Cited by 775Nitric Oxide and Endothelin EffectsAtherosclerosis and Cardiovascular DiseasesAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record.

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life

Yoshizumi, M, Perrella, M A, Burnett, J C, Lee, M E·1993·Circulation Research

DOI 10.1161/01.res.73.1.205

Open this paper in CoChat — free account

Abstract

Nitric oxide (NO), which accounts for the biological properties of endothelium-derived relaxing factor, is generated by NO synthase (NOS). The vascular endothelium contains two types of NOS: one is constitutively expressed (cNOS), and the other is inducible. Endothelium-mediated vasorelaxation is impaired in atherosclerotic vessels. To determine whether tumor necrosis factor (TNF)-alpha, which is commonly found in atherosclerotic lesions, has an effect on NOS message, we measured cNOS mRNA levels in TNF-treated human umbilical vein endothelial cells (HUVECs) by RNA blot analysis with a cNOS cDNA probe. TNF-alpha markedly reduced cNOS mRNA levels in HUVECs in a dose- and time-dependent manner. In response to 3 ng/mL TNF-alpha, cNOS mRNA levels began to decrease at 4 hours and diminished to only 5% of control levels at 24 hours. As little as 0.1 ng/mL TNF-alpha reduced cNOS mRNA levels by 50%. This reduction in cNOS message in response to TNF-alpha depended on protein synthesis as it was blocked by cycloheximide. In nuclear runoff experiments, TNF-alpha did not change the rate of cNOS gene transcription. cNOS mRNA is very stable under basal conditions, with a half-life of 48 hours; however, treatment with TNF-alpha shortened this half-life to 3 hours. TNF-alpha thus appears to decrease cNOS mRNA levels by increasing the rate of mRNA degradation. TNF-induced reductions in cNOS mRNA levels may have an important effect on impaired endothelium-mediated vasorelaxation in atherosclerosis.

Integrity signals

Registry

Crossref · 10.1161/01.res.73.1.205

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 401–500 of 775

Inflammation: A Link Between Hypertension and Atherosclerosis
Cachofeiro, V., Miana, M., Heras, N. D. L., Martín‐Fernández, B., Ballesteros, S., Balfagón, G., & Lahera, V. (2009) · Current Hypertension Reviews · doi:10.2174/157340209787314333 · Cited by 38
Induction of Endothelial Nitric Oxide Synthase Expression by IL-17 in Human Vascular Endothelial Cells: Implications for Vascular Remodeling in Transplant Vasculopathy
Liu, A. C., Lee, M. W., McManus, B. M., & Choy, J. C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102527 · Cited by 36
Self-citation
The Link Between Unpredictable Chronic Mild Stress Model for Depression and Vascular Inflammation?
ŞAHİN, T. D., Utkan, T., Karson, A., Yazır, Y., Bayramgürler, D., & Gacar, N. (2014) · Inflammation · doi:10.1007/s10753-014-9867-4 · Cited by 36
“On the other hand, TNF-α is known to decrease eNOS expression [36] or increase NO inactivation [37], thus reducing NO availability.”
Background
The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase
Chen, J., Zhang, J., Shaik, N. F., Yi, B., Wei, X., Yang, X., Naik, U. P., Summer, R. S., Yan, G., Xu, X., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011317 · Cited by 36
“Because many pathological conditions are known to decrease eNOS expression in endothelial cells by reducing mRNA stability (5, 6, 28, 29), identification of tubacin as a potent eNOS enhancer suggests that tubacin or its analogues might be effective in ameliorating systemic vascular complications of disease.”
Background
Interleukin-6 Correlates with Endothelial Dysfunction in Young Post-Myocardial Infarction Patients
Eržen, B., Šabović, M., Šebeštjen, M., Keber, I., & Poredoš, P. (2006) · Cardiology · doi:10.1159/000094588 · Cited by 39
Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction
Um, J., & Kim, H. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.11.019 · Cited by 35
Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria
Keating, A. K., Freehauf, C. L., Jiang, H., Brodsky, G. L., Stabler, S. P., Allen, R. H., Graham, D. K., Thomas, J. A., Hove, J. L. K. V., & Maclean, K. N. (2011) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2011.04.012 · Cited by 33
Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection
Palma, C. D., Falcone, S., Panzeri, C., Radice, S., Bassi, M. T., & Clementi, E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05351.x · Cited by 35
“Indeed TNF-a affects eNOS expression in a timedependent way, by inducing first an increase and then a downregulation (Yoshizumi et al. 1993; Bove et al. 2001).”
