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Homeometric Autoregulation in the Heart
Abstract
The effect of increasing the activity of the ventricle on its contractility was investigated. Several beats after the ventricle increases the amount of tension it develops per unit of time, it exhibits an increased contractility as shown by the increase in work and the more rapid development of pressure from a given end-diastolic pressure or fiber length. This has been termed homeometric autoregulation in contradistinction to the Frank-Starling or heterometric type of autoregulation. It was found that changes in coronary flow are not essential to the exhibition of this phenomenon. Possible mechanisms and the physiologic significance of the findings are discussed.
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Cited by
Glower, D. D., Spratt, J. A., Snow, N. D., Kabas, J. S., Davis, J. W., Olsen, C. O., Tyson, G. S., Sabiston, D. C., & Rankin, J. S. (1985) · Circulation · doi:10.1161/01.cir.71.5.994 · Cited by 855
Lymphatic pumping: mechanics, mechanisms and malfunction
Scallan, J. P., Zawieja, S. D., Castorena‐Gonzalez, J. A., & Davis, M. J. (2016) · The Journal of Physiology · doi:10.1113/jp272088 · Cited by 424
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
Hill, J. A., Karimi, M., Kutschke, W., Davisson, R. L., Zimmerman, K., Wang, Z., Kerber, R. E., & Weiss, R. M. (2000) · Circulation · doi:10.1161/01.cir.101.24.2863 · Cited by 309
Intrinsic increase in lymphangion muscle contractility in response to elevated afterload
Davis, M. J., Scallan, J. P., Wolpers, J. H., Muthuchamy, M., Gashev, A. A., & Zawieja, D. C. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01097.2011 · Cited by 133
Metadata
- Authors
- SARNOFF, S. J., MITCHELL, J. H., GILMORE, J. P., & REMENSNYDER, J. P.
- Venue
- Circulation Research
- Published
- 1960-09
- Volume
- 8
- Issue
- 5
- Pages
- 1077-1091
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2141066416
- Cited by
- 327
- References
- 0
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Homeometric Autoregulation in the Heart. https://app.cochat.ai/papers/10.1161/01.res.8.5.1077
- The paper
- SARNOFF, S. J., MITCHELL, J. H., GILMORE, J. P., & REMENSNYDER, J. P. (1960). Homeometric Autoregulation in the Heart. Circulation Research. https://doi.org/10.1161/01.res.8.5.1077
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.