Metabolism and transcapillary escape rate of albumin in acromegaly
Abstract
Albumin metabolism was studied with 131 I-labeled albumin in 6 patients with acromegaly and raised plasma levels of growth hormone. The objective was to see whether the rate of albumin synthesis was increased, as animal experiments may suggest. The fractional catabolic rate of albumin (i.e. fraction of intravascular albumin mass catabolized per unit time) was increased by 64 % (form 8.5 to 13.8 % per 24 h), and the rate of synthesis must have been increased to the same extent, since the intravascular albumin mass was quite normal. Plasma albumin concentration and the intravascular and total masses were normal. The transcapillary escape rate, i.e. the fraction of the intravascular mass passing extravascularly per unit time, was increased on an average 40% above normal levels. It is concluded that growth hormone acts primarily by increasing albumin production.
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Turnover time of serum albumin has been found to be shortened in hypertension, acromegaly, nephrotic syndrome, and protein-losing enteropathy.
“This has been rarely measured, but turnover time has been found to be shortened in hypertension, acromegaly, nephrotic syndrome, and protein‐losing enteropathy.65, 74, 75, 76”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [74]
The half-life of albumin is shortened in some disease states, decreasing total albumin mass.
“The half‐life of albumin has been shown to shorten, decreasing total albumin mass.”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [74]
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- Authors
- Rossing, N., Parving, H. H., & Korsgaard, O.
- Affiliations
- Bispebjerg Hospital (DK)
- Rigshospitalet (DK)
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1974-01
- Volume
- 33
- Issue
- 1
- Pages
- 39-44
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2004266110
- Cited by
- 12
- References
- 21
- Citations by year
- 2021: 1 · 2018: 1 · 2016: 1
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- acromegaly, albumin metabolism, transcapillary escape rate, fractional catabolic rate, albumin synthesis, growth hormone, serum albumin
- MeSH terms
- Acromegaly, Adult, Albumins, Capillary Permeability, Female, Glucose, Humans, Immunoelectrophoresis, Male, Middle Aged, Plasma Volume, Radioimmunoassay, Serum Albumin, Radio-Iodinated, Growth Hormone, Time Factors
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