Background
Role of Renal Cortical Neovascularization in Experimental Hypercholesterolemia
Chade, A., Krier, J. D., Galili, O., Lerman, A., & Lerman, L. O. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.093989 · Cited by 35
Role of nitric oxide, endothelin-1, and inflammatory cytokines in blood pressure regulation in hemodialysis patients
Erkan, E., Devarajan, P., & Kaskel, F. J. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.33915 · Cited by 35
Cardiovascular disease risk in patients with psoriasis receiving biologics targeting TNF-α, IL-12/23, IL-17, and IL-23: A population-based retrospective cohort study
Lin, T., Fan, Y., Fan, K.-S., Juan, C., Chen, Y.-J., & Wu, C.-Y. (2025) · PLoS Medicine · doi:10.1371/journal.pmed.1004591 · Cited by 38
“The upstream pathogenic cytokine of PsO, tumor necrosis factor-α (TNF-α), can trigger oxidative stress and augment angiotensin effects, resulting in endothelial damage and vasomotor disruption [6,7].”
Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-κB) and HOXA9
Trivedi, C. M., Patel, R. C., & Patel, C. V. (2007) · Gene · doi:10.1016/j.gene.2007.11.001 · Cited by 34
Evaluation of inflammatory mediators in the deciduas of pregnant women with pre-eclampsia/eclampsia
Peixoto, A. B., Júnior, E. A., Ribeiro, J. U., Rodrigues, D. B. R., Castro, E. C. C., Caldas, T. M. R. D. C., & Rodrigues, V. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.987117 · Cited by 34
“(eNOS) and induces apoptosis of trophoblast tissue [7,12].”
Background
EXPRESSION OF ENDOTHELIAL CONSTITUTIVE NITRIC OXIDE SYNTHASE mRNA IN GASTROINTESTINAL MUCOSA AND ITS DOWNREGULATION BY ENDOTOXIN
Chen, K., Inoue, M., Wasa, M., Fukuzawa, M., Kamata, S., & Okada, A. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00677-2 · Cited by 34
Dual Role for Nitric Oxide in the Regulation of Plasma Volume and Albumin Escape During Endotoxin Shock in Conscious Rats
Filep, J. G., Delalandre, A., & Beauchamp, M. (1997) · Circulation Research · doi:10.1161/01.res.81.5.840 · Cited by 34
Amelioration of atherosclerotic inflammation and plaques via endothelial adrenoceptor-targeted eNOS gene delivery using redox-sensitive polymer bearing l -arginine
Ain, Q. U., Chung, H., Chung, J. Y., Choi, J., & Kim, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.019 · Cited by 33
Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study
Yacoub, S., Lam, P. K., Huynh, T. T., Ho, H. H. N., Thi, H. T. D., Van, N. T., Lien, L. T., Ha, Q. N. T., Le, D. H. T., Mongkolspaya, J., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix567 · Cited by 34
“We found no changes in levels of ADMA, making competitive inhibition of eNOS as a cause of the endothelial dysfunction less likely; however, the associated inflammatory response, specifically the inhibitory effect of TNF-α on eNOS, may play a role [28].”
Background
Tumour necrosis factor α G−308A polymorphism and risk for coronary artery disease
Wang, X. L., & OOSTERHOF, J. (2000) · Clinical Science · doi:10.1042/cs0980435 · Cited by 35
FSH suppression of nitric oxide synthesis in porcine oocytes
Hattori, M., Nishida, N., TAKESUE, K., et al. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0240065 · Cited by 33
“For example, tumor necrosis factor- is known to desensitize eNOS by controlling the fate of eNOS mRNA (Yoshizumi et al. 1993).”
