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Homeometric Autoregulation in the Heart

SARNOFF, S. J., MITCHELL, J. H., GILMORE, J. P., REMENSNYDER, J. P.·1960·Circulation Research

Abstract

The effect of increasing the activity of the ventricle on its contractility was investigated. Several beats after the ventricle increases the amount of tension it develops per unit of time, it exhibits an increased contractility as shown by the increase in work and the more rapid development of pressure from a given end-diastolic pressure or fiber length. This has been termed homeometric autoregulation in contradistinction to the Frank-Starling or heterometric type of autoregulation. It was found that changes in coronary flow are not essential to the exhibition of this phenomenon. Possible mechanisms and the physiologic significance of the findings are discussed.

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Metadata

Authors
SARNOFF, S. J., MITCHELL, J. H., GILMORE, J. P., & REMENSNYDER, J. P.
Venue
Circulation Research
Published
1960-09
Volume
8
Issue
5
Pages
1077-1091
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2141066416
Cited by
327
References
0
FWCI
13.25
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Homeometric Autoregulation in the Heart. https://app.cochat.ai/papers/10.1161/01.res.8.5.1077
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SARNOFF, S. J., MITCHELL, J. H., GILMORE, J. P., & REMENSNYDER, J. P. (1960). Homeometric Autoregulation in the Heart. Circulation Research. https://doi.org/10.1161/01.res.8.5.1077

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.