Monitoring Disease Progression in CADASIL With Diffusion Magnetic Resonance Imaging: A Study With Whole Brain Histogram Analysis
Open accessAbstract
Background and Purpose— In cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a large increase in water diffusion has been found both inside and outside the cerebral lesions as detected on conventional MRI. The aim of the present study was to assess the sensitivity of diffusion tensor imaging for monitoring the progression of cerebral tissue damage during the course of CADASIL. Methods— With the use of diffusion tensor imaging, whole brain trace of the diffusion tensor [Trace(D)] histograms were obtained in 22 CADASIL patients and 12 age-matched controls at baseline, in 14 patients after a mean delay of 21 months, and in 5 controls after a mean delay of 29 months. Parameters derived from these histograms (mean value, peak height, and peak location) were analyzed at baseline and during the follow-up. Results— At baseline, all the histogram parameters differed between patients and controls and were found to be significantly correlated with both the Mini-Mental State Examination score and Rankin Scale score in the patient group. The follow-up study showed a decrease in the peak height associated with an increase in the mean value of whole brain Trace(D) histograms in the 14 CADASIL patients scanned twice. The diffusion changes appeared larger in the patients whose Rankin score increased during the study period. Conclusions— These results suggest that the measurement of water diffusion over time is a sensitive marker for the progression of tissue damage in the brain. Thus, quantitative diffusion MRI can be used to monitor disease progression in CADASIL and possibly in other types of small-vessel brain disorders.
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Whole-brain diffusion trace histograms differ significantly between CADASIL patients and age-matched controls, indicating widespread microstructural tissue damage.
“Significant differences in histograms representing the whole-brain trace of the diffusion have been observed between CADASIL patients and age-matched controls, pointing to the presence of widespread microstructural tissue damage in this disease [48].”
From Clinical and research applications of magnetic resonance imaging in the study of CADASIL (2019) · cites this paper as [48]
DTI studies support significant correlations between measures of disability or global cognitive functioning and diffusion parameters in CADASIL.
“Overall, these studies support significant correlations between measures of disability or global cognitive functioning and diffusion parameters.”
From Clinical and research applications of magnetic resonance imaging in the study of CADASIL (2019) · cites this paper as [48]
Molko et al. (2002) reported larger changes in whole-brain diffusion parameters in patients experiencing clinical deterioration over time than in patients maintaining a stable status.
“Additionally, Molko et al. (2002) reported larger changes in whole-brain diffusion parameters in patients experiencing clinical deterioration over time than in patients maintaining a stable status [48].”
From Clinical and research applications of magnetic resonance imaging in the study of CADASIL (2019) · cites this paper as [48]
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Clinical and research applications of magnetic resonance imaging in the study of CADASIL
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- Authors
- Molko, N., Pappata, S., Mangin, J.-F., Poupon, F., LeBihan, D., Bousser, M.-G., & Chabriat, H.
- Affiliations
- Inserm (FR)
- From INSERM U562 (N.M., S.P.) and UNAF (J-F.M., F.P., D.L., M-G.B., H.C.), IFR 49, SHFJ-CEA, Orsay, and Department of Neurology, CHU Lariboisière (H.C.), Paris, France.
- Venue
- Stroke
- Published
- 2002-12
- Volume
- 33
- Issue
- 12
- Pages
- 2902-2908
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2167399961
- Cited by
- 116
- References
- 33
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Assistance Publique - Hôpitaux de Paris
- Assistance publique-Hôpitaux de Paris
- Topics
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- CADASIL, disease progression monitoring, diffusion tensor imaging, water diffusion, cerebral white matter damage, quantitative diffusion MRI
- MeSH terms
- Adult, Aged, Brain, Cross-Sectional Studies, Diffusion, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Proto-Oncogene Proteins, Receptors, Cell Surface, Regression Analysis, Sensitivity and Specificity, Dementia, Multi-Infarct, Disease Progression, Diffusion Magnetic Resonance Imaging
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