Background
Characterization of the murine endothelial nitric oxide synthase promoter
Teichert, A.-M., Karantzoulis-Fegaras, F., Wang, Y., Mawji, I. A., Bei, X., Gnanapandithen, K., & Marsden, P. A. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00236-x · Cited by 33
NO from smooth muscle cells decreases NOS expression in endothelial cells: role of TNF-α
de Frutos, T., de Miguel, L. S., Garcı́a-Durán, M., González-Fernández, F., Rodríguez-Feo, J. A., Montón, M., Guerra, J. I., Farré, J., Casado, S., & López-Farré, A. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.4.h1317 · Cited by 32
“It was also demonstrated that TNF-a decreases eNOS expression in endothelial cells (40).”
BackgroundInfluential
Evidence that an endothelial cytosolic protein binds to the 3′-untranslated region of endothelial nitric oxide synthase mRNA
Sánchez de Miguel, L., Alonso, J., González-Fernández, F., de la Osada, J., Montón, M., Rodríguez-Feo, J. A., Guerra, J. I., Arriero, M. M., Rico, L., Casado, S., et al. (1999) · Journal of Vascular Research · doi:10.1159/000025643 · Cited by 32
Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-α
Li, W., Cui, N., Mazzuca, M. Q., Mata, K. M., & Khalil, R. A. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00207.2017 · Cited by 32
“TNF may also 506 downregulate eNOS (8, 96) and mitochondrial biogenesis, leading to mitochondrial 507 dysfunction, oxidative stress and increased ROS (81).”
Background
Berry-Derived Polyphenols in Cardiovascular Pathologies: Mechanisms of Disease and the Role of Diet and Sex
Najjar, R. S., Turner, C. G., Wong, B. J., & Feresin, R. G. (2021) · Nutrients · doi:10.3390/nu13020387 · Cited by 33
“TNF-α decreases eNOS mRNA in endothelial cells in a time-dependent manner [128], as well as eNOS protein expression [129], leading to reduced NO metabolite concentration.”
Nitric oxide deficiency, leukocyte activation, and resultant ischemia are crucial to the pathogenesis of diabetic retinopathy/ neuropathy — preventive potential of antioxidants, essential fatty acids, chromium, ginkgolides, and pentoxifylline
McCarty, M. F. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90217-1 · Cited by 32
MUTATION OF THE VON HIPPEL-LINDAU TUMOUR SUPPRESSOR GENE IN CAPILLARY HAEMANGIOBLASTOMAS OF THE CENTRAL NERVOUS SYSTEM
Oberstraß, J., Reifenberger, G., REIFENBERGER, J., Wechsler, W., & Collins, V. P. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199606)179:2 · Cited by 76
MODULATION OF CORONARY VASOMOTOR TONE BY CYTOKINES IN CARDIAC TRANSPLANT RECIPIENTS
Weis, M., Wildhirt, S. M., Schulze, C. J., et al. (1999) · Transplantation · doi:10.1097/00007890-199911150-00008 · Cited by 32
The Nitric Oxide Pathway and Oxidative Stress in Heart Failure
Searles, C. D. (2002) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2002.00715.x · Cited by 31
Effects of exercise training on the vascular reactivity of the whole kidney circulation in rabbits
de Moraes, R., Gioseffi, G., da Nóbrega, A. C. L., et al. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00923.2003 · Cited by 31
“Interestingly, it has been shown that TNF- induces a downregulation of eNOS, which results from a destabilization of eNOS mRNA with no effect on transcription (25, 60).”
Background
Poor Oral Health, That Is, Decreased Frequency of Tooth Brushing, Is Associated With Endothelial Dysfunction
Kajikawa, M., Nakashima, A., Maruhashi, T., Iwamoto, Y., Iwamoto, A., Matsumoto, T., Hidaka, T., Kihara, Y., Chayama, K., Goto, C., et al. (2014) · Circulation Journal · doi:10.1253/circj.cj-13-1330 · Cited by 31
Gestational Diabetes, Preeclampsia and Cytokine Release: Similarities and Differences in Endothelial Cell Function
Rao, R., Sen, S., Han, B., Ramadoss, S., & Chaudhuri, G. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-1031-1_6 · Cited by 32
The Endothelial Cell Nitric Oxide Synthase: Is It Really Constitutively Expressed?
