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Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon.
Open accessAbstract
The effect of chronic renovascular hypertension on the autoregulation of cerebral blood flow was studied in anesthetized baboons. Cerebral blood flow was measured by the intracarotid 133Xe clearance method. Six baboons with renal hypertension of 8-12 weeks' duration were compared with six normotensive controls. The lower limit of autoregulation was determined following controlled hemorrhage. In the initially normotensive baboons, cerebral blood flow remained constant until mean arterial pressure had decreased to the range of 45-59 mm Hg. Thereafter, cerebral blood flow decreased with each further decrease in mean arterial pressure. In the chronically hypertensive baboons cerebral blood flow autoregulated until the mean arterial pressure had decreased to the range of 75-89 mm Hg. Therefore, the lower limit of autoregulation of cerebral blood flow was shifted to higher absolute levels of mean arterial pressure in baboons with chronic renovascular hypertension presumably due to adaptive changes in the cerebral circulation.
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Cited by
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
Claassen, J. A. H. R., Thijssen, D. H. J., Panerai, R. B., & Faraci, F. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00022.2020 · Cited by 915
Responses of cerebral arteries and arterioles to acute hypotension and hypertension
Kontos, H. A., Wei, E. P., Navari, R. M., Levasseur, J. E., Rosenblum, W. I., & Patterson, J. L. (1978) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1978.234.4.h371 · Cited by 699
Toth, P., Tarantini, S., Csiszar, A., & Ungvari, Z. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00581.2016 · Cited by 522
Neurovascular and Cognitive Dysfunction in Hypertension: Epidemiology, Pathobiology, and Treatment
Iadecola, C., & Gottesman, R. F. (2019) · Circulation Research · doi:10.1161/circresaha.118.313260 · Cited by 502
Factors involved in the physiological regulation of the cerebral circulation
Busija, D. W., & Heistad, D. D. (1984) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0027696 · Cited by 267
Metadata
- Authors
- Jones, J. V., Fitch, W., MacKenzie, E. T., Strandgaard, S., & Harper, A. M.
- Venue
- Circulation Research
- Published
- 1976-10
- Volume
- 39
- Issue
- 4
- Pages
- 555-557
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2098704952
- Cited by
- 162
- References
- 0
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jones, J. V., Fitch, W., MacKenzie, E. T., Strandgaard, S., & Harper, A. M. (1976). Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circulation Research. https://doi.org/10.1161/01.res.39.4.555
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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