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Cited by 41Blood Pressure and Hypertension StudiesBlood properties and coagulationPregnancy and preeclampsia studies

Increased metabolic turnover rate and transcapillary escape rate of albumin in essential hypertension

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PARVING, HANS-HENRIK, ROSSING, NIELS, JENSEN, HENRIK AE.·1974·Circulation Research
DOI 10.1161/01.res.35.4.544
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Abstract

The metabolic turnover rate and the transcapillary escape rate of albumin were studied using 131 I-labeled human albumin in nine untreated subjects suffering from essential hypertension. The average mean arterial blood pressure of these subjects was 162/109 mm Hg; seven subjects had grade I-II funduscopic changes. Plasma albumin concentration was normal, but plasma volume was reduced ( P < 0.05) in these subjects. Thus, the previously reported moderate decrease in the intravascular albumin mass of hypertensive subjects was confirmed; the average value for intravascular albumin mass in the present study was 62.8 g/m2 surface area compared with a normal value of 70.6 g/m 2 (-11%, P < 0.05). A surprising finding was a marked enhancement of albumin metabolic rate in essential hypertension. The fraction of intravascular albumin mass metabolized per 24-hour period was on the average 14.4% compared with a normal value of 8.4% (+72%, P < 0.001). The rate of synthesis was 9.1 g/24 hours m -2 compared with a normal value of 5.9 g/24 hours m -2 (+54%, P < 0.001). Total body albumin mass was decreased proportionally to intravascular albumin mass. Confirming a previous observation, we found an increase in the transcapillary escape rate of albumin (fraction of intravascular mass passing to the extravascular space per unit time) from a normal average of 5.6%/hour to 7.5%/hour (+34%, P < 0.001). There was a statistically significant positive correlation between the transcapillary escape rate of albumin and blood pressure ( P < 0.05). These findings can best be explained by increased filtration due to the high arterial blood pressure. There was also a positive correlation between the transcapillary escape rate and the fractional catabolic rate of albumin ( P < 0.05). This finding supports the concept that albumin is catabolized in connection with its permeation through the capillary endothelium.

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  • The half-life of albumin is shortened in some disease states, decreasing total albumin mass.

    “The half‐life of albumin has been shown to shorten, decreasing total albumin mass.”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [65]

    The Results and Table 2 (page not supplied) show faster albumin turnover and lower total albumin mass in subjects with essential hypertension than in controls, consistent with a shorter albumin half-life in this disease state. The paper does not establish that the shorter half-life caused the lower total mass; it also reports increased synthesis and describes the subjects as metabolically steady. (LLM, conf=0.86)

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  • In most disease states in which synthesis rates have been measured, fractional synthesis rate in plasma is normal or mildly increased.

    “However, in most disease states in which synthesis rates have been measured, fractional synthesis rate (FSR) in plasma has been reported to be normal or mildly increased (Table 1).63, 64, 65, 66, 67, 68, 69, 70, 71”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [65]

    The discussion (page unavailable) says that under most conditions involving hypoalbuminemia from increased albumin catabolism or plasma protein loss, the synthesis rate rises only moderately or not at all. That supports a narrower version of the claim, but not its generalization to most disease states or its specific reference to fractional synthesis rate in plasma. The Results (page unavailable) report a 54% increase in synthesis rate in the paper’s hypertensive subjects. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Turnover time of serum albumin has been found to be shortened in hypertension, acromegaly, nephrotic syndrome, and protein-losing enteropathy.

    “This has been rarely measured, but turnover time has been found to be shortened in hypertension, acromegaly, nephrotic syndrome, and protein‐losing enteropathy.65, 74, 75, 76”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [65]

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Cites

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Research works printed but not linked: 7

  1. PARVING H-H, ROSSING N, NIELSEN SL, LASSEN NA: In- creased transcapillary escape rate of albumin, IgG and IgM after acute plasma volume expansion in man. Am J Physiol, in press 5. Documenta Geigy. Wissenschaftliche Tabellen, 6th ed. Folia Medica Geigy 2, J. R. Geigy, Basel, 1960
  2. ROSSINC N: Normal metabolism of '"I-labelled albumin. Clin Sci 33:593-602, 1967 Circulation Research, Vol. 35, October 1974
  3. NOSSLIN B: Metabolism of Human Gamma Globulin, edited by SB Andersen. Oxford, Blackwell Scientific Publica- tions, 1964, pp 115-120
  4. ANDERSEN SB, ROSSING N: Metabolism of albumin and 7G in man during albumin infusions and during plasma- phoresis. In Physiology and Pathophysiology of Protein Metabolism. New York, Pergamon Press, 1969, pp 135-143
  5. ROSSING N: Physiology and Pathophysiology of Plasma Protein Metabolism. New York, Pergamon Press, 1969, pp 19-26
  6. MCFARLANE AS: Physiology and Pathophysiology of Plasma Protein Metabolism. New York, Pergamon Press, 1969, p 87
  7. PARVING H-H, NIELSEN SL, LASSEN NA: Increased trans- capillary escape rate of albumin, IgG and IgM during angiotensin II induced in man. Scand J Clin Lab Invest, in press

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Authors
PARVING, H.-H., ROSSING, N., & JENSEN, H. A.
Affiliations
  • Bispebjerg Hospital (DK)
  • Department of Clinical Physiology, Bispebjerg Hospital, and Medical Department C, Diakonissestiftelsen Copenhagen, Denmark
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1974-10
Volume
35
Issue
4
Pages
544-552
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.35.4.544
OpenAlex
W2014894774
Cited by
41
References
24
Citations by year
2021: 1 · 2018: 2 · 2016: 2 · 2012: 1
FWCI
5.23
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
essential hypertension, albumin, transcapillary escape rate, albumin synthesis, fractional catabolic rate, plasma volume, capillary filtration, blood pressure
MeSH terms
Body Height, Body Surface Area, Body Weight, Capillary Permeability, Female, Humans, Hypertension, Male, Plasma Volume, Serum Albumin, Radio-Iodinated

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