Harrison, D. G., Venema, R. C., Arnal, J., Inoue, N., Ohara, Y., Sayegh, H. S., & Murphy, T. J. (1995) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7346-8_16 · Cited by 32
Association between dietary inflammation and erectile dysfunction among US adults: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2001–2004
Ruan, Z., Xie, X., Yu, H., Liu, R., Jing, W., & Lü, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.930272 · Cited by 30
Proteasome inhibition prevents experimentally-induced endothelial dysfunction
Lorenz, M., Wilck, N., Meiners, S., et al. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.04.016 · Cited by 30
Impairment by interleukin 1β and tumour necrosis factor α of the glucagon-induced increase in phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis in cultured rat hepatocytes
Christ, B., & Nath, A. (1996) · Biochemical Journal · doi:10.1042/bj3200161 · Cited by 30
Emerging concepts regarding pannexin 1 in the vasculature
Good, M. E., Begandt, D., DeLalio, L. J., Keller, A., Billaud, M., & Isakson, B. E. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150045 · Cited by 27
Role of Tumor Necrosis Factor-α and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive Rat
Small, H. Y., Nosalski, R., Morgan, H. L., Beattie, E. C., Guzik, T. J., Graham, D., & Delles, C. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07933 · Cited by 28
Predictors of endothelial dysfunction and atherosclerosis in rheumatoid arthritis in Indian population
Verma, I., Syngle, A., & Krishan, P. (2016) · Indian Heart Journal · doi:10.1016/j.ihj.2016.10.013 · Cited by 29
“[96_TD$DIFF] The proinflammatory cytokine, TNF-a also degrades endothelial nitric oxide synthase (eNOS) mRNA and impaired NO bioavailability[97_TD$DIFF].(31,32) This impaired NO bioavailability is a primary manifestation of endothelial dysfunction, leading to impairment in EDV.”
Background
Exploring the role of body mass index in relationship of serum nitric oxide and advanced glycation end products in apparently healthy subjects
Foroumandi, E., Alizadeh, M., Kheirouri, S., & Jafarabadi, M. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213307 · Cited by 29
Regulation of Nitric Oxide Synthase Expression and Activity
Förstermann, U. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57077-3_4 · Cited by 29
Tyrosine-kinase-dependent regulation of the nitric oxide synthase gene by endothelin-1 in human endothelial cells
Marsen, T. A., Egink, G., Suckau, G., et al. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004249900079 · Cited by 29
Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess
Luk, C., Haywood, N. J., Bridge, K., & Kearney, M. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.882923 · Cited by 30
Expression of Endothelial Nitric Oxide Synthase in Human Peritoneal Tissue
Arriero, M., Rodríguez-Feo, J. A., Celdrán, Á., de Miguel, L. S., González-Fernández, F., Fortes, J., Reyero, A., Frieyro, O., de la Pinta, J. C., Franco, A., et al. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11101848 · Cited by 28
Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways
Shin, C. S., Lecanda, F., Sheikh, S., Weitzmann, L., Cheng, S., & Civitelli, R. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20000915)78:4 · Cited by 104
Major Depressive Disorder and Inflammatory Markers in Elderly Patients With Heart Failure
Andrei, A. M., Fráguas, R., Telles, R. M. S., Alves, T. C. T. F., Strunz, C. M. C., Nussbacher, A., Rays, J., Iosifescu, D. V., & Wajngarten, M. (2007) · Psychosomatics · doi:10.1176/appi.psy.48.4.319 · Cited by 28
Analysis of expression and promoter function of the human inducible nitric oxide synthase gene in DLD-1 cells and monkey hepatocytes
Laubach, V. E., Zhang, C. X., Russell, S. W., Murphy, W. J., & Sherman, P. A. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(96)06909-6 · Cited by 28
Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats.
Weigert, A. L. L., Higa, E. M. S., Niederberger, M., et al. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v5122067 · Cited by 28
Up‐regulation of endothelial nitric oxide synthase expression by cyclic guanosine 3′,5′‐monophosphate
Ravichandran, L. V., & Johns, R. A. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01134-z · Cited by 28
Inflammation and endothelial dysfunction in rheumatoid arthritis.
