Relation between vasa recta blood flow and renal interstitial hydrostatic pressure during pressure natriuresis
Abstract
Pressure natriuresis may be mediated through increases in inner medullary vasa recta blood flow (QVR). By means of acute renal decapsulation to prevent increases in renal interstitial hydrostatic pressure (RIHP), the effect of increases in QVR in the presence and absence of changes in RIHP in the natriuretic and diuretic responses to increases in renal perfusion pressure (RPP) was evaluated. Blood flow in descending (QDVR) and ascending (QAVR) vasa recta was determined in the exposed papilla by fluorescence videomicroscopy in anesthetized euvolemic Munich Wistar rats. In rats with intact renal capsules (n = 12), increases in RPP from 101 +/- 0.5 to 132 +/- 2.9 mm Hg caused significant increases in QDVR (from 4.7 +/- 0.9 to 5.5 +/- 0.9 nl/min, p < 0.001) and QAVR (from 2.8 +/- 0.2 to 3.5 +/- 0.2 nl/min, p < 0.001) in association with increases in RIHP (from 4.6 +/- 1.3 to 7.6 +/- 1.3 mm Hg, p < 0.001), urine flow (from 16.2 +/- 2.6 to 20.2 +/- 3.2 microliters.min-1 x g kidney wt-1, p < 0.01), and urinary sodium excretion (from 2.10 +/- 0.38 to 3.36 +/- 0.62 mu eq.min-1 x g kidney wt-1, p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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RIHP is a function of peritubular capillary pressure, and particularly the vasa recta, according to Starling's law.
“RIHP is a function of peritubular capillary pressure, and particularly the vasa recta,36, 37 according to Starling's law.”
From A Quantitative Systems Physiology Model of Renal Function and Blood Pressure Regulation: Model Description (2017) · cites this paper as [36]
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- Authors
- Farrugia, E., Lockhart, J. C., & Larson, T. S.
- Affiliations
- Mayo Clinic (US)
- Venue
- Circulation Research
- Published
- 1992-11
- Volume
- 71
- Issue
- 5
- Pages
- 1153-1158
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2164676315
- Cited by
- 24
- References
- 14
- Citations by year
- 2023: 1 · 2022: 3 · 2021: 1 · 2018: 3 · 2017: 1 · 2015: 1 · 2012: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl014133-23)
- National Heart, Lung, and Blood Institute (HL 14133)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- pressure natriuresis, renal interstitial hydrostatic pressure, renal perfusion pressure, sodium excretion, urine flow, renal papilla, diuresis, renal medulla
- MeSH terms
- Animals, Arterioles, Blood Pressure, Extracellular Space, Hydrostatic Pressure, Kidney, Male, Natriuresis, Rats, Inbred Strains, Renal Circulation, Rats
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