. W. S. (2015) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2015.09.002 · Cited by 875
Scientific and Medical Aspects of Ozone Therapy. State of the Art
Bocci, V. A. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.08.006 · Cited by 676
“It is known that the release of NO and S-nitrosothiols represents the physiological mechanism for vasodilation (51,52) and contrasts the release of the anion superoxide, which causes vasoconstriction and deploys negative influences on platelets and endothelial cells.”
BackgroundSingel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481
Self-citationTaubert, D., Roesen, R., Lehmann, C., Jung, N., & Schömig, E. (2007) · JAMA · doi:10.1001/jama.298.1.49 · Cited by 476
Cocoa and Cardiovascular Health
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The ozone paradox: Ozone is a strong oxidant as well as a medical drug
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“These S-nitrosothiols possess NO-like effects, such as vasodilatation and platelet inhibition (29), but have half-lives in hours (9) and have the physiologic benefit of being resistant to superoxide, unlike free NO (30).”
BackgroundOettl, K., & Stauber, R. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707251 · Cited by 359
“…that the level in healthy humans is in the nanomolar range (Marley et al., 2001; Tsikas and Frölich, 2002; Tsikas et al., 2002; Ng et al., 2004; Stamler, 2004; Zhang and Hogg, 2005), while under pathological conditions, micromolar concentrations of SNO-alb may occur (Ottesen et al., 2001;…”
BackgroundDetection of protein S-nitrosylation with the biotin-switch technique
Forrester, M. T., Foster, M. W., Benhar, M., & Stamler, J. S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.034 · Cited by 302
“Although this method has been applied successfully in a number of cases—including S-nitrosylated hemoglobin [51–53], caspase-3 [11,54], thioredoxin-1 [55], c-Jun N-terminal kinase [56], G-protein-coupled receptor kinase 2 [5], ryanodine receptor [57,58] and prokaryotic OxyR [59]—the arduous nature of the approach has…”
Self-citationS-Nitrosothiols: cellular formation and transport
Zhang, Y., & Hogg, N. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.016 · Cited by 257
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Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence
MacArthur, P. H., Shiva, S., & Gladwin, M. T. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.12.012 · Cited by 235
Nitric oxide-releasing vehicles for biomedical applications
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Potential Oxidative Stress of Gold Nanoparticles by Induced-NO Releasing in Serum
Jia, H., Liu, Y., Zhang, X. J., Han, L., Du, L. B., Tian, Q., & Xu, Y. C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja808033w · Cited by 228
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans
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Hydrogen sulfide and nitric oxide interactions in inflammation
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“production of peroxynitrite (ONOO) by reaction with the superoxide radical anion (O2 ̇ ) (32); 3) reactive nitrogen species (RNS)-mediated post-translational modification of cysteine thiols to yield S-nitrosothiols (33-38).”
BackgroundInfluentialHemoglobin conformation couples erythrocyte S -nitrosothiol content to O 2 gradients
Doctor, A., Platt, R., Sheram, M. L., Eischeid, A. C., McMahon, T., Maxey, T., Doherty, J., Axelrod, M. J., Kline, J. M., Gurka, M. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407490102 · Cited by 206
New Insights into Protein S-Nitrosylation
Foster, M. W., & Stamler, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313853200 · Cited by 177
Self-citationHemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation
Allen, B. W., Stamler, J. S., & Piantadosi, C. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.08.002 · Cited by 165
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
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“Circulating S-nitros(yl)ated proteins are able to convey nitric oxide-like bioactivity in an endocrine fashion.(28) Nitric oxide can initiate cellular signaling through activation of soluble guanylate cyclase after a secondary increase in cyclic guanosine monophosphate formation.”