González-Gay, M. Á., González‐Juanatey, C., & Martin, J. J. (2006) · PubMed · Cited by 28
Etanercept Improves Cognitive Performance and Increases eNOS and BDNF Expression During Experimental Vascular Dementia in Streptozotocin- induced Diabetes
Utkan, T., Yazır, Y., Karson, A., & Bayramgürler, D. (2015) · Current Neurovascular Research · doi:10.2174/1567202612666150311111340 · Cited by 27
“In endothelial cell cultures, TNF- decreases the expression of endothelial nitric oxide synthase (eNOS), which is the primary enzyme involved in NO production in the vasculature [23].”
Background
Angiotensin II type 1 receptor blockers prevent tumor necrosis factor-α-mediated endothelial nitric oxide synthase reduction and superoxide production in human umbilical vein endothelial cells
Kataoka, H., Murakami, R., Numaguchi, Y., Okumura, K., & Murohara, T. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.025 · Cited by 27
Control and Consequences of Endothelial Nitric Oxide Formation
Fleming, I., & Busse, R. (1995) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61086-8 · Cited by 29
Increased Nitric Oxide in Proportion to the Severity of Heart Failure in Patients With Dilated Cardiomyopathy. Close Correlation of Tumor Necrosis Factor-.ALPHA. With Systemic and Local Production of Nitric Oxide.
Sugamori, T., Ishibashi, Y., Shimada, T., Takahashi, N., Sakane, T., Ohata, S., Kunizawa, Y., Inoue, S., Nakamura, K., Ohta, Y., et al. (2002) · Circulation Journal · doi:10.1253/circj.66.627 · Cited by 27
Dysfunction of Microcirculation in Atherosclerosis: Implications of Nitric Oxide, Oxidative Stress, and Inflammation
Aleksandrowicz, M., Konop, M., Rybka, M., Mazurek, Ł., Stradczuk‐Mazurek, M., Kciuk, M., Bądzyńska, B., Dobrowolski, L., & Kuczeriszka, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136467 · Cited by 31
“Additionally, eNOS mRNA levels in endothelial cells are directly decreased by high TNF-α concentrations [22,23].”
Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review
Naidoo, N., Moodley, J., & Naicker, T. (2021) · Hypertension Research · doi:10.1038/s41440-020-00604-y · Cited by 27
Endothelial membrane potential regulates production of both nitric oxide and superoxide – a fundamental determinant of vascular health
McCarty, M. F. (1999) · Medical Hypotheses · doi:10.1054/mehy.1998.0758 · Cited by 27
Infliximab improves endothelial dysfunction in a mouse model of antiphospholipid syndrome: Role of reduced oxidative stress
Benhamou, Y., Miranda, S., Armengol, G., et al. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.03.014 · Cited by 25
“This unreported effect may be in part the consequence of the elevated level of TNFα which is known to shorten the half-life of eNOS mRNA and to diminish the transcription rate of eNOS [22].”
Background
The effect of etanercept on aortic nitric oxide-dependent vasorelaxation in an unpredictable chronic, mild stress model of depression in rats
Bayramgürler, D., Karson, A., Yazır, Y., Celikyurt, I. K., Kurnaz, S., & Utkan, T. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.007 · Cited by 27
“In endothelial cell culture, TNF-α decreases the expression of eNOS, which is the primary enzyme involved in NO production in the vasculature (Yoshizumi et al., 1993).”
