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Cited by 103Platelet Disorders and TreatmentsExtracellular vesicles in diseaseNeuroinflammation and Neurodegeneration Mechanisms

Platelets: The missing link between the blood and brain?

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Leiter, Odette, Walker, Tara L.·2019·Progress in Neurobiology
DOI 10.1016/j.pneurobio.2019.101695
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Abstract

It is becoming increasingly clear that interactions between the peripheral immune system and the central nervous system are important in maintaining healthy brain function. Platelets are small blood cells traditionally known for their role in wound healing. However, platelets have recently been shown to exhibit many alternative functions. In this perspective, we summarize the repertoire of platelet functions, focusing on how these cells contribute to the maintenance of brain homeostasis and propose the mechanisms via which they could communicate with brain cells, including exosome and microparticle release and receptor interactions at local sites. In particular, we highlight the potential role that platelets play in maintaining brain plasticity via the modulation of new neuron generation from neural precursor cells, an interaction which could have important implications in the development of therapeutic interventions to promote cognitive function in aging and disease.

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Cited by

Sorted by citations

Authors
Leiter, O., & Walker, T. L.
Affiliations
The University of Queensland (AU)
Corresponding author
Walker, Tara L.
ORCID
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2019-12
Volume
183
Pages
101695
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/j.pneurobio.2019.101695
OpenAlex
W2973587148
Cited by
103
References
11
Citations by year
2026: 14 · 2025: 20 · 2024: 23 · 2023: 11 · 2022: 10 · 2021: 17 · 2020: 7 · 2019: 1
FWCI
1.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • German Academic Exchange Service
  • Brazil Family Program for Neurology, Australia
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
platelets, platelet function, brain homeostasis, peripheral immune system, central nervous system, exosomes, microparticles, neuroplasticity, neural progenitor cells, neurogenesis, cognitive function, aging, neurodegenerative diseases
MeSH terms
Animals, Blood Platelets, Brain, Cell Communication, Humans, Neuronal Plasticity, Neurogenesis

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