BackgroundHydrogen sulfide and nitric oxide interactions in inflammation
Whiteman, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.021 · Cited by 141
Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology
Premont, R. T., Reynolds, J. D. H., Zhang, R., & Stamler, J. S. (2019) · Circulation Research · doi:10.1161/circresaha.119.315626 · Cited by 149
Self-citationTsikas, D. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.04.018 · Cited by 135
Nitrite is an alternative source of NO in vivo
Tsuchiya, K., Kanematsu, Y., Yoshizumi, M., Ohnishi, H., Kirima, K., Izawa, Y., Shikishima, M., Ishida, T., Kondo, S., Kagami, S., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2004 · Cited by 127
“(55) and Stamler (82) proposed that HbNO transfers NO to cysteine 93 to form S-nitrosohemoglobin, which in turn interacts with physiologically relevant millimolar concentrations of GSH to transfer the NO from erythrocytes (23) or with cysteine thiols in the cytoplasmic domain of membrane-associated band 3 protein (AE1…”
BackgroundOxidative stress following exposure to silver and gold nanoparticles in mice
Shrivastava, R., Kushwaha, P. K., Bhutia, Y. C., & Flora, S. J. S. (2014) · Toxicology and Industrial Health · doi:10.1177/0748233714562623 · Cited by 125
“These reactions trigger cellular responses ranging from subtle modulations of cell signaling to overwhelming oxidative injury, committing cells to necrosis or apoptosis (Stamler, 2004; Yang et al., 2006; De-silva et al., 2004).”
BackgroundResultS-Nitrosothiol-Modified Dendrimers as Nitric Oxide Delivery Vehicles
Stasko, N. A., Fischer, T. H., & Schoenfisch, M. H. (2008) · Biomacromolecules · doi:10.1021/bm7011746 · Cited by 123
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“These findings proposed that anaesthetic binding to HSA may change by the nitric oxide and support the fact that anaesthetic-like noncovalent bonding to proteins results from a few physiological effects of nitric oxide (Ascenzi et al., 2001; Sampath et al., 2001; Stamler, 2004).”
BackgroundHemoglobin-Mediated, Hypoxia-Induced Vasodilation via Nitric Oxide
Robinson, J. M., & Lancaster, J. R. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f292 · Cited by 104
Assessment of nitric oxide signals by triiodide chemiluminescence
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“In large part, these differences can be traced to a lack of sensitivity and specificity in certain techniques when applied to biological molecules and matrices (6, 12, 19, 28).”
BackgroundNagababu, E., Ramasamy, S., & Rifkind, J. M. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.012 · Cited by 86
Effect of Processing and Storage on Red Blood Cell Function In Vivo
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Measurement of Nitric Oxide Levels in the Red Cell
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Detection of Human Red Blood Cell-bound Nitric Oxide
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Nitric oxide metabolism in asthma pathophysiology
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“On the other hand, NO also may be exchanged between transition metal ion and thiols in proteins [136,137].”
BackgroundNitric Oxide Transport in Blood: A Third Gas in the Respiratory Cycle
Doctor, A., & Stamler, J. S. (2011) · Comprehensive physiology · doi:10.1002/cphy.c090009 · Cited by 78
Self-citationNeufeld, M. J., Lutzke, A., Tapia, J. B., & Reynolds, M. M. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b14937 · Cited by 74
Sonveaux, P., Lobysheva, I. I., Féron, O., & McMahon, T. J. (2007) · Physiology · doi:10.1152/physiol.00042.2006 · Cited by 71
“Incorrect conclusions have thus been drawn from experiments using these promiscuous probes (40, 41, 148, 163).”
BackgroundAlbumin is an interface between blood plasma and cell membrane, and not just a sponge
van de Wouw, J., & Joles, J. A. (2021) · Clinical Kidney Journal · doi:10.1093/ckj/sfab194 · Cited by 80
“as the single free cysteine, Cys-34, is particularly capable of binding NO as an SNO adduct [60, 61, 64].”
BackgroundWater-Soluble Triarylphosphines as Biomarkers for Protein S-Nitrosation
Bechtold, E., Reisz, J. A., Klomsiri, C., Tsang, A. W., Wright, M. W., Poole, L. B., Furdui, C. M., & King, S. B. (2010) · ACS Chemical Biology · doi:10.1021/cb900302u · Cited by 67
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Nitric oxide and blood: a review
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“Opposing views on this unresolved debate can be found in two recent editorials (Gladwin & Schechter, 2004; Stamler, 2004).”
BackgroundChoudhry, S., Que, L. G., Yang, Z., Liu, L., Eng, C. S., Kim, S. O., Kumar, G., Thyne, S. M., Chapela, R., Rodríguez‐Santana, J., et al. (2010) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328337f992 · Cited by 63
Self-citationRegulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation
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“These data also highlight the potential role of AE-1 activity and circulating nitrite levels in determining RBC SNO concentrations, an area of considerable recent interest (12, 21, 49, 57).”