Background
Antiobesogenic Role of Endothelial Nitric Oxide Synthase
Sansbury, B. E., & Hill, B. G. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00013-1 · Cited by 26
Correlation between Flicker-Induced Retinal Vessel Vasodilatation and Plasma Biomarkers of Endothelial Dysfunction in Hypertensive Patients
Machalińska, A., Pius‐Sadowska, E., Babiak, K., et al. (2017) · Current Eye Research · doi:10.1080/02713683.2017.1358372 · Cited by 25
Endothelial dysfunction in chronic heart failure: clinical and therapeutic implications
Adamopoulos, S. N., Parissis, J., & Kremastinos, D. T. (2002) · European Journal of Internal Medicine · doi:10.1016/s0953-6205(02)00033-x · Cited by 25
Mitochondria As Potential Targets of Flavonoids: Focus on Adipocytes and Endothelial Cells
Duluc, L., Soleti, R., Clere, N., Andriantsitohaina, R., & Simard, G. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712803251467 · Cited by 24
“Indeed, endothelial dysfunction, considered as the first step in the progression of vascular diseases, has been reported in obese patients and is induced by TNF through a down-regulation of endothelial nitric oxide (NO) synthase (eNOS) expression [11]; or by leptin, whose circulating levels are closely related to body…”
Background
Integrated proteomic analysis of tumor necrosis factor α and interleukin 1β-induced endothelial inflammation
Béguin, E. P., van den Eshof, B. L., Hoogendijk, A. J., Nota, B., Mertens, K., Meijer, A. B., & van den Biggelaar, M. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.08.011 · Cited by 24
Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence
Chen, Y., Stampley, J., Irving, B. A., & Dugas, T. R. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz203 · Cited by 22
Ethanol Suppresses Mycobacteria tuberculosis‐Induced mRNA for Nitric Oxide Synthase in Alveolar Macrophages, In Vivo
Greenberg, S. S., Xie, J., Kolls, J. K., Nelson, S., Didier, P. J., & Mason, C. M. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01521.x · Cited by 24
C-reactive protein, inflammation and atherosclerosis: do we really understand it yet?
Weintraub, W. (2000) · European Heart Journal · doi:10.1053/euhj.2000.2109 · Cited by 24
“European Heart Journal (2000) 21, 958–960 doi:10.1053/euhj.2000.2109, available online at http://www.idealibrary.com on”
BackgroundInfluential
Endothelial protective and antishock effects of a selective estrogen receptor modulator in rats
Ma, X. L., Gao, F., Chen, J., Christopher, T. A., Lopez, B. L., Ohlstein, E. H., & Yue, T. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h876 · Cited by 24
Infection with respiratory syncytial virus and water-soluble components of cigarette smoke alter production of tumour necrosis factor α and nitric oxide by human blood monocytes
Raza, M. W., Essery, S. D., Weir, D. M., et al. (1999) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1999.tb01310.x · Cited by 24
Vasodilation by intrathecal lipopolysaccharide of the cerebral arteries after subarachnoid haemorrhage in dogs
Tanazawa, T., Suzuki, Y., Anzai, M., et al. (1996) · Acta Neurochirurgica · doi:10.1007/bf01411745 · Cited by 24
Megakaryocyte Diversity in Ontogeny, Functions and Cell-Cell Interactions
Khatib-Massalha, E., & Méndez‐Ferrer, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.840044 · Cited by 26
“during inflammation, hypoxia or exposure to damaging stimuli (75, 76)], which is characterized by higher levels of reactive oxygen species (ROS) and apoptosis, impaired migration and angiogenesis , may contribute to the pathogenesis of aplastic anemias and contribute to graft failure after BM transplantation (77–79).”
Background
Immunogenetic biomarkers in inflammatory bowel diseases: Role of theIBD3region
Muro, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15037 · Cited by 23
Chronic Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase and Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2) Augments Vascular Response to Limb Ischemia in Type 2 Diabetic Mice
Choi, S. K., Galán, M., Partyka, M., Trebak, M., Belmadani, S., & Matrougui, K. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.09.016 · Cited by 21
Weight Loss and Race Modulate Nitric Oxide Metabolism in Overweight Women
Fenster, C. P., Darley-Usmar, V. M., Landar, A. L., Gower, B. A., Weinsier, R. L., Hunter, G. R., & Patel, R. P. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.021 · Cited by 23
“For example, stimuli capable of downregulating eNOS expression and NO production include glucose, tumor necrosis factor a (TNF-a) [20], and high levels of oxidized low-density”
Background
Basal and nitroglycerin-induced exhaled nitric oxide before and after cardiac surgery with cardiopulmonary bypass
̈vesi, T. K., Royston, D., Yacoub, M. H., et al. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg114 · Cited by 23
The Role of Nitric Oxide in Heart Failure
Macdonald, P. S., Schyvens, C. G., & Winlaw, D. S. (1996) · Drugs & Aging · doi:10.2165/00002512-199608060-00007 · Cited by 23
Influence of amlodipine and atenolol on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1, IL-6 in spontaneously hypertensive rats (SHR).
