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A Sensitive Double-Isotope Derivative Assay for Norepinephrine and Epinephrine: NORMAL RESTING HUMAN PLASMA LEVELS
Open accessAbstract
A sensitive and specific double-isotope dilution method for assaying norepinephrine and epinephrine separately is described. The method is based on enzymatic conversion of these two catecholamines to their respective metanephrines and was applied successfully to measurement of resting plasma concentrations of norepinephrine and epinephrine in normal subjects with the finding that norepinephrine (0.20 ± 0.08 µg/liter) normally constitutes approximately 80% of the plasma catecholamine content and epinephrine (0.05 ± 0.03 µg/liter) 20%.
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Citations
Cited by
Pheochromocytoma: Diagnosis, Localization and Management
Bravo, E. L., & Gifford, R. W. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411153112007 · Cited by 471
Circulating catecholamine levels in human and experimental hypertension.
de Champlain, J., Farley, L., Cousineau, D., & van Ameringen, M. R. (1976) · Circulation Research · doi:10.1161/01.res.38.2.109 · Cited by 355
Alexander, R. W., Gill, J. R., Yamabe, H., Lovenberg, W., & Keiser, H. R. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107743 · Cited by 276
Christensen, N. J., Alberti, K. G. M. M., & Brandsborg, O. (1975) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1975.tb00473.x · Cited by 97
Plasma and Urinary Dopamine: Studies During Fasting and Exercise and in Tetraplegic Man
Christensen, N. J., Mathias, C. J., & Frankel, H. L. (1976) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1976.tb00535.x · Cited by 45
Metadata
- Authors
- ENGELMAN, K., PORTNOY, B., & HURLEY, N.
- Venue
- Circulation Research
- Published
- 1970-01
- Volume
- 26
- Issue
- 1
- Pages
- 53-57
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2164788882
- Cited by
- 267
- References
- 0
- FWCI
- 39.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- ENGELMAN, K., PORTNOY, B., & HURLEY, N. (1970). A Sensitive Double-Isotope Derivative Assay for Norepinephrine and Epinephrine: NORMAL RESTING HUMAN PLASMA LEVELS. Circulation Research. https://doi.org/10.1161/01.res.26.1.53
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
