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Cited by 317Nitric Oxide and Endothelin EffectsHemoglobin structure and functionCardiovascular and exercise physiology

The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.

Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.

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Shen, W, Xu, X, Ochoa, M, Zhao, G, Wolin, M S, Hintze, T H·1994·Circulation Research
DOI 10.1161/01.res.75.6.1086
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Abstract

The role of nitric oxide (NO) in the regulation of O2 consumption was studied in chronically instrumented conscious dogs. A specific NO synthesis inhibitor, nitro-L-arginine (NLA, 30 mg/kg i.v.), significantly increased mean arterial pressure from 100 +/- 4 to 134 +/- 5 mm Hg (mean +/- SEM) and total peripheral resistance by 157 +/- 16% and reduced cardiac output by 47 +/- 3% and heart rate by 34 +/- 6% after 120 minutes. Changes in arterial blood gases were not observed. There were significant changes in PO2 (-14 +/- 2 mm Hg), O2 saturation (-21 +/- 2%), the percentage of hemoglobin as oxyhemoglobin (-21 +/- 2%), and O2 content (-3.0 +/- 0.9 vol%) and a significant increase in percent reduced hemoglobin (21 +/- 1%) in mixed venous blood, associated with an increase in O2 extraction (5.1 +/- 0.2 vol%) (all P < .01). O2 consumption was increased from 124 +/- 6 to 155 +/- 9 mL/min (P < .05). Methoxamine, titrated to have hemodynamic effects similar to those of NLA (eg, mean arterial pressure increased from 97 +/- 4 to 131 +/- 5 mm Hg), had much smaller effects on venous blood gases, hemoglobin, and O2 extraction (2.3 +/- 0.7 vol%) and no significant effect on O2 consumption. NLA also caused an increase in O2 consumption of 37 +/- 8% (P < .01) in quietly resting conscious dogs that had undergone pretreatment with hexamethonium and atropine, but no significant change in O2 consumption in dogs anesthetized with barbiturate.(ABSTRACT TRUNCATED AT 250 WORDS)

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Research works printed but not linked: 6

  1. Drapier SR, Hibbs JB. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. J Clin Invest. 1986;78:790-797.
  2. Geng YJ, Hansson GK, Holme E. Interferon-y and tumor necrosis factor synergize to induce nitric oxide production and inhibit mito- chondrial respiration in vascular smooth muscle cells. Circ Res. 1992;71:1268-1276.
  3. Shen W, Wang J, Xu X, Hintze TH. EDRF-mediated coronary dilation following carotid chemoreflex stimulation in conscious dogs. FASEB J. 1993;7:A213. Abstract.
  4. Hintze TH, Shen W, Wang J, Lundborg M. Role of EDRF/shear rate in the control of blood flow during exercise. JAm Coll Cardiol. 1993;21:432A. Abstract.
  5. Sakuma I, Togashi H, Yoshioka M, Saito H, Yanagida M, Tamura M, Kobayashi T, Yasuda H, Gross SS, Levi R. N0-methyl-L- arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ Res. 1992;70:607-61 1.
  6. Buxton IL, Cheek DL, Eckman D, Westfall DP, Sanders KM, Keef KD. N-Nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res. 1993;72: 387-395. Downloaded from http://ahajournals.org by on March 9, 2024

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Metadata

Authors
Shen, W., Xu, X., Ochoa, M., Zhao, G., Wolin, M. S., & Hintze, T. H.
Affiliations
New York Medical College (US)
ORCID
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1994-12
Volume
75
Issue
6
Pages
1086-1095
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.75.6.1086
OpenAlex
W2059418292
Cited by
317
References
34
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 8 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 5
FWCI
9.29
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute (HL50142, P01HL043023, P01 HL 43023, HL 43023, R01HL050142, HL-31068)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
nitric oxide, oxygen consumption, nitric oxide synthase inhibition, nitro-L-arginine, methoxamine, oxygen extraction, hemodynamics, arterial blood gases, hemoglobin decrease, conscious dogs
MeSH terms
Amino Acid Oxidoreductases, Animals, Arginine, Cardiac Output, Consciousness, Dogs, Hemodynamics, Methoxamine, Nitric Oxide, Oxygen Consumption, Time Factors, Nitric Oxide Synthase, Nitroarginine

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