BackgroundHwang, S., Cha, W., & Meyerhoff, M. E. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503588 · Cited by 60
Role of the Red Blood Cell in Nitric Oxide Homeostasis and Hypoxic Vasodilation
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“This paradigm was later extended by the Stamler group to S-nitrosated KHPRJORELQ��612�+E��������:KLOH� WKLV�oHOG�LV�H[WUHPHO\�FRQWURYH UVLDO��ODUJHO\�VHFRQGDU\� to major questions about the concentrations and importance of SNO-albumin and SNO-he-PRJORELQ�LQ�WKH�KXPDQ�FLUFXODWLRQ��UHSRUWHG�YDOXHV�UDQJH�IURP�D with more…”
Miller, W. H., Brosnan, M. J., Graham, D., Nicol, C. G., Morecroft, I., Channon, K. M., Danilov, S. M., Reynolds, P. N., Baker, A. H., & Dominiczak, A. F. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.02.025 · Cited by 59
“These factors have recently been the subject of detailed reviews, with a common conclusion that most of the currently used methods are inappropriate for use with complex biological samples [45,46].”
BackgroundOxygen-Ozone Therapy in Medicine: An Update
Bocci, V. A., & Paolo, N. D. (2009) · Blood Purification · doi:10.1159/000236365 · Cited by 60
“As a consequence, a patient with chronic limb ischemia undergoing ozone therapy can have clinical improvement due to the formation of successive cohorts of erythrocytes progressively becoming more capable of delivering oxygen to the ischemic tissues. However, the final improvement is also due to the localized release…”
BackgroundAccelerating in Situ Endothelialisation of Cardiovascular Bypass Grafts
Goh, E. T., Wong, E., Farhatnia, Y., Tan, A., & Seifalian, A. M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010597 · Cited by 55
“The supply of NO is thus from endogenous sources and potentially unlimited [157].”
BackgroundElectron Paramagnetic Resonance Analysis of Nitrosylhemoglobin in Humans during NO Inhalation
Piknova, B., Gladwin, M. T., Schechter, A. N., & Hogg, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506292200 · Cited by 52
Nitric Oxide and the Cardiovascular System
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A Three‐Coordinate Copper(II) Amide from Reductive Cleavage of a Nitrosamine
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“The detection of S-nitrosylated proteins in cells and tissues has involved a multitude of approaches and is the subject of intense debate (see [ 16 ]), due to inherent problems with available assays to measure and quantitate S-nitrosylated proteins.”
BackgroundInfluentialSonnenschein, K., de GROOT, H., & Kirsch, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405987200 · Cited by 47
Delivery of Antioxidant and Anti-inflammatory Agents for Tissue Engineered Vascular Grafts
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“The use of SNOs was likely inspired by the native SNOs found in the body that provide a reservoir of NO (Stamler, 2004).”
BackgroundAlternate and Additional Functions of Erythrocyte Hemoglobin
Kosmachevskaya, O. V., & Topunov, A. F. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918120155 · Cited by 51
Role of Circulating S -Nitrosothiols in Control of Blood Pressure
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Self-citationTsikas, D., Schmidt, M., Böhmer, A., Zoerner, A. A., Gutzki, F., & Jordan, J. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.01.023 · Cited by 47
Nitric oxide: To be or not to be an endocrine hormone?
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The role of globins in cardiovascular physiology
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Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols
Cardenas, A. J. P., Abelman, R. A., & Warren, T. H. (2013) · Chemical Communications · doi:10.1039/c3cc46102e · Cited by 36
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Vibrational Signatures of S -Nitrosoglutathione as Gaseous, Protonated Species
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A Copper(II) Thiolate from Reductive Cleavage of an S-Nitrosothiol
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Dark chocolate: consumption for pleasure or therapy?
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“The unstable nitric oxide reacts with thiol groups to form stable S-nitrosothiols [47] that have been suggested to contribute to BP regulation [48].”
