The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Neurovascular and Cognitive Dysfunction in Hypertension: Epidemiology, Pathobiology, and Treatment
Open accessAbstract
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long known to be associated with dementia caused by vascular factors, hypertension has more recently been linked also to Alzheimer disease—the major cause of dementia in older people. Thus, although midlife hypertension is a risk factor for late-life dementia, hypertension may also promote the neurodegenerative pathology underlying Alzheimer disease. The mechanistic bases of these harmful effects remain to be established. Hypertension is well known to alter in the structure and function of cerebral blood vessels, but how these cerebrovascular effects lead to cognitive impairment and promote Alzheimer disease pathology is not well understood. Furthermore, critical questions also concern whether treatment of hypertension prevents cognitive impairment, the blood pressure threshold for treatment, and the antihypertensive agents to be used. Recent advances in neurovascular biology, epidemiology, brain imaging, and biomarker development have started to provide new insights into these critical issues. In this review, we will examine the progress made to date, and, after a critical evaluation of the evidence, we will highlight questions still outstanding and seek to provide a path forward for future studies.
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Cites
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Cited by
Hypertension-induced cognitive impairment: From pathophysiology to public health
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00430-6 · Cited by 544
Alzheimer’s Disease and Vascular Aging
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Hypertension is associated with reduced hippocampal connectivity and impaired memory
Feng, R., Rolls, E. T., Cheng, W., & Feng, J. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103082 · Cited by 49
Metadata
- Authors
- Iadecola, C., & Gottesman, R. F.
- Venue
- Circulation Research
- Published
- 2019-03-29
- Volume
- 124
- Issue
- 7
- Pages
- 1025-1044
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2942762932
- Cited by
- 502
- References
- 41
- FWCI
- 39.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Iadecola, C., & Gottesman, R. F. (2019). Neurovascular and Cognitive Dysfunction in Hypertension: Epidemiology, Pathobiology, and Treatment. Circulation Research. https://doi.org/10.1161/circresaha.118.313260
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
