The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Mechanisms of Hemorrhagic Transformation After Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke
Open accessAbstract
Reperfusion therapy with tissue plasminogen activator (tPA) is a rational therapy for acute ischemic stroke. Properly titrated use of tPA improves clinical outcomes. However, there is also an associated risk of hemorrhagic transformation after tPA therapy. Emerging data now suggest that some of these potentially neurotoxic side effects of tPA may be due to its signaling actions in the neurovascular unit. Besides its intended role in clot lysis, tPA is also an extracellular protease and signaling molecule in brain. tPA mediates matrix remodeling during brain development and plasticity. By interacting with the NMDA-type glutamate receptor, tPA may amplify potentially excitotoxic calcium currents. At selected concentrations, tPA may be vasoactive. Finally, by augmenting matrix metalloproteinase (MMP) dysregulation after stroke, tPA may degrade extracellular matrix integrity and increase risks of neurovascular cell death, blood–brain barrier leakage, edema, and hemorrhage. Understanding these pleiotropic actions of tPA may reveal new therapeutic opportunities for combination stroke therapy.
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Cites
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Self-citationMetalloproteinases in biology and pathology of the nervous system
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Self-citationLRP: a multifunctional scavenger and signaling receptor
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Cited by
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
Yang, C., Hawkins, K. E., Doré, S., & Candelario-Jalil, E. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00136.2018 · Cited by 871
A new penumbra: transitioning from injury into repair after stroke
Lo, E. H. (2008) · Nature Medicine · doi:10.1038/nm1735 · Cited by 611
Self-citationBlood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke
Khatri, R., McKinney, A. M., Swenson, B., & Janardhan, V. (2012) · Neurology · doi:10.1212/wnl.0b013e3182697e70 · Cited by 478
Delivery of peptide and protein drugs over the blood–brain barrier
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Metadata
- Authors
- Wang, X., Tsuji, K., Lee, S.-R., Ning, M., Furie, K. L., Buchan, A. M., & Lo, E. H.
- Venue
- Stroke
- Published
- 2004-11
- Volume
- 35
- Issue
- 11_suppl_1
- Pages
- 2726-2730
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2096316234
- Cited by
- 334
- References
- 51
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, X., Tsuji, K., Lee, S.-R., Ning, M., Furie, K. L., Buchan, A. M., & Lo, E. H. (2004). Mechanisms of Hemorrhagic Transformation After Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke. Stroke. https://doi.org/10.1161/01.str.0000143219.16695.af
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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