BackgroundAmperometric S-nitrosothiol sensor with enhanced sensitivity based on organoselenium catalysts
Cha, W., Anderson, M. R., Zhang, F., & Meyerhoff, M. E. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2008.12.022 · Cited by 29
“%) of RSNOs in plasma (Jourd’heuil et al. 2000; Stamler 2004).”
BackgroundTsikas, D., Dehnert, S., Urban, K., Surdacki, A., & Meyer, H. H. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.06.032 · Cited by 29
Novel Method for Measuring S-Nitrosothiols Using Hydrogen Sulfide
Teng, X., Isbell, T. S., Crawford, J. H., Bosworth, C. A., Giles, G. I., Koenitzer, J. R., Lancaster, J. R., Doeller, J. E., Kraus, D. W., & Patel, R. P. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)01209-3 · Cited by 28
“It has been argued that methods evaluating RSNO concentrations should be performed at physiological pH to ensure that the protein bearing RSNO is in its native conformation, as protein denaturation may alter RSNO reactivity and stability, hence concentration detected (Stamler, 2004).”
BackgroundMethodLi, X., Shen, F., Wang, K., Lin, S., Zhou, L., Chen, S., Wang, J., & Huang, N. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01976b · Cited by 28
Lu, J., Shi, T., Shi, C., Chen, F., Yang, C., Xie, X., Wang, Z., Shen, H., Xu, J., Leong, K. W., et al. (2023) · Research · doi:10.34133/research.0204 · Cited by 27
Determination of S-nitrosoglutathione in plasma: Comparison of two methods
Bramanti, E., Angeli, V. W., Mester, Z., Alfonso Pompella, C., Paolicchi, A., & D’Ulivo, A. (2010) · Talanta · doi:10.1016/j.talanta.2010.02.024 · Cited by 28
Sandmann, J., Schwedhelm, K. S., & Tsikas, D. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.06.040 · Cited by 26
“important controversy over the mechanisms by which erythrocytic SNOHb releases NO [2,9].”
BackgroundA kinetic study of gamma-glutamyltransferase (GGT)-mediated S-nitrosoglutathione catabolism
Angeli, V. W., Tacito, A., Paolicchi, A., Barsacchi, R., Franzini, M., Baldassini, R., Vecoli, C., Alfonso Pompella, C., & Bramanti, E. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.10.027 · Cited by 26
Routes for Formation of S-Nitrosothiols in Blood
Nagababu, E., & Rifkind, J. M. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9321-2 · Cited by 25
“the photolysis chemiluminescence method in plasma of healthy humans primarily as S-nitrosoalbumin (albSNO), which can serve as a reservoir of NO for physiological functions [35, 36].”
MethodWang, Q., Akhavan, B., Jing, F., Cheng, D., Sun, H. L., Xie, D., Leng, Y. X., Bilek, M., & Huang, N. (2018) · Advanced Materials Interfaces · doi:10.1002/admi.201701487 · Cited by 24
Darder, M., Karan, A., del Real, G., & DeCoster, M. A. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110369 · Cited by 24
Fioramonti, X., Deák, Á., Deshpande, S., Carneiro, L., Zhou, C., Sayed, N., Orban, B., Berlin, J. R., Pénicaud, L., Leloup, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068709 · Cited by 26
“S-nitrosylation is a non-enzymatic reaction consisting of the covalent attachment of a NO moiety to the thiol side chain of cysteine to form SNO adducts, altering the properties of proteins/enzymes [15,25].”
BackgroundInfluentialHuang, B., Liao, C. L., Lin, Y.-P., Chen, S. C., & Wang, D. L. (2009) · Journal of Proteome Research · doi:10.1021/pr9005662 · Cited by 22
S‐nitrosothiols as selective antithrombotic agents – possible mechanisms
Gordge, M. P., & Xiao, F. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00670.x · Cited by 22
“Circulating RSNO concentrations are a matter of dispute, largely through differences in methodology (Stamler, 2004); however, most reports put them in the low nanomolar range.”
