The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.
Open accessAbstract
The role of nitric oxide (NO) in the regulation of O2 consumption was studied in chronically instrumented conscious dogs. A specific NO synthesis inhibitor, nitro-L-arginine (NLA, 30 mg/kg i.v.), significantly increased mean arterial pressure from 100 +/- 4 to 134 +/- 5 mm Hg (mean +/- SEM) and total peripheral resistance by 157 +/- 16% and reduced cardiac output by 47 +/- 3% and heart rate by 34 +/- 6% after 120 minutes. Changes in arterial blood gases were not observed. There were significant changes in PO2 (-14 +/- 2 mm Hg), O2 saturation (-21 +/- 2%), the percentage of hemoglobin as oxyhemoglobin (-21 +/- 2%), and O2 content (-3.0 +/- 0.9 vol%) and a significant increase in percent reduced hemoglobin (21 +/- 1%) in mixed venous blood, associated with an increase in O2 extraction (5.1 +/- 0.2 vol%) (all P < .01). O2 consumption was increased from 124 +/- 6 to 155 +/- 9 mL/min (P < .05). Methoxamine, titrated to have hemodynamic effects similar to those of NLA (eg, mean arterial pressure increased from 97 +/- 4 to 131 +/- 5 mm Hg), had much smaller effects on venous blood gases, hemoglobin, and O2 extraction (2.3 +/- 0.7 vol%) and no significant effect on O2 consumption. NLA also caused an increase in O2 consumption of 37 +/- 8% (P < .01) in quietly resting conscious dogs that had undergone pretreatment with hexamethonium and atropine, but no significant change in O2 consumption in dogs anesthetized with barbiturate.(ABSTRACT TRUNCATED AT 250 WORDS)
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“In vivo, NOS inhibition, which would reduce endogenous NO production, increases oxygen consumption () in dogs [20] and rats [21]”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [20]
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Cites
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Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080
Nitric oxide signaling in health and disease
Lundberg, J. O., & Weitzberg, E. (2022) · Cell · doi:10.1016/j.cell.2022.06.010 · Cited by 879
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759
Nitric Oxide and Cardiac Function
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Metadata
- Authors
- Shen, W., Xu, X., Ochoa, M., Zhao, G., Wolin, M. S., & Hintze, T. H.
- Affiliations
- New York Medical College (US)
- Venue
- Circulation Research
- Published
- 1994-12
- Volume
- 75
- Issue
- 6
- Pages
- 1086-1095
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2059418292
- Cited by
- 317
- References
- 34
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 8 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 5
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (HL50142, P01HL043023, P01 HL 43023, HL 43023, R01HL050142, HL-31068)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- nitric oxide, oxygen consumption, nitric oxide synthase inhibition, nitro-L-arginine, methoxamine, oxygen extraction, hemodynamics, arterial blood gases, hemoglobin decrease, conscious dogs
- MeSH terms
- Amino Acid Oxidoreductases, Animals, Arginine, Cardiac Output, Consciousness, Dogs, Hemodynamics, Methoxamine, Nitric Oxide, Oxygen Consumption, Time Factors, Nitric Oxide Synthase, Nitroarginine
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