The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Adherent Platelets Recruit and Induce Differentiation of Murine Embryonic Endothelial Progenitor Cells to Mature Endothelial Cells In Vitro
Open accessAbstract
The homing and differentiation mechanisms of endothelial progenitor cells (EPCs) at sites of vascular lesions are unclear. To investigate whether platelets play a role in the recruitment and differentiation of EPCs, we made use of a robust mouse embryonic EPC (eEPC) line that reliably differentiates to a mature endothelial phenotype. We found that platelets stimulate chemotaxis and migration of these murine eEPCs. Further, the substantial adhesion of murine eEPCs on immobilized platelets that occurs under dynamic flow conditions is inhibited by neutralizing anti–P-selectin glycoprotein ligand-1 and anti–VLA-4 (β 1 -integrin) monoclonal antibodies but not by anti-CD11b (a M -integrin; macrophage antigen-1). Coincubation of murine eEPCs with platelets for 5 days induced differentiation of EPCs to mature endothelial cells as verified by positive von Willebrand factor immunofluorescence and detection of Weibel Palade bodies through electron microscopy. We conclude that platelets may play a critical part in the capture and subsequent differentiation of murine eEPCs at sites of vascular lesions, revealing a possible new role of platelets in neoendothelization after vascular injury.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
Hill, J. M., Zalos, G., Halcox, J. P. J., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A., & Finkel, T. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022287 · Cited by 3,423
Cited by
Yang, J., Chen, Z., Pan, D., Li, H., & Shen, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s249129 · Cited by 522
Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications
Silvestre, J.-S., Smadja, D. M., & Lévy, B. I. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2013 · Cited by 255
Feng, W., Madajka, M., Kerr, B. A., Mahabeleshwar, G. H., Whiteheart, S. W., & Byzova, T. V. (2011) · Blood · doi:10.1182/blood-2010-08-304808 · Cited by 133
Platelets: The missing link between the blood and brain?
Leiter, O., & Walker, T. L. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101695 · Cited by 103
Metadata
- Authors
- Langer, H., May, A. E., Daub, K., Heinzmann, U., Lang, P., Schumm, M., Vestweber, D., Massberg, S., Schönberger, T., Pfisterer, I., Hatzopoulos, A. K., & Gawaz, M.
- Venue
- Circulation Research
- Published
- 2006-02-03
- Volume
- 98
- Issue
- 2
- Pages
- e2-10
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2121263655
- Cited by
- 187
- References
- 2
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Langer, H., May, A. E., Daub, K., Heinzmann, U., Lang, P., Schumm, M., Vestweber, D., Massberg, S., Schönberger, T., Pfisterer, I., Hatzopoulos, A. K., & Gawaz, M. (2006). Adherent Platelets Recruit and Induce Differentiation of Murine Embryonic Endothelial Progenitor Cells to Mature Endothelial Cells In Vitro. Circulation Research. https://doi.org/10.1161/01.res.0000201285.87524.9e
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