Andrzejczak, D., Górska, D., & Czarnecka, E. (2006) · PubMed · Cited by 23
Endothelial apoptosis and circulating endothelial cells after bypass grafting with and without cardiopulmonary bypass☆
Schmid, F., Vudattu, N. K., Floerchinger, B., et al. (2006) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2006.01.029 · Cited by 22
“It has been reported that cytokine receptors of the tumornecrosis factor family regulate a number of stages of inflammation [14—16] especially endothelial cell activation [1,17,18].”
Background
Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats
Göçmez, S. S., Yazır, Y., Gacar, G., ŞAHİN, T. D., Arkan, S., Karson, A., & Utkan, T. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113019 · Cited by 22
Disrupted eNOS activity and expression account for vasodilator dysfunction in different stage of sepsis
Hu, S., Pi, Q., Xu, X., Yan, J., Guo, Y., Tan, W., He, A., Cheng, Z., Luo, S., & Xia, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118606 · Cited by 22
Effects of endotoxic shock on neuronal NOS and calcium transients in rat cardiac myocytes
Comini, L., Boraso, A., Bachetti, T., Bernocchi, P., Pasini, E., Bastianon, D., Curello, S., Terracciano, C. M., Ceconi, C., & Ferrari, R. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2004.11.001 · Cited by 22
Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity
Ali, M. I., Chen, X., & Didion, S. P. (2015) · Physiological Reports · doi:10.14814/phy2.12630 · Cited by 22
“Several stimuli are known to influence expression of eNOS (Balligand et al. 2009; Cosentino et al. 1997; Drummond et al. 2000; Saura et al. 2006; Srinivasan et al. 2004; Sun et al. 2012; Yoshizumi et al. 1993).”
Background
Identification of an Arginase II Inhibitor via RapidFire Mass Spectrometry Combined with Hydrophilic Interaction Chromatography
Asano, W., Takahashi, Y., Kawano, M., & Hantani, Y. (2018) · SLAS DISCOVERY · doi:10.1177/2472555218812663 · Cited by 23
Nitric oxide synthases: regulation in disease
Wong, G. K. T., & Marsden, P. A. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.1.215 · Cited by 23
“TNF-a-mediated decrease in ecNOS mRNA content in endothelial cells is dependent on new protein synthesis as it can be blocked by cycloheximide [34].”
Background
Síndrome X cardiovascular y disfunción endotelial
Vázquez‐Rey, E., & Kaski, J. C. (2003) · Revista Española de Cardiología · doi:10.1016/s0300-8932(03)76843-2 · Cited by 23
Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels
Hauck, W., Samlalsingh-Parker, J., Glibetić, M., et al. (1999) · Seminars in Perinatology · doi:10.1016/s0146-0005(99)80070-6 · Cited by 22
HIV-Associated Myocarditis
Bárbaro, G. (2005) · Heart Failure Clinics · doi:10.1016/j.hfc.2005.06.006 · Cited by 22
“Vascular production of NO could lead to vasodilation but, conversely, TNF-a could also be down-regulating the isoform of iNOS in the endothelium, because TNF-a reduces the stability of endothelial NOS-RNA [30].”
Background
Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences
González, A., & Valencia, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073632 · Cited by 22
“…of placental Furthermore, interleukins such as TNF-α and IL-6 lead to an increase in vascular permeability, and TNF-α can activate endothelial cells, decrease the amount of mRNA in nitric oxide synthase, and increase the production of endothelin-1, which is a potent vasoconstrictor [129–131].”
Background
The biology of exhaled nitric oxide (NO) in ischemia–reperfusion-induced lung injury: A tale of dynamism of NO production and consumption
Marczin, N. (2005) · Vascular Pharmacology · doi:10.1016/j.vph.2005.08.011 · Cited by 21
Serum From Advanced Heart Failure Patients Promotes Angiogenic Sprouting and Affects the Notch Pathway in Human Endothelial Cells
Pannella, M., Caliceti, C., Fortini, F., Aquila, G., Sega, F. V. D., Pannuti, A., Fortini, C., Morelli, M. B., Fucili, A., Francolini, G., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25373 · Cited by 22
“…are highly predictive of cardiovascular events in HF patients (Harutyunyan et al., 2013; Osmancik et al., 2013) and a large body of evidence suggests that this may be related to the induction of endothelial dysfunctions (Yoshizumi et al., 1993; Agnoletti et al., 1999a; Crook et al., 2002).”