BackgroundNO metabolite flux across the human coronary circulation
Rogers, S. C., Khalatbari, A., Datta, B. N., Ellery, S. M., PAUL, V., Frenneaux, M. P., & JAMES, P. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.019 · Cited by 22
“We recognise that actualmetabolitelevelsarenottheprimaryconcern[4, 7 ]given thatonlya verysmall amountofNOrelated moietyisrequired to induce vasodilatation via activation of soluble guanylyl cyclase (∼20 nM) [8] .A –V gradients in NO metabolites also tell us little about the physiological relevance of individual metab…”
BackgroundS‐Nitrosothiol Chemistry at the Single‐Molecule Level
Choi, L., & Bayley, H. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201202365 · Cited by 21
The Clinical Application of Ozonetherapy
Bocci, V. A. (2010) · Springer eBooks · doi:10.1007/978-90-481-9234-2_9 · Cited by 24
“…for vasodilation (Barnes and Liew, 1995; Warren and Higenbottam, 1996; Jindal and Dellinger, 2000; Zhang and Hogg, 2004; Gladwin et al., 1999; 2004; Stamler, 2004) and contrasts the release of the anion superoxide, which causes vasoconstriction and deploys negative influences on platelets and…”
BackgroundS-nitroso-albumin carries a thiol-labile pool of nitric oxide, which causes venodilation in the rat
Orie, N. N., Vallance, P. J., Jones, D. P., & Moore, K. P. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01014.2004 · Cited by 22
“Despite this, publications are still emerging that challenge the findings of numerous investigators, without an equally rigorous validation of the assays under contention (5, 29).”
BackgroundDetecting physiologic fluctuations in the S-nitrosohemoglobin micropopulation: triiodide versus 3C
Doctor, A., & Gaston, B. M. (2006) · Blood · doi:10.1182/blood-2006-05-026047 · Cited by 20
Warnecke, A., Lueßen, P., Sandmann, J., Ikic, M., Rossa, S., Gutzki, F., Stichtenoth, D. O., & Tsikas, D. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.11.035 · Cited by 20
Rogers, N. M., Zammit, N. W., Nguyen-Ngo, D., Souilmi, Y., Minhas, N., Meijles, D. N., Self, E., Walters, S. N., Warren, J. A., Cultrone, D., et al. (2023) · Kidney International · doi:10.1016/j.kint.2023.02.030 · Cited by 19
Goździk, W., Albert, J., Harbut, P., Zieliński, S., Ryniak, S., Lindwall, R., Dzięgiel, P., Podhorska‐Okołów, M., Kübler, A., & FROSTELL, C. G. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01908.x · Cited by 19
“It has been shown previously that NO can form adducts with amino acids containing sulphur, forming thiols (Stamler et al. 2001, Stamler 2004).”
BackgroundYapor, J. P., Lutzke, A., Pegalajar-Jurado, A., Neufeld, B. H., Damodaran, V. B., & Reynolds, M. M. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01625h · Cited by 18
Karmakar, S., Patra, S., Halder, R., Karmakar, S., & Majumdar, A. (2024) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.4c03555 · Cited by 20
S-Nitrosoglutathione Acts as a Small Molecule Modulator of Human Fibrin Clot Architecture
Bateman, R. M., Ellis, C. G., Suematsu, M., & Walley, K. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043660 · Cited by 18
“Possible local sources of GSNO within blood clots are red blood cells, which release S-nitrosothiols in response to hypoxic gradients [19,40,41] platelet derived nitric oxide [42] and S-nitrosylated-albumin [43] which could both transnitrosate [44] plasma glutathione forming GSNO.”
BackgroundAtta, S., Mandal, A., Saha, R., & Majumdar, A. (2023) · Dalton Transactions · doi:10.1039/d3dt03768a · Cited by 18
Metadata
- Authors
- Stamler, J. S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Stamler, Jonathan S.
- ORCID
- Stamler, Jonathan S.
- Venue
- Circulation Research
- Published
- 2004-03-05
- Volume
- 94
- Issue
- 4
- Pages
- 414-417
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2164531124
- Cited by
- 170
- References
- 32
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 9
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Keywords
- S-nitrosothiols, blood, nitric oxide, nitrosation, hemoglobin, nitrite
- MeSH terms
- Forecasting, Hemoglobins, Humans, Models, Biological, Nitric Oxide, Nitroso Compounds, Oxidation-Reduction, Oxygen, Reference Standards, Serum Albumin, Bovine, Sulfhydryl Compounds, Superoxides, Vasodilation, S-Nitrosoglutathione
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