The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Open accessAbstract
Atherosclerosis, a hyperlipidemia-induced chronic inflammatory process of the arterial wall, develops preferentially at sites where disturbed laminar flow compromises endothelial cell (EC) function. Here we show that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation. Endothelial recovery after denudation was impaired in Mir126−/− mice because lack of miR-126-5p, but not miR-126-3p, reduced EC proliferation by derepressing Dlk1. At nonpredilection sites, high miR-126-5p levels in endothelial cells confer a proliferative reserve that compensates for the antiproliferative effects of hyperlipidemia, such that atherosclerosis was exacerbated in Mir126−/− mice. In contrast, downregulation of miR-126-5p by disturbed flow abrogated EC proliferation at predilection sites in response to hyperlipidemic stress through upregulation of Dlk1 expression. Administration of miR-126-5p rescued EC proliferation at predilection sites and limited atherosclerosis, introducing a potential therapeutic approach.
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Cites
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Self-citationPhenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms
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The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
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Self-citationmiR-126 Regulates Angiogenic Signaling and Vascular Integrity
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Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
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Self-citationPlasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
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Circulating MicroRNAs in Patients With Coronary Artery Disease
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Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Liang, X., Zhang, L., Wang, S., Han, Q., & Zhao, R. C. (2016) · Journal of Cell Science · doi:10.1242/jcs.170373 · Cited by 554
Self-citationVascular endothelium – Gatekeeper of vessel health
Cahill, P. A., & Redmond, E. M. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.007 · Cited by 518
Targeting vascular (endothelial) dysfunction
Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13517 · Cited by 501
Biomechanical factors in atherosclerosis: mechanisms and clinical implications
Kwak, B. R., Bäck, M., Bochaton-Piallat, M.-L., Caligiuri, G., Daemen, M. J. A. P., Davies, P. F., Hoefer, I. E., Holvoet, P., Jo, H., Krams, R., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu353 · Cited by 502
Self-citation
Metadata
- Authors
- Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T. A., Heyll, K., Noels, H., Hristov, M., Wang, S., Kiessling, F., Olson, E. N., & Weber, C.
- Venue
- Nature Medicine
- Published
- 2014-03-02
- Volume
- 20
- Issue
- 4
- Pages
- 368-376
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2148937727
- Cited by
- 630
- References
- 50
- FWCI
- 19.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T. A., Heyll, K., Noels, H., Hristov, M., Wang, S., Kiessling, F., Olson, E. N., & Weber, C. (2014). MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nature Medicine. https://doi.org/10.1038/nm.3487
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