The DOI matches its Crossref record.
Aortic endothelial cell replication. I. Effects of age and hypertension in the rat.
Abstract
The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the rate of replication rises 10-fold to an average value of 1.6%. This increase may represent an increase in turnover; however, it probably represent, at least in part, a proliferative response to cover the expanded luminal surface of the dilated vessel.
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Citations
Cited by
The Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,877
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818
Alexander, R. W. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.155 · Cited by 785
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T. A., Heyll, K., Noels, H., Hristov, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3487 · Cited by 630
Shimokawa, H., & Vanhoutte, P. M. (1989) · Circulation Research · doi:10.1161/01.res.64.5.900 · Cited by 353
Metadata
- Authors
- Schwartz, S. M., & Benditt, E. P.
- Venue
- Circulation Research
- Published
- 1977-08
- Volume
- 41
- Issue
- 2
- Pages
- 248-255
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2097933389
- Cited by
- 204
- References
- 0
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
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