Decreased frequency and duration of tooth brushing is a risk factor for endothelial dysfunction
Matsui, S., Kajikawa, M., Maruhashi, T., Iwamoto, Y., Iwamoto, A., Oda, N., Kishimoto, S., Hidaka, T., Kihara, Y., Chayama, K., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.03.049 · Cited by 20
Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice
Hiroi, Y., Noma, K., Kim, H.-H., Sladojević, N., Tabit, C. E., Li, Y., Soydan, G., Salomone, S., Moskowitz, M. A., & Liao, J. K. (2018) · Circulation Journal · doi:10.1253/circj.cj-17-0732 · Cited by 21
Effect of IBD sera on expression of inducible and endothelial nitric oxide synthase in human umbilical vein endothelial cells
Palatka, K. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i11.1730 · Cited by 21
Nitric oxide and biopterin: a study in Chiaroscuro.
Nathan, C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117176 · Cited by 21
Phenotypic changes in rat and guinea pig coronary microvascular endothelium after culture: loss of nitric oxide synthase activity
Lang, D. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00336-8 · Cited by 21
Effect of chronic angiotensin-converting enzyme inhibition on endothelial function in patients with chronic heart failure
Drexler, H., Kurz, S. K., Jeserich, M., et al. (1995) · The American Journal of Cardiology · doi:10.1016/0002-9149(95)90045-4 · Cited by 21
Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells
Zhao, J. H., Suyama, A., Chung, H., Fukuda, T., Tanaka, M., & Matsui, T. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.12.044 · Cited by 20
Improvement of Function and Morphology of Tumor Necrosis Factor-.ALPHA. Treated Endothelial Cells With 17-.BETA. Estradiol A Preliminary Study for a Feasible Simple Model for Atherosclerosis
Suwannaprapha, P., Chaisri, U., Riyong, D., & Maneerat, Y. (2005) · Circulation Journal · doi:10.1253/circj.69.730 · Cited by 19
Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Ischemia-Reperfusion in Rats
Zhang, Y., Li, H., Wang, M., Meng, G., Wang, Z., Deng, J., Wang, M., Zhang, Q., Yang, S., & Jiang, H. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9208949 · Cited by 20
“reported inhibiting eNOS expression could lead to endothelial dysfunction in human umbilical vein endothelial cells [34].”
Associations of inflammatory markers and vascular cell adhesion molecule-1 with endothelial dysfunction in collagen-induced arthritis
Mokotedi, L. P., Millen, A. M. E., Mogane, C., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172786 · Cited by 20
Long-Term Effect of Phytoestrogens from Curcuma comosa Roxb. on Vascular Relaxation in Ovariectomized Rats
Intapad, S., Saengsirisuwan, V., Prasannarong, M., et al. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203173b · Cited by 20

Authors: Yoshizumi, M., Perrella, M. A., Burnett, J. C., & Lee, M. E.
Affiliations: Harvard University (US)
ORCID: Yoshizumi, M
Perrella, M A
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1993-07
Volume: 73
Issue: 1
Pages: 205-209
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.73.1.205
OpenAlex: W2145570729
Cited by: 771
References: 0
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 12 · 2018: 16 · 2017: 14 · 2016: 11 · 2015: 17 · 2014: 35 · 2013: 19 · 2012: 18
FWCI: 21.77
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: TNF-α, endothelial nitric oxide synthase, constitutive nitric oxide synthase, mRNA stability, mRNA degradation, human umbilical vein endothelial cells, atherosclerosis, cycloheximide, gene transcription
MeSH terms: Amino Acid Oxidoreductases, Base Sequence, Endothelium, Vascular, Half-Life, Humans, Molecular Sequence Data, RNA, Messenger, Transcription, Genetic, Tumor Necrosis Factor-alpha, Umbilical Veins, Down-Regulation, Polymerase Chain Reaction, Nitric Oxide Synthase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks